ライフサイエンスコーパス: methylmalonic

1 B-12 function (vitamin B-12 <200 pmol/L and methylmalonic acid >0.27 micromol/L) in the total group

2 in B-12 concentrations <150 pmol/L, or serum methylmalonic acid >376 nmol/L.

3 tus [ie, plasma vitamin B-12 < 148 pmol/L or methylmalonic acid (MMA) > 210 nmol/L] with respect to a

4 racteristics of metabolic biomarkers such as methylmalonic acid (MMA) and holotranscobalamin II, whos

5 exists at which the relation between plasma methylmalonic acid (MMA) and SB-12 changes slope to diff

6 al, cognitive, routine diagnostic, and serum methylmalonic acid (MMA) and total homocysteine (tHcy) t

7 olate, serum vitamin B-12, homocysteine, and methylmalonic acid (MMA) concentrations in US children b

8 12, and plasma total homocysteine (tHcy) and methylmalonic acid (MMA) in the US population.

9 Methylmalonic acid (MMA) is a by-product of propionic ac

10 sis on the association between rs1801198 and methylmalonic acid (MMA) lacked statistical power.

11 Urinary methylmalonic acid (MMA) may be a more informative bioma

12 anscobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA) were measured before and after

13 B(12) status, total homocysteine (tHcy) and methylmalonic acid (MMA), among adult participants in ph

14 min B-12, holotranscobalamin (holoTC), tHcy, methylmalonic acid (MMA), and folate with the use of lin

15 amin B-12, plasma total homocysteine (tHcy), methylmalonic acid (MMA), and holotranscobalamin into on

16 However, diagnostic algorithms using Cbl, methylmalonic acid (MMA), and homocysteine (HCys) measur

17 tus used in past NHANES--serum vitamin B-12, methylmalonic acid (MMA), and total homocysteine (tHcy)-

18 parison of baseline serum cobalamin, folate, methylmalonic acid (MMA), total homocysteine (tHcy), and

19 Methylmalonic acid (MMA), total homocysteine, and other

20 ma cobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA).

21 n and elevated total homocysteine (tHcy) and methylmalonic acid (MMA).

22 plasma total homocysteine (tHcy), and plasma methylmalonic acid (MMA)].

23 the use of vitamin B-12 than with the use of methylmalonic acid (MMA; 3-26% and 2-6%, respectively).

24 vels of cobalamin (normal, 200 to 900 pg/mL) methylmalonic acid (normal, 73 to 271 nmol/L), and homoc

25 in the brain was evident from the increased methylmalonic acid (P<0.01-0.04), homocysteine (P<0.01),

26 th higher concentrations of homocysteine and methylmalonic acid and higher odds ratios for cognitive

27 w serum vitamin B12 levels or elevated serum methylmalonic acid and homocysteine levels.

28 the C-H and C-N modulated CSA experiments on methylmalonic acid and N-tBoc-glycine, respectively.

29 e highest concentrations of homocysteine and methylmalonic acid and the lowest concentration of holot

30 eficiency who received treatment (15 of 21), methylmalonic acid and total homocysteine levels decreas

31 sorders characterized by the accumulation of methylmalonic acid and/or homocysteine in blood and urin

32 Elevated methylmalonic acid and/or total homocysteine are sensiti

33 ry results were significantly raised urinary methylmalonic acid compared with age-matched controls (p

34 n B-12 concentration < 148 pmol/L or a serum methylmalonic acid concentration > 210 nmol/L-the maximu

35 n B-12 concentration <148 pmol/L or a plasma methylmalonic acid concentration > or =210 nmol/L, the p

36 re, each 2-fold increment in homocysteine or methylmalonic acid concentration was associated with a d

37 with vitamin B-12 was associated with lower methylmalonic acid concentrations (P < 0.001).

38 Mean serum vitamin B-12 and methylmalonic acid concentrations did not differ; howeve

39 In addition, mean methylmalonic acid concentrations were significantly low

40 one users also had significantly lower serum methylmalonic acid concentrations.

41 ed blood cell folate, serum homocysteine, or methylmalonic acid concentrations.

42 and beta-carotene and lower homocysteine and methylmalonic acid concentrations.

43 vitamin B-12 deficiency with elevated serum methylmalonic acid concentrations.

44 ither vitamin B-12 or folate deficiency, and methylmalonic acid for detection of vitamin B-12 deficie

45 One year after transplant, urine methylmalonic acid indicates good vitamin B12 absorption

46 depression, had a significantly higher serum methylmalonic acid level and a nonsignificantly lower se

47 2 level less than 221 pmol/L and an elevated methylmalonic acid level; 2) a serum vitamin B12 level l

48 The higher serum cobalamin and lower serum methylmalonic acid levels at 4 months posttreatment in t

49 alization of elevated total homocysteine and methylmalonic acid levels may prevent the development of

50 Methylmalonic acid may contribute to neuronal injury in

51 ene of Pseudomonas aeruginosa, which encodes methylmalonic acid semialdehyde dehydrogenase (MSDH) and

52 mentation may be effective in lowering serum methylmalonic acid values in the elderly.

53 s of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured.

