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1 h IC50 of 0.5 and 150 muM, respectively, and were shown to be 2-4 magnitudes more potent than the pre
3 The tumor immune microenvironment (TIME) has been shown to be a critical driver of treatment response
5 While twist angle between the bilayer has been shown to be a critical parameter in engineering the
8 gh the presence of AML-related mutations has been shown to be a harbinger of relapse in multiple stud
11 h the FGFR4/beta-klotho receptor complex has been shown to be a key driver of growth and survival in
12 which contains a nonnative trans Pro-32, has been shown to be a key precursor of WT-beta(2)m aggregat
15 macological selective inhibition of hOAT has been shown to be a potential therapeutic approach for HC
16 CNV associations, kernel-based methods have been shown to be a powerful tool due to their flexibilit
18 ent years, organic electronic materials have been shown to be a promising tool, even transplanted in
20 18)F-fluoroethyl)-l-tyrosine ((18)F-FET) has been shown to be a useful tool for detecting TP and TRCs
21 Planar pore-spanning membranes (PSMs) have been shown to be a versatile tool to resolve elementary
22 n evolution at PtNP at this buried interface is shown to be a function of Nafion thickness, with the
24 troscopy with molecular dynamics simulations is shown to be a powerful tool for the study and interpr
32 o, Aedes aegypti Nix, a gene in the M-locus, was shown to be a male-determining factor (M factor) as
33 iple in vivo and in vitro assays, and StMKK1 was shown to be a negative regulator of plant immunity,
35 driven by the endogenous promotor for Pdgfra was shown to be a powerful new tool for isolating and ch
37 omised in bzip60-2, and the HSFTF13 promoter was shown to be a target of bZIP60 in maize protoplasts.
39 script abundance of C(4)-CAM signature genes was shown to be a useful indicator of the C(4)-CAM-C(4)
41 tress produced by the overgrowth of lamellae is shown to be able to create a twist moment that is res
43 pling and electrooxidation of benzyl alcohol were shown to be accelerated by more than an order of ma
49 nd its inhibition in small-animal models has been shown to be an effective antifibrotic strategy in v
50 ation of the ABX(3) perovskite structure has been shown to be an effective route to improve the stabi
52 endothelial growth factor (VEGF) therapy has been shown to be an effective treatment option for DME,
53 e of somatic mutations in a tumor, which has been shown to be an emerging biomarker for both anti-PD-
54 clic small molecule (64)Cu-CuCB-bicyclam has been shown to be an imaging agent for the CXCR4 receptor
57 teristic soap fraction, [Formula: see text], is shown to be an effective benchmark for relating infor
58 is Perspective, positional analogue scanning is shown to be an effective strategy for multiparameter
60 lasmic space of the mycobacterial cell wall, was shown to be an essential and vulnerable antimycobact
62 catchment in Chernobyl, the conceptual model is shown to be applicable to other accidental releases o
63 ting cell-free DNA (cfDNA) concentration has been shown to be associated to hospital length of stay (
64 ring gastrulation has, in several organisms, been shown to be associated with a planar cell polarity
65 s, higher admission LDL-C and TG levels have been shown to be associated with better clinical outcome
67 of free-grazing ducks (FGD) has consistently been shown to be associated with highly pathogenic avian
68 ations in mental and bodily states have both been shown to be associated with negative affective expe
69 uvate dehydrogenase kinase 4 (PDK4) gene has been shown to be associated with the development of dila
70 ponse to oxidative stress, all of which have been shown to be associated with the MM phenotype and cl
72 0, which encodes a NAC transcription factor, is shown to be associated with early fruit maturity, and
73 -Fourier transform infrared spectroscopy, Pb is shown to be associated with fatty acid phosphate, sul
74 ysteroid 17-beta dehydrogenase 13 (HSD17B13) was shown to be associated with a reduced risk for devel
75 iew, minimally invasive radical hysterectomy was shown to be associated with worse disease-free survi
78 e necessity for combination therapies as has been shown to be beneficial in the treatment of HIV infe
81 he antiviral lectin, Griffithsin (GRFT), has been shown to be both safe and efficacious against HSV-2
82 ation of enamines leading to 3-aminopyrroles was shown to be both kinetically and thermodynamically m
83 ve binding affinity calculations, which have been shown to be capable of driving discovery projects.
84 de the tissue microenvironment, immune cells were shown to be carrying IAV antigens, especially B and
85 the first time, bis(pyridine)Au(I) complexes are shown to be catalytically active, with their reactiv
86 rved by (31)P{(1)H} NMR, and these complexes were shown to be catalytically and kinetically competent
87 ioperative stress-inflammatory responses has been shown to be clinically feasible and could potential
88 lding the genomes of breast cancers and have been shown to be clinically useful for prognostic and th
90 ide robust quantification in human serum and are shown to be compatible with each of the most commonl
92 retentivity of phosphonate versus sulfonate was shown to be completely switched on this polymer when
94 TOP2-DNA complexes stabilized by etoposide were shown to be conjugated to ubiquitin, and this was r
95 es, when unadjusted for surface availability are shown to be considerably lower than those estimated
96 rapeutic evaluation of RA mice by NIR-II PMI is shown to be consistent with clinical micro-CT and his
97 lutionary rate and divergence date estimates were shown to be consistent for these three approaches a
98 he in vitro release mechanism of the peptide was shown to be controlled either by kinetics of polymer
99 features and the flow development timescales are shown to be correlated with in-situ imaging of the f
100 ation and extracellular material uptake have been shown to be coupled in some immune cells, the mecha
103 ida albicans, utilization of amino acids has been shown to be critical for survival, immune evasion,
105 generation of potent Ab responses, and have been shown to be critically involved in the pathogenesis
109 al current effects, at a level of muA, which are shown to be dependent upon the state of charge.
