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1 mally invasive esophagectomy, a multicenter, randomized trial).
2 onary Syndrome Quality Improvement in Kerala randomized trial.
3 with myelodysplastic syndrome (MDS) within a randomized trial.
4 ss the question of first-line treatment in a randomized trial.
5 ion (nAMD) who participated in a large-scale randomized trial.
6 he baseline assessment of an ongoing cluster-randomized trial.
7 lacebo in a double-blind, placebo-controlled randomized trial.
8 herapy use and IOP in the context of a large randomized trial.
9                                 We did a non-randomized trial.
10 5 emergency departments within a multicenter randomized trial.
11 h neurocognitive effects in a recent phase 3 randomized trial.
12                       Stepped-wedge, cluster randomized trial.
13 ties in the SEARCH Study, an ongoing cluster randomized trial.
14 n uncertain because of lack of evidence from randomized trials.
15  in the observational studies but not in the randomized trials.
16 vational results be addressed in prospective randomized trials.
17 onvenience cohort, nested within two ongoing randomized trials.
18 left untreated, thus confirming results from randomized trials.
19 t been compared with PCI in such patients in randomized trials.
20 to-moderate risk kidney transplantation in 3 randomized trials.
21 icted mean survival times (RMST) in oncology randomized trials.
22 g, complementing and extending evidence from randomized trials.
23 o subsequent clinical development, including randomized trials.
24 D need improvement, including development of randomized trials.
25  patients with pneumonia could enrich future randomized trials.
26 pilepsy, but additional data are needed from randomized trials.
27 ntially more efficient than standard two-arm randomized trials.
28                  METHODS AND In this cluster-randomized trial, 10 primary health facilities in the ci
29                            In the absence of randomized trials, 2 possible approaches are the paramet
30 nction in elderly men.In this parallel-group randomized trial, 29 men aged >70 y [mean +/- SD body ma
31                                          One randomized trial, 3 quasi-experimental studies, and 40 o
32                             In the ABSORB II randomized trial, 383 lesions (n = 359) were investigate
33 =0.75 g/dl over any 4-week period during the randomized trial; 57 [48.7%] versus 17 [14.8%] with plac
34 entified 425 eligible articles, including 31 randomized trials (7%), 116 cross-sectional studies (27%
35                                       Eleven randomized trials (8 peer-reviewed publications, 3 abstr
36 abilities of clinical outcomes from a recent randomized trial and hospital costs (2013 US$) from a un
37       Survival estimates were derived from a randomized trial and scaled relative to published US sur
38                             These included 9 randomized trials and 1 observational study.
39                      Sixty-seven studies (11 randomized trials and 56 observational studies) examinin
40                                          Two randomized trials and 6 other studies examining outcomes
41  the era of drug-eluting stents, large-scale randomized trials and all-comer registries have shown ex
42  estimating population-level impact, cluster-randomized trials and mechanistic models play particular
43  (through October 7, 2015) were searched for randomized trials and observational studies examining pa
44    PCNSL is an uncommon tumor, and only four randomized trials and one phase III trial have been comp
45                                              Randomized trials and systematic reviews of trials that
46  of clinical guidelines, systematic reviews, randomized trials, and intervention studies on hepatitis
47 from broad patient populations, contemporary randomized trials, and multiple recent studies with phar
48 ocardial infarction has been demonstrated in randomized trials, and the radial approach has become th
49             Double-blind, placebo-controlled randomized trial (April 2013-February 2015; 28-day follo
50                                Seven ongoing randomized trials are evaluating the influence of weight
51 herapy has not been conclusively proven, and randomized trials are lacking.
52                                 Multicenter, randomized trials are needed to ascertain the optimal pr
53                                              Randomized trials are needed to determine optimal screen
54 Given the limitations of observational data, randomized trials are needed to determine the role of MV
55                    More convincing data from randomized trials are required to inform the management
56 he efficacy of KNO3 and suggests that larger randomized trials are warranted.
