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4 p (RGD) integrin ligand and matrix softening confer resistance to a number of drugs, cells become sen
5 ates the transfer of plasmids that variously confer resistance to a range of drugs, including vancomy
7 pounds with little chemical similarity, thus conferring resistance to a broad spectrum of antibiotics
8 ntrogression of a wild relative-derived gene conferring resistance to a fungal pathogen was detected
9 ntegrated into the Bacillus subtilis genome, confers resistance to a broad range of phages, including
10 kinase, the rice (Oryza sativa) protein XA21 confers resistance to a broad spectrum of Xanthomonas or
13 ne A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome-targeting anti
14 he NorA efflux pump of Staphylococcus aureus confers resistance to a wide range of unrelated substrat
19 oprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanosomes, and certa
20 over, PKC activation alone was sufficient to confer resistance to ALK inhibitors, whereas combined AL
21 verexpression of NmU in drug-sensitive cells conferred resistance to all HER-targeting drugs, whereas
22 domain gatekeeper mutation Thr315Ile (T315I) confers resistance to all approved ABL1 inhibitors excep
23 uced IL-10(+)IFN-gamma(+)CD4(+) cells, which confer resistance to allogeneic proliferation in an IL-1
26 (3')II, a Tn5 transposon-derived kinase that confers resistance to aminoglycoside antibiotics, in Esc
27 in the RmbetaAOR, a gene that we proposed to confer resistance to amitraz, to determine whether selec
30 e FWPV block to induction of ChIFN2 but does confer resistance to an established antiviral state.
31 dentify single-nucleotide polymorphisms that confer resistance to an experimental inhibitor effective
32 in the myeloid lineage promoted survival and conferred resistance to an in vivo group B streptococcus
35 the administered drug, as well as genes that confer resistance to antibiotics unrelated to the admini
36 in epidemic strains, other HA mutations can confer resistance to antibodies that recognize the K166
38 ressed in human cancer, and its activity may confer resistance to antitumoral drugs such as Taxol.
39 functions during viral infection, including conferring resistance to antiviral interferon induction,
44 timulating factor 1 receptor (CSF-1R), which confers resistance to apoptotic pathways driven by tumor
45 ion of ligand-independent AR splice variants confers resistance to AR-targeted therapy and progressio
46 scherichia coli, gapdh and arsJ specifically conferred resistance to arsenate and decreased accumulat
47 pe malaria DNA and mutant malaria DNA, which confers resistance to artemisinin drugs, was also demons
48 nhances FtsZ protofilament bundling, thereby conferring resistance to assembly inhibitors and bypassi
53 es induced apoptosis, and its overexpression conferred resistance to BCL-2 family-targeting BH3 mimet
56 D458G/V459A, N462K, N462H, G464E, and I483R conferred resistance to both FIP and AS-48 without compr
57 s with GPI-VHH JM4, but not with GPI-VHH E4, confers resistance to both cell-free and T cell-T cell t
59 laps with the pathogen infection pathway and confers resistance to both oxidative stress and heat sho
60 elevated expression of either of these genes confers resistance to both type I (permethrin) and type
62 wnregulation (CASP3/DR) in tumors frequently confers resistance to cancer therapy and is significantl
65 hibition of IFNbeta by neutralizing antibody conferred resistance to cell death, and (iii) mouse embr
66 levels of aa-PG in the bacterial membrane to confer resistance to certain antimicrobial compounds and
68 in turn, leads to elevated Akt activation to confer resistance to chemotherapeutic drugs in Rb-profic
70 reas an increase in antioxidant capacity can confer resistance to chemotherapy and is associated with
71 increased nucleotidase activity in vitro and conferred resistance to chemotherapy with 6-mercaptopuri
74 and the double mutant E1-K61T E2-D59N) that conferred resistance to CHK-152 and CHK-166 and tested t
75 R) and single strand annealing (SSA), and in conferring resistance to cisplatin and olaparib in human
77 ecular function of ClbS, a gene product that confers resistance to colibactin toxicity in host bacter
78 ads to a modest increase in kinase activity, conferring resistance to competitive ATP inhibitors in a
82 ons in HNSCC and demonstrated that mutations confer resistance to conventional and molecular targeted
83 licited a higher frequency of Th17 cells and conferred resistance to costimulation blockade following
84 ify mutations in the ROS1 kinase domain that confer resistance to crizotinib and demonstrate that the
86 egion correspond to mutations in the rt ORF, conferring resistance to current antiviral therapies.
