ライフサイエンスコーパス: progastrin

1 oned media from CCD18Co cells incubated with progastrin.

2 rproliferative and cocarcinogenic effects of progastrin.

3 re required for the proliferative effects of progastrin.

4 n the transgenic mice that overexpress human progastrin.

5 Overexpression of progastrin, a nonamidated and incompletely processed pro

6 We investigated whether progastrin affects signaling between colonic epithelial

7 Biosynthetic precursors and intermediates (progastrin and Gly-gastrins) are putative growth factors

8 t of human lung cancers was found to express progastrin and/or glycine-extended gastrin.

9 gastrin such as glycine-extended gastrin and progastrin are also expressed in human lung cancers, the

10 stal crypts of FVB/N mice injected with 1 nM progastrin associated with a significant increase in cel

11 r the rapidity of the changes in cleavage of progastrin at Lys residues after omeprazole.

12 residues, but did not influence cleavage of progastrin at pairs of arginine residues.

13 Cleavage of [3H]- and [35S]-labelled progastrins at Arg-94-95 or Arg-57-58, and amidation at

14 ines, CCK2R was necessary and sufficient for progastrin binding and induction of proliferation; these

15 Cells were analyzed for progastrin binding, proliferation, changes in gene expre

16 ressed abundant human gastrin mRNA and human progastrin but were unable to process this peptide to th

17 increased in mice expressing high levels of progastrin, but not amidated gastrins.

18 are associated with selective modulation of progastrin cleavage, possibly by raising intragranular p

19 ed with mice that did not express transgenic progastrin (controls).

20 Murine deletion of Cck2r abrogated progastrin-dependent increases in colonic proliferation,

21 onism of Cck2r resulted in the inhibition of progastrin-dependent increases in progenitors expressing

22 Newly synthesized progastrin-derived peptides in rat antral mucosa were la

23 The effects of progastrin-derived peptides on gastric epithelial functi

24 Dietary amines also modulate cleavage of progastrin-derived peptides, but do so by a VMAT1-indepe

25 Progastrin downregulation also decreased the frequency o

26 Progastrin expression and secretion were highly enriched

27 Progastrin expression promoted CSC self-renewal and surv

28 nic crypts of transgenic mice overexpressing progastrin (Fabp-PG mice).

29 -293 cells that stably expressed full-length progastrin (HEK-mGAS) or an empty vector (HEK-C).

30 mice that produce high circulating levels of progastrin (hGAS) have increased proliferation of coloni

31 ned in transgenic mice overexpressing either progastrin (hGAS) or amidated gastrin (INS-GAS), compare

32 In this study, we investigated the role of progastrin in regulating CSC phenotype in advanced color

33 sion is required for the biologic effects of progastrin in vivo and in vitro and mediates the stimula

34 ned how processing of the gastrin precursor, progastrin, in rat antral mucosa is influenced by modula

35 Incubation with progastrin increased the number of CD44(+), bromodeoxyur

36 n together, these observations indicate that progastrin induces proliferative effects, primarily in c

37 ole of bone morphogenetic proteins (BMPs) in progastrin induction of colonic cell proliferation via C

38 Progastrin is a secreted peptide that exhibits tumor-for

39 Progastrin itself stimulates colonic epithelial prolifer

40 d form, resulting in markedly elevated serum progastrin levels and normal amidated gastrin levels.

41 ay was down-regulated in the colons of human progastrin mice compared with controls.

42 Progastrin might therefore alter colonic epithelial cell

43 but few studies have examined the effects of progastrin on mucosal proliferation in vivo.

44 vitro and mediates the stimulatory effect of progastrin on p65NF-kappa, beta-catenin, and the putativ

45 rproliferative and anti-apoptotic effects of progastrin on proximal colonic crypts of transgenic mice

46 ntegral to the hyperproliferative effects of progastrin on proximal colonic crypts.

47 e compared with either ANXA2(-/-) mice given progastrin or ANXA2(+/+) and ANXA2(-/-) mice given salin

48 lls that expressed CCK2R were incubated with progastrin or Bmp2; levels of beta-arrestin 1 and 2 were

49 ctal carcinogenesis, Cck2r deletion in human progastrin-overexpressing mice resulted in markedly decr

50 Progastrin (PG) exerts proliferative and antiapoptotic e

51 Mice overexpressing progastrin (PG) in intestinal mucosa (fatty acid-binding

52 d others have reported the presence of novel progastrin (PG)/gastrin receptors on normal and cancerou

53 ance of VMAT1 function for the modulation of progastrin processing by biogenic and dietary amines.

54 e of mRNAs encoding proteins associated with progastrin processing in rat antral mucosa.

55 Progastrin processing was studied using a pulse-chase pr

56 Progastrin processing was studied using region-specific

57 Human gastrin gene expression and progastrin processing were therefore studied in transgen

58 e investigated whether Annexin A2 (AnxA2), a progastrin receptor, activates NF-kappaB and beta-cateni

59 of the small cell lung cancer (SCLC) markers progastrin releasing peptide (ProGRP) and neuron specifi

60 ry (LC-MS) for biomarker determination using ProGastrin Releasing Peptide (ProGRP), a highly sensitiv

61 /+)) mice were studied, along with clones of progastrin-responsive HEK-293 cells that stably expresse

62 blasts were incubated with recombinant human progastrin (rhPG)(1-80) for 18 hours, and proliferation

63 ittle is known about the mechanisms by which progastrin stimulates colonic cell proliferation.

64 Progastrin stimulates colonic mucosal proliferation and

65 Progastrin stimulates colonic myofibroblasts to release

66 Progastrin stimulates proliferation in colons of mice an

67 bp-PG mice) and acute (wild type FVB/N mice) progastrin stimulation.

68 Progastrin suppressed transcription of Bmp2 through a pa

69 ermediates of preprogastrin (gly-gastrin and progastrin), termed nonamidated gastrins, are mitogenic

70 g and self-renewal capabilities by secreting progastrin, thereby contributing to the tumor microenvir

71 The conversion of progastrin to smaller peptides is regulated by multiple

72 colonic mucosa of mice that express a human progastrin transgene, gastrin knockout mice, and C57BL/6

73 generated mice (MTI/G-GLY) that overexpress progastrin truncated at glycine-72 to evaluate the troph

74 and C57BL/6 mice (controls); the effects of progastrin were also determined on in vitro colonic cryp

75 reported that transgenic mice overexpressing progastrin were at a higher risk for developing colon ca

76 sponse to acute and chronic stimulation with progastrin, were similar and specific to proximal colons

77 strin gene products, including the precursor progastrin, which causes proliferation of the colonic ep

78 Many colon cancers produce the hormone progastrin, which signals via autocrine and paracrine pa