ライフサイエンスコーパス: at the leading edge of

1 Individuals at the leading edge of a biological invasion experience

2 of chemoattractants elicit signaling events at the leading edge of a cell even though chemoattractan

3 echanics of the dense branched network found at the leading edge of a crawling cell.

4 The expression of Notch1 was reduced at the leading edge of a healing corneal epithelium both

5 expression of cytosolic PLAC8, CDH3, and VIM at the leading edge of a human colorectal tumor, support

6 The extension of a pseudopod at the leading edge of a migratory cell and the formatio

7 addressed include the rate of actin assembly at the leading edge of a moving cell, the disassembly ra

8 rude forward from the lamellipodium, located at the leading edge of a neuronal growth cone, are neede

9 domains specific for PI(3,4,5)P3 accumulate at the leading edge of a number of migrating cells and t

10 Protrusions at the leading-edge of a cell play an important role in

11 Atomic clocks are at the leading edge of accuracy and precision and are es

12 At the leading edge of adherent cells, curvature waves a

13 , the co-localization of RAGE and amphoterin at the leading edge of advancing neurites indicated thei

14 revealed rapid relocation to and clustering at the leading edge of alpha7 nicotinic and M(1) muscari

15 may massively underestimate dispersal rates at the leading edge of an expanding population.

16 we present observations of temporal changes at the leading edge of an interface between sub-thermocl

17 trophic position of L. humile remained high at the leading edge of an invasion front but declined, o

18 d climate affect Japanese beetle occurrences at the leading edge of an invasion front in the central

19 lation in most new species introductions, or at the leading edge of an ongoing invasion, is likely to

20 from focal adhesions to lamellipodia located at the leading edge of AND-34 overexpressing cells.

21 of coordination of the protrusive activities at the leading edge of ARPC3(-/-) fibroblasts.

22 In addition, p35/Cdk5 kinase concentrates at the leading edges of axonal growth cones and regulate

23 required for the generation of motile force at the leading edge of both lamellipodia and filopodia a

24 d for its proper localization in invadopodia at the leading edge of breast cancer cells during three-

25 sin II assembly, colocalizes with myosin IIA at the leading edge of cancer cells, suggesting direct r

26 2 directly binds and phosphorylates stathmin at the leading edge of cancer cells.

27 calization of a key regulatory protein (tTG) at the leading edges of cancer cells and the important c

28 d a condensation of focal adhesion complexes at the leading edges of cell processes and FAK-paxillin

29 increase in the number of protrusions formed at the leading edge of cells after invasion through geom

30 reorganization of the cortical cytoskeleton at the leading edge of cells and extracellular Ca(2+) en

31 he phosphorylation of the myosin light chain at the leading edge of cells and increases the phosphory

32 AINT revealed a link between platelet forces at the leading edge of cells and the dynamic actin-rich

33 which translocates to inositol phospholipids at the leading edge of cells during chemotaxis.

34 However, F-actin was polymerized at the leading edge of cells during electrotaxis.

35 o activation of Rac and inactivation of RhoA at the leading edge of cells moving in 3D matrix.

36 show that alpha4beta1 forms transient puncta at the leading edge of cells that begin to protrude lame

37 ling by showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM

38 ng in the nanoscale clustering of hyaluronan at the leading edge of cells, cell invasion and the spre

39 eceptor, DOCK4, and Dynamin, which is formed at the leading edge of cells.

40 arized actin formation and single pseudopods at the leading edge of cells.

41 ic nucleation model for actin polymerization at the leading edge of cells.

42 o control actin filament length and geometry at the leading edge of cells.

43 trated that SOCE regulates membrane ruffling at the leading edge of cells.

44 ium, leading to the positioning of adhesions at the leading edge of cells.

45 ation by hindering the turnover of adhesions at the leading edge of cells.

46 This pathway is prominent at the leading edges of cells where phosphatidylinositol

47 ocalizes with beta1-integrin on lamellipodia at the leading edges of cells.

