ライフサイエンスコーパス: DAP kinase

1 ase P1, and death-associated protein kinase (DAP-kinase).

2 DNA-methyltransferase; and 18% (17 of 92) at DAP-kinase.

3 -deoxycytidine resulted in the expression of DAP-Kinase.

4 nes are unmethylated in the 5' CpG island of DAP-Kinase.

5 and proapoptotic genes, including p21, Bak, DAP kinase 2, and Bax.

6 3 (11%), E-cad (7%), THBS1 (7%), hMLH1 (4%), DAP kinase (2%), and MGMT (0%).

7 Death Associated Protein kinase (DAP kinase) a novel calmodulin-dependent serine/threonin

8 proapoptotic protein kinase with homology to DAP kinase, a protein kinase implicated in apoptosis.

9 terminal domain of death-associated protein (DAP) kinase, a calcium/calmodulin-dependent serine/threo

10 eukemia samples examined had hypermethylated DAP-Kinase alleles.

11 DAP kinase and DAP kinase-interacting protein 1 (DIP-1)

12 This study provides the first description of DAP kinase and DIP-1 in human brain and suggests DAP kin

13 on was found between promoter methylation of DAP-kinase and k-ras or p53 mutation.

14 53 genes, as well as with methylation at the DAP-kinase and p14(ARF) loci.

15 the carcinomas with only three loci (E-cad, DAP kinase, and MINT2) harboring methylation in some nor

16 ransferase (MGMT), death-associated protein (DAP) kinase, and Ras effector homologue (RASSFIA) genes

17 mmunoprecipitation analysis showed increased DAP kinase binding to calmodulin, DIP-1, and the Fas-ass

18 Biochemical studies demonstrate that DAP kinase binds to and phosphorylates syntaxin-1 at ser

19 d the methylation and deletion status of the DAP kinase CpG island as possible mechanisms for the ina

20 sociated with methylation or deletion of the DAP kinase CpG island.

21 expression; dense methylation throughout the DAP-kinase CpG island detected by bisulfite sequencing s

22 merase chain reaction (MSP), we examined the DAP-Kinase CpG island for hypermethylation in cancer.

23 gkin's lymphomas were hypermethylated in the DAP-Kinase CpG island.

24 ined promoter methylation of the p16(INK4a), DAP-kinase, E-Cadherin, and RASSF1A genes using methylat

25 The prevalence of p16(INK4a), DAP-kinase, E-Cadherin, and RASSF1A promoter methylation

26 U937, an unmethylated, DAP-Kinase-expressing leukemia cell line, was treated wi

27 Although loss of DAP kinase expression has been reported in several cell

28 Loss of DAP kinase expression was first demonstrated in highly m

29 Statistical analysis showed that loss of DAP kinase expression was significantly (P=<0.001) assoc

30 Loss of DAP kinase expression was significantly (P=0.004) associ

31 Eleven of 32 (34%) tumours had undetectable DAP kinase expression, by Western blot and/or RT-PCR ana

32 receptor activation and calcium, we examined DAP kinase expression, localization, and interactions in

33 A previous study suggested that DAP-Kinase expression may be lost epigenetically in canc

34 Of 11 tumours that failed to express DAP kinase, five (45%) showed de novo methylation of the

35 DAP-kinase functions as a positive mediator of apoptosis

36 exclusive mechanisms associated with loss of DAP kinase gene expression.

37 DAP kinase gene promoter methylation was also seen in sp

38 Methylation of the DAP kinase gene was seen in only 1 site from 5 cases and

39 sible mechanisms for the inactivation of the DAP kinase gene.

40 expression of the death-associated protein (DAP)-kinase gene by aberrant promoter methylation may pl

41 tumors suggest that hypermethylation of the DAP-Kinase gene and loss of gamma interferon-mediated ap

42 on-specific PCR detected inactivation of the DAP-kinase gene in 43% of tumors associated with cigaret

43 mine the commonality for inactivation of the DAP-kinase gene in adenocarcinomas induced in mice by ch

44 at methylation of the promoter region of the DAP-kinase gene is not associated with exposure to tobac

45 nificant correlation between the presence of DAP-kinase gene promoter hypermethylation and lymph node

46 The DAP-kinase gene was not expressed in three of five NNK-i

47 ylation status of the promoter region of the DAP-kinase gene.

48 he odds ratios describing the association of DAP-kinase hypermethylation with stage were 2.70 (1.13--

49 Expression of DAP kinase in adult rat brain is restricted to particula

50 DAP kinase and DAP kinase-interacting protein 1 (DIP-1) localized to mi

51 kinase and DIP-1 in human brain and suggests DAP kinase is a novel molecular regulator of neuronal de

52 Death-associated protein (DAP) kinase is a novel calcium/calmodulin-activated kina

53 Death associated protein (DAP)-kinase is a 16 kDa calmodulin-dependent serine/thre

54 Recent studies suggest that DAP-kinase is involved in tumor metastasis and that it c

55 Death-associated protein kinase (DAP-Kinase) is a novel serine/threonine kinase whose exp

56 ) locus was detected, and methylation of the DAP-kinase locus was not associated with either p16 meth

57 However, they strongly suggest that DAP-kinase may be important in the progression of non-sm

58 In addition, DAP-kinase methylation was detected in 52%, 60%, and 50%

59 poptosis; however, Raji, a fully methylated, DAP-Kinase nonexpressing Burkitt's lymphoma cell line, o

60 ion of the p16 gene, and to a lesser extent, DAP kinase, occurs frequently in the bronchial epitheliu

61 Syntaxin-1A phosphorylation by DAP kinase or its S188D mutant, which mimics a state of

62 tor (TNF) pathway, death-associated protein (DAP) kinase, p53, and p21/Waf1; and down-regulation of i

63 Stage I cases with DAP-kinase promoter methylation had worse overall surviv

64 graphic and clinical factors associated with DAP-kinase promoter methylation in non-small cell lung c

65 DAP-kinase promoter methylation was significantly associ

66 obacco carcinogen and asbestos exposure with DAP-kinase promoter methylation, and the demographic and

67 s that are associated with the occurrence of DAP-kinase promoter methylation.

68 Forty-seven (25%) of 185 tumors showed DAP-kinase promoter methylation.

69 Methylation of the DAP-kinase promoter was also associated with an increase

70 In addition, we also show that loss of the DAP kinase protein and associated genetic aberrations pr

71 adic pituitary tumours for expression of the DAP kinase protein and transcript.

72 Our results suggest that syntaxin is a DAP kinase substrate and provide a novel signal transduc

73 Finally, immunohistochemistry determined DAP kinase was coexpressed with DIP-1 in neurons.

74 Promoter methylation for p16 and DAP kinase was seen as frequently in bronchial epitheliu

75 Expression and phosphorylation of DAP kinase was significantly increased in epilepsy brain