ライフサイエンスコーパス: cellular function

1 les of genomic "clothing" and restore normal cellular function.

2 response (ISR), which is critical to normal cellular function.

3 RNA modifications play a fundamental role in cellular function.

4 ed processes that can be targeted to improve cellular function.

5 PS plays in bacteria and how it may regulate cellular function.

6 he regulation of actin is key for controlled cellular function.

7 oles in establishing tissue architecture and cellular function.

8 ding blocks for tools that report or control cellular function.

9 otease domain of CaWss1 is essential for its cellular function.

10 tate underlies gene expression potential and cellular function.

11 he synaptic remodelling attributed to normal cellular function.

12 icrotubule (MT) attachment, and blocks their cellular function.

13 cation in humans and is essential for normal cellular function.

14 n is critical for the maintenance of optimal cellular function.

15 etermined the effects on in vivo binding and cellular function.

16 they can be fuelled appropriately to restore cellular function.

17 ous secondary messenger that is critical for cellular function.

18 raction with the primosome protein PriB, and cellular function.

19 transformations that underpin chemistry and cellular function.

20 a ubiquitous and critical process for proper cellular function.

21 d expressed in cells to probe and manipulate cellular function.

22 increasingly understood to be important for cellular function.

23 ization of a specific chromosomal domain and cellular function.

24 mechanistic insight into PAR4 regulation of cellular function.

25 en incompletely understood, contributions to cellular function.

26 d fast muscle that may underlie the improved cellular function.

27 gnaling networks can help coordinate diverse cellular functions.

28 les ensure spatiotemporal control of various cellular functions.

29 n diverse cellular RNAs allows for its broad cellular functions.

30 n aggregates capable of disrupting essential cellular functions.

31 auxiliary and regulatory subunits, for their cellular functions.

32 iched for controls and show changes in basic cellular functions.

33 distinct and oftentimes opposite effects on cellular functions.

34 eria and Eukarya with large-scale effects on cellular functions.

35 olecular mechanisms used to repair perturbed cellular functions.

36 ting our understanding of their dynamics and cellular functions.

37 x endomembrane system that compartmentalizes cellular functions.

38 s have profound effects on a wide variety of cellular functions.

39 tubules are biopolymers that perform diverse cellular functions.

40 lies is critical to decoding and controlling cellular functions.

41 Organelle crosstalk is vital for cellular functions.

42 mework for how chromatin condensates promote cellular functions.

43 pertoire of dynamic protein interactions and cellular functions.

44 d kinases), with a subset that suggest novel cellular functions.

45 rich spatial dynamics and are vital to many cellular functions.

46 eins into eukaryotic cells to subvert normal cellular functions.

47 t in the cellular milieu and control various cellular functions.

48 g proteins that play key roles in regulating cellular functions.

49 on between cellular metabolism and important cellular functions.

50 brane ectopeptidase involved in many crucial cellular functions.

51 lipid category that is involved in many key cellular functions.

52 esponse of OGG1 and affecting its downstream cellular functions.

53 n cell development, morphogenesis, and other cellular functions.

54 lower-dimensional spaces is used for various cellular functions.

55 nputs, serving as the basis for wide-ranging cellular functions.

56 tes, also facilitate compartmentalization of cellular functions.

57 target proteins to regulate a wide range of cellular functions.

58 ous molecular mechanism that drives numerous cellular functions.

59 huttling factors, implicated in a variety of cellular functions.

60 evolved to mediate distinct antiviral and/or cellular functions.

61 s, the glycans to which they contribute, and cellular functions.

62 etween microbiota and host to influence host cellular functions.

63 motion, membrane trafficking, and many other cellular functions.

64 ple circuits, are used to control individual cellular functions.

65 ntify the activities of diverse pathways and cellular functions.

66 through type I and type II FcgammaR-mediated cellular functions.

67 e cytoskeletal polymers that perform diverse cellular functions.

68 nomes in gene regulation and other essential cellular functions.

69 hance therapeutic efficacy and install novel cellular functions.

70 ly diffusing molecules that are integral for cellular functions.

71 and function as well as on a wide variety of cellular functions.

72 causally related to transcription and other cellular functions.

73 ently been recognized as key players in many cellular functions.

74 ytic TCC concentrations can modulate various cellular functions.

75 to host cells during infections to modulate cellular functions.

76 cross various organisms and regulate diverse cellular functions.

