ライフサイエンスコーパス: be known to

1 use model of familial ALS, since mutant SOD1 is known to accumulate in the IMS of neural tissue and c

2 the forefront of cancer research, where they are known to act as critical regulators of disease.

3 ciency of melanocortin MC4R receptors, which are known to activate Gsalpha.

4 dividual G-protein-coupled receptors (GPCRs) are known to activate one or more G proteins, the GPCR-G

5 cule associated with cardiovascular disease, is known to activate extracellular signal regulated kina

6 Maturation by proteolytic cleavage is known to activate the enzyme.

7 Starvation, or caloric restriction, is known to activate the transcription factor EB (TFEB),

8 h Set1) family of histone methyltransferases is known to activate transcription of Hox genes in other

9 al reactive oxygen species production, which is known to activate transient receptor potential ankyri

10 ases have flexible surface-exposed loops and are known to adopt higher and lower activity conformatio

11 Certain cytogenetic abnormalities are known to adversely impact outcomes in patients with

12 tissue-specific chemical modifications that are known to affect TF binding (such as DNA methylation)

13 Many ions are known to affect the activity, stability, and structu

14 MicroRNAs (miRNAs) have been known to affect various biological processes by rep

15 ancer-promoting gene expression.Inflammation is known to affect cancer development, yet the mechanism

16 the nucleosome binding proteins H1 and HMGN is known to affect chromatin dynamics, but the biologica

17 MEF2C is the only gene that is known to affect heart development in mammals and migh

18 ene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell differentiatio

19 rease in the quantity of available resources is known to affect temporal variability of aggregate com

20 protein post-translational modification that is known to affect the association between histone and D

21 However, confinement effects are known to alter reaction equilibria.

22 olid tumor progression, and tissue stiffness is known to alter cell behaviors including proliferation

23 Although early-life stress is known to alter health, its long-term consequences on

24 Cancer is known to alter the local optical properties of tissue

25 Phytoestrogen-rich soy is known to ameliorate menopause-associated obesity and

26 thin the aggregation end products of fibrils are known to arise due to microstructural differences am

27 The 5q14.3 locus is known to associate with variation in retinal vascular

28 Type 1 interferons (T1-IFN) are known to be a constituent of the autoinflammatory mi

29 ls, and variations in charged tRNA fractions are known to be a useful parameter in cellular responses

30 ily integrity, family, or social structures, are known to be associated with cardiometabolic outcomes

31 tely altered bodily sensations-both of which are known to be associated with insular functioning.

32 Although these plants are known to be associated with natural biocide producti

33 Furthermore, the derived P-values are known to be conservative when sample size is small,

34 of reading, a crucial ability in which there are known to be considerable individual differences in t

35 response to two immunodominant epitopes that are known to be dependent on Ag cross-presented by DCs,

36 For seabirds, the impacts of cyclones are known to be detrimental at breeding colonies, but im

37 While a myriad non-coding RNAs are known to be essential in cellular processes and misr

38 ical and structural properties of these gels are known to be governed by the conditions under which f

39 These aspects of daily life are known to be impaired after extended wake, yet, the u

40 PS-ASOs are known to be internalized via a number of endocytotic

41 Many identified candidate modulators are known to be involved in biological meaningful proces

42 t of LC3 proteins and GABARAPs, all of which are known to be involved in canonical autophagy.

43 s ligand stromal cell-derived factor (SDF)-1 are known to be involved in inflammation.

44 Tight junction (TJ) proteins are known to be involved in proliferation and differenti

45 n and nuclear envelope A-type lamin proteins are known to be key nuclear mechanical components pertur

46 S-mutated colorectal liver metastases (CRLM) are known to be more aggressive than KRAS wild-type tumo

47 ing two tridentate chelates (bis-tridentate) are known to be more robust compared to those with three

48 HDACs are known to be powerful negative regulators of memory f

49 Cell proliferation and migration are known to be regulated by the Notch receptor, which p

50 Membrane-bound transporters are known to be relevant, but passive permeation may als

51 are not induced, including at enhancers that are known to be repressed by a transcriptional repressor