48 rotein regulated the localization of F-actin at the leading edge of chemokine-stimulated cells and wa

49 or of Ras signaling, C2GAP1, which localizes at the leading edge of chemotaxing cells and is activate

50 and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regula

51 Ras activation occurs at the leading edge of chemotaxing cells, and this local

52 l activation of TORC2 are tightly controlled at the leading edge of chemotaxing cells.

53 , and activated Rap1 is preferentially found at the leading edge of chemotaxing cells.

54 opy approach showed local activation of RacC at the leading edge of chemotaxing cells.

55 ing cell signaling events, including signals at the leading edge of chemotaxing cells.

56 e Osmotic Engine Model, polarization of NHE1 at the leading edge of confined cells facilitates water

57 y ubiquitous GTPase that localizes in a ring at the leading edge of constricting plasma membranes dur

58 ldarius and observed a distinct protein belt at the leading edge of constriction furrows in dividing

59 e demonstrate that P2X7 expression increases at the leading edge of corneal epithelium after injury i

60 been proposed to generate the actin network at the leading edge of crawling cells in vivo [3, 4, 8].

61 activated alpha(M)beta(2) integrin clusters at the leading edge of crawling neutrophils, allowing ca

62 y mechanism for controlling signaling events at the leading edge of directionally migrating cells.

63 epithelial surface such that it is enriched at the leading edge of each cell.

64 Receptors on the growth cone at the leading edge of elongating axons play critical gu

65 n is most likely related to its localization at the leading edge of emerging protrusions.

66 um synthesizes high-density storage granules at the leading edges of engulfing membranes.

67 d evolution of distinctive phenotypic traits at the leading edges of expansions.

68 nsformed fibroblasts: ezrin was concentrated at the leading edge of extending pseudopodia of Fos-tran

69 ly that co-localizes with the Arp2/3 complex at the leading edge of fibroblasts, and co-immunoprecipi

70 Brain disorders are at the leading edge of global disease burden worldwide.

71 h proteins is colocalized with actin patches at the leading edge of growth cones.

72 and increased levels of CASK and E-cadherin at the leading edge of healing wounds, consistent with i

73 astasis, with heightened expression observed at the leading edge of HNSCC patient tissue.

74 n a paracrine manner to direct cell motility at the leading edge of infection.

75 cking its cargo-binding tail moves laterally at the leading edge of lamellipodia and induces filopodi

76 veals that LASP1 is selectively concentrated at the leading edge of lamellipodia in migrating cells a

77 vealed a new finding: ZO-1 was also detected at the leading edge of lamellipodia, especially in motil

78 cate that Ena/VASP proteins rapidly exchange at the leading edge of lamellipodia, whereas virtually n

79 that microglial cells express CB2 receptors at the leading edge of lamellipodia, which is consistent

80 tion and triggers CA IX protein accumulation at the leading edge of lamellipodia.

81 The presence of an "arc" of Rac2 at the leading edge of leukocyte pseudopodia and PLD2 ph

82 and increased Stat3 activity was identified at the leading edge of lung tumors invading adjacent non

83 are actin- and fimbrin-containing adhesions at the leading edge of macrophages.

84 cytomas, and colocalizes with RAC1 and CDC42 at the leading edge of migrating astrocytoma cells.

85 ctivation of WNK1 and its downstream pathway at the leading edge of migrating CD4(+) T cells, resulti

86 are actin-rich fingerlike protrusions found at the leading edge of migrating cells and are believed

87 integrin and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patte

88 more, beta2-adaptin is enriched in adhesions at the leading edge of migrating cells and depletion of

89 Nascent adhesions form at the leading edge of migrating cells and either underg

90 a1 and Kir4.2 colocalized in focal adhesions at the leading edge of migrating cells and inhibition or

91 e data we show that Larp1 protein is present at the leading edge of migrating cells and interacts dir

92 ow that PKA activity gradients are generated at the leading edge of migrating cells and provide addit

93 r basis of the formation of 'sticky fingers' at the leading edge of migrating cells and show that an

94 cortex upon chemoattractant stimulation and at the leading edge of migrating cells and this localiza

