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3 icularly strong; each copy of the Thr allele conferred 42% lower triglycerides (beta=-0.92+/-0.059 SD
5 x) co-occurring with PTEN germline mutations confer a 2-fold increased prevalence (OR 2.7) of thyroid
6 in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protei
7 induce Lgr5(+) ISC self-renewal, but instead confer a basal competency by maintaining RSPO receptor e
8 ool of transcripts where their manipulations confer a better performance of wheat varieties under dro
9 that are mutated in a variety of cancers to confer a gain-of-function activity resulting in the accu
12 etic variants of complex diseases often only confer a marginal increase in disease risk, which is add
13 rus via vector-virus trait combinations that confer a propensity toward associations in an ecological
15 pared with therapeutic normothermia, did not confer a significant benefit in survival with a favorabl
16 NA as a live attenuated vaccine was shown to confer a strong IAV-specific CD8(+) T-cell response and
17 ment with lomustine plus bevacizumab did not confer a survival advantage over treatment with lomustin
21 inal region of SS4 alone or when fused to GS conferred a patchy subchloroplastic localization similar
23 marked increase in virus growth kinetics and conferred a robust growth advantage over wild-type rVSV-
24 alent, neutralizing antibodies did not bind, conferred a selective advantage in the immune systems of
26 NA interference screens and identified genes conferring a clonal growth advantage on normal and neopl
27 elerates Kras-induced carcinogenesis without conferring a specific phenotype to pancreatic tumors or
39 nt-level analysis suggests that the RT boost confers a statistically significant benefit in decreasin
40 n galactose, GAL gene transcriptional memory confers a strong fitness benefit in Saccharomyces cerevi
42 y underpinning metal-organic framework (MOF) confers a versatile platform to contrive next-generation
45 ant genotypes, Hamiltonella infection rarely conferred additional protection, often further reduced f
46 e repair (DDR) and their over-activation may confer aggressive molecular features, being an adaptive
47 ealed that both small molecules were able to confer albumin affinity to GLP-1 and indicated that affi
49 at the expense of complement activation, has conferred an advantage in some B-cell disorders while re
50 ations in the binK sensor kinase gene, which conferred an exceptional selective advantage that could
53 d genes in human tumors and are critical for conferring and maintaining the oncogenic phenotype in tu
54 stance to DNA methylation from the A2UCOE is conferred, and whether the anti-silencing effect from th
56 induces TREM-1 expression in macrophages and confers anti-apoptotic attributes.NF-kappaB p65 silencin
59 e suggests that the PfKelch13 mutations that confer artemisinin resistance in falciparum malaria have
60 aine sensitivity in the mouse SNc circuit is conferred at the level of three glutamate afferents: dor
62 by amplifying CTX-M and NDM, two genes that confer bacterial resistance to cephalosporins and carbap
66 k factor with a relatively large effect size conferred by a partial dominant-negative function phenot
70 ding the mechanisms and selective advantages conferred by both of these symplastic-loading processes.
71 ealed that the most significant effects were conferred by changes in the constant domain of the light
73 h the magnitude of short- and long-term risk conferred by DM and the incremental risk conferred by in
75 isk conferred by DM and the incremental risk conferred by insulin dependency in the performance of TA
76 leotide binding domains and coupling helices conferred by intracellular loops extending from the chan
78 Tumors in which castration resistance was conferred by NEK6 were predominantly squamous in histolo
79 ished estimates of the lifetime cancer risks conferred by pathogenic germline mutations in that gene.
82 ion supply rate, (b) the level of resistance conferred by the resistance mechanism, (c) the fitness o
83 We suggest that protection against predators conferred by their high toxicity might help to explain w
86 Mammalian target of rapamycin inhibitors may confer cardioprotective advantages, but clinical data ar
88 esidues, Arg(30) and Tyr(51), as critical in conferring CD1c-restricted autoreactivity, thus elucidat
89 y which cancer-associated fibroblasts (CAFs) confer chemoresistance in ovarian cancer is poorly under
92 loss of neighbouring housekeeping genes can confer collateral lethality, we sought to determine whet
95 induced Stc2 gene expression, which in turn confers cytoprotection to liver cells exposed to chemica
97 ed this both for co-infecting symbionts that confer different phenotypes on their hosts (protection a
99 ates with chromatin via distinct mechanisms, conferring different transcriptional properties includin
100 monstrate that modulation of SPOP expression confers differential H3K36me3 on SETD2 target genes, and
101 rence if only a particular class of variants confers disease risk and can suggest particular disease
109 ma complexes, whose regulatory gamma subunit confers energy sensor function by binding adenine nucleo
110 he response to infected erythrocytes without conferring enhanced protection against febrile malaria.
