ライフサイエンスコーパス: regulation

1 ng their functional roles in gene expression regulation.

2 criptomes, as well as their organization and regulation.

3 nce of multiple, less well-defined layers of regulation.

4 g ADP inhibition may be a mechanism of Hsp90 regulation.

5 ) is crucial to the study of gene expression regulation.

6 and as a result, they have relevance in gene regulation.

7 reasingly used to dissect the nature of gene regulation.

8 t angiogenesis inhibitor, through epigenetic regulation.

9 to drought depend on stomatal and xylem flow regulation.

10 isms of replication timing establishment and regulation.

11 or binding with particular relevance for cis-regulation.

12 Smad4 to target specific genes for cell fate regulation.

13 onsible for various aspects of T-cell immune regulation.

14 onist approach, perhaps masking differential regulation.

15 e top of the hierarchy of the transcriptomic regulation.

16 can be modulated through posttranscriptional regulation.

17 ance of metastable states for RNA-based gene regulation.

18 holds the key to elucidate its role in cell regulation.

19 ting interplay between these factors in gene regulation.

20 haracterization of a novel mechanism of ICOS regulation.

21 ) cell fusion, as well as DC-mediated immune regulation.

22 ate multidrug resistance and ion conductance regulation.

23 nificant conformational changes for affinity regulation.

24 limbic nuclei as the core of reward behavior regulation.

25 Without the positional regulation afforded by radial confinement, chromosomes a

26 Finally, we show that USP36 down-regulation alters cell proliferation in human cancer cel

27 n the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional s

28 ed the effect of dietary salt intake on ENaC regulation and activity in VP neurons.

29 s an important role for ACC enzymes in redox regulation and cell survival.

30 nts potentially involved in fibre metabolism regulation and cell wall formation.

31 k the outside environment to epigenetic gene regulation and cellular function, and their actions may

32 ilability are supposed to mediate sleep-wake regulation and cognitive performance.

33 We found evidence for substantial common regulation and conservation of gene expression regionall

34 pattern which includes myogenin and Myf5 up-regulation and Cyclin D1 decrease.

35 in atherosclerotic plaques, we examined its regulation and function in murine macrophages, compared

36 ocyte precursors can now be defined, and the regulation and function of adipose plasticity in develop

37 eview will provide an overview of the normal regulation and function of Runx factors in hematopoiesis

38 stitutive activity, but how they affect MEK1 regulation and function remains largely unknown.

39 Understanding gene regulation and function requires a genome-wide method ca

40 eness, this research advances theory on self-regulation and illuminates how even highly efficacious i

41 llospira decrease coupled to a 2-butanone up-regulation and increases in Ruminococcus and Dorea were

42 serotonin (5-HT) is important for emotional regulation and is implicated in the pathogenesis and tre

43 id foods are proposed to improve energy self-regulation and lower obesity risk.

44 marks actually have causative roles in gene regulation and other processes.

45 kappaB p65(ser536) phosphorylation, c-Myc up-regulation and reduced cell proliferation.

46 ults in heritable epigenetic changes of gene regulation and trans-homologue interactions.

47 nimal research requires adherence to various regulations and standards, the manner in which complianc

48 We report 4 novel loci associated with BP regulation, and 1 independent variant at an established

49 The expression, regulation, and function of TJs were determined in air-l

50 e ACC are implicated in memory and emotional regulation, and the ACC has motor areas and is thought t

51 Code of Federal Regulations, and state legislative codes.

52 trolled and the function of L1s in host gene regulation are not completely understood.

53 the lysine residues was necessary for fusion regulation, as alanine substitutions induced a 440% incr

54 s, Ki-67 expression varies due to cell-cycle regulation, but it remains a reliable readout for effect

55 primate genes, but neither the VDREs nor the regulation by 1,25D is present in mice.

56 ubject to a dual and interdependent feedback regulation by chemoreceptors.