57                                          The randomized trial, assessed as having high risk of bias,
58 icle) study is a prospective multicenter non-randomized trial assessing the safety and performance of
59                                              Randomized trials assessing the efficacy of this strateg
60           After adjustment for age, sex, and randomized trial assignment, the hazard ratio for 60-day
61                  We conducted a multicenter, randomized trial at 14 CF centers with subjects at least
62                               We conducted a randomized trial at five U.S. emergency departments to d
63                               We conducted a randomized trial at two hospitals.
64 h the use of data from 2 placebo-controlled, randomized trials at 2 academic medical centers in the U
65   A total of 12,233 patients enrolled to the randomized trials C-07, C-08, N0147, MOSAIC (Adjuvant Tr
66                The results of a recent large randomized trial (Cancer and Leukemia Group B/Alliance f
67                            In a prospective, randomized trial cohort of 13,164 patients with stable C
68 DS Clinical Trials Group Longitudinal Linked Randomized Trials cohort participants not receiving a st
69 Program (RAISE-ETP) study, a 34-site cluster-randomized trial, compared NAVIGATE, a coordinated speci
70                      In a recently published randomized trial, compared with intensified treatment of
71 pose To report on the long-term results of a randomized trial comparing a standard dose (400 mg/d) ve
72 the final results on treatment outcomes of a randomized trial comparing conventional and hypofraction
73       The original study was a double-blind, randomized trial comparing IIV-HD to IIV-SD in adults ag
74 st this hypothesis, we performed a phase III randomized trial comparing MAC with RIC in patients with
75 ith severe, symptomatic aortic stenosis in a randomized trial comparing TAVR (performed with the use
76 r interim results of the 5-year prospective, randomized trial comparing the 2 procedures (Swiss Multi
77 lar testing, but there are limited data from randomized trials comparing anatomic with functional tes
78 earched MEDLINE, Scopus, and web sources for randomized trials comparing BVS and EES.
79        METHODS AND Patient-level data from 5 randomized trials comparing CRT with no CRT were used to
80 ials, two reviewers independently identified randomized trials comparing HFOV with conventional venti
81 f individual participant data from completed randomized trials comparing PFO closure versus medical t
82 the second-line setting, three of which were randomized trials comparing programmed cell death protei
83                                       In two randomized trials comparing the PCSK9 inhibitor bococizu
84                                 Multicenter, randomized trial conducted at 120 intensive care units (
85   The Danish Calmette Study is a multicenter randomized trial conducted from 2012-2015 at 3 Danish ho
86                                              Randomized trial data support the superiority of coronar
87                            Given the lack of randomized trial data to guide management strategies, we
88                                              Randomized-trial data on the risks and benefits of antir
89                              Conclusion This randomized trial demonstrated efficacy of ConquerFear co
90 ectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer
91 Anti-Restenosis Treatment) was a multicenter randomized trial designed to estimate the effect of DA b
92                                     Within a randomized trial designed to examine nonspecific effects
93                                              Randomized trials designed to assess the impact of baria
94      From December 2012 to March 2014, three randomized trials, each implementing a unique interventi
95                                         In a randomized trial, effect size is often summarized using
96                  SUMMARY BACKGROUND DATA: No randomized trial evaluating alginate staple-line reinfor
97                         Results from ongoing randomized trials evaluating biomarkers and other checkp
98  men for entry at the time of PSA nadir onto randomized trials evaluating the impact on survival of s
99                                              Randomized trials evaluating treatment levels significan
100 s-even in most emergencies; for individually randomized trials-even in many emergencies; and for six
101 encies, we highlight three needs: for formal randomized trials-even in most emergencies; for individu
102                  However, there is a lack of randomized trial evidence supporting these recommendatio
103                                          Few randomized trials exist with an observation time greater
104 matic review of the literature that included randomized trials, exploratory comparative studies, and
105                                   Given that randomized trials exploring adjuvant chemotherapy for bl
106 cal outcomes of patients included in a large randomized trial for 10 years to enable detection of lat
107 emohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cance
108 monly prescribed by primary care physicians, randomized trials for effectiveness, and trials and obse
109                            This prospective, randomized trial found that treat and extend dosing of r
110                                 In a cluster-randomized trial from 22 March to 15 April 2012, we rand
111 s, based primarily on the results of 3 large randomized trials (grade D recommendation).