77 otein complexes is crucial for understanding cellular functions.

78 a discrete subset of proteins with different cellular functions.

79 nd secondary messengers, involved in diverse cellular functions.

80 e of life and regulate nearly all aspects of cellular functions.

81 cell-matrix interactions to influence normal cellular functions.

82 of those motions to link local processes to cellular functions.

83 e-gated calcium influx and calcium-dependent cellular functions.

84 e the epigenome and consequently appropriate cellular functioning.

85 iquitous and have been implicated in diverse cellular functions(1).

86 organelles are of key importance for normal cellular functions, a growing number of recent observati

87 Disruption of each of these essential cellular functions acts to suppress the interferon respo

88 Many other proteins with diverse cellular functions also contain Ubl domains and can asso

89 and their integrity is essential to maintain cellular function and appropriate responses to extracell

90 Phospholipids are important to cellular function and are a vital structural component o

91 ar vesicles (EVs) are a universal feature of cellular function and can be detected in different bodil

92 t is essential to examine how alterations in cellular function and cell-to-cell interactions of pulmo

93 in have crucial functions in most aspects of cellular function and embryonic development in both anim

94 of different TCA cycle metabolites controls cellular function and fate in different contexts.

95 ons (GIs) can reveal important insights into cellular function and has potential translational applic

96 how mechanical forces are harnessed to drive cellular function and how force can also be a mode of bi

97 aches for uncovering the basic properties of cellular function and identity.

98 ted mitochondrial networks are essential for cellular function and implicated in multiple diseases.

99 rapidly and efficiently repaired to maintain cellular function and integrity.

100 of actin-a protein playing a crucial role in cellular function and motility-make it attractive for ob

101 of insoluble tau aggregates and the loss of cellular function and neuronal death.

102 t is widely considered to be dispensable for cellular function and organismal development.

103 rface proteins are often integral markers of cellular function and serve as primary targets for thera

104 membrane fluidity; examine genes involved in cellular function and survival in the cold; assess capab

105 2+)) homeostasis is a crucial determinant of cellular function and survival.

106 key epigenetic processes involved in normal cellular function and tumorigenesis.

107 ines, myosins are involved in myriad pivotal cellular functions and are frequently sites of mutations

108 ids (Sia) are involved in numerous different cellular functions and are receptors for many pathogens.

109 g organelles that regulate a wide variety of cellular functions and can dictate cell fate.

110 platform to develop and optimize engineered cellular functions and can serve as a model to implement

111 New cellular functions and developmental processes can evolv

112 important role in the future for monitoring cellular functions and disease progression.

113 is that it appears to be many things to many cellular functions and diseases - a pleiotropic actor at

114 f condensate liquidity, which is key to both cellular functions and diseases.

115 they have been applied to a range of complex cellular functions and engineered networks.

116 e a mesodermal microenvironment, and display cellular functions and extracellular interactions that a

117 ng nuclear shape morphology and in affecting cellular functions and gene regulation.

118 s of neurodegeneration through disruption of cellular functions and inducing mitochondria damage and

119 ety of readouts and are uncovering important cellular functions and mechanisms.

120 triphosphorylated RNAs (ppp-RNAs) to promote cellular functions and prevent recognition by antiviral

121 partments that produce requisite ATP to fuel cellular functions and serve as centers of metabolite pr

122 reports differential regulation of critical cellular functions and signaling pathways during product

123 rotein 7B (OTUD7B)), a DUB that controls key cellular functions and signaling pathways.

124 enerate alternative mechanisms for conserved cellular functions and test hypotheses concerning the ge

125 transitions relate to pleiotropic defects in cellular functions and the accrual of proteinaceous depo

126 Cellular functions and transcriptional targets of HDAC e

127 the role of individual components and their cellular function, and to engineering new molecular func

128 ific molecular targets, characterize various cellular functions, and model central nervous system (CN

129 LncRNAs possess multiple cellular functions, and they regulate chromatin remodeli

130 ntracellular metabolism, which in turn alter cellular function; and (2) intercellular immunometabolis

131 Emerging methods to infer cellular functions are beginning to shed new light on th

132 Consequently, many cellular functions are carried out not by long, isolated

133 Its precise molecular and cellular functions are currently unknown, precluding our

134 Cellular functions are established through biological ev

135 mbin versus APC signaling to induce opposing cellular functions are largely unknown.