52 tion factor G and ribosome recycling factor, are known to be required for recycling, but there is con

53 BALB/c mice are known to be resistant to high fat diet (HFD)-induced

54 Even though sulfur atoms on the basal plane are known to be stable and inert, we find that they can

55 ubset of never-smokers, and these two probes are known to be strongly associated with maternal smokin

56 methylation levels of neighboring CpG sites are known to be strongly correlated, methods that incorp

57 with changing task-sets and motor responses are known to be strongly interactive: switch costs at th

58 Cinnamon and cocoa are known to be valuable sources of bioactive phytochemi

59 Dysregulation of BCL-2 has long been known to be a crucial part of the pathophysiology o

60 mbination of land subsidence, which has long been known to be present in the region, and rising seas

61 mong patients with acute stroke who had last been known to be well 6 to 24 hours earlier and who had

62 proximal middle cerebral artery who had last been known to be well 6 to 24 hours earlier and who had

63 Bone mineral density is known to be a heritable, polygenic trait whereas gene

64 Although Pcdh19 is known to be a homophilic cell-cell adhesion molecule,

65 Orange-fleshed sweet potato (OFSP) is known to be a rich source of beta-carotene, a precurs

66 nd the average fluorescence lifetime of EGFP is known to be affected by pH.

67 Subclinical hypothyroidism is known to be associated with increased serum cholester

68 Traffic-related air pollution is known to be associated with skin aging manifestations

69 e is due to the flexural phonons, whose flow is known to be ballistic and distance-independent up to

70 The growth of several biological tissues is known to be controlled in part by local geometrical f

71 epigenetic marks, as tumor mutational burden is known to be coupled to chromatin structure, we examin

72 Although AOM is known to be coupled to reductions of sulfate, nitrite

73 While the medial preoptic area (MPOA) is known to be critical for maternal behavior, the speci

74 45, which is crucial for AMPAR recycling and is known to be dephosphorylated in the presence of Abeta

75 DLS is known to be disrupted after chronic drug abuse; howev

76 mobility of organic semiconducting polymers is known to be enhanced when the energetic disorder of t

77 TFIIH, whose recruitment to the PIC is known to be facilitated by the Mediator, then acts to

78 e TFs regulating NHX1 gene expression, which is known to be highly induced under salt stress, we have

79 Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but

80 ich contains a hydrophobic triad W1L4L8 that is known to be important in the interaction with centrin

81 ng the directionality of other group members is known to be important to maintain cohesion, it is not

82 tal particles and their interactions, but it is known to be incomplete.

83 a stressor.Animals' response to acute stress is known to be influenced by sex and genetics.

84 The electrochemical reduction of CO2 is known to be influenced by the identity of the alkali

85 ion and homologous recombination repair, and is known to be involved in cancer development.

86 While contractility is known to be largely RhoA-dependent, the process by wh

87 Autism spectrum disorder (ASD) is known to be more prevalent among males than females i

88 NS5A is known to be phosphorylated by cellular protein kinase

89 Hydrogen is known to be present as an impurity in amorphous oxide

90 Astroglial dysfunction is known to be present in HE.

91 In the mammalian brain, auditory information is known to be processed along a central ascending pathw

92 Although this process is known to be regulated by follicular helper T (TfH) ce

93 lta mutant and bcr1Delta/Delta mutant, which is known to be severely defective in biofilm formation w

94 Malaria transmission is known to be strongly impacted by temperature.

95 on-like, low sequence-complexity domain (LC) is known to be targeted for phosphorylation.

96 The xanthine scaffold is known to be the forefather of a class of biological a

97 ign and control of the platinum shell, which is known to be the structural feature responsible for th

98 this process can lead to fibrosis, and LOXL2 is known to be upregulated in fibrotic tissue.

