1 est in targeting RAS, exciting and promising 
progress has been made.                                 
 
     2 se investigations worldwide, and significant 
progress has been made.                                 
 
     3 he DSPEC is of recent origin but significant 
progress has been made.                                 
 
     4                                Although much 
progress has been made, 
a comprehensive understanding of
 
     5                                Although much 
progress has been made, 
adequate methodologies reliably 
 
     6                       In humans, substantial 
progress has been made at the neural level in characteri
 
     7                                  Substantial 
progress has been made, 
but cigarette smoking remains on
 
     8                                         Much 
progress has been made, 
but research opportunities are s
 
     9                       Evidence suggests that 
progress has been made, 
but there is room for much impro
 
    10                         Recently, remarkable 
progress has been made, 
but to date all proposed synthes
 
    11                                         Much 
progress has been made by adopting a synthetic and mecha
 
    12                                  Exceptional 
progress has been made by recording from single neurons 
 
    13                                        Major 
progress has been made clinically in inhibiting the prog
 
    14                                     Although 
progress has been made developing antiviral therapeutics
 
    15                        Although considerable 
progress has been made during the last years in understa
 
    16                                         Much 
progress has been made during the past five years to cir
 
    17                                     Although 
progress has been made, 
existing understanding of the st
 
    18                                              Progress has been made for directed aromatic substitutio
 
    19 possible in many materials classes, but less 
progress has been made for oxide materials with differen
 
    20                               Although great 
progress has been made, 
further study to understand indi
 
    21 lso shows that, while significant scientific 
progress has been made, 
greater advances, particularly i
 
    22 t the NMJ is bi-directional and considerable 
progress has been made identifying mechanisms underlying
 
    23 djuvant chemotherapy in 2004, no substantial 
progress has been made in adjuvant treatment.           
 
    24                                  Substantial 
progress has been made in agenda setting and policy form
 
    25 lerotic cardiovascular disease (CVD), little 
progress has been made in agreeing a role for lipoprotei
 
    26                                              Progress has been made in aligning with existing organiz
 
    27                        In recent years great 
progress has been made in applying nanomaterials to desi
 
    28                                   Tremendous 
progress has been made in basic neuroscience in recent d
 
    29                                         Much 
progress has been made in brain-machine interfaces (BMI)
 
    30                                  Since then, 
progress has been made in cancer care delivery, which ha
 
    31                                  Substantial 
progress has been made in cancer diagnosis and treatment
 
    32                         Although significant 
progress has been made in characterizing and pharmacolog
 
    33                        Although considerable 
progress has been made in characterizing calcium release
 
    34                                        While 
progress has been made in characterizing humoral immunit
 
    35                         Although significant 
progress has been made in characterizing kinesin motors 
 
    36                                        Major 
progress has been made in characterizing RNA-protein int
 
    37                                   Tremendous 
progress has been made in characterizing the bidirection
 
    38                        In recent years, much 
progress has been made in characterizing the needs of tr
 
    39 type 1 diabetes, and since then, significant 
progress has been made in clinical care for all forms of
 
    40                                 Considerable 
progress has been made in converting human pluripotent s
 
    41                                         Much 
progress has been made in deciphering gene regulatory ne
 
    42                                  Significant 
progress has been made in deciphering the basic building
 
    43                                         Much 
progress has been made in deciphering the role of sequen
 
    44 parity for asthma attack prevalence and that 
progress has been made in decreasing disparities in asth
 
    45                        It is unknown whether 
progress has been made in decreasing their mortality rat
 
    46                         Although significant 
progress has been made in defining endotypes for asthma,
 
    47 lable to score gene essentiality, and recent 
progress has been made in defining essentiality in the n
 
    48                                   Tremendous 
progress has been made in defining the genomic landscape
 
    49                                     Although 
progress has been made in defining the role of APC in a 
 
    50                   In recent years, extensive 
progress has been made in defining the temporal progress
 
    51                        Recently, significant 
progress has been made in defining the transcriptional n
 
    52         Over the last 18 months, substantial 
progress has been made in demonstrating the clinical eff
 
    53                                  While great 
progress has been made in describing this diversity, it 
 
    54          Over the past two decades, enormous 
progress has been made in designing fluorescent sensors 
 
    55                                         Much 
progress has been made in designing heme and dinuclear n
 
    56 ed CYP1A activity in fishes; however, little 
progress has been made in determining causative agents. 
 
