ライフサイエンスコーパス: pre-existing

1 disease undergoing lung transplantation have pre-existing Abs against lung-restricted self-Ags, colla

2 e previously unappreciated reorganization of pre-existing actin filaments around WPBs before fusion,

3 Using pre-existing activity profiles of each inhibitor, we gen

4 ions driven by environmental change toward a pre-existing adaptive optimum.

5 Older adults commonly have pre-existing ADCC antibodies in the absence of high HAI

6 of diet-induced obesity, but did not affect pre-existing adiposity and body weight in obese mice.

7 ith mating disruption tactics to enhance the pre-existing Allee effect.

8 ts host population, into a population with a pre-existing Allee effect.

9 of Wolbachia introductions to capitalize on pre-existing Allee effects and consequently eradicate in

10 Pre-existing AMPK activity is further amplified by ligat

11 Pre-existing and induced anti-poly(ethylene glycol) (PEG

12 at the selected beneficial mutations are not pre-existing and that the initial slow phage growth is e

13 d bind to PEG (anti-PEG Abs), including both pre-existing and treatment-induced Abs.

14 s and some critical animal studies regarding pre-existing and treatment-induced anti-PEG Abs.

15 adulthood yielded a mosaic pool of unmarked (pre-existing) and marked (newly-formed) oocytes.

16 bition of necroptosis with Nec-1s stabilizes pre-existing aneurysms by diminishing inflammation and p

17 sistencies between newly identified ORFs and pre-existing annotations of coding-regions.

18 ence, quantitative levels, and Ab isotype of pre-existing anti-PEG Ab remain poorly understood.

19 The widespread prevalence of pre-existing anti-PEG Ab, coupled with high Ab levels in

20 However, some healthy individuals have pre-existing anti-PEG antibodies and certain patients de

21 Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma c

22 ociated with APOE epsilon4 allele frequency, pre-existing ARIA-H, treatment with bapineuzumab and use

23 Arteriogenesis, or the lumenal expansion of pre-existing arterioles in the presence of an upstream o

24 blocked endocytosis of retrievable membrane pre-existing at the surface, and was impaired by oxidati

25 date for developing a cell-based therapy for pre-existing autoimmune diseases.

26 f immune tolerance mechanisms, which inhibit pre-existing autoimmune inflammation, may provide us wit

27 clustered growth of active spines contacting pre-existing axonal boutons.

28 ching of NMR assignments), directly exploits pre-existing bioinformatics algorithms to match experime

29 tive resection and appears to be superior to pre-existing biomarkers.

30 acellular matrix protein actively disrupting pre-existing BMs.

31 wings were derived from a modification of a pre-existing branch at the dorsal base (subcoxa) of the

32 Heterozygous BRCA2 truncations, by lowering pre-existing BRCA2 expression, sensitize to BRCA2 haploi

33 On multivariable analysis (MVA), pre-existing cardiac disease (hazard ratio [HR], 2.96; 9

34 Pre-existing cardiac disease and higher mean heart dose

35 eceived concurrent chemotherapy, and 27% had pre-existing cardiac disease.

36 cyte renewal occurs via the proliferation of pre-existing cardiomyocytes, and is regulated by aerobic

37 es into the cell cycle; dedifferentiation of pre-existing cardiomyocytes, which assume an immature re

38 the newly formed myocardium is derived from pre-existing cardiomyocytes.

39 arts, mediated primarily by proliferation of pre-existing cardiomyocytes.

40 des strong evidence for its emergence from a pre-existing Caribbean epidemic.

41 to suppression of ground-state absorption by pre-existing carriers.

42 troducing transversally-oriented clones into pre-existing cartilage.

43 f the corneal edema cases were likely due to pre-existing causes other than the aqueous shunt.

44 We also observed pre-existing CCNB1-specifc IgG Abs in both healthy and c

45 With a pre-existing chiral center at any of the backbone sp(3)-

46 a that has just entered the nucleus exploits pre-existing chromatin looping to exert its multimodal r

47 We found little evidence that pre-existing chytrid emergence was associated with ranav

48 aptic integration of new neurons affects the pre-existing circuit.

49 the effect can be observed in patients with pre-existing cirrhosis.