88 ; identified genotypic substitutions did not confer resistance to cytomegalovirus antivirals in vitro
89 esting established that ald loss of function conferred resistance to D-cycloserine, and susceptibilit
90 dition to aberrant apoptotic signaling might confer resistance to death signals delivered by CTL.
92 w that a whole-body knockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoho
97 emptively determine mutations in ERK1/2 that confer resistance to either ERK inhibitors or combined R
98 EK1 and MEK2 (MEK1/2) MAPK genes in melanoma confer resistance to emerging therapeutic MEK inhibitors
99 hiolation can be conditionally advantageous, conferring resistance to endoplasmic reticulum stress.
100 , we recently reported that DUSP3 deficiency confers resistance to endotoxin- and polymicrobial-induc
101 rsH catalyzes a novel biotransformation that confers resistance to environmental methylated and aroma
104 ospectively identify AR mutations that might confer resistance to enzalutamide, we performed a report
108 t to alter the expression of EMT genes or to confer resistance to erlotinib, it caused downregulation
109 g the known role of MET and EPHA2 kinases in conferring resistance to erlotinib in TKI sensitive stra
112 RG26 strain, and multiple mutations in ERG26 confer resistance to FR171456 in growth and enzyme assay
113 ich maps to the side of the FtsZ subunit and confers resistance to FtsZ assembly inhibitory factors i
116 of these two allergens with lipid components confers resistance to gastrointestinal digestion, reduce
120 hat reduce intrinsic Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs).
121 al muscle-specific deletion of MED13 in mice conferred resistance to hepatic steatosis by activating
123 omas select for expression of a pathway that confers resistance to high oxygen tension and protects c
124 Heterologous SlRd2 overexpression in yeast conferred resistance to highly toxic LiCl, whereas SlRd2
126 encoding a putative glycosyltransferase that confers resistance to HMOs, suggesting that HMOs may fun
134 l stabilization of the convertase enzyme and confer resistance to innate control mechanisms; unregula
135 ic (MON810 event with the Cry1Ab gene, which confers resistance to insects) and non-transgenic maize
136 hat intestinal colonization with Barnesiella confers resistance to intestinal domination and bloodstr
137 maturation, (2) a remodelled epithelium that confers resistance to intracellular bacterial colonizati
138 and RHD-defective (K83N, N109D) mutant RUNX1 conferred resistance to ionizing radiation when overexpr
139 oltheta is highly expressed in cancer cells, confers resistance to ionizing radiation and chemotherap
140 single nucleotide polymorphisms (SNPs) that confer resistance to isoniazid, rifampin, ofloxacin, and
141 well as the most frequent mutations in genes conferring resistance to isoniazid (katG and inhA) and r
142 he katG mutation encoding p.Ser315Thr, which confers resistance to isoniazid, overwhelmingly arose be
143 in III of eEF1A prevent ternatin binding and confer resistance to its cytotoxic effects, implicating
144 as is observed frequently in human cancers, confers resistance to killing by DNA-damaging agents.
146 A single amino acid substitution of IKZF3 conferred resistance to lenalidomide-induced degradation
147 huringiensis Cry genes (Bt G. hirsutum) that confer resistance to lepidopteran pests, is extensively
148 the Grb2-binding site on EGFR (Y1068F-EGFR) conferred resistance to ligand-induced degradation, whic
149 503 of 23S rRNA by the Cfr methyltransferase confers resistance to linezolid (and a variety of other
151 ntrol of expression of genes associated with conferring resistance to low-level antibiotics to the ba
154 ) are the three major ABC transport proteins conferring resistance to many structurally diverse antic
155 ATP-binding cassette (ABC) transporter that confers resistance to many anticancer drugs and plays a
156 s expressed in Escherichia coli and shown to confer resistance to MAs(III) and Rox(III) but not to in
159 de and nicotinamide riboside are reported to confer resistance to metabolic defects induced by high f
164 data, we identified polymorphisms in E2 that confer resistance to multiple broadly neutralizing mAbs.
