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1 tion, in which AKR1B10-S1P signaling plays a pivotal role.
2 , for which natural killer (NK) cells play a pivotal role.
3 regulatory network in which miR-429 plays a pivotal role.
4 ch excessive chronic inflammation may play a pivotal role.
5 factor beta (TGF-beta), is thought to play a pivotal role.
6 and reliable reactions which have acquired a pivotal role as one of the most useful synthetic tools w
11 uring various viral infections, might have a pivotal role during BKPyVAN infection in the grafted kid
12 ulfate-reducing conditions and emphasize the pivotal role Fe-rich organic freshwater flocs play in tr
14 These results identify for the first time a pivotal role for Arg-dependent polyamine production duri
16 Intrinsic ionic guanidinium unit plays the pivotal role for both self-exfoliation and antibacterial
18 y ATP-activated human macrophages and show a pivotal role for calpains in the activation of the infla
20 thermore, our findings provide evidence of a pivotal role for GM3-induced insulin resistance in impai
22 revented and reduced resistance suggesting a pivotal role for immunity in deterring antibiotic resist
23 ecreased patient survival, consistent with a pivotal role for KLF10 in distinguishing the antiprolife
30 viviruses with no known vector, suggesting a pivotal role for sfRNA in the flavivirus life cycle.
33 and that this molecular interaction plays a pivotal role for successful Plasmodium liver-stage devel
37 the topological winding number which plays a pivotal role for the determination of the emergent prope
38 ttention, despite overwhelming evidence of a pivotal role for the PAG in coordinating motor responses
45 receptors in the ephrin system that plays a pivotal role in a variety of cell-cell interactions, mos
46 iously shown that cofilin activation plays a pivotal role in Abeta-induced mitochondrial and synaptic
48 ensitive and accurate diagnostics can play a pivotal role in achieving disease elimination goals.
49 uggest that specific allosteric sites play a pivotal role in activating structural fluctuations that
51 vaccine candidates and that TFH cells play a pivotal role in aiding B cell maturation, quantifying va
52 TH2 cells have long been believed to play a pivotal role in allergic immune responses, including IgE
53 system, and specifically the phloem, plays a pivotal role in allocation of fixed carbon to developing
54 ption factor LATERAL SUPPRESSOR (Ls) plays a pivotal role in AM determination during the vegetative p
58 levels of IGF-1 receptor (IGF1R) and play a pivotal role in atherogenesis, but the potential effects
60 rsolateral prefrontal cortex (DLPFC) plays a pivotal role in automating this process of rule inductio
63 -coupled receptor family member that plays a pivotal role in brain angiogenesis and in ensuring a tig
64 e expression by alternative splicing plays a pivotal role in brain, where it affects neuronal develop
65 ral microm) current filaments, which plays a pivotal role in building up the cancer inhibition proper
67 -associated molecular patterns, which play a pivotal role in cardiovascular diseases, inflammation, a
68 transcription factor complex, which plays a pivotal role in cell growth, differentiation, and surviv
71 he 20 most common natural amino acids, has a pivotal role in cellular physiology as it is being invol
72 these results, we propose that NTRC plays a pivotal role in chloroplast redox regulation, being nece
73 erleukin 23 receptor (IL23R) pathway plays a pivotal role in chronic inflammatory diseases such as Cr
74 -density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-den
76 yclic nucleotide-gated (CNG) channels play a pivotal role in cone phototransduction, which is a proce
77 phagy is a programmed mechanism that plays a pivotal role in controlling cell fate and, consequently,
78 athway.IMPORTANCE The DNA sensor STING plays pivotal role in controlling HSV-1 infection both in cell
81 ars unusual sauropod trackways have played a pivotal role in debates about the swimming ability of sa
82 findings demonstrate that astrocytes play a pivotal role in demyelination, making them a potential t
85 studies demonstrate that the solvent plays a pivotal role in determining the reaction thermodynamics
88 PKCzeta, a cell polarity protein that has a pivotal role in directing asymmetric division of mammali
89 an malaria transmission studies and played a pivotal role in dissecting the mosquito immune response
92 s between lipid and protein molecules play a pivotal role in efficiently sequestering the amyloid fol
93 pathophysiology of schizophrenia, given its pivotal role in emotion and extensive connectivity with
97 complex-mediated histone methylation plays a pivotal role in gene expression associated with diseases
98 ther, our results indicate that RCN2 plays a pivotal role in HCC cell proliferation and tumor growth
99 and their combined toxic effects can play a pivotal role in health and disease, yet are largely unex
101 se diagnosis of these infections will play a pivotal role in health care, pharmacological and biomedi
102 eptor potential (TRP) ion channel C6 plays a pivotal role in hereditary and sporadic glomerular kidne
104 basis of filament instability, which plays a pivotal role in host cell invasion, and thus infectivity
105 sts are potent immunostimulators that play a pivotal role in host response to virulent P. aeruginosa
106 han catabolism (IDO1, KMO, KYNU) that play a pivotal role in immune evasion by certain other microbia
107 NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease m
110 rtain nuclear hormone receptors (NRs) play a pivotal role in lipid and carbohydrate metabolism and ha
112 essing the transcription factor FOXP3 play a pivotal role in maintaining immunologic self-tolerance.