57 ggest that completion of germination and its regulation by dormancy also depend on the degradation of

58 The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical mod

59 mental clues into the molecular basis of MMP regulation by N-TIMP2 and identifies a promising MMP-14

60 ADPH oxidase RBOHD, suggesting its potential regulation by PLC2.

61 supports a crucial role for transcriptional regulation by the GR in this cell type.

62 motifs of a PAS appear to differentiate its regulation by the PAPs.

63 ore, we demonstrate that the transcriptional regulation by the psychiatric risk gene TCF4 enhances NM

64 We demonstrate differential regulation by two distinct mSWI/SNF assemblies, BAF and

65 r BRD4 plays a vital role in transcriptional regulation, cellular growth control, and cell-cycle prog

66 We propose that this regulation constitutes a global 'silent code' mechanism

67 on the global market, yet most research and regulation continues to focus on a limited selection of

68 of adipogenic differentiation since its down-regulation (DR) in both ex vivo bone marrow-derived mese

69 r data provide new insights into microtubule regulation during axonal morphogenesis and may shed ligh

70 monstrated the dynamic and conditional miRNA regulation during cancer progression.

71 iated neurodegeneration links to altered PNS regulation during mental effort in older adults, and tha

72 t new biological pathways for blood pressure regulation enriched for genes expressed in vascular tiss

73 AS-specific manner, but whether this mode of regulation extends to related FOXO family members is unk

74 itude and determinants of differences in cis-regulation for regulatory sequences residing in episomes

75 e endonuclease cleavage is a likely point of regulation for RNA editing, we elucidated endonuclease s

76 ycomb group (PcG) and Trithorax group (TrxG) regulation has been on an extraordinary journey over the

77 ts play an important role in transcriptional regulation; however, the extent to which these interacti

78 The enhanced TLR3 up-regulation in AMPhi augmented the expression of cytokine

79 , in a complementary way, involved in growth regulation in Arabidopsis.

80 he fact that allostery is a common means for regulation in biological molecules suggests that it is a

81 ication provides an additional layer of gene regulation in cells.

82 Despite growing evidence for RNA-based regulation in meningococci, their transcriptome structur

83 Also, the significance of this regulation in response to chromosome detachment has not

84 GPCR priming suggests another layer of regulation in the classic GPCR ternary-complex model, wi

85 ealing pervasive behavioral effects of miRNA regulation in the early larva.

86 highlighted the importance of such metabolic regulation in the endothelium and uncovered core metabol

87 ypertrophy and define a new paradigm of gene regulation in the heart, where controlled changes in pol

88 n, may disrupt responses to fear and anxiety regulation in these individuals.

89 rmore, we identified conserved miRNA-targets regulations in the control of double flowers, and we fou

90 Central to this regulation is Aurora B kinase, which phosphorylates kine

91 f many RBR E3s are poorly defined, and their regulation is complex, involving post-translational modi

92 by Toll-like receptors on T cells, and this regulation is conserved in human T cells.

93 ity of the germinal centre reaction, but how regulation is contained to ensure generation of high-aff

94 resulting tissue selective negative feedback regulation is essential to establish sex-specific differ

95 uggesting that additional, auxin-independent regulation is needed.

96 se processes alter tumour progression, their regulation is poorly understood.

97 KEY POINTS: Intracellular pH regulation is vital to neurons as nerve activity produce

98 n of both regulation mechanisms to oxygen up-regulation likely varies over depth.

99 tokine signaling through a negative feedback regulation loop involving down-regulation of TLR4, IRAK1

100 ltiple Galpha proteins, an even more complex regulation may exist, which likely contributes to the sp

101 PTEN down-regulation may promote beta-oxidation through beta-caten

102 the proposed US Food and Drug Administration regulations may severely limit the ability of plastic su

103 However, the contribution of both regulation mechanisms to oxygen up-regulation likely var

104 nteractions between DNA methylation and gene regulation mechanisms.

105 ings provide new insights into how chromatin regulation modulates stochastic gene expression and tran

106 When applied to Escherichia coli, the regulation network constructed by our proposed ESPACE me

107 dings reveal novel features of human EC gene regulation not present in their murine counterparts.