136 The liver's cellular functions are sustained by a hierarchical, segm

137 Their main cellular functions are to proofread errors of transcript

138 biologically relevant cations, execute their cellular functions associated with the conformational ch

139 toxic phage gene has been co-opted for core cellular function at the root of a large bacterial clade

140 s) of mRNAs emerged as central regulators of cellular function because they contain important but poo

141 ries have revealed that the NPC has multiple cellular functions besides mediating the molecular excha

142 lear pore complexes (NPCs) are important for cellular functions beyond nucleocytoplasmic trafficking,

143 provided insight into the molecular basis of cellular function, but current approaches have limited t

144 to have a regulatory role in development and cellular function, but the mechanism involved in TAD est

145 ion, and hemifusion rupture are essential to cellular function, but their molecular details, energeti

146 various protein complexes to confer distinct cellular functions, but how the multi-subunit complexes

147 There are 11 human H1 isoforms with diverse cellular functions, but how they interact with the nucle

148 Heme is an essential cofactor for numerous cellular functions, but release of free heme during hemo

149 f an enzyme active site can therefore impact cellular function by disruption of critical protein-prot

150 Chemotrophic microorganisms gain energy for cellular functions by catalyzing oxidation-reduction (re

151 ases to ensure proteome fidelity and control cellular functions by promoting protein degradation.

152 more generally suggest that m(6)A may exert cellular functions by reshaping the kinetics of RNA conf

153 te proteoglycans that perform many important cellular functions by way of heparan sulfate-protein int

154 ially expressed genes were mostly belongs to cellular functions (calcium and MAPK), phytohormones (au

155 nd includes regulatory elements whose normal cellular functions can be disrupted by mutation.

156 oordinating hub in which seemingly disparate cellular functions converge, and from which a variety of

157 n indicative of an inflammatory response and cellular function deficits.

158 resents a mechanism for spatially segregated cellular functions during neuronal development.

159 on of cells is an important prerequisite for cellular function, e.g., in the context of cell migratio

160 ks of any biological network to decipher how cellular function emerges from their interactions.

161 ltivalent interactions and are platforms for cellular functions, especially receptor-mediated signali

162 on of FRAXA under folate stress and define a cellular function for human SLX1.

163 new approaches to regulate and direct these cellular functions for the purposes of regenerative medi

164 anylate (c-di-GMP) regulates a wide range of cellular functions from biofilm formation to growth and

165 Retinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood,

166 hich legionellae have coopted genes and thus cellular functions from their eukaryotic hosts, providin

167 necks, a process that is essential for many cellular functions, from cell division to lysosome degra

168 ng systems can generate an enormous range of cellular functions, from mechanical infrastructure and s

169 However, proteome-wide investigation of its cellular functions has been limited due to numerous tech

170 Conserved protein kinases with core cellular functions have been frequently redeployed durin

171 r targets and the growing knowledge of their cellular functions have led to the development of small

172 -based methods for reporting and controlling cellular function in eukaryotes.

173 dence for a role of metabolism in modulating cellular function in four distinct contexts.

174 erate heat stress on molecular signaling and cellular function in HCC cells in vitro.Materials and Me

175 ped technologies can offer new insights into cellular function in natural and human-made systems and

176 l hold clues to understanding differences in cellular function in organisms that are of pressing impo

177 broad impact on the proteomic landscape and cellular function in the pathophysiology of this illness

178 How mRNA decay pathways regulate cellular function in vivo with specificity is poorly und

179 post-translational modification with crucial cellular functions in all domains of life.

180 ortant in reprogramming, (2) sGRP78 promotes cellular functions in both pluripotent and breast cancer

181 plays critically important roles in numerous cellular functions in eukaryotes, and it does so across

182 onal regulatory mechanism that controls many cellular functions in eukaryotes.

183 contributes to the epigenetic regulation of cellular functions in Gram-positive bacteria.

184 t is unclear how H(2)O(2) influences various cellular functions in health and disease differentially,

185 perties of lipid membranes are important for cellular functions in health and disease.

186 yrosine kinases (RTKs) are key regulators of cellular functions in metazoans.

187 teins causally linked to various detrimental cellular functions in pathological conditions including

188 tions undergo changes in gene expression and cellular functions in primordial and mature valves.

189 Glycosyltransferases carry out important cellular functions in species ranging from bacteria to h

190 activated and integrated with many different cellular functions in the autoinflammatory process.