99 reased heparan sulfate levels on ASCs, which are known to bind pro-survival cytokines, leading to inc

100 Although PGC1alpha is known to bind and activate LRH-1, mechanisms through

101 CTCF is known to bind several sites in the HSV-1 genome durin

102 e incubated with rat liver microsomes, which are known to bioactivate APAP to the reactive metabolite

103 While DNAN is known to biotransform in soils to aromatic amines and

104 0 individuals with breast cancer, of whom 22 were known to carry a germline BRCA1 or BRCA2 mutation,

105 Although a number of Gram-negative bacteria are known to catabolize quinate and shikimate, only limi

106 CAG trinucleotide repeats are known to cause 10 late-onset progressive neurodegene

107 d superalloy, resulting from heat treatment, is known to cause disastrous failure, but its mechanism

108 Picornavirus replication is known to cause extensive remodeling of Golgi and endo

109 Influenza is known to cause persistent alveolitis in animal models

110 Traumatic brain injury (TBI) is known to cause perturbations in the energy metabolism

111 phase-relationship to sleep in a manner that is known to cause switches from depression to mania.

112 eavage of transmembrane proteins, and ADAM17 is known to cleave Nectin-4 in breast cancer.

113 Myocytes and non-myocytes are known to communicate and exert mutual regulatory eff

114 o other antimalarials drugs for which PfMDR1 is known to confer resistance.

115 Spinach is known to contain significant amounts of oxalates, whi

116 This transcriptional regulator is known to contribute to neuronal differentiation durin

117 These internal surfaces are known to control the activation and motion of disloc

118 Dozens of proteins are known to convert to the aggregated amyloid state.

119 Invasive Ae. albopictus males are known to copulate with and effectively sterilize Ae.

120 The onset of ER stress is known to correlate with various disease processes, an

121 Shifts in visual attention are known to covertly enhance processing at locations aw

122 of the industrially relevant alloy Ti-6Al-4V is known to create a multitude of phases and microstruct

123 ed as guanine by polymerases, but no enzymes are known to deaminate adenine in DNA.

124 Glucocorticoid steroids, like prednisone, are known to delay loss of ambulation in patients with D

125 While the origins of physiological tremor are known to depend on muscle afferentation, it is possi

126 by chemical oxidants in various DNA systems are known to deprotonate, at most, within a few microsec

127 nature of cortical organization, because it is known to develop only through experience (i.e., readi

128 tum and heat transport in rarefied gas flows is known to deviate from the classical laws of Navier an

129 apered junctions of orthopaedic hip implants are known to differ and the debris generated varies in s

130 l gene gagIMPORTANCE HIV disease progression is known to differ between individuals, and defining whi

131 nutritional intake from an energy-dense diet is known to disrupt metabolic homeostasis and contribute

132 Licorice consumption is known to disrupt the ability of the placental enzyme

133 ile cholinergic receptor activation has long been known to dramatically enhance the excitability of c

134 ttributes of the extracellular matrix (ECM), are known to drive cell branching and shape change large

135 mediate(s) and solvent (Bronsted-Lowry base) is known to drive the reaction, the gas-phase reaction f

136 O. tauri is known to efficiently produce docosahexaenoic acid (DH

137 OSMOTICALLY RESPONSIVE GENES 1 (HOS1), which is known to either act as E3 ubiquitin ligase or affect

138 1 are mainly ATP-competitors and, therefore, are known to elicit side effects due to lack of specific

139 Celastrol is known to elicit a cellular stress response resembling

140 r the cerebellum in cognition, granule cells are known to encode only sensory and motor context.

141 ked excitation in peripheral olfactory cells is known to encode odor information, the molecular mecha

142 Aminated linkers are known to enhance the absorption of light and afford

143 ecifically targets cardiac muscle myosin and is known to enhance cardiac muscle performance, yet its

144 ring vertebrate somitogenesis, retinoic acid is known to establish the position of the determination

145 Both humans and animals are known to exhibit a violation of rationality known as

146 Eyeballs having these refractive errors are known to exhibit abnormal eye shape at the anterior

147 Melanoma cells treated using these agents are known to exhibit increased levels of melanin pigment

148 various task-relevant cerebral regions that are known to exhibit lateralization.