108 ptability and specificity to OGA in O-GlcNAc regulation.O-linked beta-N-acetyl glucosamine (O-GlcNAc)

109 aled that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of ci

110 raulic stomatal closure and the stomatal VPD regulation of ABA-deficient mutants may be conditional o

111 which are implicated in the development and regulation of allergic disease independent of their anti

112 e thus reveal the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and pro

113 e of epithelial barrier in the intestine via regulation of apical junction integrity.

114 sses, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuclear transcription.

115 Regulation of aquaporins is a key process of living orga

116 veal an unexpected new role for NKG2D in the regulation of B1a cell development.

117 ytokines and their involvement in epigenetic regulation of barrier function were investigated.

118 n summary, we identified a novel pathway for regulation of beta-catenin levels and define PKC as an i

119 K-Ras-beta-catenin tumors showed up-regulation of beta-catenin targets like glutamine synthe

120 peripheral Treg cell homeostasis through the regulation of BIC/microRNA 155 (miR-155) and its target,

121 Regulation of blood glucose requires precise coordinatio

122 ase promoter binding protein 1 (Xpp1) in the regulation of both primary and secondary metabolism of T

123 The regulation of bronchial epithelial TJs by TH2 cells and

124 le effect on HR, potentially reflecting down-regulation of cardiac beta-adrenergic receptor function

125 ting that other activators contribute to the regulation of CCC1 transcription.

126 own here for hepatocytes, in tissue-specific regulation of CD1d-restricted immunity and further sugge

127 Moreover, the unique up-regulation of CD64A/B and its significant correlation wi

128 ature of signal transduction networks in the regulation of cell contractility is not entirely clear.

129 gnaling molecules plays diverse roles in the regulation of cell proliferation, migration, and differe

130 The up-regulation of cell surface adhesion molecules by BMP9/10

131 In striking contrast, the regulation of cell-cycle and differentiation gene progra

132 toward a role for protein AMPylation in the regulation of cellular protein homeostasis beyond the en

133 esentative of systemic problems plaguing the regulation of chemicals in food.

134 Our studies further suggest that the regulation of chemotaxis by c-di-GMP through MapZ orthol

135 amage, and may control cell fate through the regulation of CHK1.

136 Epigenetic regulation of chromatin plays a critical role in control

137 RVE3 and RVE5, play only minor roles in the regulation of clock function.

138 hypothalamus and that HS contributes to the regulation of cocaine seeking and taking.

139 cytochrome c oxidase (COX) assembly and the regulation of copper homeostasis.

140 ggest a new paradigm where IL-4-dependent up-regulation of Cox-1 expression may play a key role in ti

141 STIM1, at least in part as a result of redox regulation of cytokine gene expression.

142 Mitotic area expansion is largely driven by regulation of cytoplasmic pressure.

143 olecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair re

144 data are the first demonstration of microRNA regulation of DCC and suggest that, by regulating DCC, m

145 collaboration is not through redundancy, but regulation of distinct pathways.

146 14-3-3 proteins have been implicated in the regulation of diverse biological processes by phosphoryl

147 esting a potential role for EAF2 in androgen regulation of DNA repair in prostate cancer cells.

148 e precise molecular mechanism underlying the regulation of early B cell lymphopoiesis is unclear.

149 ndings provide novel insights concerning the regulation of effector function by T1-IFN in human antig

150 een these two areas could play a role in the regulation of emotions and in procedural motor and emoti

151 th CSC and also plays a distinct role in the regulation of endosome dynamics during fungal developmen

152 P10 synergize with TNFalpha to induce the up-regulation of endothelial selectins and adhesion molecul

153 tion and expression of genes involved in the regulation of energy homeostasis were found to relate to

154 Perfusion-independent regulation of epithelial pattern formation by the vascul

155 ly age correlated well with the differential regulation of ER stress sensors, in particular Perk.

156 is, highlighting heme and translation in the regulation of erythropoiesis.

157 substrate of importance in the higher-order regulation of feeding behavior.