191 chloroplasts perform a variety of important cellular functions in the plant cell, which can, for exa

192 as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP

193 h type II FcgammaRs; these receptors mediate cellular functions including antiinflammatory activity o

194 Phosphoinositides (PIs) regulate a myriad of cellular functions including membrane fusion, as exempli

195 r of human cells and facilitates a myriad of cellular functions including organization of the mitotic

196 cificity in transmitting signals involved in cellular function, including germ cell maturation.

197 branes is a vital process for all aspects of cellular function, including growth, metabolism, and com

198 types and is required for numerous essential cellular functions, including cardiac and skeletal muscl

199 Sphingolipids have important roles in many cellular functions, including cell cycle regulation and

200 xperience mechanical forces during essential cellular functions, including cell motility and endocyto

201 membrane (PM) is crucial to a broad range of cellular functions, including cell motility, signal tran

202 chondria are involved in a number of diverse cellular functions, including energy production, metabol

203 y proteins play an essential role in several cellular functions, including growth, differentiation, a

204 MAM regulates a number of key cellular functions, including lipid and calcium homeosta

205 n directly and indirectly influence many key cellular functions, including metabolic pathways, DNA re

206 s, signal transduction pathways control core cellular functions, including metabolism, to couple the

207 n cytoskeleton exhibits a number of critical cellular functions, including regulation of cell shape a

208 a broad network of genes mediating a host of cellular functions, including repression of the cell-cyc

209 identified that encompass a wide variety of cellular functions, including roles in DNA repair, mRNA

210 e of biopolymers, regulating a vast array of cellular functions, including signaling, phase separatio

211 Cellular function is generally depicted at the level of

212 However, their full cellular function is inadequately understood.

213 An important aspect of cellular function is the correct targeting and delivery

214 e proteins, not mRNA molecules, mediate most cellular functions, it is desirable to know the identity

215 ogether, our results support a model for the cellular function of ADAP1, where KIF13B transports ADAP

216 In particular, the cellular function of chloroplast Suc reserves and the tr

217 e, we report the transcriptional program and cellular function of ERRalpha in endothelial cells (ECs)

218 rt for this activity being important for the cellular function of FtsQLB was provided by the identifi

219 In summary, we have identified the cellular function of HspX in Mycobacterium smegmatis as

220 -protein complexes plays a major role in the cellular function of membraneless organelles (MLOs).

221 on of miRNAs can bring new insights into the cellular function of miRNA and a further improvement in

222 Understanding the cellular function of proteasome activation in more detai

223 We additionally investigated the cellular function of several PfCCT truncated constructs

224 ow used routinely to study the molecular and cellular functions of a gene within an identified cell t

225 The molecular and cellular functions of ANGUSTIFOLIA (AN) were characteris

226 Cellular functions of arrestins are determined in part b

227 s representative examples of biochemical and cellular functions of biomolecular condensates from the

228 Finally, we discuss the multifaceted cellular functions of biomolecular condensates, includin

229 for achieving a better understanding of the cellular functions of DUBs.

230 twork (TRN) of Bacillus subtilis coordinates cellular functions of fundamental interest, including me

231 he expression, processing, localization, and cellular functions of human NOCT.

232 nstrate the ability of 2D MoS(2) to modulate cellular functions of human stem cells through photother

233 r radial glial (oRG) progenitors, suggesting cellular functions of LIS1 in regulating neural progenit

234 el for disseminated candidiasis and that the cellular functions of Mac1p extend beyond Cu uptake and

235 e amino acid (Phe) restores the more dynamic cellular functions of NMII, such as myosin filament form

236 We investigated the cellular functions of POU3F2 and TRIM8 as they co-regula

237 Here, we discuss the cellular functions of SIRT6 with a focus on attributing

238 c studies have revealed critical homeostatic cellular functions of SIRT6, underscoring the need to be

239 enance of microcirculation and molecular and cellular functions of the intact pig brain under ex vivo

240 We discuss the predicted cellular functions of these domains and provide evidence

241 o these species and in doing so affect their cellular function or be the basis for molecular probes.