50 Pre-existing CKD and ESRD, and postoperative AKI were th

51 In surgical patients, pre-existing CKD and postoperative AKI are associated wi

52 ns, with genetic barcoding studies revealing pre-existing clonal populations with no shared resistanc

53 he trivalent influenza vaccine, with boosted pre-existing clonotypes accounting for approximately 60%

54 We used pre-existing clusters of communities randomised as part

55 with agriculture, but rather developed from pre-existing cognitive and social mechanisms.

56 Two intervention participants, one with a pre-existing complex seizure disorder and another who ex

57 ly and stratified by hospital according to a pre-existing computer-generated list in a 1:1 ratio to r

58 Based on recent studies of pre-existing conditions in patients with malignancies an

59 rs from developing countries and donors with pre-existing conditions such as obesity.

60 Glycosylation stabilized the pre-existing conformations of this peptide construct, re

61 f the inflammasome highlight the assembly of pre-existing core components shortly after infection or

62 Hospital cost accounting data and pre-existing cost data within the PHIS database provided

63 riking outcome is: despite the presence of a pre-existing crack, the crack sensitivity of nc-silicene

64 c-silicene) sheet of varying grain sizes and pre-existing cracks at room temperature.

65 However, nc-silicene with pre-existing cracks exhibits anomalous crack propagation

66 Our study confirms that, given a pre-existing crystal structure of the target protein-pro

67 Participants with pre-existing CVD were excluded from the analyses.

68 limited to the 130 843 participants without pre-existing CVD.

69 Our results provide a structural basis for pre-existing data describing the excisive and integrativ

70 ng RNA-seq analysis coupled with analysis of pre-existing databases, we found that Olfr mRNAs have se

71 inelastic ionization can effectively anneal pre-existing defects and restore the structural order.

72 And interaction with pre-existing defects led to the slowdown of the transfor

73 nclear if boosting progranulin could correct pre-existing deficits.

74 218 patients (median age 67.5 years) without pre-existing dementia who were alive at 6 months follow-

75 e older, male, Caucasian, spouseless, with a pre-existing dementia.

76 Whether pre-existing DENV immunity can cross-protect or enhance

77 while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more sever

78 Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo.

79 hen ZIKV infection occurs in the presence of pre-existing DENV immunity.

80 significant associations between SJS/TEN and pre-existing depression, lupus erythematosus, recent pne

81 ear after a stroke event was associated with pre-existing diabetes (146.9), mental disorder (141.2),

82 In case 1, a 74-year-old gentleman with pre-existing diabetes mellitus and hypertension was elec

83 2000 individuals aged 40 to 79 years without pre-existing diabetes mellitus or CVD from the 2011 to 2

84 To determine the association of pre-existing diabetes, hyperglycemia, and hypoglycemia d

85 The association between 90-day mortality and pre-existing diabetes, hyperglycemia, and hypoglycemia,

86 CI, 1.19-7.32), whereas in patients without pre-existing diabetes, several combinations of abnormal

87 diabetes, family history of glaucoma, and/or pre-existing diagnosis of glaucoma.

88 HD in a child or encountering a child with a pre-existing diagnosis.

89 in their characteristic locations because of pre-existing differences in the extrinsic connectivity o

90 ] of 53), and most of these participants had pre-existing disabilities.

91 de I evidence indicative of complex roles of pre-existing disease (frailty, carotid atherosclerosis,

92 da albicans in patients with EoE is owing to pre-existing disease and its underlying abnormal epithel

93 assortative mixing alone could not sustain a pre-existing disparity in prevalence of HIV between blac

94 accination in England will initially widen a pre-existing disparity in the incidence of HPV-related c

95 xorubicin resulted in complete regression of pre-existing distant metastases in 65% of the animals an

96 Previous studies have suggested that pre-existing disulfide links are absolutely required to

97 at chemotherapy facilitates the expansion of pre-existing drug-resistant glioblastoma stem cells.

98 s of additional pharmacogenomic profiling of pre-existing drugs for novel therapeutic effects with of

99 his observation allowed us to test whether a pre-existing dysbiotic skin microbiota influences diseas

100 ients with contraindications to antibiotics, pre-existing dysphagia, or known infections, or who were

101 re, we modelled the treatment of muscle with pre-existing dystrophic pathology using antisense oligon

102 red by an interaction with another same-sign pre-existing edge dislocation.