    57                            Relatively little 
progress has been made in determining the in vivo regula
 
    58           Over the last decade, considerable 
progress has been made in determining the roles of the p
 
    59                                 Considerable 
progress has been made in developing antifibrotic agents
 
    60                          Notably, tremendous 
progress has been made in developing interventions that 
 
    61                         Although significant 
progress has been made in developing microfluidic system
 
    62                                  Significant 
progress has been made in developing model representatio
 
    63                       Recently, considerable 
progress has been made in developing new drugs that targ
 
    64                         Although significant 
progress has been made in developing therapeutics agains
 
    65                 In recent years, significant 
progress has been made in developing ZIFs into membranes
 
    66                                Although much 
progress has been made in development and implementation
 
    67                                  Significant 
progress has been made in diagnostic tools such as compo
 
    68                                              Progress has been made in discovery of biomarkers to gui
 
    69 oduced by protein-coding (pc) genes, limited 
progress has been made in distinguishing functional RNA 
 
    70                                 Considerable 
progress has been made in ecological and evolutionary ge
 
    71                         By now, considerable 
progress has been made in elucidating GATA factor-depend
 
    72                 During the last decade, much 
progress has been made in elucidating hepcidin regulatio
 
    73                        Unfortunately, little 
progress has been made in elucidating the adhesion mecha
 
    74                                       Recent 
progress has been made in elucidating the location and c
 
    75 usceptibility to type 2 diabetes, but little 
progress has been made in elucidating the molecular mech
 
    76                                     Although 
progress has been made in elucidating the neural basis o
 
    77          Over the past 10 years, significant 
progress has been made in endoscopic diagnosis and treat
 
    78                                  Significant 
progress has been made in engineering novel aptamer doma
 
    79                             Site positioning 
progress has been made in established platforms includin
 
    80                  In recent years, tremendous 
progress has been made in ferroelectric oxide thin film 
 
    81                        In Arabidopsis, great 
progress has been made in functional analysis of N-glyca
 
    82 iency virus type 1 (HIV-1) infection, little 
progress has been made in generating an effective HIV-1 
 
    83  human genome project in 2003, extraordinary 
progress has been made in genome sequencing technologies
 
    84                                However, less 
progress has been made in harnessing these data to revea
 
    85                                     Although 
progress has been made in identifying brain regions that
 
    86                     Furthermore, substantial 
progress has been made in identifying CD1-restricted T c
 
    87  have been performed in recent years, little 
progress has been made in identifying disease-causing ge
 
    88 arch into the aetiology of allergies, little 
progress has been made in identifying effective strategi
 
    89          Despite this interest, only limited 
progress has been made in identifying functional inhibit
 
    90          In the past few years, considerable 
progress has been made in identifying many features of a
 
    91                                     Although 
progress has been made in identifying PD proteins, the r
 
    92 eneral (e.g., cognitive impairment), limited 
progress has been made in identifying phenotype-genotype
 
    93                         Although significant 
progress has been made in identifying the components req
 
    94  with episodic memory retrieval, but limited 
progress has been made in identifying the contributions 
 
    95                                        Major 
progress has been made in identifying the drivers of oes
 
    96                                              Progress has been made in identifying the factors that i
 
    97                                Although much 
progress has been made in identifying the mechanisms tha
 
    98 rome (ARDS) was first described, substantial 
progress has been made in identifying the risk factors f
 
    99                         Overall, substantial 
progress has been made in improving CNT quantification d
 
   100                                       Little 
progress has been made in improving viral suppression ra
 
   101                                         Much 
progress has been made in interventions to prevent HIV i
 
   102                            Thus, significant 
progress has been made in last few decades on core-modif
 
   103                                  Significant 
progress has been made in moving toward this goal.      
 
   104                                 Considerable 
progress has been made in optimizing the frequency of gr
 
   105                         Although significant 
progress has been made in our understanding of AD pathog
 
   106                        Although considerable 
progress has been made in our understanding of asthma in
 
   107                                Although some 
progress has been made in our understanding of how human
 
   108                               Although great 
progress has been made in our understanding of sensory m
 
   109                                  Substantial 
progress has been made in our understanding of the patho
 
   110                    In the past decade, rapid 
progress has been made in our understanding of the patho
 
   111                                              Progress has been made in preclinical studies, exploitin
 
   112                    We found no evidence that 
progress has been made in preventing new-onset epilepsy 
 
   113                        It is unclear whether 
progress has been made in preventing new-onset epilepsy.
 
   114                           Whereas remarkable 
progress has been made in probing phonon-phonon interact
 
   115                                              Progress has been made in profiling the type 2 immune re
 
   116                                        Rapid 
progress has been made in realizing battery electrode ma
 
   117                        Although considerable 
progress has been made in recent years for computational
 
   118                                        Major 
progress has been made in recent years in deciphering th
 
   119                                  Substantial 
progress has been made in recent years in identifying th
 
   120 ucture and excellent properties, significant 
progress has been made in recent years in the developmen
 
