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1 anamivir (3-7-fold increase in IC(50) or 50% effective concentration).

2 gainst chemotherapeutic agents (half-maximal effective concentration).

3 -response curves and estimate ECx values (x% effective concentration).

4 ay be regions where only one drug reaches an effective concentration.

5 eral features of a worm-like chain model for effective concentration.

6 nefficiently charged, and 80% reduced in its effective concentration.

7 he cooperation of EGF at lower than normally effective concentrations.

8 unds by themselves were not cytotoxic at the effective concentrations.

9 nctional effects, but different half-maximal effective concentrations.

10 erify the success of injections and estimate effective concentrations.

11 efficient delivery of agents to the tumor at effective concentrations.

12 lity to deliver these agents to the tumor at effective concentrations.

13 to 15,000-fold higher than their therapeutic/effective concentrations.

14 d biocides from the membrane, lowering their effective concentrations.

15 good agreement between in vivo and in vitro effective concentrations.

17 promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotecti

18 halographic effect, 12.7% over baseline; 50% effective concentration, 13.1 ng/mL; and effect-site equ

20 ethylene (E) production demonstrated similar effective concentration(50) values of 68, 45, and 87 fmo

22 rotein-protein interaction by increasing the effective concentration and enabling spatial co-ordinati

23 s also indicate that C3, administered in the effective concentration and timeframe, may play a pivota

24 ther, the link between them influences their effective concentrations and therefore the frequency of

25 nomeric peptides, consistent with the higher effective concentration, and hence increased aggregation

27 drug levels that paralleled the human median effective concentration, and with limited toxicities.

28 inositol monophosphatase at therapeutically effective concentrations, and it has been hypothesized t

29 asing Isc was 5'adenosine-triphosphate (ATP; effective concentration at half maximal response [EC50]

31 anchors to increase protein localization and effective concentration at sites of injury, cell activat

33 of virus to cells at 4 degrees C at the same effective concentrations at which they prevent viral inf

34 ntration-versus-time curve over half-maximal effective concentration (AUC:EC50) of 108.6 is estimated

35 ffects of nociceptin (0.31 mM, the maximally effective concentration), but not endomorphin-2 (0.6 mM;

39 e fact that FCS and FRAP report on different effective (concentration dependent) diffusion coefficien

40 either male or female mouse urine, with the effective concentrations differing as much as a thousand

41 , which delivers therapeutic molecules at an effective concentration directly to the brain, may provi

42 ion for delivery, often do not accumulate in effective concentrations distant from vasculature and ar

44 ied by population sequencing, the median 50% effective concentration (EC(50) ) values for BMS-790052

45 A concentration of 4 times the viral 50% effective concentration (EC(50) [i.e., approximately EC(

46 tation showed a 2.9-fold increase in the 50% effective concentration (EC(50)) for adefovir compared t

47 0.2 pM tissue factor (TF), the half maximal effective concentration (EC(50)) for DHG inhibition was

48 ons approximately 100-fold the antiviral 50% effective concentration (EC(50)) for genotype 1 virus.

49 iciently neutralized LT in vitro, with a 50% effective concentration (EC(50)) of 0.1 nM, and provided

52 t A(2A) occupancy in humans, based on median effective concentration (EC(50)) values estimated from t

53 /Cys270Ser double mutants had similar median effective concentration (EC(50)) values for ADP and 2-me

54 tion response profiles, and the half-maximal effective concentration (EC(50)) values for glucose were

56 f-maximal inhibition of PrP(Sc) formation at effective concentrations (EC(50)) between 0.3 microM and

57 and activates human GPR7 or GPR8 with median effective concentrations (EC(50)) of 0.23 nM and 15.8 nM

59 protein that exhibits picomolar half-maximum effective concentrations (EC(50)) towards replicons expr

60 s and cell culture infectious virus with 50% effective concentrations (EC(50)s) of 46.8 and 16.1 pM,

61 cose-excited neurons increased (half-maximal effective concentration [EC(50)] = 0.54 mmol/l) and gluc

62 induce the dimerization of Tp34; Cu(2+) (50% effective concentration [EC(50)] = 1.7 muM) and Zn(2+) (

63 catabolites, caused cell death (half-maximal effective concentration [EC(50)] = 2 nM) by a mechanism

64 tration-dependent contractions (half-maximal effective concentration [EC(50)] = 2.5 microM and 3.9 nM

65 its time- and dose-dependently (half maximal effective concentration [EC(50)] = 27 +/- 3 nM) oxygen/g

69 with the following agonist potencies (median effective concentration; EC(50)): travoprost acid (EC(50

70 CXCR4(+) cancer cells in vitro (half maximal effective concentration (EC50 ) approximately 80-100 pM)

71 r hand, with large variation of half-maximum effective concentration (EC50) across tested NPs (5.4 to

72 ctivation, causing a 66% decrease in the 50% effective concentration (EC50) for activation through CD

74 e effectively neutralized by 81.39a at a 50% effective concentration (EC50) of <0.01 to 4.9 mug/ml.