112                         To our knowledge, no randomized trial has been conducted for recurrent/refrac
113                                           No randomized trial has demonstrated superiority of chemoem
114         Although risk reductions observed in randomized trials have been relatively consistent across
115                                          Few randomized trials have compared disease-free survival ou
116                                              Randomized trials have demonstrated increased morbidity
117                                              Randomized trials have demonstrated the efficacy of tran
118                                              Randomized trials have found that therapy including tamo
119 d cells can be stored for up to 6 weeks, but randomized trials have not assessed the effects of this
120                                              Randomized trials have studied bisphosphonates in the ad
121                  We performed a multicenter, randomized trial in 27 hospitals in the Netherlands in w
122 y was a prospective 2 x 2 factorial, cluster-randomized trial in 467 FT-LBW infants during 2 periods:
123                               We conducted a randomized trial in patients with nonbulky limited-stage
124 12249 Treatment as Prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal, South Africa.
125 n +/- SEM)] participated in a parallel-group randomized trial in which they adapted to either a LOW P
126 ta from eight induction and five maintenance randomized trials in 3,837 evaluable patients were analy
127                                              Randomized trials in breast cancer have demonstrated the
128                                         In 2 randomized trials in Guinea-Bissau of early BCG-Denmark
129 etocytes (targeting Pf3D7_1469900 mRNA) in 2 randomized trials in Kenya and Mali, comparing dihydroar
130 were combined for borderline personality and randomized trials in PubMed, PsycINFO, EMBASE, and the C
131 ata meta-analysis of three large prospective randomized trials in which sorafenib was the control arm
132 efore, we chose to conduct a multicenter non-randomized trial, in which all patients would receive fa
133           This was a multicenter prospective randomized trial including 143 patients with moderate-se
134 ce and mortality, and there are many ongoing randomized trials investigating the effects of metformin
135                                         This randomized trial involved 99 colorectal surgery patients
136                   We conducted a multicenter randomized trial involving 446 patients who were assigne
137              INOVATE-HF was a multinational, randomized trial involving 85 centers including patients
138         We evaluated the two procedures in a randomized trial involving intermediate-risk patients.
139                             Conclusions In a randomized trial involving patients who received either
140                          In this open-label, randomized trial involving patients with locally advance
141          A large prospective cohort study or randomized trial is needed.
142                                            A randomized trial is needed.
143                          A larger and longer randomized trial is warranted to assess the effectivenes
144                        An adequately powered randomized trial is warranted.
145                     Further information from randomized trials is critical to evaluate clinical outco
146             Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2
147 clusion Long-term follow-up data of the four randomized trials largely support the current risk-adapt
148                          In this multicenter randomized trial, long-term endoscopic variceal ligation
149 at the benefits seen with empagliflozin in a randomized trial may be a class effect applicable to a b
150 d long-term survival by means of prospective randomized trials may offer more definitive conclusions
151       Twenty studies (17 observational and 3 randomized trials) met eligibility criteria.
152                                  One cluster randomized trial (n = 1737) demonstrated noninferiority
153                                          One randomized trial (n = 302) reported significantly reduce
154 dical Research Council UKALL2003 multicenter randomized trial (NCT00222612) between 2003 and 2011.