   121                                Although much 
progress has been made in recent years in the understand
 
   122                                         Much 
progress has been made in recent years linking long-dist
 
   123                                  Significant 
progress has been made in recent years to decipher how a
 
   124  of this process remain obscure, significant 
progress has been made in recent years to decipher vario
 
   125                                         Much 
progress has been made in recent years to understand how
 
   126                      Nevertheless, important 
progress has been made in recent years, and new emerging
 
   127  for the field of bio-nano science: enormous 
progress has been made in recent years, especially in ac
 
   128 the oxymoron "constant change," and enormous 
progress has been made in recent years.                 
 
   129                                        Great 
progress has been made in reducing cardiovascular mortal
 
   130                         Although significant 
progress has been made in reducing malaria transmission 
 
   131                                  Significant 
progress has been made in reducing methicillin-resistant
 
   132                 In terms of treatment, major 
progress has been made in reducing mortality from ARDS w
 
   133  mortality over the past 2 decades, but less 
progress has been made in reducing neonatal mortality.  
 
   134                                              Progress has been made in reducing the number of childre
 
   135                                              Progress has been made in reducing US rates of interpers
 
   136                            While significant 
progress has been made in regulating insulin secretion f
 
   137                                         Much 
progress has been made in research for prostate cancer i
 
   138                                    Promising 
progress has been made in studying cardiac regeneration.
 
   139                         Although significant 
progress has been made in the care of patients with paed
 
   140                               Although great 
progress has been made in the characterization of the of
 
   141 ince its initial description in 1956, marked 
progress has been made in the clinical characterisation,
 
   142 espite its increasing incidence, significant 
progress has been made in the clinical management of HCC
 
   143                                  Substantial 
progress has been made in the derivation of disease-rele
 
   144                                   Tremendous 
progress has been made in the design and implementation 
 
   145 gh COFs are in their initial research stage, 
progress has been made in the design and synthesis of CO
 
   146                                Although much 
progress has been made in the determination of potential
 
   147    Over the past several decades, remarkable 
progress has been made in the development and applicatio
 
   148                                        While 
progress has been made in the development of chemical pr
 
   149                            While significant 
progress has been made in the development of modern diag
 
   150                                  While great 
progress has been made in the development of new methodo
 
   151                                    Recently, 
progress has been made in the development of vaccines an
 
   152               In recent decades, significant 
progress has been made in the diagnosis and management o
 
   153                    Consequently, significant 
progress has been made in the discovery of selective sma
 
   154                                              Progress has been made in the electrical control of magn
 
   155                                  Substantial 
progress has been made in the functional annotation of g
 
   156 troduced more than 10 years ago, significant 
progress has been made in the identification of genes an
 
   157                                         Much 
progress has been made in the identification of specific
 
   158                   In recent years, important 
progress has been made in the knowledge of the molecular
 
   159                                   While much 
progress has been made in the last 10 years on various m
 
   160 ze is an ideal crop for GWAS and significant 
progress has been made in the last decade.              
 
   161               However, although considerable 
progress has been made in the last two decades, its phyl
 
   162 ates in Acute Myeloid Leukemia (AML), little 
progress has been made in the long-term survival of rela
 
   163                                  Substantial 
progress has been made in the methods of presurgical ass
 
   164                                         Much 
progress has been made in the past 5 years, and in this 
 
   165                                  Significant 
progress has been made in the past decade regarding the 
 
   166  regeneration remains to be elucidated, much 
progress has been made in the past decade.              
 
   167                                         Much 
progress has been made in the past few years thanks to t
 
   168                                    Important 
progress has been made in the past two decades in unders
 
   169                                  While great 
progress has been made in the recent years, some key cha
 
   170                         In particular, great 
progress has been made in the study of the molecular and
 
   171 rms of synthetic cell-like entities, minimal 
progress has been made in the sustained excitation of ar
 
   172                                              Progress has been made in the symptomatic management of 
 
   173           Over the past decade, considerable 
progress has been made in the synthesis and applications
 
   174                                     Although 
progress has been made in the the development of diagnos
 
   175                                Although much 
progress has been made in the understanding of macrophag
 
   176                 In recent years, significant 
progress has been made in the understanding of proteasom
 
   177                In recent years, considerable 
progress has been made in the understanding of the molec
 
   178                                 Considerable 
progress has been made in the untangling of the epigenet
 
   179 udies on the undercooling phenomenon, little 
progress has been made in the use of undercooled metals,
 
   180                           Recently, however, 
progress has been made in these areas: revised consensus
 
   181                         Whereas considerable 
progress has been made in this area, much is yet to be e
 
   182 s for therapeutic intervention, and exciting 
progress has been made in this direction.               
 
