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1 and the low sensitivity of biological tests raise the question of a possible role of P. ovale varian
3 denced postmortem in cases of fatal disease, raising the question of a possible link between these tw
4 cells is mediated by endothelial activation, raising the question of a potential role for endothelial
5 arance of aggregated proteins, these results raise the question of beneficial use of NPs in biomedici
6 to regulate rapid sensorimotor integration, raising the question of cerebellar contributions to free
10 Both these features of the B-cell response raise the question of how important antibody fine-specif
11 rning of bilaterian nervous systems but also raise the question of how neural circuit compositions an
12 ults highlight the potency of this model and raise the question of how useful it is for interpreting
14 mergence of several PCs at the same position raised the question of how developmental time controlled
15 mph before reaching the CNS [3], our finding raised the question of how ecdysone enters the CNS throu
16 ed coexudation of reductants and ligands has raised the question of how redox reactions might affect
18 g the world's rapidly growing population has raised the question of how to systematically utilize lar
21 refore not a simple water-filled pore, which raises the question of how anomalous water behavior affe
24 pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively ac
26 ve a size limit of 39 nanometres(4-7), which raises the question of how larger cytoplasmic molecules
27 suggest a high degree of lipid order, which raises the question of how membrane proteins function in
28 ey inferior temporal cortex ("face patches") raises the question of how neural selectivity for faces
29 haracteristic temperature sensitivity, which raises the question of how neurons and neuronal circuits
33 conventional muscle spindles in face muscles raises the question of how sensory input from the face i
34 in the 1800s; its abrupt extinction in 1914 raises the question of how such an abundant bird could h
36 t for thalamic input in sensory areas, which raises the question of how thalamocortical synapses form
41 ientation relative to, the rat's head, which raises the question of how the rat might determine the p
43 is makes sense in terms of host defense, but raises the question of how these remarkable cells balanc
44 addition to the encoded amino acid sequence, raises the question of how these signals and overlapping
45 y master equation, even approximately, which raises the question of how they can occur in the real wo
46 stribution around important regulatory genes raises the question of how they relate to 3D conformatio
48 e development of small-scale quantum devices raises the question of how to fairly assess and detect q
51 s with 4E10 specificity are counterselected, raising the question of how 4E10 was generated in the pa
52 competitiveness and self-renewal potential, raising the question of how a mutant HSC can sustainably
53 in model prebiotic RNA synthesis reactions, raising the question of how a single sequence could serv
54 does not absolutely require kinase activity, raising the question of how Arg might modulate actin ass
55 igh-frequency multiparameter time series and raising the question of how best to extract insights fro
56 t axon regeneration in different cell types, raising the question of how broadly mTOR regulates axona
57 ynapse enlargement balanced by fewer spines, raising the question of how clusters form despite this h
58 een native populations and immigrant groups, raising the question of how conflict can be overcome.
59 regionalization are expressed in gradients, raising the question of how discrete domains are generat
60 s conserved across distantly related plants, raising the question of how diverse inflorescence archit
61 lular denitrosylase has not been identified, raising the question of how extracytoplasmic proteins ar
62 coexist within a common nondelimited space, raising the question of how functional compartmentalizat
63 ugs have been shown to worsen heart failure, raising the question of how glucose mediates protective
64 nt in some but not all non-bilaterian phyla, raising the question of how Hox-TALE interactions evolve
65 may also enhance or limit hyperpolarization, raising the question of how intrinsic conductances shape
68 most effectively at depolarized potentials, raising the question of how lidocaine-like compounds aff
69 ngless (Wg) ligands secreted 50 microm away, raising the question of how long-distance Wg spreading o
71 after greenhouse gas emissions have ceased, raising the question of how much sea-level commitment is
72 n this system, nuclei divide asynchronously, raising the question of how nuclear timing differences a
73 stroyed, this log singularity is suppressed, raising the question of how pairing occurs in the absenc
74 6)A biosynthesis by archaeal KEOPS in vitro, raising the question of how precisely Pcc1-mediated dime
75 site remote from the site of ligand binding, raising the question of how proteolytic sensitivity is a
76 during the performance of behavioral tasks, raising the question of how recorded activity relates to
77 ns do not themselves mediate synaptogenesis, raising the question of how SPARCL1 enhances synapse for
78 airless is present only in the Pancrustacea, raising the question of how Su(H) in other protostomes g
79 tion paradoxically induces similar movement, raising the question of how such chemical modifications
80 led-coil domain in its proximal tail region, raising the question of how such divergent motors perfor
81 rctic stratospheric season occurred in 2011, raising the question of how the Arctic ozone chemistry i
82 sion produces heterogeneous methylomes, thus raising the question of how the DNA methylome remains st
83 ess small peptide fragments from ssDNA ends, raising the question of how the ~90 kDa TOP1 protein is
84 ecursors into functional sensory structures, raising the question of how their development is coordin
85 nded by sugar-rich food most of their lives, raising the question of how these animals modulate food-
86 in seconds by the sensory detection of food, raising the question of how these cells can promote feed
87 like structures that are in the ER membrane, raising the question of how these nascent LDs bud from t
88 a specific set of Esx, PE, and PPE proteins, raising the question of how these substrates are recogni
89 tered within the known ASF1-H3-H4 interface, raising the question of how these two proteins are found
90 ving closely related biochemical activities, raising the question of how these two proteins can perfo
91 account for <3% of total flight muscle mass, raising the question of how they can modulate the vastly
92 olarity in embryos of different fly species, raising the question of how they evolve this function.
