ライフサイエンスコーパス: alpha3beta1 integrin

1 umor cell adhesion and directly binds to the alpha3beta1 integrin.

2 4SF proteins may link PI 4-K activity to the alpha3beta1 integrin.

3 t their interactions are mediated in part by alpha3beta1 integrin.

4 ot for the association between KAI1/CD82 and alpha3beta1 integrin.

5 -5 and adhere to exogenous laminin-5 through alpha3beta1 integrin.

6 t alpha3 and beta1 integrins, and by soluble alpha3beta1 integrin.

7 t alpha3 and beta1 integrins, and by soluble alpha3beta1 integrin.

8 ectin also enhanced TSP1 binding to purified alpha3beta1 integrin.

9 ance the ability of TSP1 to be recognized by alpha3beta1 integrin.

10 a TSP1 substrate, which was also mediated by alpha3beta1 integrin.

11 o depends on interactions between Reelin and alpha3beta1 integrin.

12 everal signals that regulate activity of the alpha3beta1 integrin.

13 s, including the gB-specific alphaVbeta3 and alpha3beta1 integrins.

14 binding of alpha3(IV)NC1 to alphaVbeta3 and alpha3beta1 integrins.

15 prostate cancer metastasis via depletion of alpha3beta1 integrin, a correlation observed in a signif

16 In this study, we demonstrate that alpha3beta1 integrin, a major laminin receptor involved

17 tional cell-surface proteins associated with alpha3beta1 integrin, a monoclonal antibody selection pr

18 Antibodies directed against the alpha3beta1 integrin also reduce the size and number of

19 PP interacted with alpha3beta1 integrin, and alpha3beta1 integrin altered APP trafficking and process

20 AK-negative mouse DU3 cells suggest that the alpha3beta1 integrin and FAK play roles in the HHV-8 med

21 romote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated ce

22 s with cell surface heparan sulfate (HS) and alpha3beta1 integrin and plays roles in the initial bind

23 poprotein E receptor 2 (ApoER2; refs 9-11 ), alpha3beta1 integrin and protocadherins.

24 This enhancement of adhesion was mediated by alpha3beta1 integrin and required that the alpha3beta1 i

25 ant role in post-translation modification of alpha3beta1 integrin and strongly suggest that changes i

26 On the basis of these results, the alpha3beta1 integrin and sulfated glycolipids cooperate

27 These findings implicate a role for alpha3beta1 integrin and the associated signaling pathwa

28 Here we describe an association between alpha3beta1 integrin and transmembrane-4 superfamily (TM

29 ements for the interaction of CD151 with the alpha3beta1 integrin and with other tetraspanins.

30 ced glomerular epithelial cell expression of alpha3beta1 integrins and impaired adhesion to type IV c

31 We confirmed that APP interacted with alpha3beta1 integrin, and alpha3beta1 integrin altered A

32 Addition of an alpha3beta1 integrin antibody prevented APP and Reelin-i

33 We suggest that alpha3beta1-integrins are important for immature and tra

34 data therefore indicate that the function of alpha3beta1 integrin as a mediator of keratinocyte migra

35 We have now identified alpha3beta1 integrin as an additional receptor for TSP1

36 ell surface heparan sulfate and utilizes the alpha3beta1 integrin as one of its entry receptors.

37 HHV-8 utilizes alpha3beta1 integrin as one of the receptors for its ent

38 s bound by the alpha1beta1, alpha2beta1, and alpha3beta1 integrins, as well as cell surface proteogly

39 In contrast, alpha3beta1 integrin association of TF is constitutive i

40 CD151 silencing disrupted alpha3beta1 integrin association with tetraspanin-enrich

41 y alpha3beta1 integrin and required that the alpha3beta1 integrin be in an active state.

42 F-beta receptor signaling complex containing alpha3beta1 integrins, beta-catenin, TGF-beta receptor I

43 Moreover, both alphavbeta3 and alpha3beta1 integrin bind with high affinity to G(919-12

44 ible signal transduction pathways induced by alpha3beta1 integrin binding have been evaluated.

45 e of a peptide (alpha325) that disrupts uPAR/alpha3beta1 integrin binding prevented uPA induction.

46 s a signaling platform; migration depends on alpha3beta1 integrin binding to laminin 332 (LN332; also

47 that was much more pronounced in the case of alpha3beta1 integrin binding.

48 TSP1 and an alpha3beta1 integrin-binding peptide from TSP1 also inhi

49 Recognition of TSP1 and an alpha3beta1 integrin-binding peptide from TSP1 by normal

50 In solution, both intact TSP1 and the alpha3beta1 integrin-binding peptide from TSP1 inhibit p

51 column indicated that D-Hep-III binds to the alpha3beta1 integrin but not to the alpha2 or alpha6 int

52 panins CD9 and CD81 physically link EWI-2 to alpha3beta1 integrin, but not to other integrins.

53 ored the hypothesis that lateral ligation of alpha3beta1 integrin by uPAR contributes to uPA regulati

54 nd raised the question of how the tumor cell alpha3beta1 integrin contacts its best-defined ligand, l

55 retraction and both the alpha6 integrins and alpha3beta1 integrin contribute to lamellae formation.