103 er mutation can occur either by selection of pre-existing EGFR(T790M)-positive clones or via genetic

104 echanistically, prenatal LPS exposure led to pre-existing elevated peroxisome proliferators-activated

105 t increase in long-range interactions within pre-existing enhancer networks.

106 Pre-existing epilepsy was the only predictor of intellec

107 he observed fast motions are fluctuations in pre-existing equilibrium configurations.

108 so alters the structural organization of the pre-existing ERE/ERalpha/SRC-3/p300 complex.

109 ellular reprogramming in which repression of pre-existing ES cell-associated gene expression program

110 e the admission, 4% and 8% of the cohort had pre-existing ESRD and CKD not requiring renal replacemen

111 dence interval, 5.00-6.49) for patients with pre-existing ESRD.

112 ib resistance have progressive enrichment of pre-existing FBW7 hotspot mutations, and are cross-resis

113 amental understanding of the importance that pre-existing flaws at the intaglio surface have on fatig

114 an nucleate median cracks in samples with no pre-existing flaws, while indenters with larger indenter

115 tablished immune responses in the setting of pre-existing food allergy.

116 g how a de novo gene becomes integrated into pre-existing functions and becomes essential.

117 s with quality baseline images, 22 (35%) had pre-existing GA.

118 und and randomization will be stratified for pre-existing gallstones and for type of surgery.

119 e galaxies is possible; the interaction with pre-existing gas funnels the gas into nuclear regions (<

120 New genes arise from pre-existing genes, but some de novo origin from non-gen

121 To investigate whether a pre-existing genetic component contributed to this pheno

122 w piRNA acquisition modality by activating a pre-existing genomic locus, and extend piRNA defense rol

123 glaucomatous field defects, and 1 case with pre-existing glaucoma had progression of glaucomatous fi

124 tabilized in three quarters of the eyes with pre-existing glaucoma.

125 This study makes use of a pre-existing governmental natural experiment to show tha

126 Moreover, pre-existing (hazard ratio = 1.91; P <0.001) and new ons

127 and is likely due to incomplete degassing of pre-existing He during the casting process.

128 Subjects had minimal pre-existing hemagglutination inhibiting (HAI) antibodie

129 Many patients with a pre-existing hemiparesis, however, experience no deterio

130 eased during neonatal cardiac surgery, where pre-existing hemodynamic instability and metabolic abnor

131 ubstrate preference towards nucleosomes with pre-existing histone H3 lysine 14 acetylation.

132 nical trial); if they assessed the effect of pre-existing HSV-2 infection on HIV acquisition; and if

133 Pre-existing hypertrophy in the newborn heart can exacer

134 f antibodies and suggest that high levels of pre-existing immune complexes could limit the effectiven

135 ovide new insights into interactions between pre-existing immunity and pandemic viruses.

136 Additionally, pre-existing immunity to related flaviviruses could gene

137 ngue-1, 2, 3 and 4 serotypes suggesting that pre-existing immunity to Zika virus could potentially en

138 In our exploratory analysis, patients with pre-existing immunity, defined by high T-effector-interf

139 To minimize the impact of anti-vector pre-existing immunity, we developed a chimeric Ad5/3 vec

140 Background from pre-existing in vivo analytes is lower for RNAs than for

141 els for age, but patients were able to clear pre-existing infections and those acquired later.

142 is achieved in minutes without the need for pre-existing information or candidate structures.

143 trating that cSCC progression is governed by pre-existing injury-driven changes in the RDEB tissue mi

144 ses regulating trafficking and/or release of pre-existing insulin granules rather than for those regu

145 Here we show that pre-existing, intrinsically committed DASC(p63/Krt5) und

146 th Ebola virus disease, including absence of pre-existing isolation and treatment facilities, patient

147 by database-oriented approaches that require pre-existing knowledge of the DD elements to be detected

148 to be constructed of durable materials than pre-existing latrines, but were equally clean, and more

149 A post hoc multivariable analysis identified pre-existing lesion volume and valve type as predictors

150 e of a tumour, and come to dominate a large, pre-existing lesion, has been unclear.