93 y impasse and soon disappear from the lungs, raising the question of how they induce such durable imm
94 cells that organize into tissues, naturally raising the question of how this collective organization
95 f them lack evidence for anthropogenic fire, raising the question of how this period of global coolin
96 miRNA biogenesis machineries remain obscure, raising the question of how tumour cells efficiently coo
97 th the dendrites of every compass neuron(6), raising the question of how visual cues are integrated i
98 The active site is 15 A from the membrane, raising the question of how water-soluble and membrane-e
99 d or proposed for many DNA-binding proteins, raising the question of how widespread or specific to ce
100 G1 phase cells and accumulate as cells grow, raising the questions of how SBF/MBF are dynamically dis
101 The presence of PLP-EGFP expression in OPCs raises the question of its role in this migratory popula
102 idea and Unionoidea but not in Etherioidea), raising the question of its origin in these bivalves.
103 nt when other processing enzymes are absent, raising the question of its primary physiological role.
105 reasing time since vaccination was observed, raising the question of optimal vaccination timing.
108 lants, including freezing-sensitive species, raising the question of SFR2 function beyond freezing to
109 The complexity of these roles in the mouse raises the question of similar functions in other rodent
110 a gain in enzyme selectivity is achieved but raise the question of the binding mode operating with th
111 creased levels of RNA editing in squids thus raise the question of the nature and effects of these ev
112 2 genes and their limited biological impact raise the question of the potential role of dysregulated
113 ry of a charge order in underdoped YBa2Cu3Oy raised the question of the interplay between superconduc
114 responses in patients with low tumor burden raised the question of the mechanisms of DC dysfunction.
115 ny outer-membrane translocon homologs, which raised the question of the origin of E. gracilis's middl
116 by high amounts of the peptide in the brain, raised the question of the physiological role of Abeta r
119 rtheless useful for quantum key distribution raises the question of the feasibility of a quantum key
120 low-energy photons into high-energy photons-raises the question of the possibility of "electron upco
121 mes in relation with comorbid conditions and raises the question of the relevant endpoints in clinica
122 nent presence of French soldiers in Djibouti raises the question of the risk of being infected with M
123 pronounced during interglacial periods, this raises the question of the significance of bird migratio
125 to a wide diversity of ferric heme proteins, raising the question of the biological relevance of domi
126 sted the presence of putative Jumonji genes, raising the question of the conservation of this family
127 3N2 IAVs circulating during the past decade, raising the question of the degree of immunity that the
128 d to isolate the many contributing variants, raising the question of the existence of alternate proce
129 soform usage across tissues is nonconserved, raising the question of the extent of its functional imp
130 genetic characteristics with the gonococcus, raising the question of the extent to which these strain
131 some subpopulations are entirely eliminated, raising the question of the importance of such demise fo
132 ective against pathogens of both lifestyles, raising the question of the level of interplay between e
133 lex with single-strand DNA binding proteins, raising the question of the mechanism behind their prote
134 ficant decrease in their catalytic activity, raising the question of the occurrence of the conformati
135 scence establishment, maintenance, and exit, raising the question of the physiological raison d'etre
136 ssociated with changes in crystal structure, raising the question of the relative roles of the electr
137 ut in many organisms, only Nbp35 is present, raising the question of the unique roles played by Cfd1
138 nd related alterations in immune homeostasis raise the question of their mutual impact on each other'
139 he high diversity of the plant lipid mixture raises the question of their respective involvement in t
142 s incidences of subtype transdifferentiation raise the question of to what extent the tumor character
143 t cases, NLPHL has an indolent course, which raises the question of to what extent these patients req
146 plant lineages like the Brassicaceae, which raises the question of what alternative nutrition strate
149 se plate invalidates this interpretation and raises the question of what events actually do lead to N
150 r very little further tumor evolution, which raises the question of what is the real window of opport
151 TRIP8b and PEX5, this difference in function raises the question of what mechanism accounts for their
152 during female meiosis in most animals, which raises the question of what prevents the sperm DNA from