165 odifies C8 of A2503 via a similar mechanism, conferring resistance to multiple classes of antibiotics
166 istance (R) gene in Medicago truncatula that confers resistance to multiple races of Colletotrichum t
168 er the nuclear import pathways used by HIV-1 confer resistance to MX2, whereas preventing cell divisi
170 We identify a single-amino acid mutation conferring resistance to mycolactone, which localizes it
171 domain that decrease enzymatic activity but confer resistance to NA inhibitors have been characteriz
172 ich (4 in N4, 4 in N5, 4 in N6, and 4 in N8) conferred resistance to NAIs (oseltamivir carboxylate, z
173 single point mutations within 16S rRNA that confer resistance to negamycin are in close proximity of
174 ) was up-regulated by dual stress in leaves, conferring resistance to nematodes when overexpressed.
175 which are not at mAb contact residues, also conferred resistance to neutralization by plasma from HC
176 nly for occluding many epitopes but also for conferring resistance to neutralization by all but a sma
177 his report, we identify a viral polymorphism conferring resistance to neutralization by both polyclon
181 tance associated mutation in the NS5A region conferring resistance to NS5A inhibitors, such as ledipa
182 However, in 10 patients the V321I change conferring resistance to nucleos(t)ide NS5B polymerase i
183 (dNTP)-binding pocket, including those that confer resistance to nucleoside/nucleotide analogs, affe
186 -glycosylation of Tfp with O-ag specifically confers resistance to opsonization during host-mediated
188 ions and methylations in helices H89 and H91 confer resistance to orthosomycins and revealed the sequ
190 ations selected for in FLT3/ITD alleles that confer resistance to other TKIs, including the F691L gat
195 dent microbiota can promote immune function, conferring resistance to pathogens and parasites by both
196 hairpin RNA-mediated down-regulation of Puma conferred resistance to PDGF-mediated apoptotic priming.
198 transformation, and that elevated MYC levels confer resistance to pharmacologic inhibitors of BCR sig
200 Stable expression of mutant PIK3CB variants conferred resistance to PI3K inhibition that could be ov
203 -root invasion, non-lethal synthetic peptide confers resistance to plantain against the key nematode
204 ely disables its abilities to promote HR and confer resistance to platinum salts and PARP inhibitors.
205 ression of ERAS in human melanoma cell lines conferred resistance to PLX4720 and induced hyperphospho
210 expression specifically in macrophages also confers resistance to Pseudomonas infection, highlightin
211 se PpsA, which converts pyruvate to PEP, can confer resistance to pyruvate-induced lysis when ppsA is
215 ed mutation in the rigosertib-binding pocket conferred resistance to rigosertib, establishing that ri
216 n does not lie at the gatekeeper residue, it confers resistance to ROS1 kinase inhibition through ste
218 , we identified 211 amino-acid substitutions conferring resistance to ruxolitinib (INCB018424) and cr
220 strategy in the context of AR mutations that confer resistance to second-generation AR antagonists.
221 iferative and invasive capacity in vitro and confers resistance to selective PI3Kdelta inhibitor, CAL
223 l components in Mycobacterium smegmatis that confer resistance to several structurally and mechanisti
224 pha2 ouabain binding site (alpha2(R/R) mice) confers resistance to several forms of hypertension.
226 falciparum ATPase 4 (pfatp4) mutations that confer resistance to (+)-SJ733 carry a high fitness cost
227 d as treatment-emergent variants but did not confer resistance to sofosbuvir in the replicon system.
231 that ATP-binding cassette member B5 (ABCB5) confers resistance to standard-of-care MCC chemotherapeu
232 ich result in multicellular communities that confer resistance to stress conditions such as desiccati
233 pumps function as multidrug efflux pumps by conferring resistance to structurally diverse antibiotic
234 dium channel gene previously demonstrated to confer resistance to synthetic pyrethroids to quantify c
236 tified by genome-wide association studies to confer resistance to T1D and result in the reduction in
237 hages in the pancreas as both types of cells confer resistance to T1D upon transfer to 13R(+/+) mice.