111 othesized that the acquisition of germ plasm confers enhanced evolvability, resulting from the releas
114 nteraction could occur in tap water and thus confer enteric viruses protection against temperature an
115 imized CTLA4 moieties with human Fc variants conferring extended plasma t1/2 In a cynomolgus model of
116 Charged residues were poorly tolerated, conferring extreme temperature-sensitive and lethal phen
117 that culturing RS-hAFSCs under ET conditions confers faster proliferation and enhances the efficiency
118 hics encodes images on a single-pixel level, conferring fine details at the expense of large file siz
120 ven alleles of pastrel from around the world conferring four phenotypically distinct levels of resist
121 NPs and/or genes, which if accumulated would confer full resistance to an otherwise susceptible strai
124 y two additional genes, ybaS and ybaT, which confer glutamine (Gln)-dependent acid tolerance and cont
126 ering receptor expressed on myeloid cells 2) confer greatly elevated risk for developing the disease.
127 to uncharacterized motif, termed AcidicN, to confer H4-tail sensitivity and discriminate between DNA
128 cobalt can bind to the same nonheme site and confer HCO activity in a heme-nonheme biosynthetic model
133 HC Ca(2+) current with slow inactivation and confer high sensitivity to nifedipine and to internal EG
134 The heart team believed surgical palliation conferred high operative risk due to the patient's compl
142 ic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe VZV disease in
143 Even mild-to-moderate chronic kidney disease conferred increased risk of incident peripheral artery d
144 Higher prevalence of LPDs and GPDs also conferred increased seizure risk (37% frequent vs 45% ab
145 nce of the G1-like M gene in H9N2 viruses in conferring increased infection severity and infectivity
147 t non-inducible temperature, and thus likely confer inducibility of gene expression and higher respon
148 the B2M locus in human PSCs in a manner that confers inducible, regulated, surface expression of HLA-
152 2 transformation and that its overexpression confers invasive properties to ErbB2-positive human mamm
154 to directly affect the mesenchymal state and confer it with aggressive phenotype and drug resistance.
155 mented immigrants, as offered by DACA, could confer large mental health benefits to such individuals.
156 Although WR is necessary to enable Nanog to confer LIF-independent self-renewal, the mechanism of di
157 its with A-kinase-anchoring proteins (AKAPs) confers location, and catalytic (C) subunits phosphoryla
158 Euro-American lineage, and known resistance-conferring loci accounted for the majority of phenotypic
159 P following treatment of CMV disease did not confer long-term protection against relapse, although it
160 acceptable short-term blister control while conferring long-term safety advantages over starting tre
161 Further, developmental stressor exposure confers long-term habit biases across rodent-primate spe
163 stored at 60 degrees C, the use of WPI alone conferred lower stability to the beetroot extract powder
164 ed cloning of the Ms2 gene and show that Ms2 confers male sterility in wheat, barley and Brachypodium
173 pose that similar DNA codes might be used to confer multiple regulatory functions of other polydactyl
176 OF BACKGROUND DATA: Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact
177 a response and provide evidence that IFNbeta confers neuronal protection against HIVgp120 toxicity.
179 Amino acid substitutions K599E and T601M conferred no ganciclovir resistance, while A591V conferr
180 and ZF9 span the backbone of the DNA duplex, conferring no sequence specificity but adding to overall
181 that fetal exposure to oral cholera vaccine confers no significantly increased risk of pregnancy los
184 wn what sequence of changes in lipid content confers on the vesicles their distinct identity at each
185 hesis", we reveal that geometric frustration confers, on a system at ambient temperature, structural
188 mapping of a dominant monogenic locus, Prs, conferring Papaya ring-spot virus (PRSV) resistance in b
190 purified from haemolymph of infected flies, confer passive protection against virus challenge in nai
192 evidence that elevated expression of GADD45B confers poor clinical outcomes in most human cancers.
194 ecular precision or monomer sequence control confers potential for molecular targeting, recognition a
196 vealed a C-terminal extension in CsxA, which conferred processivity because of the existence of a sec
197 e absence of endogenous Treg, IVIg failed to confer protection against AHR and airway inflammation.
198 sruption of host-associated microbiota might confer protection against diseases later in life.Early-l
200 ent in the liver expresses IFN-gamma and can confer protection against M. avium infection in immunoco
201 hydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria,
203 ive transfer of monoclonal bNAb proteins can confer protection in animal models of HIV infection at m
204 he results presented demonstrate that EBOTAb conferred protection against EBOV when given post-exposu
205 mergent population of peripheral CD4 T cells conferred protection against new tumors and was signific
206 vivo in immunization experiments in mice and conferred protection in a murine model of Mycobacterium
207 licated in these studies are truly the genes conferring protection from or risk of disease but also t
212 1 knockout cell line models showed that Pak1 confers protection to keratinocytes from UV-B-induced ap
213 ptic activity in APP mice; and that SS31 may confer protective effects against mitochondrial and syna
214 nduced superior humoral immune responses and conferred protective immunity against a lethal challenge
215 dentified in a PZA resistant strain does not confer PZA resistance when reconstructed in a laboratory
218 DCC (deleted in colorectal cancer) appear to confer resilience or susceptibility to psychopathologies
219 ytotoxic T-lymphocyte response may, in part, confer resilience to SIV-induced intestinal damage.
