1                                       Progression of kidney 
disease was defined as a doubling of baseline serum creatinin
 
     2                                              Chronic kidney 
disease was defined as a glomerular filtration rate less than
 
     3                                              Cardiovascular 
disease was defined as a history of angina, myocardial infarc
 
     4                                                     Cardiac 
disease was defined as a history of atrial fibrillation, isch
 
     5 cording to standard clinical criteria, while cardiovascular 
disease was defined as a history of heart attack or heart sur
 
     6                             Gluten avoidance without celiac 
disease was defined as adherence to a gluten-free diet withou
 
     7                                         Peripheral arterial 
disease was defined as an ankle brachial index <0.9 in at lea
 
     8                                         Peripheral arterial 
disease was defined as an ankle-brachial blood pressure index
 
     9                                    Lower extremity arterial 
disease was defined as an ankle/arm systolic blood pressure r
 
    10                                              Chronic kidney 
disease was defined as an estimated GFR of less than 60 mL/mi
 
    11                                              Chronic kidney 
disease was defined as an estimated glomerular filtration rat
 
    12                                      Active coronary artery 
disease was defined as any elevated serum enzyme levels, coro
 
    13                                                      Active 
disease was defined as ASDAS >/= 2.1.                        
 
    14                                        Extracranial carotid 
disease was defined as cervical internal carotid artery steno
 
    15                                                 Unfavorable 
disease was defined as clinical stage I and II with bulky per
 
    16                                              Chronic kidney 
disease was defined as confirmed (>3 months apart) eGFR lower
 
    17                                              Chronic kidney 
disease was defined as creatinine clearance <60 mL/min.      
 
    18                              Moderate-to-severe periodontal 
disease was defined as cumulative numbers of teeth exhibiting
 
    19                                                    Incident 
disease was defined as development of OA defined as a modifie
 
    20                                             Diabetic kidney 
disease was defined as diabetes with albuminuria (ratio of ur
 
    21                                             End-stage renal 
disease was defined as dialysis attributed to diabetic nephro
 
    22                                              Chronic kidney 
disease was defined as eGFR<60 mL/min per 1.73 m2.           
 
    23                                              Chronic kidney 
disease was defined as estimated glomerular filtration rate l
 
    24                                               Major chronic 
disease was defined as fatal or nonfatal cardiovascular disea
 
    25                                              Coronary heart 
disease was defined as fatal or nonfatal myocardial infarctio
 
    26                                             Coronary artery 
disease was defined as &
gt; or =70% stenosis of > or =1 coronary
 
    27                                                    Advanced 
disease was defined as hepatic insufficiency leading to OLT w
 
    28                                                   Malignant 
disease was defined as high-grade dysplasia or invasive adeno
 
    29                                                CMV GI tract 
disease was defined as histopathologic evidence of CMV on bio
 
    30                                              Valvular heart 
disease was defined as history or baseline echocardiography e
 
    31        A probable case of laboratory-acquired meningococcal 
disease was defined as illness meeting the case definition fo
 
    32 ed airway disease as juveniles, in which exacerbated airway 
disease was defined as increased cellular infiltration into t
 
    33                                                SLN-positive 
disease was defined as individual tumor cells or cell aggrega
 
    34                         Severe angiographic coronary artery 
disease was defined as left main disease, three-vessel diseas
 
    35                                       Advanced histological 
disease was defined as Ludwig stages 3 or 4.                 
 
    36                                              Chronic kidney 
disease was defined as moderate-to-severe reduction of kidney
 
    37                                    Non-fatal cardiovascular 
disease was defined as non-fatal coronary heart disease or no
 
    38                                          Platinum-resistant 
disease was defined as progression on platinum-based chemothe
 
    39                 Clinical response for patients with luminal 
disease was defined as reduction in CDAI score of >150 points
 
    40 underwent invasive coronary angiography and coronary artery 
disease was defined as stenosis >/=50% luminal diameter (quan
 
    41                                                Incident PAC 
disease was defined as the development of PAC disease during 
 
    42                                               Major chronic 
disease was defined as the initial occurrence of cardiovascul
 
    43                                                    Incident 
disease was defined as the occurrence of new radiographic OA 
 
    44                                  Progression of periodontal 
disease was defined as the percentage of teeth per decade tha
 
    45                                   The duration of untreated 
disease was defined as the period of time from the onset of r
 
    46                                          Active periodontal 
disease was defined as the presence of moderate/severe period
 
    47                                                 Periodontal 
disease was defined as two or more teeth with clinical attach
 
    48                                                   Gallstone 
disease was defined as ultrasound-documented gallstones or ev
 
    49                            Gallstone-associated gallbladder 
disease was defined as ultrasound-documented gallstones or ev
 
    50                                                 Gallbladder 
disease was defined as ultrasound-documented gallstones or ev