75 mRNA and JNK1 protein expression with a 50% effective concentration (EC50) of <0.1 microM but did no

79 ependently activates Kir6.2/SUR1 with a half-effective concentration (EC50) of approximately 7 muM, i

80 nsition for the Asn-700 constructs; the half-effective concentration (EC50) of Ca Asn-700 was 390 mic

82 rane at concentrations near the half maximal effective concentration (EC50) of several microorganisms

83 it is highly unlikely that ASM half-maximum effective concentration (EC50) or Vmax contribute to AHR

84 ted esters exhibited antiviral activity (50% effective concentration (EC50) ranging from 1.7 to 20 mi

85 cells and prostaspheres, with a half-maximal effective concentration (EC50) ranging from a multiplici

87 se-response characteristics and half-maximal effective concentration (EC50) values using image-based

88 HE, 9-OHPHE, and 1,9-OHPHE, were toxic, with effective concentrations (EC50's) ranging from 0.5 to 5.

89 ion is linked to the toxicity of ILs, median effective concentrations (EC50) and critical micelle con

91 within an order of magnitude of half-maximal effective concentrations (EC50) of nontarget invertebrat

92 ll lines (HeLa, SK-MEL-28, A549, MCF-7) with effective concentrations (EC50) typically below 5 nM, at

94 d compared the phenotypic sensitivities (50% effective concentration [EC50]) of mutant and wild-type

95 osine monophosphate inhibition (half maximal effective concentration [EC50]: 0.21 +/- 0.18 vs. 1.38 +

97 ing 95% confidence intervals of their median effective concentrations: EC50(PBZ) = 0.07-0.09 mM; EC50

99 aboratory HIV-1 strain (HIV-1(WT)), with 50% effective concentrations (EC50s) of 3.0 to 49 nM, and ex

102 and CD4(+) T cells were used to identify 90% effective concentration (EC90) ratios of TFVdp to dATP a

103 proportion of participants reaching the 90% effective concentration (EC90) was 77% after 5 doses and

104 f U. parvum occurred at 6.6 days, with a 95% effective concentration (EC95) of 39 ng/mL for the maxim

106 s spp. under all conditions, but the minimal effective concentration end point, defined as the lowest

107 of disorder in the RAM linker region on the effective concentration enhancement of Notch transcripti

108 esponse threshold away from the basal median effective concentration established by ligand-receptor i

109 ly attached response regulator domain, whose effective concentration exceeds that of all soluble resp

110 cycle and is inhibited by victorin, with an effective concentration for 50% inhibition of 81 pM.

115 redicted a significantly higher half-maximal effective concentration for IL-1beta-induced pathway act

116 However, it displayed a 2.5-fold-lower 50% effective concentration for insulin stimulation of autop

117 ensitivity to bortezomib than FL (median 50% effective concentration for viability, 209 nmol/L v 1,31

119 turally occurring mAbs with low half-maximal effective concentrations for binding, 5 of which possess

120 the six-Cys form, were also used to estimate effective concentrations for forming a third disulfide o

122 ns also reproduced experimentally determined effective concentrations for the formation of disulfide

123 heir correlation with either MICs or minimum effective concentrations (for caspofungin only), and the

124 0.5 and 1 mumol/g WMS) suggested a 'minimum effective concentration' for epicatechin and caffeic aci

126 s (likely late endosomes or lysosomes) where effective concentrations (>2.5 microM) were greater than

127 were used to derive species-specific median effective concentrations, i.e., pH50, and pH10, via logi

128 e native state (71 M) and an anomalously low effective concentration in the denatured state (40 micro

130 s, crossed the blood-brain barrier, achieved effective concentrations in mouse brain, prevented ethan

131 fflux and metabolism of ARV drugs to prolong effective concentrations in target cells need to be deve

132 gical effect data are generally expressed as effective concentrations in the external exposure medium

133 DENV-1-4 and DENV-1 ADE infections, with 50% effective concentrations in the low micromolar range.

134 es suppressed both HIV-1 and HSV-2 at median effective concentrations in the submicromolar range in e

135 ne compound, BILS 179 BS, displayed an EC50 (effective concentration inhibiting viral growth by 50%)

136 First, antibiotics are frequently below effective concentrations inside granulomas, leading to b

137 n by the liver is such that a half-maximally effective concentration is at or slightly below the horm

138 ative tetrameric TTR; however, their minimal effective concentration is in the micromolar range.