56 These results suggest that alpha3beta1 integrin deficiency impairs distinct pattern

57 Previously we found that alpha3beta1 integrin-deficient neonatal mice develop mic

58 raspanin association were both important for alpha3beta1 integrin-dependent initial adhesion and rapi

59 in alpha3beta1; however, unlike alphavbeta3, alpha3beta1 integrin did not mediate cell adhesion to im

60 The upregulation of keratinocyte alpha3beta1 integrin during reepithelialization suggests

61 s with cell surface heparan sulfate (HS) and alpha3beta1 integrin during the early stages of infectio

62 s 8 (KSHV/HHV-8) interacts with cell surface alpha3beta1 integrin early during in vitro infection of

63 monstrate that the fragment acts through the alpha3beta1-integrin/extracellular matrix metalloprotein

64 The alpha3beta1 integrin forms complexes with other cell-sur

65 ly displace the receptor tyrosine kinase and alpha3beta1 integrin from the syndecan with an IC50 of 1

66 ortical neurons occurs following the loss of alpha3beta1 integrin function.

67 reepithelialization but suggest instead that alpha3beta1 integrin has a major new in vivo role as an

68 Because the alpha3beta1 integrin has been shown to mediate neurite o

69 cell morphological responses that depend on alpha3beta1-integrin have not been defined.

70 high affinity ligand for the alphavbeta3 and alpha3beta1 integrin heterodimers and that these integri

71 In this paper, we define a novel role for alpha3beta1 integrin in association with the tetraspanin

72 ing Schwann cells, and specifically with the alpha3beta1 integrin in some cells, we tested whether th

73 The interaction of TIMP-2 with alpha3beta1 integrin in the cerebral cortex suggests tha

74 trate the involvement of both galectin-3 and alpha3beta1 integrin in the EC response to NG2 and show

75 Here, we examined the role of alpha3beta1-integrin in ErbB2-dependent proliferation of

76 HHV-8 gB-neutralizing antibodies and soluble alpha3beta1 integrin inhibited the virus-induced signali

77 lustrated in models with altered function of alpha3beta1 integrin, integrin-linked kinase, laminin-52

78 , slowing cell locomotion, whereas laminin-5-alpha3beta1 integrin interaction inhibits RhoA and activ

79 alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543.

80 ecific guidance mechanisms, such as netrin-1-alpha3beta1 integrin interactions, modulate distinct rou

81 vitro and in vivo findings demonstrate that alpha3beta1 integrin is critical for alpha3(IV)NC1-media

82 a indicate that a complex comprising LN5 and alpha3beta1 integrin is multifunctional and contributes

83 Here, we show that alpha3beta1 integrin is necessary for neuron-glial recog

84 TSP1 binding activity of the alpha3beta1 integrin is not stimulated by CD47-binding p

85 Loss of alpha3beta1 integrin leads to increased CD151 homodimer

86 We show that binding of alpha3(IV)NC1 to alpha3beta1 integrin leads to inhibition of COX-2-mediat

87 However, on laminin-5 (alpha3beta1 integrin ligand), A431 cell reaggregation an

88 3 or beta1 integrin subunits, and by soluble alpha3beta1 integrin ligands.

89 Here, we show that the tumor cell alpha3beta1 integrin makes an important contribution to

90 tatic tumor, and the decreased expression of alpha3beta1 integrin may contribute to its virulence.

91 herefore, recognition of immobilized TSP1 by alpha3beta1 integrin may stimulate endothelial cell prol

92 ry structure) can directly influence several alpha3beta1 integrin-mediated signal transduction events

93 e IV collagen, alpha1(IV)531-543, can induce alpha3beta1 integrin-mediated signal transduction in mel

94 ial cells do not spread on a TSP1 substrate, alpha3beta1 integrin mediates efficient spreading on TSP

95 These results suggest first, that alpha3beta1 integrin mediates homotypic adhesion of SCLC

96 endent of proliferation, but ligation of the alpha3beta1 integrin modulates endothelial cell prolifer

97 ssion levels of the terminal sialic acids of alpha3beta1 integrin N-glycans play an important role in

98 In vivo analysis of interneuron-specific alpha3beta1 integrin, netrin-1-deficient mice (alpha3(lo

99 sed by an antibody that specifically engages alpha3beta1 integrins, P1B5.

100 < 20 nM) and binding was blocked by a 17-mer alpha3beta1 integrin peptide (alpha325) homologous to th

101 ch are binding sites for the alpha2beta1 and alpha3beta1 integrins, respectively.

102 2.35 cells express relatively high levels of alpha3beta1-integrins, similar to that previously shown

103 on of SCLC cells, and second, that unengaged alpha3beta1 integrin suppresses the growth of disaggrega

104 Because uPAR is redistributed to clustered alpha3beta1 integrins, the requirement for uPAR/alpha3be

105 e beta1-chain-derived fragment interacts via alpha3beta1-integrins, thereby triggering the down-regul

106 rcinoma cells have been shown to utilize the alpha3beta1 integrin to bind to models of the alpha1(IV)

107 ed by GABAergic interneurons, interacts with alpha3beta1 integrin to promote interneuronal migration.

108 erface as well as impaired relocalization of alpha3beta1 integrin to the basement membrane zone.

109 interactions with host receptors, including alpha3beta1 integrin, trigger localized actin rearrangem

110 Because multivalent aggregation of alpha3beta1 integrin up-regulates uPA and induces a dram

111 HHV-8 also interacts with the alpha3beta1 integrin via its glycoprotein gB, and virus

112 alpha3 integrin null eggs, we found that the alpha3beta1 integrin was not essential for sperm-egg bin

113 by alpha3(IV)NC1 in endothelial cells, only alpha3beta1 integrin was sufficient to regulate COX-2 in

114 F did not induce increased expression of the alpha3beta1 integrin, which also has been implicated in

115 The alpha3beta1 integrin, which is responsible for the motil

116 g N-linked oligosaccharides, most notably on alpha3beta1 integrin, which is the predominant integrin

117 Recombinant and native Reelin associate with alpha3beta1 integrin, which regulates neuron-glia intera

118 pulmonary vasculature through interaction of alpha3beta1 integrin with LN-5 in exposed BM provides bo