95 within the treadmilling actin filament array at the leading edge of migrating cells are interdependen

96 Dcx localization and function are regulated at the leading edge of migrating cells by a balance of k

97 directional sensing and pseudopod extension at the leading edge of migrating cells during chemotaxis

98 MP accumulated in lamellipodia and filopodia at the leading edge of migrating cells in association wi

99 ivation of the Par6-PKCzeta complex by Cdc42 at the leading edge of migrating cells promotes both the

100 Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulat

101 t state, but the phosphorylated CaD is found at the leading edge of migrating cells where dynamic act

102 phorylation of GSK-3beta occurs specifically at the leading edge of migrating cells, and induces the

103 Filopodium, a spike-like actin protrusion at the leading edge of migrating cells, functions as a s

104 Focal adhesions are dynamic constructs at the leading edge of migrating cells, linking them to

105 At the leading edge of migrating cells, protrusion of th

106 leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression o

107 role in the stabilization of focal contacts at the leading edge of migrating cells, the mechanisms a

108 and phospho-alpha4 were in distinct clusters at the leading edge of migrating cells, whereas unphosph

109 AG3 protein partially colocalizes with actin at the leading edge of migrating cells, wherein active a

110 (IQGAP1) is recruited and overlaps with ARF6 at the leading edge of migrating cells.

111 l migration is the formation of lamellipodia at the leading edge of migrating cells.

112 ed PKA biosensor to reveal activation of PKA at the leading edge of migrating cells.

113 ck180/Elmo complex to promote Rac activation at the leading edge of migrating cells.

114 Wave-2 is required for actin polymerization at the leading edge of migrating cells.

115 actin to facilitate lamellipodial protrusion at the leading edge of migrating cells.

116 clathrin and AP2 in clathrin-coated pits and at the leading edge of migrating cells.

117 ociated with sites of dynamic actin assembly at the leading edge of migrating cells.

118 of the actin network that drives protrusion at the leading edge of migrating cells.

119 with paxillin to rudimentary focal complexes at the leading edge of migrating cells.

120 phs the formation of branched actin networks at the leading edge of migrating cells.

121 orces that would otherwise impede protrusion at the leading edge of migrating cells.

122 eas the cytoplasmic APC protein concentrated at the leading edge of migrating cells.

123 e colocalization of SMURF1/p27 and UbcH7/p27 at the leading edge of migrating cells.

124 sor to reveal activation of Rab13 by DENND2B at the leading edge of migrating cells.

125 I, and Scrib, Lgl1, and myosin II colocalize at the leading edge of migrating cells.

126 ze P-Rex1 guanine nucleotide exchange factor at the leading edge of migrating cells.

127 ll-matrix adhesion, and cellular protrusions at the leading edge of migrating cells.

128 zyxin recruits zyxin to force-bearing sites at the leading edge of migrating cells.

129 perties in that it predominantly accumulates at the leading edge of migrating cells; however, the pat

130 ction in a complex at adherens junctions and at the leading edge of migrating endothelial cells to mo

131 and beta-catenin at cell-cell junctions and at the leading edge of migrating endothelial cells.

132 ZO-1's appearance at the leading edge of migrating fibroblasts makes it a

133 We also find ZW10 enriched at the leading edge of migrating fibroblasts, suggesting

134 entation of sparsely labeled F-actin network at the leading edge of migrating human keratinocytes, re

135 found to be concentrated in the lamellipodia at the leading edge of migrating MDA-MB-231 cells.

136 to also result in reduced filamentous actin at the leading edge of migrating neurons, associated wit

137 Precise optoPlexin activation at the leading edge of migrating osteoblasts readily ind

138 Par3 is recruited at the leading edges of migrating cells and in focal adh

139 s of Arp2, Arp3, cofilin, and phosphocofilin at the leading edges of migrating cells, in wound-healin

140 ctioning in exocytosis, also regulates actin at the leading edges of migrating cells, therefore coord

141 bstratum interfaces, at focal adhesions, and at the leading edges of migrating cells.