151 7me3 and loss of H3K27ac correlates with the pre-existing levels of the modifications, and overall th

152 gent in a higher proportion of patients with pre-existing liver disease compared with those without l

153 , compared with planned LM PCI performed for pre-existing LM disease, resulted in increased 30-day (1

154 e-control matching between 167 patients with pre-existing LM stents undergoing TAVR and 1,188 control

155 Pre-existing lung allograft injury from donor-directed A

156 uction in tumor burden in multiple models of pre-existing malignancy in B6 and BALB/c mice.

157 ix is highly fibrous and interdigitates with pre-existing matrix, while in more developed constructs,

158 Our findings identify a pre-existing mechanism of stress-induced susceptibility,

159 sm in this cohort and patients with multiple pre-existing mechanisms (T790M and MET) experience infer

160 to multicellularity required modification of pre-existing mechanisms for extracellular matrix synthes

161 ature recruit ATP-independent endocytosis of pre-existing membrane (in addition to ATP-dependent endo

162 endent redistribution of Kv2.1 channels from pre-existing membrane clusters to diffuse localization.

163 endocytosis primarily involved retrieval of pre-existing membrane, which depended on Ca(2+) and the

164 x process that involves both modification of pre-existing memories and formation of new ones, and the

165 Pre-existing memory B cells in these children differenti

166 However, the effect of ART on restoring pre-existing memory CD4(+) T cells specific for common c

167 Thus, SIgM may emerge from pre-existing memory rather than newly activated naive Ig

168 nships, effects that are not attributable to pre-existing mental health, substance use or social prob

169 he epidemic clones emerged by acquisition of pre-existing metabolic gene variants, rather than 'virul

170 cose control in diet-induced obese mice with pre-existing metabolic syndrome.

171 he control group) were ineligible because of pre-existing metastases and were therefore excluded from

172 Pre-existing methods for pseudotime estimation have pred

173 xperimentalist because neither intuition nor pre-existing methods work well for identifying oscillato

174 When accessible pre-existing microhomologies do not exist, we have postu

175 esis is the growth of new blood vessels from pre-existing microvessels.

176 erior pole progenitors were specified at the pre-existing midline of regenerating fragments, even whe

177 ior pole formation: a polarized AP axis, the pre-existing midline, and the dorsal-ventral median plan

178 currence arose through clonal selection of a pre-existing minor clone present at diagnosis.

179 Pre-existing MNV-specific Trm cells provided partial pro

180 perceptual regions must interact to balance pre-existing models of the environment with new incoming

181 Patients with pre-existing morbidities are often at increased risk of

182 on of new daughter centrioles is guided by a pre-existing, mother centriole.

183 er adjustment for age, sex, body mass index, pre-existing musculoskeletal conditions, years in profes

184 vaccination with neoantigens can both expand pre-existing neoantigen-specific T-cell populations and

185 ons with inappropriate nearby targets in the pre-existing neural network.

186 AND were aged </=4 years; less than half had pre-existing neurological disease or other risk factors

187 ns and may reduce Ab levels in patients with pre-existing neutralizing Abs to Pseudomonas exotoxin, a

188 r patients with hemophilia or blindness, but pre-existing neutralizing antibodies (Nab) are common in

189 nknown to what extent pre-fusion F can boost pre-existing neutralizing responses in RSV seropositive

190 ories of PTSD were characterized: resilient, pre-existing, new-onset, and moderate stable.

191 Selection of both pre-existing non-mucoid subpopulations and of novel phen

192 in contrast to suggested pathological roles, pre-existing non-neutralizing antibodies (NNAbs) were no

193 This deletion of pre-existing nuclear DNA suggests that the genetic impac

194 ather than simple physical perturbation of a pre-existing nuclear envelope.

195 These transposons insert between pre-existing nucleosomes, so that multiple nearby insert

196 tudies and mathematical models, we integrate pre-existing observations with our meta-analyses of the

197 000 patients (ie, 10% absolute benefit) with pre-existing occlusive vascular disease (secondary preve

198 Patients with pre-existing ocular comorbidity that impacted visual pot

199 patients due to confounding factors such as pre-existing ocular diseases in some but not others.

200 pool ("new soil C"), or accelerate losses of pre-existing ("old") soil C.

