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1                            Both descriptive and inferential analyses were done with 95% confidence intervals (CIs) at a p
2                                          Population genomic analyses were done with a hierarchical gene-by-gene approach.
3                                                        Meta-analyses were done with a random effects model.
4                                                             Analyses were done with all eligible patients who started pro
5                                         Efficacy and safety analyses were done with all randomly assigned patients who re
6                                                         All analyses were done with and without inclusion of the SHOCK tr
7                    Large-restriction-fragment (LRF) pattern analyses were done with AseI.
8                                 Univariate and multivariate analyses were done with Cox proportional hazard regression.
9                                                             Analyses were done with Cox regression analyses adjusted for
10                                                             Analyses were done with Cox regression analyses and adjusted
11 nd lack of cooperation were used as exclusion criteria, and analyses were done with data from 4869 eyes.
12                                Multiple logistic regression analyses were done with every primary outcome as the dependen
13                                                  Additional analyses were done with finer categorisation of heart rate, a
14 whom a PICC was not inserted from safety analyses, as these analyses were done with groups defined by the PICC used.
15                                          Intention-to-treat analyses were done with linear regression.
16                                                 Sensitivity analyses were done with regard to how the value of a statisti
17                                                     Kinetic analyses were done with software using a 1-tissue-compartment
18                                                 All further analyses were done with the BCI-L model.
19                                                 Comparative analyses were done with the deletions and the parental wild t
20                                                         All analyses were done with the entire sample of 13-24-year-olds
21                                                        Meta-analyses were done with the Mantel-Haenszel method with a ran
22                                                         All analyses were done with the modified intention-to-treat popul
23                                                  Mutational analyses were done with VZV cosmids generated from parent Oka