   183                        However, not too much 
progress has been made in this field.                   
 
   184                                  Substantial 
progress has been made in this regard for common primary
 
   185       To our surprise and gratification much 
progress has been made in this short time.              
 
   186                                  Substantial 
progress has been made in this subject especially on mag
 
   187                                    Recently, 
progress has been made in understanding both the breakin
 
   188                                              Progress has been made in understanding direct, moderate
 
   189                                  Substantial 
progress has been made in understanding genetic suscepti
 
   190                         Although significant 
progress has been made in understanding HCV entry, the p
 
   191                                 Considerable 
progress has been made in understanding how cells monito
 
   192 vailable in regenerative biology, but little 
progress has been made in understanding how organisms su
 
   193                               Recently, much 
progress has been made in understanding meiotic recombin
 
   194                         Although significant 
progress has been made in understanding natural resoluti
 
   195                                  Significant 
progress has been made in understanding neuron-glia sign
 
   196         Over the last 30 years, considerable 
progress has been made in understanding normal and patho
 
   197                                              Progress has been made in understanding redox-dependent 
 
   198                                        Rapid 
progress has been made in understanding SL biosynthesis,
 
   199                                      Whereas 
progress has been made in understanding such generalizat
 
   200                                        Great 
progress has been made in understanding the atomic struc
 
   201                                Although much 
progress has been made in understanding the basic physic
 
   202    Combining data from multiple disciplines, 
progress has been made in understanding the biochemistry
 
   203                                 Considerable 
progress has been made in understanding the biology and 
 
   204                                              Progress has been made in understanding the broad spectr
 
   205             In the past 30 years, tremendous 
progress has been made in understanding the causes and p
 
   206                         Although substantial 
progress has been made in understanding the effects of s
 
   207                                   Tremendous 
progress has been made in understanding the functions of
 
   208                  In recent years, an immense 
progress has been made in understanding the link between
 
   209        However, in recent years, significant 
progress has been made in understanding the mechanism of
 
   210                                   Remarkable 
progress has been made in understanding the molecular ba
 
   211                                              Progress has been made in understanding the molecular me
 
   212 ury of scientific interrogation, significant 
progress has been made in understanding the neuronal reg
 
   213                                     Although 
progress has been made in understanding the normal funct
 
   214                         Although significant 
progress has been made in understanding the origins of a
 
   215                  Over the years, substantial 
progress has been made in understanding the regulation o
 
   216                                  Significant 
progress has been made in understanding the toxicity of 
 
   217 rome P450 monooxygenases (CYPs/P450s), great 
progress has been made in understanding their structure-
 
   218                         Although significant 
progress has been made in understanding these pathways, 
 
   219                                  Significant 
progress has been made in understanding ultrasmall gold 
 
   220                                 Considerable 
progress has been made in unraveling the genetic etiolog
 
   221                                  Substantial 
progress has been made in unraveling the sensory transdu
 
   222                                  To be fair, 
progress has been made-
in both our understanding of chro
 
   223 ated disorders is complex, and although some 
progress has been made, 
it has proved challenging to pin
 
   224                                     Research 
progress has been made mainly on PSA as a predictive mar
 
   225                                     Although 
progress has been made, 
modifications to existing core p
 
   226                            While substantial 
progress has been made, 
much more must be achieved to pr
 
   227                                Nevertheless, 
progress has been made, 
notably in terms of standard dru
 
   228 f the functional genomics of these loci, and 
progress has been made on a limited number of novel CAD 
 
   229                                              Progress has been made on a third, complementary treatme
 
   230                                         Much 
progress has been made on materials performance; however
 
   231                        Recently, substantial 
progress has been made on the characterization of new me
 
   232 tement on limb muscle dysfunction, important 
progress has been made on the characterization of this p
 