139 5-FU above the predicted preclinical minimum effective concentration is maintained, without evidence

144 ng), plasma pharmacokinetic (time-to-minimum-effective-concentration (MEC, 25 ng/mL) and pharmacodyna

145 ution (MIC), microscopic evaluation (minimal effective concentration [MEC]), and a new method to meas

146 (percentage of time greater than the minimum effective concentration [MEC], 96-h area under the plasm

147 ee echinocandins--anidulafungin (50% minimum effective concentration [MEC50], 0.007 microg/ml; MEC90,

148 tive against Aspergillus spp. (MIC90/minimum effective concentration [MEC90] range, 0.015 to 2 mug/ml

150 od), with the broth dilution MICs or minimum effective concentrations (MECs) (CLSI M38-A method) of f

152 A. terreus to caspofungin (MICs and minimum effective concentrations [MECs]) by using standard RPMI

153 d 72 h) and two end points (MICs and minimum effective concentrations [MECs]) for evaluating anidulaf

155 , binding of the second dimer occurs with an effective concentration much lower than that expected if

156 centration, mainly because of the lack of an effective concentration normalization method for cell me

159 n in in vitro cytotoxicity assays with a 50% effective concentration of 0.65 ng/ml for the lead candi

160 oietic progenitor cells (HPCs) with a median effective concentration of 1 microg/mL but not after exp

164 cing four peptides in a box of water with an effective concentration of 158 mg/ml to enhance the rate

165 ensors can reliably detect SEB at 10-100 fg (effective concentration of 2.5 and 25 fg/mL) in complex

166 nd inside the nucleotide site of S1, with an effective concentration of 20 mM as judged by the concen

167 a Microcystis aeruginosa with a half maximal effective concentration of 21 and 5 mug/mL, respectively

168 pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, ther

170 o model of cerebral ischemia: at a maximally effective concentration of 50 ng/ml, VEGF approximately

171 270430 specific binding, with a half maximal effective concentration of 69.4 ng/mL in plasma PF-05180

172 lemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genot

174 hus, the conformational ensemble reduces the effective concentration of a particular peptide with res

175 eration in intracellular environment and the effective concentration of AAO released after being subj

176 ogs were contracted in tissue baths with the effective concentration of acetylcholine that produces h

178 a brief (5-8 ms) application of a maximally effective concentration of agonists was 319 +/- 34 ms.

180 n of glycogen synthase (GS) with a maximally effective concentration of approximately 2 micromol/l.

184 suggests that, in the coupled reaction, the effective concentration of carbamoyl phosphate in the vi

185 original and control populations if the 20% effective concentration of Cd was considered (cross-tole

186 t a holding potential of -70 mV, a maximally effective concentration of Cd2+ (> 30 mM) reduced curren

188 ings indicate that factors that increase the effective concentration of CXCR4 enhance FIV infectivity

189 Glucocorticoid receptor (GCR) number and the effective concentration of dexamethasone resulting in a

190 ous oxidative membrane damage lowers the 50% effective concentration of direct-acting antivirals in v

191 ate of CO production on Au by increasing the effective concentration of dissolved CO2 near the electr

194 unds were found to be sufficient to mimic an effective concentration of enzymatic superoxide dismutas

195 tions show that the glycocalyx increases the effective concentration of FGFs, leading to FGF oligomer

196 c side of the pore is characterized by a low effective concentration of free FG repeats and a weak FG

198 n (1 to 100 microg/ml) independently; (3) an effective concentration of glucose (500 microg/ml) with

199 NR1/NR2C receptors activated by a maximally effective concentration of glutamate and glycine had two

200 plication of 50 muM PYD-106 with a maximally effective concentration of glutamate and glycine increas

201 ty of PEG scaffolds is too high to raise the effective concentration of glyco ligands above a value t

202 hypothesize this translocation provides the effective concentration of H2O2 required to selectively

203 gnitude of contraction caused by a maximally effective concentration of IK29C, consistent with the tw

205 f various concentrations of L-glutamine, the effective concentration of L-glutamine in the M. tubercu

207 an IgE-coated sensor chip suggested that the effective concentration of lz-CD23 was lower at the high

208 A fluorescence method for measuring the effective concentration of Mg2+ in the presence of an RN

209 are derived from an assay that measures the effective concentration of Mg2+ in the presence of RNA.