142 gs show that Ang-1 triggers Cdc42 activation at the leading edges of migrating ECs, which is dependen

143 egulates contractile force and Rac1 activity at the leading edge of migratory cells and the spine hea

144 les in their more stable regions - localizes at the leading edge of migratory cells and trims microtu

145 s localized and was preferentially activated at the leading edge of migratory cells in response to ad

146 but they have only been extensively studied at the leading edges of migratory fibroblasts, where the

147 exes containing kinesin-1 and RIC-7 polarize at the leading edge of mitochondria and are required for

148 Arp2/3 complex is concentrated at the leading edge of motile Acanthamoeba, and its loca

149 f cell surface tissue transglutaminase (tTG) at the leading edge of motile cancer cells.

150 rk assembly and disassembly in two contexts--at the leading edge of motile cells and in the actin com

151 es the formation of branched actin filaments at the leading edge of motile cells and in the comet tai

152 RhoA is activated at the leading edge of motile cells by unknown mechanism

153 The actin filament network at the leading edge of motile cells relies on localized

154 Studies of actin dynamics at the leading edge of motile cells with single-molecule

155 nique capability of producing pushing forces at the leading edge of motile cells without the implicat

156 ex nucleates and cross-links actin filaments at the leading edge of motile cells, and its activity is

157 the formation of the dendritic actin network at the leading edge of motile cells, but it is still unc

158 However, at the leading edge of motile cells, talin colocalises w

159 plex stimulates formation of actin filaments at the leading edge of motile cells.

160 rane ruffles and in a gradient of activation at the leading edge of motile cells.

161 flow toward the cell center, such as occurs at the leading edge of motile cells.

162 ly of a branching network of actin filaments at the leading edge of motile cells.

163 the structure of the actin filament network at the leading edge of motile cells.

164 cleates actin filaments to generate networks at the leading edge of motile cells.

165 tin filament branches during endocytosis and at the leading edge of motile cells.

166 These sites colocalized with beta-actin mRNA at the leading edge of motile myoblasts, confirming that

167 the dynamics and geometry of actin networks at the leading edges of motile cells, and one that has c

168 sides of actin filaments and is concentrated at the leading edges of motile cells.

169 ty-dependent infiltrating population present at the leading edge of mouse and human tumours that is e

170 Piezo1 recruitment at the leading edge of moving T cells is dependent on an

171 R/WAVE complex controls actin polymerization at the leading edges of moving cells, but its mechanism

172 To drive growth at the leading edge of myelin at the interface with the

173 that inhibits axonal growth, activates GSK-3 at the leading edge of neuronal growth cones and in Sema

174 ns suggest that the pericellular proteolysis at the leading edge of neutrophils not only facilitates

175 y that HL investigation and treatment remain at the leading edge of oncological research.

176 e, extensive leukocyte adhesion was observed at the leading edge of pathological, but not physiologic

177 signals that lead to the activation of Mac-1 at the leading edge of PMNs, thereby allowing RBC captur

178 tubulin binding decrease microtubule density at the leading edge of polarized cells, suggesting that

179 table receptors for ATX, which are localized at the leading edge of polarized cells.

180 re is a significant step in machine learning at the leading edge of quantum computing.

181 Populations at the leading edge of range expansion harbored higher l

182 body sizes and (vi) longevity in populations at the leading edge of range expansion in relation to se

183 etwork immediately under the plasma membrane at the leading edge of rapidly moving cells consists of

184 eral PKC isoforms colocalized with L-plastin at the leading edge of SDF-1alpha-stimulated lymphocytes

185 ound that L-plastin colocalized with F-actin at the leading edge of SDF-1alpha-stimulated T lymphocyt

186 lmost constant chemoattractant concentration at the leading edge of single pseudopods during their gr

187 2+) influx is required for positive feedback at the leading edge of spontaneously polarized macrophag

188 Abi1 colocalizes with phosphorylated alpha4 at the leading edge of spreading cells.

189 membrane ruffles and lamellae usually found at the leading edge of spreading cells.