158 ernary complex, representing a novel mode of regulation of G protein-coupled receptor signaling by sc

159 Regulation of gene expression by alternative splicing pl

160 In bacteria, the regulation of gene expression by cis-acting transcriptio

161 een one major approach for sequence-specific regulation of gene expression in eukaryotic organisms.

162 Our results suggest that regulation of gene expression in sensory neurons can fun

163 cross talk between metabolism and epigenetic regulation of gene expression.

164 y critical roles in the post-transcriptional regulation of gene expression.

165 m activation and repressive functions in the regulation of gene expression.

166 Translation initiation is a key step in the regulation of gene expression.

167 splay higher IRS-1 phosphorylation, stronger regulation of genes in metabolic pathways and more drama

168 h ubiquitination is an important step in the regulation of glucose metabolism.

169 ecreased PCa cell proliferation through down-regulation of GR and up-regulation of manganese superoxi

170 and splenomegaly in adulthood due to the up-regulation of granulocyte-colony stimulating factor (G-C

171 tion and the importance of posttranslational regulation of growth factor signaling in this process.

172 Furthermore, differential regulation of HDP-induced mast cell degranulation by PgL

173 proteins in vitro and in vivo; however, the regulation of HSJ1 function is little understood.

174 Our results provide new insight into the regulation of humoral immunity.

175 ns and provides mechanistic insight into the regulation of IL7R exon 6 splicing and its impact on MS

176 ry and others have shown several pathways of regulation of ILC2s by co-stimulatory molecules such as

177 th previous observations of species-specific regulation of immunity by vitamin D, the VDREs are prese

178 gans, phagocytic clearance of parasites, and regulation of immunity.

179 tudies that have implicated miR-17-92 in the regulation of important molecular components of the TGFB

180 g us to better understand cell-type-specific regulation of inflammation mediators and shedding new li

181 molecular explanation for BCAP-mediated down-regulation of inflammatory signaling.

182 tting analysis of PELP1-cyto HMECs showed up-regulation of inhibitor of kappaB kinase (IKK) and incre

183 t SIRT1 levels are required for OGT-mediated regulation of invasion and metastasis in breast cancer c

184 ic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.

185 Unexpectedly, we observed only mild up-regulation of ISGs in STING N153S fibroblasts and spleno

186 expression and impaired by Gab2 deletion via regulation of Jak2 and signal transducer and activator o

187 n membrane electrophysiology through dynamic regulation of K(+) transport.

188 molecular mechanisms supporting coordinated regulation of KCNQ and VGSCs and the cellular mechanisms

189 cohorts, underlining the role of epigenetic regulation of key cardiac transcription regulators.

190 In the retina, delay in up-regulation of key photoreceptor genes underlies delayed

191 identify a role of PLD2-generated PA in the regulation of kinesin-1 motor functions and breast cance

192 e utility of proximity labeling to study the regulation of LD proteomes.

193 Hyperactive Hnf4 signaling leads to up-regulation of lipase 3 and enzymes for mitochondrial bet

194 nd this property is central to PITP-mediated regulation of lipid signaling.

195 experiments as autotoxins can influence the regulation of longevity by other factors including diet,

196 Regulation of macrophage dynamics during these processes

197 fference defines their distinct roles in the regulation of macrophage migration.

198 eration through down-regulation of GR and up-regulation of manganese superoxide dismutase and reduced

199 hat this single protein is implicated in the regulation of MAP kinase-controlled processes involved i

200 feron production and apoptosis; however, the regulation of MAVS-mediated apoptosis is poorly understo

201 est that LPS-induced IL-10 promotes the down-regulation of MC surface FcepsilonRI expression and lead

202 unique to virus-infected cells and relies on regulation of MCL-1 mitochondrial localization and BFL-1

203 The molecular mechanisms underlying the regulation of MCU, in conditions requiring chronic incre

204 of LRTOMT, has an unexpected function in the regulation of mechanotransduction by hair cells.

205 ed transmembrane protein, is involved in the regulation of membrane composition, cellular polarity an

206 al effects through their posttranscriptional regulation of messenger RNA targets.