210 concentration was >10 times the half maximal effective concentration of miltefosine (median, 30.2 day

212 yte from the junction and an increase in the effective concentration of negatively charged species (s

214 that when a tight binding event occurs, the effective concentration of nucleophile(s) will be signif

215 , the addition of calcium does not alter the effective concentration of one cysteine for the other.

217 lectivity by the Tenax TA polymer allowed an effective concentration of PAHs while eliminating n-hexa

218 nuggets observed was used to recalculate an effective concentration of precious metals for the analy

220 cal dosimeter is needed that can measure the effective concentration of radical that is delivered to

221 diffusion corridors, thereby increasing the effective concentration of select membrane proteins to p

222 on of tethered sigma70, we conclude that the effective concentration of sigma70 in E. coli (i.e., its

228 iated molecule domain of Notch increases the effective concentration of the ankyrin domain for its bi

229 or and a PIC component but only increase the effective concentration of the correctly oriented PIC co

230 ceptional stabilization arises from a modest effective concentration of the Cys11-Cys11' disulfide in

231 helix association is stabilized by the high effective concentration of the helices caused by the pre

232 yme to be "tethered", thereby increasing the effective concentration of the histone tail and permitti

233 protein U1A into dimers and trimers, a high effective concentration of the monomers is achieved, tog

235 catalyzing ubiquitination by increasing the effective concentration of the substrate lysine at the E

238 ngle channel currents activated by maximally effective concentrations of agonist but only had modest

239 suggest a novel strategy for achieving more effective concentrations of anti-oxidants in lipoprotein

241 rrier (BTB) significantly limits delivery of effective concentrations of chemotherapeutic drugs to br

242 hat treatment of human cancer cells with low effective concentrations of DAP specifically activates t

243 Spectra of the largest clusters, which have effective concentrations of divalent calcium that are le

244 iles of PiDSD, determined the enhanced local effective concentrations of DNA probes that are involved

245 s caused cell proliferation, with the lowest effective concentrations of E(2) (10(-15) M) > E(1) (10(

246 ld potentiation of the response to maximally effective concentrations of glutamate and glycine but ha

250 r ECs to a greater extent than did maximally effective concentrations of interleukin-1beta or tumor n

251 ons of insulin (1 to 100 microg/ml); and (4) effective concentrations of nicotine (250 microg/ml), gl

254 ive concentrations of IL-8 and less than the effective concentrations of other neutrophil chemoattrac

259 e (transient) native structure increases the effective concentrations of the reactive thiol and disul

260 ditional benefits by achieving sustained and effective concentrations of therapeutic antibodies direc

262 four human colon cancer cell lines with iso-effective concentrations of this agent resulted in deple

263 arly phase I clinical testing indicates that effective concentrations of TNFalpha can be delivered to

265 e chemical activity (Ea-50) of 0.029 and the effective concentration on a lipid basis (EC(lipid, eq.)

268 cytes or retinal pigment epithelial cells at effective concentrations; protects human aortic endothel

270 five different concentrations that cover the effective concentration range needed for downstream cell

273 both a dose- and time-dependent manner with effective concentrations ranging from 40 to 100 muM.

274 in the 100 nM range, a value similar to the effective concentration required for observation of the

279 l (0.2 mg/L), 10-fold lower than the minimal effective concentration shown to promote Abeta clearance

280 , can introduce oligonucleotides at a higher effective concentration than conventional transfection a

281 eutic resistance, with a higher half-maximal effective concentration than that of cells that had not

283 sis of the combination revealed that the 90% effective concentration threshold of posaconazole activi

286 RASs in NS5A that increased the half-maximal effective concentration to ledipasvir by more than 100-f

287 o provide controlled release of cisplatin in effective concentrations to kill the tumor cells that th

290 n this subject was 117 nM and the median 50% effective concentration value for a GT-1a H77c replicon

291 (5)(0) x 100, where EC(5)(0) is half maximal effective concentration) value was independently associa

292 the cardiac MPS show half maximal inhibitory/effective concentration values (IC(5)(0)/EC(5)(0)) that

293 essing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no

294 were found that exhibit EC(50) (half-maximal effective concentration) values for c-di-GMP as low as 9

295 F1609-0442, and F1750-0048) having EC50 (50% effective concentration) values of 4.8 +/- 2.3, 12.5 +/-

297 ations of 10-6 M and above; the half-maximal effective concentration was estimated to be 5.9 x 10-7 M

298 aused prolactin release at 1 min; the lowest effective concentrations were 10(-11) M E(2), 10(-10) M

300 no methods exist to systematically vary the effective concentration within this intramolecular inter

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