190 Peridermal cells at the leading edge of Spry-mutant eyelids showed reduce

191 The precise mechanisms governing invasion at the leading edge of squamous cell carcinoma (SCC) and

192 e associated with periodontitis, is abundant at the leading edge of subgingival plaque, where it inte

193 trate an association between actin anchoring at the leading edge of T24 cells and the establishment o

194 icularly in men and women 40-60 years of age at the leading edge of the 'baby boom' demographic expan

195 mplex, which sediments in glycerol gradients at the leading edge of the 10S terminal uridylyltransfer

196 IF4E-eIF4G-eIF3-40S interactions place eIF4E at the leading edge of the 40S subunit, and mRNA is thre

197 that Acam and myosin VI precisely colocalize at the leading edge of the actin cones and that myosin V

198 TNP-470 reduced the permeability of BEVs at the leading edge of the advancing vascular plexus as

199 Our analyses reveal that at the leading edge of the biofilm, highly coherent grou

200 traditional measures and more novel methods at the leading edge of the biological sciences.

201 of the embryonic shield, a slight thickening at the leading edge of the blastoderm during the formati

202 t cell cluster that forms a wedge-shaped cap at the leading edge of the blastoderm.

203 es the formation of F-actin-rich protrusions at the leading edge of the cell behind.

204 e uropod is thought to aid integrin adhesion at the leading edge of the cell by removing steric hindr

205 ubtilis, FtsZ plays a role in ring formation at the leading edge of the cell division septum.

206 hoinositide lipids PI(3,4,5)P3 and PI(3,4)P2 at the leading edge of the cell in response to an extern

207 bset of "leader cells" that extend filopodia at the leading edge of the cell sheet.

208 y forming lamellipodia-actin-rich extensions at the leading edge of the cell that have been well char

209 us MSP polymerization to the plasma membrane at the leading edge of the cell thereby generating protr

210 rix, production of transient focal complexes at the leading edge of the cell, and retraction of the r

211 ntering locally activated small G protein(s) at the leading edge of the cell, becomes activated and p

212 romoting actin-dependent membrane protrusion at the leading edge of the cell, but the molecular mecha

213 biology that particularly affect structures at the leading edge of the cell, including the structure

214 sphatidylinositol-3,4,5-trisphosphate signal at the leading edge of the cell.

215 involving formation of a scaffolding complex at the leading edge of the cell.

216 During migration, GFP-myosin VII is found at the leading edge of the cell.

217 nsion and formation of new actin barbed ends at the leading edge of the cell.

218 focal nucleation and polymerization of actin at the leading edge of the cell.

219 d a vesicle derived from the plasma membrane at the leading edge of the cell.

220 on by securing the formation of lamellipodia at the leading edge of the cell.

221 r the integrin LFA1 (CD11a/CD18) recruitment at the leading edge of the chemotactic human T cells.

222 atenin homologue Armadillo (Arm) accumulates at the leading edge of the cleavage furrow, and later to

223 use a population of migratory myofibroblasts at the leading edge of the closing VBW that express the

224 in turns over throughout the cone, with that at the leading edge of the cones turning over with sligh

225 teinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating

226 weeps to dominance or declines to extinction at the leading edge of the COVID-19 pandemic.

227 CTPsyn was co-enriched with Actin at the leading edge of the Drosophila border cell cluste

228 migration is driven by cell wall remodeling at the leading edge of the engulfing membrane, with pept

229 ced in the dermis and granulation tissue and at the leading edge of the epidermis in the healing woun

230 mistry studies demonstrated MMP-9 expression at the leading edge of the epithelial wound, in the the

231 he black hole, by incorporating a shock wave at the leading edge of the expansion of the galaxies, ar

232 at the 100-200-nm submembraneous compartment at the leading edge of the extending lamellipod constitu

233 was slightly more abundant than PI(3,4)P(2) at the leading edge of the forming cup.

234 span and length revealed that most filopodia at the leading edge of the growth cone achieved signific

235 for by the 'push' of plus-end actin assembly at the leading edge of the growth cone.