149 is noteworthy that glutamatergic LTD, which is known to exist on stratum lucidum interneurons, coexi

150 Mutants of the fusome, an organelle that is known to facilitate intracyst communication, compromi

151 Chiral nematic liquid crystals are known to form blue phases-liquid states of matter th

152 Iodine crystals are known to form layered structures with intralayer hal

153 rrect folding and secretion of proteins that are known to form non-native disulfides during their fol

154 The amino acid serine is known to form a very stable octamer that has properti

155 ORP1L is known to form highly dynamic contacts with endoplasmi

156 Club cells are known to function as regional progenitor cells to re

157 are mitochondrion-specific DNA effectors and are known to function in the nucleoid.

158 Circularly polarized photons are known to generate a directional helicity-dependent p

159 ne of the most widely used viral vectors and is known to generate potent T cell responses.

160 Particle shape and topology are known to guide this self-assembly process.

161 ation, a posttranslational modification that is known to hamper OCN endocrine action.

162 Two-dimensional materials are known to harbour properties very different from thos

163 y liver disease and cardiovascular disorders are known to have a major inflammatory component.

164 scence-accelerated mouse prone 8 mice, which are known to have deregulated reactive oxygen species me

165 reated with radiotherapy and/or chemotherapy are known to have increased risks of heart failure (HF),

166 nd cortical thickness, and that females, who are known to have lower gray matter volume than males, h

167 Although some serotypes of AAV are known to have nerve tropism, whether AAV can distrib

168 Plasma insulin oscillations are known to have physiological importance in the regula

169 Changes in precipitation regimes are known to have powerful effects on plant productivity

170 Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G).

171 Vimentin is known to have a significantly greater ability to resi

172 though tripartite motif-containing (TRIM)-28 is known to have an immunosuppressive role in immune cel

173 , a major player in Alzheimer's disease that is known to have immune and inflammatory components.

174 This mutation is known to have incomplete penetrance, with some patien

175 Influenza vaccine is known to have suboptimal immunogenicity in transplant

176 patients died postdischarge, and 155 (7.0%) were known to have survived to 36-months postinjury but

177 Cancer has long been known to histologically resemble developing embryon

178 low doping.Two-dimensional Dirac semimetals are known to host fermionic excitations which can mimic

179 ion, the increased use of interventions that are known to improve compliance, and the use of performa

180 Density and hardness of glasses are known to increase upon both compression at the glass

181 such as epinephrine and norepinephrine, that are known to increase virulence in several pathogens, in

182 High sodium intake is known to increase blood pressure and is difficult to

183 Generous behaviour is known to increase happiness, which could thereby moti

184 ivation (MIA) via infection during pregnancy is known to increase risk for autism spectrum disorder (

185 Riluzole is known to increase the glutamate transporter EAAT2's a

186 Although arsenic exposure is known to increase the risk of atherosclerosis, the co

187 e heavy metals cadmium (Cd) and mercury (Hg) is known to increase the risk of chronic diseases.

188 tion, when gamma activity in motor circuitry is known to increase.

189 ace protein (BTP), a monomeric glycoprotein, is known to indicate cerebrospinal fluid leakage.

190 virus (EBV) infection and lytic replication are known to induce a cellular DNA damage response.

191 Proton pump inhibitors (PPIs) have been known to induce type I hypersensitivity reactions.

192 e response evoked by interleukin (IL)-6 that is known to induce both pro inflammatory and anti-inflam

193 gene array analysis showed that ATF6, which is known to induce genes encoding ER proteins that augme

194 Optical excitation of nanostructures is known to induce local heating, a phenomenon that has

195 However, it is known to induce metformin-associated lactic acidosis

196 triction of parasite replication, Leishmania is known to induce ROS upon macrophage infection.

197 Aergic, express leptin receptors (LepR), and are known to influence reproduction.

198 While degraded water quality has long been known to influence underwater grasses worldwide, we

199 onverts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis.

200 The microbiota is known to influence the generation of hematopoietic pr

201 myloid precursor protein transthyretin (TTR) is known to inhibit amyloid-beta (Abeta) aggregation in

202 roethene (TCE) by in situ minerals, and C2H2 is known to inhibit bacterial dechlorination.