155 haracteristics of each muscle fiber type and raises the question of what sequence changes are respons
156 on in different acoustic environments, which raises the question of what the underlying presynaptic m
158 ct powerful suppression of CbN cell spiking, raising the question of what activity patterns favour ex
159 ading edge may be dispensable for migration, raising the question of what actually controls cell dire
160 of IT cortex lack any known specialization, raising the question of what general principle governs I
163 rmation at very low Abeta concentrations and raise the question of whether amyloid formation in vivo
165 gnized cause of acute leukemia in adults-and raise the question of whether children represent a subpo
166 stibular dysfunction in these Dfnb31 mutants raise the question of whether DFNB31-deficient patients
168 presentations of NRXN1 mutations in patients raise the question of whether heterozygous NRXN1 mutatio
169 echanisms involved are unclear, our findings raise the question of whether in utero exposures may aff
171 perspective on T-cell polyfunctionality and raise the question of whether maintaining polyfunctional
172 s use to get what they want from each other, raise the question of whether plants colonized by arbusc
175 expression patterns, and knockout phenotypes raise the question of whether the two proteins have redu
177 ucting gap in single-unit-cell FeSe/STO(110) raised the question of whether a similar mechanism appli
180 ould be returned in the clinical setting has raised the question of whether comparable recommendation
181 n of CXCL2 and CXCL1 inflammatory chemokines raised the question of whether IL-17 contributes to chem
182 e serum response factor (SRF) signalling has raised the question of whether MRL proteins employ alter
183 with greater exposure to active iTBS, which raised the question of whether observed effects persiste
187 the cyclic heptapeptide sanguinamide A have raised the question of whether steric occlusion of polar
189 iscovery of high-temperature superconductors raised the question of whether such strong electron-phon
192 reports of EVD in equatorial and West Africa raised the question of whether the two outbreaks were li
193 ralizing monoclonal antibody (nmAb) IgG1 b12 raised the question of whether the unusual shape observe
196 a1 activation by mechanical stimuli in vitro raised the question of whether this phenomenon was relev
198 an GPCRs and 16 different Galpha genes, this raises the question of whether a universal allosteric me
202 usually intended to capture livestock, which raises the question of whether and how these livestock a
204 sm of alternative splicing of the Drd2 gene, raises the question of whether both isoforms may equally
205 an be insufficient to ensure survival, which raises the question of whether cells possess genetic pro
206 wever, a striking lack of empirical evidence raises the question of whether chimeras are indeed chara
211 dden cardiac death in the general population raises the question of whether endurance exercise could
214 However, the widespread influence of GABA raises the question of whether interindividual variabili
215 known, but its repeated convergent evolution raises the question of whether it may result from or con
216 iomes with no apparent effect on tree growth raises the question of whether iWUE calculations reflect
218 t a surprising loss of KIT expression, which raises the question of whether loss of KIT in these tumo
227 resistivity at a nematic critical point also raises the question of whether strong nematic fluctuatio
230 ase in the number of scientific publications raises the question of whether the sciences are expandin
234 in, including the midcingulate cortex (MCC), raises the question of whether these areas contribute to
235 ion that Dorsal levels also change with time raises the question of whether these dynamics are instru
238 The global significance of such associations raises the question of whether unidentified associations
239 published from field surveys in recent years raises the question of whether we have moved beyond char
240 iatus after the big El Nino event in 1997/98 raises the questions of whether terrestrial hydrological
241 ve active brown adipose tissue (BAT) depots, raising the question of whether activation and recruitme
242 e intracellularly prior to receptor binding, raising the question of whether alternative protein-prot
243 ct molecular and biological characteristics, raising the question of whether an earlier, "naive" stat
244 n and PAF-PCNA interactions are competitive, raising the question of whether beta-catenin might regul
245 nhibitors have been less promising, however, raising the question of whether BTK kinase activity is a
246 eeding occurs at the level of pit membranes, raising the question of whether capillary failure is an
247 al nephrectomy and during high-salt feeding, raising the question of whether collectrin has any direc
248 (Solyc06g083450) is missing the first exon, raising the question of whether cultivated tomato has a