110 -3 epithelial ovarian cancer (EOC) cells has been shown to be dependent both on localized PKA activit
111 y architecture of Co(2+) -bridged frameworks is shown to be dependent on the identity and amount of a
112 translocation of these transcription factors was shown to be dependent on the T4SS, as a Dot/Icm muta
113 of each of these radionuclide analogs (RAs) was shown to be dependent upon their chemical speciation
114 The hydrogenation of the indolizine ring was shown to be diastereoselective, forming trans-6b and
117 thin the [(((t.Bu)ArO)(3)tacn)U(III)] moiety is shown to be dispersive in nature and essentially supp
119 cotransporters (SGLTs), which have recently been shown to be distributed in multiple human tissues.
120 atic coupling to the electronic ground state are shown to be driven by ballistic S-C bond extension a
121 scaffold binding/disassociation transitions are shown to be driven by interactions between C-termina
123 olipoprotein(a), and angiopoietin-like 3 has been shown to be effective in attenuating dyslipidemic s
127 ve-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children.
129 Localized surface plasmon resonance (LSPR) is shown to be effective in trapping light for enhanced
130 fluorine atom number, the fluoroalkylamines were shown to be effective cationic ion-interaction reag
131 cytochalasin B-induced microvesicles (CIMVs) were shown to be effective drug delivery mediators.
132 8, an orally bioavailable RSV inhibitor that was shown to be efficacious in a phase 2a challenge stud
134 In all cases, the immobilized biocatalyst was shown to be efficient for pomegranate juice fermenta
135 elicits minimal inflammatory responses, and is shown to be efficiently biodegraded in vivo when impl
137 t studies, the interleukin (IL)-36 cytokines were shown to be elevated in women with non-Lactobacillu
138 chy, and gamma-distributed rate-across-sites are shown to be emergent properties of this model while
139 the high selectivity of this transformation was shown to be enabled by the formation of a [Pd(II)(Ar
141 rsely, vesicles from normal pancreatic cells were shown to be enriched for immune response proteins.
142 uman sees when viewing the spin-orbit states is shown to be equal to the number (N) of radial lines i
146 Furthermore, the changes in GLP-1 secretion were shown to be essential for the maintenance of normog
149 resents a valid therapeutic target as it has been shown to be expressed on chronic lymphocytic leukae
150 derivatives ("Mukaiyama cyclization"), which is shown to be exquisitely chemoselective for terminal a
151 ures of the tumour microenvironment and have been shown to be far superior to previous 2D monolayer m
152 ctory of functional decline in the study eye was shown to be greater than that previously reported fo
155 -individual variation in gene expression has been shown to be heritable and is often associated with
156 The cardiovascular benefits of fibrates have been shown to be heterogeneous and to depend on the pres
159 -free multiple genome alignment program, has been shown to be highly accurate, but the existing imple
160 ditional "house cleaning" function as it has been shown to be highly active against modified cytidine
161 ingly, the role of Tregs in angiogenesis has been shown to be highly tissue- and context-specific and
163 hydrides to form ring opened thioester/acids is shown to be highly reversible and it is accordingly e
164 ates and solid-state (31) P NMR spectroscopy is shown to be highly sensitive to the surface curvature
165 ogenetic modulation of the cerebellar cortex was shown to be highly effective at attenuating hippocam
166 The expression of putative EZH2 target genes was shown to be highly relevant to the survival of patie
170 sharp wave-ripple events (SWRs), which have been shown to be important for memory consolidation.