207 ons suggest a potential role for CT-1 in the regulation of metabolic circadian rhythms.

208 es exerts central but diverging roles in the regulation of metabolic homeostasis depending on the ene

209 Regulation of mitochondrial activity allows cells to ada

210 is mediated by muscarinic receptor-dependent regulation of mitochondrial function via AMPK.

211 Regulation of mRNA splicing, processing and stability is

212 endogenous TGF-beta proteins to the negative regulation of muscle mass via their activation of the Sm

213 PDHK4 plays a role in the post-translational regulation of mutant KRAS activity.

214 analysis revealed a dominant pattern of down-regulation of myelin-associated genes.

215 eural circuit formation requires the precise regulation of neuronal migration, axon guidance, and den

216 cations of this functional diversity for the regulation of neuronal processes by the NRG/ErbB pathway

217 s was accompanied by cardiac fibrosis and up-regulation of NFAT-c2, reflecting increased calcineurin/

218 radoxical result was linked to NEMO-mediated regulation of NFkappaB and IL6 secretion, increased phos

219 the Piwi Argonaute PRG-1 is involved in the regulation of nictation.

220 coincides with TCP20 and NLP6&7-dependent up-regulation of nitrate assimilation and signaling genes a

221 Regulation of NPQ allows for a rapid response to changes

222 However, the extent of CMV-mediated regulation of nucleolar biology is not well established.

223 of P311 corrected the deficits, whereas down-regulation of P311 levels by lentiviral RNA interference

224 , these data reveal a novel role for Osr2 in regulation of palatal morphogenesis through preventing a

225 lighted the need to understand the molecular regulation of PD-L1 expression.

226 cells is necessary for health, survival, and regulation of physiological functions locally, at the ba

227 for this pathway in part via transcriptional regulation of PKCalpha and ITPR.

228 rming public health policies, despite strict regulation of plant protection product and biocide use.

229 Thus, species-dependent regulation of PlexA1 expression may have been crucial in

230 nscriptional bursting, with implications for regulation of pluripotency and development.Polycomb repr

231 perone activity is an ATP-induced allosteric regulation of polypeptide substrate binding and release.

232 e authors report that the post-translational regulation of PRC1 components CBX4 and CBX6 by ubiquitin

233 n is an emergent property of the independent regulation of pre- and post-Start cell-cycle periods rat

234 lines of evidence implicate chromatin in the regulation of premessenger RNA (pre-mRNA) splicing.

235 preventing nonselective proteolysis, and the regulation of proteasome activity by interacting protein

236 For the study of dynamic regulation of protein interactions in vivo, there is a n

237 K is activated by HSR and contributes to the regulation of proteome stability.

238 A history of the regulation of radiopharmaceuticals is presented.

239 ption is a rich source of information on the regulation of RNA polymerase activity.

240 ich could be attributed to differential down-regulation of Runx2, and up-regulation of Spp1 and TRAP.

241 ity faithfully monitored the transcriptional regulation of SNCA following treatment with different dr

242 e FGF control of kidney FGFR1 and subsequent regulation of soluble Klotho and TRPC6.

243 ifferential down-regulation of Runx2, and up-regulation of Spp1 and TRAP.

244 en O-GlcNAcylation, lipid metabolism and the regulation of SREBP-1 in cancer and suggests a crucial r

245 rmine the extent of their involvement in the regulation of stress responses.

246 lemented multiple mechanisms for homeostatic regulation of synaptic efficacy, including heterosynapti

247 been previously shown to be involved in the regulation of T cell proliferation and function.

248 functioning as a specificity switch for the regulation of the activities of ERfs.

249 Our findings demonstrate that the up-regulation of the ALOX5 is responsible for the Hcy-depen

250 (2+) and lead to a mechanistic model for the regulation of the cardiac TF.

251 te assimilation and signaling genes and down-regulation of the G2/M cell-cycle marker gene, CYCB1;1 T

252 cluding ERK1/2, FAK, AKT and PAK1 as well as regulation of the growth, cytoskeleton remodeling and mo

253 potential neuronal pathways involved in the regulation of the HPA axis in mice.