203 fluorinated analogues of l-carbidopa, which is known to inhibit DOPA decarboxylase (DDC), a key prot

204 death-1 (PD-1) in the tumor microenvironment is known to inhibit effective adaptive antitumor immunit

205 Clasically, progesterone (P4) is known to inhibit the expression of connexin-43 (Cx43,

206 RUNX1 expression is known to initiate at 2 alternative promoters, a dista

207 posi's sarcoma-associated herpesvirus (KSHV) are known to interact extensively with the DDR during th

208 d C1q, in particular its head regions, which are known to interact with other activators of the class

209 While BCCIP is known to interact with BRCA2, the relationship betwee

210 action of Red1 remains unclear, although it is known to interact with Hop1 and to suppress the spore

211 Selective attention is known to interact with perceptual organization.

212 R-loops are known to interfere with replication forks, and sensi

213 Treatment assignments were known to investigators, site personnel, patients, c

214 Cholecalciferol or vitamin D3 is known to isomerise under various conditions, thereby

215 telet C-type lectin-like receptor 2 (CLEC-2) is known to maintain the physiological state of blood va

216 Acoustic detection and recognition are known to mediate copula formation in opposite-sex pa

217 Several natural products are known to mediate microbial interactions through meta

218 Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regene

219 ulin-like growth factor 2 (Igf2), genes that are known to modulate memory processes.

220 human genetic diseases, and the NMD pathway is known to modulate disease severity.

221 Mycobacterium tuberculosis is known to modulate the host immune responses to facili

222 The microbiota is known to modulate the host response to influenza infe

223 Lightning strikes are known to morphologically alter and chemically reduce

224 oexistence at two sites in which the species are known to occur in sympatry.

225 Discharge in the lithium-O2 battery is known to occur either by a solution mechanism, which

226 This condition, called positive assortment, is known to occur in spatially-structured viscous popula

227 nucleophosmin/nucleoplasmin proteins, which are known to oligomerize into pentamers and decamers.

228 chment protein receptor (SNARE) protein that is known to participate in the regulation of mitochondri

229 well-described activity-dependent mechanisms are known to play a key role in learning and memory.

230 Inflammatory cytokines are known to play a key role in regulating protease expr

231 In mammals, macrophages are known to play a major role in tissue regeneration.

232 ctive peptides isolated from natural sources are known to play important physiological roles in the h

233 heir final product, prostaglandin E2 (PGE2), are known to play important roles in the modulation of b

234 Myeloid-derived suppressor cells (MDSCs) are known to play important roles in tumour immune evasi

235 They are known to play important roles in various biological

236 MicroRNAs (miRNAs) are known to play important roles in various cellular pr

237 The alphaLbeta2 integrin LFA-1 is known to play a key role in T lymphocyte migration, w

238 Dysfunction of microglia is known to play an important role in Alzheimer's diseas

239 modulates the glutaminolysis pathway, which is known to play an important role in cellular energetic

240 e adipose tissue, brown adipose tissue (BAT) is known to play critical roles for both basal and induc

241 STAT3 is known to play critical roles in cell growth, prolifer

242 KSHV episomes are known to possess bivalent chromatin domains.

243 3 species, including monocots, many of which are known to possess glandular trichomes.

244 Paramecium and Tetrahymena species have long been known to present a wide variety of mating type numb

245 suppression.SIGNIFICANCE STATEMENT Saccades are known to produce a suppression of contrast sensitivi

246 Although proteasome-mediated proteolysis is known to produce antigenic peptides in adaptive immun

247 ic proteins Munc18-1, syntaxin-1, or SNAP-25 is known to produce cell death, but the underlying featu

248 ons strongly exhibit "karstification," which is known to produce particularly strong subsurface heter