115 1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosome-associated QC pathway
116 eristics of synthetic macromolecules plays a pivotal role in many areas, in particular the life scien
117 ncovalent intermolecular interactions play a pivotal role in many biological processes such as cell a
120 ion and contractile activity and thus play a pivotal role in matching energy supply and demand in car
121 ion and contractile activity and thus play a pivotal role in matching energy supply and demand in car
123 at c-Jun amino-terminal kinase (JNK) plays a pivotal role in mediating vesicle-induced CPS in recipie
124 ved growth factor B (PDGF-B) signaling has a pivotal role in mesangial cell proliferation, we examine
126 Rs) are highly variable elements that play a pivotal role in multiple genetic diseases, population ge
129 Results suggest that platelet CD40 plays a pivotal role in neointima formation after arterial injur
132 These data indicate that MakatG1 plays a pivotal role in penetration, reacting to and detoxifying
133 Earth system where haze development played a pivotal role in planetary oxidation, hastening the conti
134 f the M28 family of carboxypeptidases with a pivotal role in plant development and stress adaptation.
135 1) is a multifunctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA
136 age-associated molecular patterns may play a pivotal role in preventing inflammation and that the ant
138 g protein apolipoprotein E4 (ApoE4), plays a pivotal role in processes as disparate as Alzheimer's di
142 eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-associated processes
144 age compensation and demonstrated H4K20me1's pivotal role in regulating higher-order chromosome struc
145 the 3'-untranslated region of RUNX2 played a pivotal role in regulating RUNX2 expression in highly me
146 This strongly suggests that AtPAT14 plays a pivotal role in regulating senescence via salicylic acid
147 e chromatin-structure regulator CTCF plays a pivotal role in regulating sites of genomic CSB occupanc
148 all, our data suggests that Aurora A plays a pivotal role in regulation of AR-V7 expression and repre
149 se of ES6 binding factors and likely plays a pivotal role in remodeling this pre-rRNA region in both
152 n evergreen forests and have likely played a pivotal role in shaping continental African forest diver
156 on results show that variant L1 loops play a pivotal role in stabilizing DNA binding to the octamer t
159 ults show that liver-derived exosomes play a pivotal role in the accumulation of Tfr cells, likely le
161 d by macroH2A1 and its cofactors, and have a pivotal role in the bladder tumor progression and the re
165 This vicious cycle is thought to play a pivotal role in the development of AD, although the mole
166 hondrial Ca(2+) suggests that MCU may play a pivotal role in the development of fibrosis and could po
167 rged that the inflammasome appears to play a pivotal role in the development of multiple inflammatory
169 and suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicat
170 mitochondrial biogenesis and function, has a pivotal role in the early dysfunction of the proximal tu
174 combined with controlled drug release has a pivotal role in the future of personalized medicine.
177 e innate branch of the immune system plays a pivotal role in the induction and perpetuation of metabo
179 issue-intrinsic local microenvironment has a pivotal role in the initial stage of tumorigenesis in Dr
180 CE KSHV productive lytic replication plays a pivotal role in the initiation and progression of Kaposi
182 xpress the transcription factor FOXP3 play a pivotal role in the maintenance of immune tolerance to s
184 isoform C4BP lacking the beta-chain plays a pivotal role in the modulation of the adaptive immune re
186 and M4 mAChRs of the dorsal striatum plays a pivotal role in the occurrence of motor symptoms in Park
187 SKN-1, are transcription factors that have a pivotal role in the oxidative stress response, cellular
188 amyloid-beta protein (Abeta) protein plays a pivotal role in the pathogenesis of Alzheimer's disease
189 yloid precursor protein (APP), which plays a pivotal role in the pathogenesis of Alzheimer's disease,
190 ing Th9 cells have been considered to play a pivotal role in the pathogenesis of atopic diseases.
191 h17 or protective T regulatory cells plays a pivotal role in the pathogenesis of autoimmune diseases.