254 The complex regulation of the IFN response allows viruses to antagon

255 Here we investigate auto-regulation of the innate immune effector protein kinase

256 ncluding inactivation of KaiA and reciprocal regulation of the mutually antagonistic signaling protei

257 suppressible Cre transgenic mouse under the regulation of the Nkx2.5 enhancer and showed that neonat

258 questions remain about the architecture and regulation of the SCF repertoire, including whether SRs

259 ese findings suggest that post-translational regulation of the Thr(567) in the MT1-MMP cytoplasmic ta

260 Up-regulation of the tRNA cognate to the mutated codon coun

261 Recent research has shown that miRNA-based regulation of the tumor suppressor gene PTEN can be modu

262 The function and regulation of these domains remain largely unknown.

263 transmission, suggesting a rationale for the regulation of these information processing features.

264 recognition and binding are critical for the regulation of this reaction.

265 tive feedback regulation loop involving down-regulation of TLR4, IRAK1, and NF-kappaB.

266 idespread effect of genetic variation on the regulation of transcription, isoform usage, and allele-s

267 XgDeltaavrHah1 revealed the differential up-regulation of two basic helix-loop-helix (bHLH) transcri

268 mino acids with functional importance in the regulation of type I interferon signaling.

269 To evaluate if the up-regulation of vascular endothelial growth factor strengt

270 E-selectin, and both ALK1 and ALK2 in the up-regulation of VCAM-1 and ICAM-1.

271 se data provide mechanistic insight into the regulation of VM and suggest that miRNAs repressed durin

272 of the molecular mechanism of transcription regulation on cellular stress and reveal functional simi

273 The effects of microRNA (miRNA) regulation on the genetic programs underlying behavior r

274 on-canonical mode of action of Wnt5a and its regulation over genes associated with progenitor prolife

275 ons are essential for proper gene expression regulation, particularly in neurons with unique spatial

276 Thus, HRI coordinates 2 key translation-regulation pathways, eIF2alphaP and mTORC1, to circumven

277 evised model of long-patch BER and a new key regulation point for pathway choice in BER.

278 GAPDH down-regulation potentiated H2O2-induced DNA damage and SMC a

279 agocytosis through disrupting actin filament regulation processes - inhibiting polymerization-promoti

280 dons plays an important role in various gene regulation programs.

281 cision; overruling harms other patients; and regulations prohibit overrule.

282 e N-terminal receiver domain of the nitrogen regulation protein NT-NtrC, and the sporulation response

283 , one pathway that is involved in cell cycle regulation, REACTOME_CHROMOSOME _MAINTENANCE, was signif

284 that CO2 directly affects acid-base and ion regulation, respiratory function and aerobic performance

285 ing to identify a suitable model to underpin regulations restricting the marketing of unhealthy foods

286 t regions associated with emotion and stress regulation, self-referential processing and cognitive co

287 ed several novel insights on transcriptional regulation such as the "hit-and-run" model and transcrip

288 This method of regulation suggests that virulence factors are only util

289 Our strategy takes advantage of the unique regulation that can be accessed through light.

290 ers on the intrinsic properties and synaptic regulation that control the activity of dopamine neurons

291 ed core metabolic pathways and mechanisms of regulation that drive the angiogenic process.

292 oncompliance with federal Animal Welfare Act regulations that carry a significant risk or specific th

293 se uptake in obesity is a physiological down-regulation to prevent excessive de novo lipogenesis.

294 ght the contribution of post-transcriptional regulation to shaping tissue-type-specific proteomes.

295 splicing, which bypasses miRNA-mediated down-regulation under drought stress.

296 lating microtubule acetylation through HDAC6 regulation, was shown to control centrosome and Golgi re

297 extensive knowledge of yeast transcriptional regulation, we uncovered significant regulatory variatio

298 Further understanding of this differential regulation will enhance efforts to improve oilseed rape

299 t-translational modifications and allosteric regulation with other protein partners.

300 est that molecular mechanisms for epigenetic regulation within the spinal cord constitute the startin