54 f folate, cobalamin, total homocysteine, and methylmalonic acid with cognitive performance at 2 occas

55 elderly population as documented by elevated methylmalonic acid with or without elevated total homocy

56 The use of serum vitamin B-12 and plasma methylmalonic acid would provide continuity with past NH

57 lasma total vitamin B-12, 3 studies measured methylmalonic acid, and 6 studies measured total homocys

58 rum and red blood cell folate, vitamin B-12, methylmalonic acid, and homocysteine concentrations amon

59 ean pretreatment values for serum cobalamin, methylmalonic acid, and homocysteine were, respectively,

60 the amount of B12 bound to TCII (holoTCII), methylmalonic acid, and homocysteine, in 128 healthy old

61 elevation of the metabolites, homocysteine, methylmalonic acid, and the ligand, transcobalamin II, i

62 serum concentrations of total vitamin B-12, methylmalonic acid, and total homocysteine are all effec

63 Serum levels of vitamin B12, folate, methylmalonic acid, and total homocysteine measured befo

64 Serum levels of vitamin B(12), folate, methylmalonic acid, and total homocysteine were assayed

65 n status (defined by low cobalamin, elevated methylmalonic acid, and/or elevated homocysteine concent

66 Homocysteine, methylmalonic acid, holotranscobalamin, ratio of holotra

67 using markers such as holotranscobalamin and methylmalonic acid, it has been found that cognition is

68 ne, kynurenine, leucine, lysine, methionine, methylmalonic acid, ornithine, phenylalanine, proline, s

69 , show failure to thrive, and show increased methylmalonic acid, propionylcarnitine, odd chain fatty

70 rum vitamin B-12, total homocysteine (tHcy), methylmalonic acid, serum folic acid, and 5-methyltetrah

71 ion test and measurement of homocysteine and methylmalonic acid, to cobalamin status has identified t

72 Methylmalonic acid, which is formed from the MCM substra

73 as associated with elevated homocysteine and methylmalonic acid, which were reduced by folate and vit

74 ular mitochondrial inhibitor and neurotoxin, methylmalonic acid.

75 total transcobalamin, total haptocorrin, and methylmalonic acid.

76 Isolated methylmalonic acidemia (MMA) is managed by dietary prote

77 Isolated methylmalonic acidemia (MMA), caused by deficiency of th

78 born error of cobalamin metabolism, combined methylmalonic acidemia and hyperhomocysteinemia, cblC ty

79 enetic basis of an X-linked form of combined methylmalonic acidemia and hyperhomocysteinemia, designa

80 nction occur in a tissue-specific fashion in methylmalonic acidemia and suggest treatment approaches

81 Methylmalonic acidemia is an autosomal recessive inborn

82 parallel, the liver from a patient with mut methylmalonic acidemia was studied in a similar fashion.

83 Two adult brothers, one documented to have methylmalonic acidemia with homocystinuria, or cobalamin

84 mimicking the human diseases propionic- and methylmalonic acidemia, in which the canonical B12-depen

85 of patients suffering from the mut- form of methylmalonic acidemia, resulting from defective AdoCbl

86 oding this enzyme result in the mut forms of methylmalonic acidemia.

87 traindicated, e.g. in propionic acidemia and methylmalonic acidemia.

88 fy the genetic basis of combined malonic and methylmalonic aciduria (CMAMMA).

89 Methylmalonic aciduria (MMAuria), caused by deficiency o

90 compound heterozygotes for mutations in the methylmalonic aciduria and homocystinuria type C (MMACHC

91 ficient for its interaction with MMADHC (the methylmalonic aciduria and homocystinuria type C protein

92 MMADHC (the methylmalonic aciduria and homocystinuria type D protein

93 min trafficking, and mutations in CblD cause methylmalonic aciduria and/or homocystinuria.

94 east two biologically compelling candidates, methylmalonic aciduria cblB type (MMAB) and mevalonate k

95 he missense mutations in MMAA that result in methylmalonic aciduria have been mapped onto MeaB and, i

96 Many of the mutations that cause methylmalonic aciduria in humans affect residues in the

97 n humans, deficiencies in the mutase lead to methylmalonic aciduria, a rare disease that is fatal in

98 in the human homolog of MeaB, MMAA, lead to methylmalonic aciduria, an inborn error of metabolism th

99 ions in the human ortholog of MeaB result in methylmalonic aciduria, an inborn error of metabolism.

100 n the human homologue of MeaB, MMAA, lead to methylmalonic aciduria, an inborn error of metabolism.

101 mutation, D180X, described in a patient with methylmalonic aciduria, and characterized the associated

102 7 days of age with poor feeding, hypotonia, methylmalonic aciduria, and elevated plasma homocysteine

103 cts in the human homologue of MeaB result in methylmalonic aciduria, but the role of this protein in

104 ase (EC 5.4.99.2) result in the mut forms of methylmalonic aciduria.

105 Failure to assemble holo-MCM leads to methylmalonic aciduria.

106 t manifest in both severe homocystinuria and methylmalonic aciduria.

107 mulation of inactive enzyme and resulting in methylmalonic aciduria.

108 dysfunction in human patients suffering from methylmalonic aciduria.

109 uman ACA have been identified in humans with methylmalonic aciduria.

110 s residues responsible for the human disease methylmalonic aciduria.

111 t defects in its encoding gene underlie cblB methylmalonic aciduria.

112 known function, MMAA, has been implicated in methylmalonic aciduria.

113 carboxylic acids, such as oxalic, malonic, 3-methylmalonic, and cyclobutanedicarboxylic acid, was uti

114 ts for the thermal decomposition of malonic, methylmalonic, and dimethylmalonic anhydrides were measu

115 Methylmalonic anhydride is the fastest, with the lowest