201 r new OMP insertion in clusters, driving the pre-existing OMP clusters towards cell poles for long-te

202 osis or from nearby extra-synaptic receptors pre-existing on the neuronal surface.

203 deprivation triggers necrosis by activating pre-existing oncogenic pathways in cystine-addicted TNBC

204 s, the development of new blood vessels from pre-existing ones.

205 cess for formation of new blood vessels from pre-existing ones.

206 They were prospectively studied as part of a pre-existing ongoing research protocol to evaluate the e

207 Their novel modulation is dependent on pre-existing OR activity and mediated by membrane-delimi

208 unctional connectivity, without the need for pre-existing or hidden pathology.

209 if differences in stress susceptibility are pre-existing or merely an effect of chronic stress.

210 [4.32-14.72], p<0.0001), aggravation of any pre-existing organ dysfunction (OR 4.35 [2.79-6.81], p<0

211 ydroarylation eliminates the common need for pre-existing ortho-substitution on benzoic acids for sub

212 Our approach can be readily adapted to any pre-existing package.

213 e most likely to be lost by coagulation with pre-existing particles, thereby failing to form new clou

214 of volatile organic compounds condense onto pre-existing particles.

215 ation for their origin is through toughening pre-existing parts of the body wall; in contrast, the su

216 Surprisingly, rather than attenuating the pre-existing pathogenic TSHR level, in TSHR/NOD.H2(h4) m

217 ggable target to dampen neuronal activity if pre-existing pathologies associate with circuit hyperexc

218 imilar efficacy of ERT and SRT in correcting pre-existing pathologies in Fabry disease.

219 for the most common PRDM9 variant, specific pre-existing patterns of histone modification and open c

220 ted, including one fatality due to worsening pre-existing peripheral arterial occlusive disease in a

221 ates (1 ms(-1)), similar calcite gouges with pre-existing phyllosilicate-bearing (clay content </=3 w

222 microglial activation and slow expansion of pre-existing plaques.

223 ned individuals are able to redistribute the pre-existing pool of PLIN proteins to an expanded LD poo

224 en by inherent pathogen transmissibility and pre-existing population immunity, and can generate unbia

225 (M4) inter-conversion, and a model with two pre-existing populations with adaptive resistance (M6).

226 and risk factors (eg, prior trauma history, pre-existing psychiatric conditions, poor social support

227 s, suggesting a moderating interplay between pre-existing psychological factors and treatment cortiso

228 nt of this risk, and whether it is linked to pre-existing psychopathology, is not known.

229 15 that included a sample of patients with a pre-existing psychotic disorder with a follow-up duratio

230 bstructive pulmonary disease, severe asthma, pre-existing pulmonary lesions, and severely immunocompr

231 Variants with the pre-existing RAS T/Y93H acquired additional NS5A changes

232 Despite similar pre-existing rates and trends of postoperative mortality

233 lizing responses to ZIKV are associated with pre-existing reactivity to DENV1 in humans.

234 One patient in the RBL group had a pre-existing rectal tumour.

235 in Ndufs4(KO) mice due to the inhibition of pre-existing reduced complex I function, reaching a crit

236 liver transplantation (LT), but the role of pre-existing renal insufficiency and proteinuria remains

237 Our data indicate that pre-existing resistance may not be a major hurdle for no

238 Chemotherapy may fail either due to pre-existing resistance or evolution of drug-resistant p

239 pe variants, and investigated the effects of pre-existing resistance-associated substitutions (RAS) o

240 protection include reducing the frequency of pre-existing resistant alleles, the probability of nonre

241 esistance remains a major challenge as minor pre-existing resistant subpopulations are often found to

242 d did not interfere with retinal function or pre-existing retinal vasculature.

243 We excluded patients with pre-existing risk factors for iron deficiency.

244 yte (myocardial infarction in a patient with pre-existing risk factors).

245 oX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking do

246 score predicts clinical outcome superior to pre-existing scores.

247 of mimicry vs generalized food deception or pre-existing sensory bias.

248 Pre-existing serum antibodies play an important role in

249 single or double uridylate (U) insertions in pre-existing short poly(U) tracts.

250 ompared with Ipc-PH were identified by using pre-existing single-nucleotide polymorphism data.