242 st cases, mild-to-severe localized losses in cellular function or matrix integrity give rise to varyi

243 They are also implicated in a wide range of cellular functions, organizing molecules that act in pro

244 ls such as iron and copper are essential for cellular functions, others such as cadmium and arsenic a

245 Many cellular functions perturbed in Alzheimer's disease can

246 to complete their replicative cycle renders cellular functions potential targets for novel antiviral

247 the PI4P it generates regulate a variety of cellular functions, ranging from control of Golgi struct

248 ndividuals with CMV is due to alterations in cellular function rather than a reduction in CD8(+) T ce

249 Cellular functioning relies on active transport of organ

250 iled mechanisms by which DeltaPsim regulates cellular function remain incompletely understood, partia

251 However, the molecular basis of Orn's unique cellular function remained unclear.

252 sms in noncoding genome regions can regulate cellular function remains largely unknown.

253 ic modulation of catalytic activity, but its cellular function remains unclear.

254 different transcriptome to mediate distinct cellular functions remains obscure.

255 Cellular function requires molecular motors to transport

256 and organism wide changes in metabolism and cellular function requires precise regulation of gene ex

257 Cellular functioning requires the orchestration of thous

258 However, its cellular function(s) and whether it plays a role in main

259 h the major product(s), metabolic roles, and cellular function(s) being essentially unknown.

260 glycan-containing ligands of CLC/Gal-10, its cellular function(s), and its role(s) in allergic diseas

261 intracellular organelle distributions affect cellular functions, several optogenetic approaches enabl

262 and consequently rescue critical microglial cellular function such as beta-Amyloid phagocytosis.

263 olymers in eukaryotic cells that support key cellular functions such as chromosome segregation, motor

264 of cells and their ability to perform basic cellular functions such as division and motility.

265 ical work and, in doing so, perform critical cellular functions such as DNA replication and transcrip

266 slational modifications (PTMs) that regulate cellular functions such that PTM dysregulation can lead

267 cromolecular structures that fulfill diverse cellular functions, such as adhesion to host cells, the

268 he molecular mechanisms underlying conserved cellular functions, such as DNA replication and cytokine

269 While mitochondria maintain essential cellular functions, such as energy production, calcium h

270 ously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TA

271 ting death domain protein, regulates various cellular functions, such as vesicle trafficking, activit

272 of mimics of small molecules with important cellular function that allow the direct observation of t

273 bacterial membrane organization and identify cellular functions that are affected by the loss of caro

274 ncreased basal autophagy and exocytosis, two cellular functions that are independently regulated by R

275 mains largely unknown, particularly for many cellular functions that are not immediately related to g

276 l the dynamics of the actin cytoskeleton and cellular functions that depend on it.

277 e cell types and consequent loss of specific cellular functions, the local release of cytokines and d

278 ite the essential nature of this process for cellular function, there is little information on the ro

279 As each isoform may have a unique cellular function, these results underscore the importan

280 Being critical to cellular functions, they are also fundamental in many ar

281 target of rapamycin (mTOR) performs diverse cellular functions through 2 distinct multiprotein compl

282 14-3-3 Proteins enact a range of cellular functions through protein-protein interactions

283 ve sphingolipid mediator involved in various cellular functions through S1PR1-5, expressed by keratin

284 duces protein-protein interactions can allow cellular function to be controlled with small molecules.

285 ranscriptome(4) and proteome(5) data enables cellular function to be studied within most physiologica

286 How EVs co-opt cellular functions to promote replication and spread is

287 In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad ti

288 ion protein gene (PRNP) and a range of other cellular functions to support their propagation and toxi

289 imental platform for real-time evaluation of cellular function under conditions that replicate native

290 fect appears as the major limiting factor of cellular functions under deuteration.

291 Autophagy is critical for maintaining cellular function via clearance of excess nutrients and

292 To better understand its cellular functions, we deleted DNA-PKcs from HeLa and A5

293 Since herpesviruses are experts at coopting cellular functions, we investigated whether Epstein-Barr

294 Most prior studies of Ded1 cellular function were conducted in steady-state conditi

295 ever, understanding of whether drugs restore cellular function will also be important, and studies of

296 tional level, it is carried out with various cellular functions with a distinguishable CCM2 protein g

297 Prohibitin 1 (PHB1) serves pleiotropic cellular functions with dynamic subcellular trafficking,

298 Approaches to safely and effectively augment cellular functions without compromising the inherent bio

299 les in the presence of noise is an important cellular function, yet the underlying computational mech

300 on and oligomerization are essential to most cellular functions, yet measurement of the size of these