250 homolog in the Entamoeba histolytica genome, raising the question of whether E. histolytica MIF (EhMI
251 ere are multiple cognitive control networks, raising the question of whether error-related activity c
252 tic cytoskeleton cross-sectional dimensions, raising the question of whether filament architectures a
253 erindividual variation in scallop sequences, raising the question of whether fish may analyze scallop
254 ast, humans encode a single functional NAIP, raising the question of whether human NAIP senses one or
255 stened by conditions that decrease lifespan, raising the question of whether it can also be slowed, f
256 ugment the rate of CD20.mAb internalization, raising the question of whether ITIM phosphorylation pla
257 he position of the AZ differs among species, raising the question of whether its anatomical structure
258 from mice causes early embryonic lethality, raising the question of whether La is required by mammal
259 an compromise speech perception performance, raising the question of whether long-term oral-motor imp
260 hat are driven by BCR and TLR corecognition, raising the question of whether MBCs are generated in th
261 o the enzymes ribonuclease A and NAD kinase, raising the question of whether metaphosphates can occur
262 notochord, floor plate and dorsal endoderm, raising the question of whether midline tissues also ari
263 me than do evolutionarily conserved regions, raising the question of whether nonconserved but biochem
264 ors target additional kinases including KIT, raising the question of whether off-target effects contr
265 e unexpected functions in DNA damage repair, raising the question of whether other amino acid metabol
266 racellular fatty acids into membrane lipids, raising the question of whether pathogens use host fatty
267 lidation-promoting factors in humans [9-14], raising the question of whether physical exercise can be
268 technique called expansion microscopy (ExM), raising the question of whether physical magnification,
269 eprogrammed, functionally compromised cells, raising the question of whether pluripotency is required
270 a otters in the North Pacific Ocean in 2004, raising the question of whether reductions in sea ice co
271 trongly biased toward the symmetric outcome, raising the question of whether symmetry confers some be
272 reported to produce hippocampal spine loss, raising the question of whether synapse size and number
273 A1 presynaptic boutons contain mitochondria, raising the question of whether synapses without mitocho
274 hanges in cytoarchitectural characteristics, raising the question of whether the anatomical connectio
275 that limit its utility as an antidepressant, raising the question of whether the clinically tolerated
276 represent an antigen-experienced population, raising the question of whether the liver is a site of N
277 ever, behavioral outcomes were not improved, raising the question of whether the newly sprouted axons
278 lex contains two separate ion-binding sites, raising the question of whether the power stroke is driv
279 collateral excitation is weak in adult mice, raising the question of whether the primary role of this
280 ees into Europe and especially into Germany, raising the question of whether the surge in non-B infec
281 valves, a precedent that currently persists, raising the question of whether the zebrafish could be u
282 ophysiology of neurodevelopmental disorders, raising the question of whether there are sex difference
283 t directly related to the bulk Dirac points, raising the question of whether there exists a topologic
284 causative agent of malaria, Plasmodium, thus raising the question of whether these parasites can sens
285 imetals consist of disjoint, open Fermi arcs raising the question of whether they can be observed by
286 nsory afferents (likely Ia) and motor axons, raising the question of whether they interact during Ren
287 unusual level of microstructural plasticity, raising the question of whether this contributes to adap
288 dually shifted to high-frequency match-runs, raising the question of whether this harms the number of
289 ments of neighbouring, connected cell pairs, raising the question of whether this prediction holds fo
290 lower seed production than selected annuals, raising the questions of whether there is a fundamental
293 ding elastic bodies that exert these forces, raising the question of which are the minimal ingredient
294 early experiences influence adult behavior, raising the question of which mechanisms underlie infant
295 rogenitors within the ventricular zone (VZ), raising the question of which source of netrin1 promotes
296 earing 1% of coding sequences in some cases, raises the question of why bacteria need so many GGDEF e
298 neurodegeneration in the cerebellum in SCA17 raises the question of why ubiquitously expressed polyQ
299 ep (SWS) and rapid eye movement sleep (REM), raising the question of why and how specialized sleep ev
300 n is prevalent among consumers worldwide but raises the question of will the use of any concurrent an