239 T3SS2) to identify human genome disruptions conferring resistance to T3SS-dependent cytotoxicity.
241 Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways
242 Our results therefore suggest that mutations conferring resistance to targeted therapy occur naturall
244 ed efflux pump of Staphylococcus aureus that confers resistance to tetracycline and certain unsaturat
245 romosomally encoded Tet38 efflux transporter confers resistance to tetracycline and fitness in absces
246 f PAX5 and CD19 and overexpress Smad7, which confers resistance to TGF-beta-mediated suppression of B
247 l domain of elongation factor Ts (EF-Ts) and confer resistance to the CdiA-CT(EC869) tRNase toxin fro
248 all secondary KD mutants previously shown to confer resistance to the first highly active FLT3 TKI qu
249 le PR inhibitors or mutant Gag proteins that confer resistance to the maturation inhibitor Bevirimat.
250 usly unreported adaptive mutations that each confer resistance to the ss-lactamase inhibitor tazobact
251 y of the most commonly selected mutations to confer resistance to the sshRNAs was confirmed in vitro
253 plemented an S1PL-deficient yeast strain and conferred resistance to the antimicrobial sphingolipid D
255 but none of the four induced Xa27-like genes conferred resistance to the dTALE-containing Xoo strains
257 R p.T790M mutation, the most common mutation conferring resistance to the EGFR inhibitor gefitinib, a
258 gamma) is the major proinflammatory cytokine conferring resistance to the intracellular vacuolar path
259 class A beta-lactamase family are capable of conferring resistance to the last resort antibiotics, ca
260 the minor allele of each respective variant conferring resistance to the miRNA either by disruption
261 ing this method, we identified two mutations conferring resistance to the mutagen 5-fluorouracil (5-F
262 ing tumor cells (CTCs) in the bloodstream by conferring resistance to the shear stress and attack fro
263 including in human breast cancer cell lines, confers resistance to the anti-cancer drug and TOP2 inhi
265 ve transposon (CTn) in Bacteroides spp. that confers resistance to the antibiotics erythromycin and t
267 ddition, the activation of HGF/MET signaling confers resistance to the effects of cancer treatments.
268 rent FLT3-ITD (internal tandem duplication), confers resistance to the FLT3 protein tyrosine kinase i
269 sses, namely the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanth
272 1/2 mitogen-activated protein kinases (MAPK) confers resistance to the RAF inhibitors vemurafenib and
275 36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to these modulators, suggesting a comm
277 oli dsbB gene and selected dsbB mutants that confer resistance to this drug using two approaches.
278 ly, overexpression of VGF in sensitive cells conferred resistance to TKIs and induced EMT, increasing
280 e transporter found in Escherichia coli that confers resistance to toxic polyaromatic cations due to
281 e, posttranslational regulation of caspase-8 confers resistance to TRAIL-induced cell death in normal
287 at protein that in addition to potato aphids confers resistance to two additional phloem-feeding inse
288 ible wheat variety Fielder was sufficient to confer resistance to Ug99, confirming that CNL13 is Sr13
289 eat (Triticum turgidum ssp. durum) gene Sr13 confers resistance to Ug99 and other virulent races, and
290 KAE609 resistance mutations in ScPMA1 do not confer resistance to unrelated antimicrobials, but do co
291 preventing spontaneous chromosome breaks and conferring resistance to UV radiation and cisplatin.
292 d in the production of virulence factors and conferring resistance to various antibiotics in pathogen
293 n and disrupts the p53/MDM2 regulatory axis, conferring resistance to various chemotherapeutics.
296 lleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii.
297 single-nucleotide changes within ORF54 that conferred resistance to VZV-specific portal protein inhi
298 the predominant mechanism of weight loss and confers resistance to weight gain from a high-fat diet,
299 Transgenic expression of the pepper Bs2 gene confers resistance to Xanthomonas campestris pv. vesicat
300 56 is a versatile antiviral host factor that confers resistance to YFV, DENV2, and HCoV-OC43 through
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