   233                            Recently exciting 
progress has been made on this problem, but the predicte
 
   234                                         Much 
progress has been made on understanding and reverse-engi
 
   235                                       Little 
progress has been made on using objective measures rathe
 
   236                                  Substantial 
progress has been made over the last decade in character
 
   237                                       Little 
progress has been made over the last year concerning cer
 
   238                                              Progress has been made over the past decade by fabricati
 
   239                                              Progress has been made over the past decade by structuri
 
   240                                Although much 
progress has been made over the past decade, some patien
 
   241                                  Significant 
progress has been made over the past years in identifyin
 
   242                                         Much 
progress has been made, 
particularly in the areas of BAT
 
   243                         Although much recent 
progress has been made possible because of the rising of
 
   244                                 Considerable 
progress has been made recently in understanding host im
 
   245 manipulating developmental cues, substantial 
progress has been made recently toward HSC generation vi
 
   246                                       Little 
progress has been made searching for risk-causative vari
 
   247                        Globally, only modest 
progress has been made since 2000, with the percentage o
 
   248                                  While great 
progress has been made since the earliest works of Brind
 
   249                                  Significant 
progress has been made since the first landmark EEG stud
 
   250                         Although significant 
progress has been made, 
the sheer enormity and scope of 
 
   251                                  Significant 
progress has been made through the development of allerg
 
   252       Over the last few decades, significant 
progress has been made to characterize the extent, sever
 
   253                                     Although 
progress has been made to determine the native fold of a
 
   254                                      Limited 
progress has been made to develop therapies that improve
 
   255                                   While much 
progress has been made to elucidate the aetiology of dis
 
   256 ergency of International Concern, remarkable 
progress has been made to gain insight into cellular tar
 
   257                 Compared with prior reports, 
progress has been made to improve diabetes screening, bu
 
   258                            Although exciting 
progress has been made to solve parts of the above issue
 
   259              In the past decade, substantial 
progress has been made to uncover the mystery of itching
 
   260                                        While 
progress has been made to understand the functions of th
 
   261                                              Progress has been made to understand the pathobiology of
 
   262 ya has been clearly defined and considerable 
progress has been made to unravel chromosome partition i
 
   263                                   Tremendous 
progress has been made toward advancing our understandin
 
   264                                        While 
progress has been made toward analyzing more rapid react
 
   265                                     Enormous 
progress has been made toward controlling the interactio
 
   266                                   Remarkable 
progress has been made toward demonstrating the cellular
 
   267 uscular dystrophy studies where considerable 
progress has been made toward dystrophin correction in m
 
   268                            While substantial 
progress has been made toward elucidating the genetic de
 
   269                                        Great 
progress has been made toward elucidating the mechanisms
 
   270                         Although significant 
progress has been made toward genetically manipulating t
 
   271                                  Since 1990, 
progress has been made toward global tuberculosis (TB) c
 
   272                                     Although 
progress has been made toward identifying extracellular 
 
   273                                              Progress has been made toward identifying potential vacc
 
   274                                        Major 
progress has been made toward our understanding of the p
 
   275                                  Substantial 
progress has been made toward the development of metal-f
 
   276 obal increase in the incidence of CC, little 
progress has been made toward the development of treatme
 
   277                                              Progress has been made toward the reduction of the burde
 
   278             Over the last decade, remarkable 
progress has been made toward understanding Argonaute pr
 
   279          Over the last 50 years, significant 
progress has been made toward understanding how small si
 
   280                                         Much 
progress has been made toward understanding the discharg
 
   281                                    Recently, 
progress has been made toward understanding the function
 
   282                                         Much 
progress has been made toward understanding the mechanis
 
   283                                       Little 
progress has been made toward understanding the molecula
 
   284                                  Substantial 
progress has been made toward understanding the neuropat
 
   285 e conditions have been elucidated, and great 
progress has been made toward understanding the normal f
 
   286 n is a national health care priority, little 
progress has been made toward understanding why only som
 
   287                                              Progress has been made towards achievement of this ambit
 
   288                      While some experimental 
progress has been made towards free-space cloaking in th
 
   289                                   Remarkable 
progress has been made towards halving of maternal death
 
   290                                       Recent 
progress has been made towards the adaptation of next-ge
 
   291                                        While 
progress has been made towards the identification of cen
 
   292                             In recent years, 
progress has been made towards understanding how the dis
 
   293 r of plant growth and development, and great 
progress has been made understanding auxin transport and
 
   294                                  While great 
progress has been made using allometric relationships to
 
   295                                    Recently, 
progress has been made using bottom-up analysis of serum
 
   296                 In cavity optomechanics much 
progress has been made using linear interactions and mea
 
   297                       Moreover, while recent 
progress has been made with intact methods for clearing,
 
   298                                Indeed, major 
progress has been made with regard to meal-related gut c
 
   299                                  Substantial 
progress has been made with regard to understanding risk
 
   300                                      Greater 
progress has been made with tandem catalysis and related