249 WASP-family proteins are known to promote assembly of branched actin networks

250 Homologous recombination and repair factors are known to promote both telomere replication and recom

251 The cleavage products of HuR are known to promote cell death; however, the underlying

252 Both HDAC10 and spermidine are known to promote cellular survival through autophagy

253 Whereas several proteins are known to promote ICAM-1 function, the molecular mech

254 T follicular helper (Tfh) and Th17 cells are known to promote inflammation and autoantibody produ

255 BABY BOOM (BBM) genes in angiosperms are known to promote somatic embryogenesis, which like a

256 Octopamine (OA), the insect homolog of NE, is known to promote both arousal and aggression.

257 n (ANG), a secreted vertebrate ribonuclease, is known to promote cell proliferation, leading to neova

258 Electrical stimulation (ES) is known to promote cutaneous healing; however, its abil

259 AKT activation is known to promote metastasis, however under certain ci

260 , is a major virulence factor of SBV, and it is known to promote the degradation of Rpb1, a subunit o

261 n of transcription factors, including STATs, is known to promote tumor initiation and progression.

262 et endotoxin tolerance-inducing TLR4 ligands are known to protect animals from infection.

263 Commensal bacteria are known to provide colonization resistance in the gut.

264 Though a few plant MSR genes are known to provide tolerance against oxidative stress,

265 pathogenesis of immune-mediated diseases and are known to reach a lasting homeostatic equilibrium fol

266 VANOL and VAPOL ligands are known to react with three equivalents of B(OPh)3 to

267 uch as the fusion proteins Fus2p and Rvs161p are known to recognize membrane curvature.

268 The pupil is known to reflect a range of psychological and physiol

269 exin/calreticulin quality control cycle that is known to regenerate the Glc1Man9GlcNAc2 moiety on gly

270 Non-coding RNAs (ncRNAs) are known to regulate gene expression at practically eve

271 phosphorylated phosphatidylinositol species are known to regulate key aspects of peripheral myelinat

272 Given that these are known to regulate muscle proliferation and different

273 iated by store-operated calcium entry (SOCE) are known to regulate neutrophil activation; however, th

274 Protein degradation and phosphorylation are known to regulate protein activity during this proce

275 The UPR has long been known to regulate phospholipid metabolism, and Lpl1

276 Src kinase is known to regulate fibroblast migration.

277 Munc18c is known to regulate Stx4 activity, and here we show tha

278 fects in pigment biosynthesis or translation are known to repress photosynthesis-associated nuclear g

279 Cro is known to repress transcription of CI from pRM to prev

280 Additionally, TUBB4A mutations are known to result in a broad phenotypic spectrum, rang

281 stelium discoideum into a multicellular slug is known to result from single-cell chemotaxis towards e

282 Omega3FA are known to reverse steatosis, but how these lipids aff

283 The fungus is known to secrete tissue-specific metabolites and caus

284 It is known to sense several stimuli that are potentially a

285 Distinct subtypes of inhibitory interneuron are known to shape diverse rhythmic activities in the co

286 rotein-protein interactions networks (PPINs) are known to share a highly conserved structure across a

287 regular porphyrins, the monoheteroporphyrins are known to stabilize metals in unusual oxidation state

288 Although the cross-linked protamine network is known to stabilize the resulting nucleoprotamine stru

289 Although glucose is known to stimulate insulin secretion by beta cells, w

290 minium and iron oxides and hydroxides, which are known to strongly adsorb P.

291 Some microRNAs (miRNAs) are known to suppress breast cancer.

292 omega-3 polyunsaturated fatty acids (PUFAs) is known to suppress inflammatory processes, making thes

293 nose tetra fish, Hemigrammus bleheri, which is known to swim in highly cohesive groups, to analyze t

294 ining if individuals with TT had scarring or are known to the health system was critical for meeting

295 ures of 7,300-10,000 kelvin), and no planets are known to transit the even hotter B-type stars.

296 The glassy state is known to undergo slow structural relaxation, where th

297 PAM sequences are known to vary considerably between systems and have

298 economic interventions.Health-related traits are known to vary geographically.

299 nomes, including GC content and genome size, are known to vary widely among different bacteria and ar

300 It is known to vary widely depending on the cultivar, agron