192 Immuno-inflammation has been shown to play a pivotal role in the pathogenesis of moyamoya disease (MM
194 l and peripheral chemoreflex pathway plays a pivotal role in the pathophysiology of HF with reduced e
198 amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmis
199 e arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis.
200 suggest that the PERK arm of the UPR plays a pivotal role in the regulation of satellite cell homeost
203 ophage and apoptotic cells, thus executing a pivotal role in the scavenging of apoptotic cells from a
209 nt in extracellular matrix, collagen holds a pivotal role in tissue development and maintaining the h
210 Three-dimensional porous scaffolds play a pivotal role in tissue engineering and regenerative medi
213 esistance, ER signaling continues to exert a pivotal role in tumor progression in the majority of cas
215 es have shown that microRNAs (miRNAs) play a pivotal role in vascular development, homeostasis and a
218 c acids (OAs) serve as metabolites that play pivotal roles in a host of different metabolic and regul
219 ate Ca(2+) signalling, and was shown to play pivotal roles in all the six major plant adaptation even
220 tease-activated receptor 2 (PAR2) that plays pivotal roles in angiogenesis and tumor development.
222 n interactions (PPIs) of these subunits play pivotal roles in assembling the functional polymerase co
223 applying NLP for clinical research can play pivotal roles in building NLP systems and, in doing so,
226 h factor receptor (EGFR) family members play pivotal roles in cell proliferation, differentiation and
227 Sponges are benthic filter feeders that play pivotal roles in coupling benthic-pelagic processes in t
229 ell polarization and directed migration play pivotal roles in diverse physiological and pathological
231 2 complex (ATM and ATR-ATRIP in humans) play pivotal roles in DNA replication, DNA damage signaling,
234 e induced by interferon (IFN)-gamma and play pivotal roles in immune and inflammatory responses.
236 ciating core binding factor-beta (CBFB) play pivotal roles in leukemogenesis, and inhibition of RUNX1
237 es that target self-antigens, which can play pivotal roles in maintaining homeostasis, distinguishing
238 In human cancer cells, driver reactions play pivotal roles in malignancy and represent potential ther
239 ciated epigenetic changes induced by HA play pivotal roles in miR-10 production leading to up-regulat
241 -23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-inflammatory T helper 17 cell respo
242 ort that the transcription factor MafB plays pivotal roles in promoting macrophage M2 polarization.
244 re are also variant histones that often have pivotal roles in regulating chromatin dynamics and in th
246 pigmentation of many bird species [1] plays pivotal roles in social signaling and mate choice [2, 3]
247 ding RNAs, and mitotic gene bookmarking play pivotal roles in stringent gene regulation during lineag
248 N-Methyl-D-aspartate receptors (NMDARs) play pivotal roles in synaptic development, plasticity, neura
252 cations via retrotransposons may have played pivotal roles in the expansion of histone modifier genes
254 peptides and CLAVATA signaling pathways play pivotal roles in the regulation of lateral root developm
255 cifically methylate histone 3 Lys4, and have pivotal roles in the transcriptional regulation of genes
257 hat contain iron-sulfur (Fe-S) clusters play pivotal roles in various metabolic processes such as pho
258 xperiments, we demonstrate that KLF8 plays a pivotal role modulating mesendoderm to DE differentiatio
266 ologenesis and lactogenesis, demonstrating a pivotal role of COBRA1 in adult tissue development.
268 These findings provide key insights into the pivotal role of deacetylase activity in SIRT6 tumor-supp
269 relapse of status epilepticus, suggesting a pivotal role of deep brain stimulation in the treatment
279 tuberculosis model further corroborated the pivotal role of SET8-responsive NQO1 and TRXR1 in mycoba
280 duction of IFN-alpha secretion, suggesting a pivotal role of sortilin in the exocytic trafficking of
282 relevant, adaptive responses, pointing to a pivotal role of the endodermal membrane in nutrient home
284 we extend these concepts by highlighting the pivotal role of the hypothalamic peptide oxytocin in aug
285 of the guaA mutant enabled us to reveal the pivotal role of the pyrB gene in the regulation of CW ri
288 macrophage infection model, we validated the pivotal role of this response in the expression of prote
291 al benefits have included elucidation of the pivotal roles of mTOR signaling in the regulation of cel
294 in dynamics of {Cr(III)Dy(III)6} reveals the pivotal role played by ferrotoroidic states in slowing d
296 ow selective tumor-targeting, and report the pivotal roles played by the affinity of the individual a
298 promoter before precancerous lesion plays a pivotal role that could help us in diagnosing and unders
300 y demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid DC devel
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