171 eas the DNA-binding activity of RAD51AP1 has been shown to be important for RAD51-mediated homologous
173 Although proper and timely uncoating has been shown to be important for reverse transcription, th
174 yl cis-trans isomerase (PPIase) enzymes have been shown to be important for virulence in a broad-spec
175 While the choice of quantification model has been shown to be important, considerably less attention
177 nically driven softening of the bulk modulus is shown to be in good agreement with elastic moduli mea
181 e (CP) subunits with catalytic activity, has been shown to be incorporated into proteasomes and commo
184 lations, learnt from protein sequences, have been shown to be informative of co-evolutionary sectors
185 obabilities of proceeding via these pathways are shown to be invariant to the stability of the interm
186 response element-binding protein (CREB1) has been shown to be involved in diverse biological pathways
187 L projections to nucleus accumbens core have been shown to be involved in driving reinstatement of co
188 cinoids accumulate in large amounts and have been shown to be involved in plant defense, their biosyn
189 mental area and projects to the striatum-has been shown to be involved in the expression of sex-speci
191 y element-binding proteins (SREBPs), BbSre1, was shown to be involved in BbOhmm-mediated LO adaptatio
194 tical for efficient antibody responses, have been shown to be key human immunodeficiency virus (HIV)-
197 n with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with co
201 heating and inefficient thermal dissipation are shown to be major obstacles toward high radiance and
203 experiments, many components of the AMR have been shown to be mobile and to undergo constant exchange
210 arallel to a semiconducting oxide electrode, was shown to be more rapid when the molecules were withi
213 DQ2-restricted epitopes, B18-26 and C22-33, were shown to be naturally processed from whole human pr
214 ciated protein (Aap) from S. epidermidis has been shown to be necessary and sufficient for mature bio
215 ric illness, but in preclinical studies have been shown to be necessary components of the behavioral
217 tes showing decreased virulence in swine has been shown to be non-hemadsorbing suggesting an associat
219 problem involving a two-mode coherent field is shown to be NP-hard, contradicting a widely held beli
221 containing only a single polyproline tract, is shown to be on the submillisecond timescale (tau (ex)
222 1 activity varies inter-individually and has been shown to be overexpressed in estrogen receptor-posi
223 eta (POLtheta) encoded by the POLQ gene, has been shown to be overexpressed in several human cancers.
224 i anemia/BRCA pathway, and these tumors have been shown to be particularly sensitive to inhibitors of
227 LF signaling peptides, which have previously been shown to be perceived by Catharanthus roseus RLK1-l
232 ection in swine, influenza D virus (IDV) has been shown to be present in multiple animal hosts, and b
235 -6 (IL-6) is a pleiotropic cytokine that has been shown to be produced acutely by skeletal muscle in
236 composite ratios and cumulative scores have been shown to be prognostic in patients with operable re
238 membrane antigen (PSMA)-binding tracers have been shown to be promising agents for the specific targe
239 ly bound to an immunostimulating agent, have been shown to be promising tools for immunotherapy.
241 n epidemiologic studies the Asian population was shown to be prone to these pathologies more than the
244 s of PAHs in real soils where CP-MIMS-LEI/CI was shown to be rapid (15 soil samples/h) and sensitive
247 en characterized, and the rate-limiting step was shown to be reductive elimination to form the C-C bo
248 ficient in B cells due to genetic disruption were shown to be refractory to recovery from the signs o
252 the initially soft (coarse grained) material were shown to be remarkably low (~10(-6) mm(3)/N-m), the
254 sence of C1q, even though C1q has previously been shown to be required for developmental synapse elim
255 Here, the transcription factor AP-2beta is shown to be required for the differentiation of dista
256 opological distinct metal-organic frameworks is shown to be reversible over four cycles through activ
257 th adeno-associated virus (AAV) vectors have been shown to be safe and efficacious in clinical trials
258 h promising, convalescent plasma has not yet been shown to be safe as a treatment for COVID-19.METHOD
259 vidin was needed - a concentration which has been shown to be safe, preventing further GAG loss and c
260 te-of-the-art graphics-processing units, and is shown to be scalable to larger networks, such as resi
261 Furthermore, expression of these CsAAPs was shown to be seasonally regulated, coincident with th
262 The choroidal vascularity index (CVI) has been shown to be sensitive in detecting changes in choro
264 perform simulations using the proposed model is shown to be similar to the time it takes to run same
266 human DNA repair enzyme MUTYH has previously been shown to be strongly associated with reduced surviv
267 he EMPA-REG study, elevations in haematocrit were shown to be strongly associated with beneficial CV
268 ation is still rated as more fluent, CUBBITT is shown to be substantially more fluent than previous s
269 uilibration plus 12 min of carrier gas flow) were shown to be sufficient for high-quality vapor press
273 /zona occludens (PDZ) domains of PSD-95 have been shown to be the key component in the formation of c
274 arity-based friendship choice heuristic, has been shown to be the main factor in selecting friends.
275 two, three, and four-five fractions into one is shown to be the most effective for high pH RP and HFB
276 n of the Castagnoli-Cushman carboxylic acids was shown to be the case, and their decarboxylation was
277 Indirect transmission via boats and trucks was shown to be the main transmission route in all scena
282 onditions of oxidative stress, and m-Tyr has been shown to be toxic to a broad range of biological sy
284 ently, almost all of the remaining fab genes were shown to be transcriptionally activated by FadR bin
286 tinal Th17 cells, both before and after ART, were shown to be two major factors associated with the a
296 for the first time in the plant kingdom and is shown to be valuable to improve tannin compositions i
298 icular stomatitis virus (rVSV) Ebola vaccine was shown to be very efficacious in a novel ring vaccina
299 The preassigned NMR chemical shift data is shown to be vital for NMR structure analysis of minor
300 tions, the proton at the water-air interface is shown to be well-hydrated, despite the limited availa