221 osphatidylinositol (GPI)-scFv X5 approach to confer resistance of human primary CD4 T cells to HIV-1.
222 in epidemic strains, other HA mutations can confer resistance to antibodies that recognize the K166
224 ely disables its abilities to promote HR and confer resistance to platinum salts and PARP inhibitors.
226 oli dsbB gene and selected dsbB mutants that confer resistance to this drug using two approaches.
228 D458G/V459A, N462K, N462H, G464E, and I483R conferred resistance to both FIP and AS-48 without compr
231 R) and single strand annealing (SSA), and in conferring resistance to cisplatin and olaparib in human
232 d in the production of virulence factors and conferring resistance to various antibiotics in pathogen
233 n and disrupts the p53/MDM2 regulatory axis, conferring resistance to various chemotherapeutics.
235 molecular beacons (MB), for detecting genes conferring resistance/susceptibility to carbapenems in A
238 ecular function of ClbS, a gene product that confers resistance to colibactin toxicity in host bacter
239 ATP-binding cassette (ABC) transporter that confers resistance to many anticancer drugs and plays a
241 onditions mimicking infection with S. aureus conferred responsiveness to IL-20 that manifested as mod
242 gene copy number variations (CNVs) known to confer risk for intellectual disability (ID) and autism
244 majority of the disease locations appear to confer risk of T2D via the regulation of expression leve
245 polymorphisms rs2070951 and rs5522 in NR3C2 conferred risk for cCSC (odds ratio, 1.39; 95% CI, 1.15-
246 ion protein (F) has previously been shown to confer robust immunity against RSV infection in mice, co
248 the native bilin phytochromobilin into PhyB confers robust Pfr --> Pr thermal reversion, that assemb
249 major insect opsin class (SW) that typically confers sensitivity to "blue" wavelengths was lost 300
250 have demonstrated that allergen-specific IgG confers sensitivity to systemic anaphylaxis that relies
251 its giant size and high mandibular strength confer shell-crushing capability matched only by other e
252 the slowly self-cleaving YscU variant P264A conferred significant protection against autoproteolysis
253 is an advanced malaria vaccine candidate and confers significant protection against Plasmodium falcip
257 ise that accumulation of putative resistance-conferring SNPs, potentially in combination with specifi
258 ence that higher levels of IGF-1 appeared to confer some protection against hearing impairment in som
260 per and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis
262 inding pocket of the phosphatase domain that confers specificity for phosphopeptides in a specific se
263 NA and RFC-D Arg-101 serving as a brake that confers specificity for ptDNA as the correct substrate f
264 ormation of this subcomplex was critical for conferring stability to the NEFs, helped fine-tune mitoc
265 ext, Drosha functions as an antiviral clamp, conferring steric hindrance on the RNA-dependent RNA pol
268 resulted in elevated frequencies of alleles conferring survival advantages for infectious diseases,
270 emonstrate that host AIC regulatory networks confer susceptibility to infection and establish a prote
271 ed with heightened proinflammatory responses confers susceptibility to stress-related depression and
272 monstrate a simple and general mechanism for conferring temporal flexibility upon sensorimotor and co
273 the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria.
274 7-eIF2alpha interaction in the closed state, confer the opposite phenotypes of hyperaccuracy and (for
276 ) in cystine-independent breast cancer cells conferred the cystine-addiction phenotype by modulating
277 ories assessed, psychoactive substance abuse conferred the highest risk for all-cause mortality (IRR,
278 nd the bound l-phenylalanine and l-tyrosine, conferring the deamination reaction through either the F
280 t packing in the rod and hook, respectively, conferring the rigidity on the rod and flexibility on th
282 oids formation of metallic Lewis adducts and confers the Au(I)/Pt(0) pair a remarkable capacity to ac
284 ental insights into a general principle that confers the substrate binding adaptability and specifici
286 ties in this family of multitarget compounds confers them a notable interest for the development of l
287 scribes critical molecular determinants that confer this high resistance to transmissible spongiform
292 the cellular microenvironment and therefore confers TRAIL resistance not only on the cell which prod
294 ish model to show that Myf5 is sufficient to confer tumor-propagating potential to RMS cells and caus
295 eins that accumulate in cancer cells and may confer unique gain-of-function (GOF) activities to promo
296 effective and one of two ineffective clones conferred upon primary CD8(+) T cells the equivalent pot
298 Our calculations show that polymerization confers upon a transcription factor the unique ability t
299 gous MADS-box TFs that repress flowering and confer vernalization requirement in the Brassicaceae spe
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