251 (ii) the time scale of ultrafast trapping at pre-existing sites (22 fs), and (iii) the initial VBE (1

252 edium between the calicoblastic ectoderm and pre-existing skeleton, separated from the overlying seaw

253 fied: APOE epsilon4, bapineuzumab treatment, pre-existing small ARIA-H and use of antithrombotics.

254 Here, we explored the relationship between pre-existing social status and salivary testosterone lev

255 the top of these cascades in the absence of pre-existing specificity.

256 ysis revealed predominant phosphorylation of pre-existing STAT3 nuclear subsets in addition to transl

257 The detection of LRP in a pre-existing stent by NIRS alone is not reliable evidenc

258 Findings were compared between pre-existing stents and a control group of freshly impla

259 RS) and intravascular ultrasound findings in pre-existing stents and to compare NIRS findings in pre-

260 Among 60 pre-existing stents implanted 5.5+/-4.0 years earlier, N

261 NIRS findings in pre-existing stents were indistinguishable from those of

262 sting stents and to compare NIRS findings in pre-existing stents, in which an increased lipid signal

263 site of LRP detected by NIRS in a cohort of pre-existing stents, intravascular ultrasound was used t

264 the potential source of the lipid signal in pre-existing stents.

265 ich lipid-rich plaques (LRPs) develop within pre-existing stents.

266 ity of this process with a ketone containing pre-existing stereocenters has been demonstrated.

267 olesterolemia patients age 30+ years without pre-existing stroke or cardiovascular disease, 532 patie

268 pregnant HS patients were younger with fewer pre-existing stroke risk factors and medications.

269 time-consuming and necessitates databases of pre-existing structures for structural assignment.

270 rity of resistant clones were part of small, pre-existing subpopulations that selectively escaped und

271 ly occupy substitutional positions replacing pre-existing sulfur vacancies.

272 l with adaptive resistance (M5), models with pre-existing susceptible and resistant populations witho

273 a manner consistent with a redistribution of pre-existing synapses to newly integrating neurons and t

274 s via internalization of AMPA receptors from pre-existing synapses.

275 f heart failure, especially in patients with pre-existing systolic dysfunction.

276 ging relevance of immunotherapies that boost pre-existing T cell responses, understanding how differe

277 tered adaptive T-cell responses by expanding pre-existing T cells or by recruiting new T cells to pro

278 Pre-existing T-cell infiltration and/or the presence of

279 By the preplay account, pre-existing temporal sequences are mapped onto new expe

280 In recent years, our understanding of how pre-existing TEs affect genome architecture, gene regula

281 We propose that three landmarks of pre-existing tissue at wounds set the location of anteri

282 n a manner that facilitates integration with pre-existing tissue in regeneration.

283 ema pattern is generated and integrated with pre-existing tissues is a central question in the field

284 ow newly generated cells are integrated into pre-existing tissues.

285 into files that can be imported into popular pre-existing tools (e.g. PLINK and HaploView), Ferret of

286 ing in megakaryocyte protein production from pre-existing transcripts and a maturation of SL-MkPs and

287 tions through RNA polymerase IV to reinforce pre-existing transposable element silencing.

288 003) increased during the crisis compared to pre-existing trends, while mortality from respiratory di

289 sbretabulin tromethamine selectively targets pre-existing tumor vasculature, which causes vascular sh

290 biquitin and histone surfaces, stabilizing a pre-existing ubiquitin orientation in NCP-ubme to form a

291 g can function as a critical addition to the pre-existing variant databases in pursuing genetic studi

292 Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE pepti

293 Our findings suggest that pre-existing variation in SP5G facilitated the expansion

294 sis, the formation of new blood vessels from pre-existing vasculature, in order to obtain nutrients r

295 n at threonine 3 of H3 (H3T3P) distinguishes pre-existing versus newly synthesized H3.

296 sis, the formation of new blood vessels from pre-existing vessels, has been validated as a target in

297 giogenesis - endothelial cell sprouting from pre-existing vessels.

298 Understanding pre-existing viewpoints may advance the field more effec

299 Two patients died of pre-existing viral infections without having thymopoiesi

300 pts the PB2-NP interaction in the context of pre-existing vRNPs or prevents the assembly of new vRNP