236 t pinpoint membrane poration can be produced at the leading edge of the HeLa cell in standoff distanc

237 , the organization of the actin cytoskeleton at the leading edge of the invaginating furrows became p

238 g cell division while maintaining a position at the leading edge of the invaginating septum.

239 d, subsequently, the initiation of FA growth at the leading edge of the lamella.

240 rbed ends, resulting in actin polymerization at the leading edge of the lamellipodium in carcinoma ce

241 the existence of an actin-rich purse string at the leading edge of the lateral epidermis and provide

242 on Rho-mediated contraction of an actin ring at the leading edge of the lesion.

243 brings the prospective mesoderm and endoderm at the leading edge of the marginal zone into vertical a

244 Microtubules at the leading edge of the matured phragmoplast were oft

245 invasion of the mesodermal-endodermal tissue at the leading edge of the mesodermal mantle might be th

246 actile and migratory proteins preferentially at the leading edge of the migratory front.

247 on of myonuclear translocation: Kinesin acts at the leading edge of the nucleus, whereas Dynein acts

248 eV backward-directed beam is mainly produced at the leading edge of the plasma column.

249 is migration is promoted by the leader cells at the leading edge of the pLLP, which express the G pro

250 fferentiated HL-60 cells, mAbp1 was enriched at the leading edge of the polarized cell.

251 for Don1p, which forms a ring-like structure at the leading edge of the prospore membrane during meio

252 s assembly of the Don1p-containing structure at the leading edge of the prospore membrane via interac

253 Ssp1, a protein found at the leading edge of the prospore membrane, is stabili

254 closely associated with the plasma membrane at the leading edge of the protrusive structures, N-WASP

255 on of the trailing edge but block expansions at the leading edge of the range.

256 Mutations of single amino acid residues at the leading edge of the recognition helix are rarely

257 nd that P-selectin-PSGL-1 bonds were relaxed at the leading edge of the rolling cell, compressed unde

258 n these organisms, FtsZ is located in a ring at the leading edge of the septum.

259 ic and coordinated organization of the cells at the leading edge of the sheet.

260 paxillin colocalize in the membrane ruffles at the leading edge of the spreading cells, providing a

261 s were 4-fold more sensitive to contact made at the leading edge of the T cell compared with the tail

262 re 3-fold more sensitive to APC contact made at the leading edge of the T cell than with contact made

263 ike invasive species in nature, cancer cells at the leading edge of the tumor possess a different phe

264 ssed during glioma progression, particularly at the leading edge of the tumor.

265 red, as these macrophages failed to localize at the leading edge of the vascular plexus and at vascul

266 unds examined, basal keratinocytes and cells at the leading edge of the wound expressed keratins K5 a

267 ed the number of proliferating keratinocytes at the leading edge of the wound, suggesting that VEGF s

268 was visible in a few epithelial basal cells at the leading edge of the wound.

269 6 mRNA expression primarily in the epidermis at the leading edge of the wound.

270 ing to the suppression of cell proliferation at the leading edge of the wound.

271 -localize to the cortical actin cytoskeleton at the leading edges of the cell.

272 nd integrin-dependent lamellipodial crawling at the leading edges of the epidermal tongue.

273 wo progenitor galaxies that are expected(11) at the leading edges of the trail.

274 ecies were not able to track climate warming at the leading edge of their distribution, and further e

275 ore restricted in their habitat associations at the leading edges of their range margins, but some sp

276 ion and actin-membrane anchorage, is present at the leading edge of these migrating epithelia and is

277 uced tumors, Activin signaling may be active at the leading edge of these tumors.

278 This flexible loop, juxtaposed at the leading edge of transcription bubble, has been pr

279 vo, which uncovered localized NCEH1 activity at the leading edge of triple-negative breast cancer tum

280 d fibroblasts for degrading stromal collagen at the leading edge of tumor invasion.

281 day 8.5 in the mouse, proliferation of cells at the leading edge of ventral-lateral endoderm, where t

282 strate an inability to activate EGF receptor at the leading edge of wounds, and we demonstrate that t

283 lying that Zip2 and associated proteins move at the leading edge of Zip1 polymerization.