155            Despite many studies, including 4 randomized trials, no consensus exists.
156 nemic.In this 2 x 2 factorial, double-blind, randomized trial, nonpregnant women (aged 18-45 y) with
157 prevent recurrent cardiovascular events in a randomized trial of 10 065 post-myocardial infarction pa
158                       We conducted a cluster randomized trial of 2 HIVST distribution mechanisms comp
159                              The study was a randomized trial of a behavioral health home developed a
160                      METHOD: The study was a randomized trial of a behavioral health home developed a
161 om 1,238 pregnant women during a 3-y cluster-randomized trial of a home visiting intervention in Cape
162 atients With Heart Failure) is a multicenter randomized trial of a patient-centered transitional care
163                       We conducted a cluster-randomized trial of adults with cough who were HIV posit
164                       We conducted the first randomized trial of behavioral weight loss for HIV-infec
165                               A well-powered randomized trial of CABG versus PCI in the ACS populatio
166 d a cooperative group phase III prospective, randomized trial of conventional versus hypofractionated
167          We performed a prospective, cluster randomized trial of CPR education for family members of
168 ed 12 months after inclusion in the TEMPRANO randomized trial of early ART, we estimated the risk of
169             REDUCE-MRSA was a 3-arm, cluster-randomized trial of either screening and isolation witho
170 p to 18 hours after symptom onset supports a randomized trial of endovascular therapy in this patient
171                                FOURIER was a randomized trial of evolocumab versus placebo in 27 564
172             Pragmatic noninferiority cluster-randomized trial of general surgery residency programs w
173                                         In a randomized trial of patients with chronic nausea and vom
174                                In a phase 2B randomized trial of patients with moderate to severe DG,
175            In 7-year extended follow-up of a randomized trial of patients with severe intermediate, p
176                                         In a randomized trial of periodic presumptive treatment (PPT)
177 amin D Antenatal Asthma Reduction Trial is a randomized trial of pregnant women at risk of having chi
178                This was a placebo-controlled randomized trial of rituximab (2 biweekly infusions of 1
179 spectively collected data from a multicenter randomized trial of sedation (Randomized Evaluation of S
180 nical trial, a pediatric multicenter cluster randomized trial of sedation.
181 E) and postoperative complication rates in a randomized trial of short-course (SC) versus long-course
182           A prospective, multi-institutional randomized trial of SRS followed by EGFR-TKI versus EGFR
183       METHODS AND We conducted an unblinded, randomized trial of standard ART initiation versus same-
184 s of data from 8 observational cohorts and 1 randomized trial of statin therapy.
185 -recorded meetings from a larger, multisite, randomized trial of structured informational and support
186                               We performed a randomized trial of the ability of the neurokinin-1 rece
187                 Conclusion This prospective, randomized trial of the European Society of Blood and Ma
188                                              Randomized trials of 9 nonpharmacologic options versus s
189 es of TP53/KRAS and TP53/EGFR comutations in randomized trials of adjuvant chemotherapy versus observ
190 therapy, we conducted a systematic review of randomized trials of any intervention applied for the em
191 of studies of de-escalation of BMAs, and two randomized trials of BMAs in control of pain secondary t
192      The authors systematically searched for randomized trials of DOAC versus warfarin for prevention
193                                              Randomized trials of FIRM-guided ablation and mechanisti
194                                              Randomized trials of medications for alcohol dependence
195                    Future placebo-controlled randomized trials of neonatal caffeine are unlikely.
196 fiber and whole-grain content, assessed in 3 randomized trials of overweight participants.After an 8-
197 ta-analysis was conducted of phase III or IV randomized trials of potent P2Y12 inhibitors, including
198                                              Randomized trials of rituximab in primary membranous nep
199 nd overall survival of 554 patients from two randomized trials of the German CLL Study Group (CLL8: f
200 ted search strategy, we searched MEDLINE for randomized trials of therapies for primary or secondary
201                                              Randomized trials of various statin types in hospitalize
202                 The guidelines were based on randomized trials of vitamin D deficiency screening and
203 nce has led to the initiation of prospective randomized trials of vitamin D supplementation in indivi
204                                      In this randomized trial, off-pump CABG led to lower rates of 5-
205                          We review data from randomized trials on relative and absolute CVD risk redu
206                     Recent meta-analyses and randomized trials on secondary prevention of squamous ce
207  include in a sequential multiple-assignment randomized trial (or randomized controlled trial) may be
208                                  In a second randomized trial, PREVAIL (Evaluation of the WATCHMAN LA
209                                   Two recent randomized trials produced discordant results when testi
210                A recent series of successful randomized trials provides new systemic therapy options
211                      Likewise, in the single randomized trial published to date, early-administered n
212                                A multicenter randomized trial recruiting 321 patients 16 years or old
213                                  METHODS AND Randomized trials reporting clinical outcomes beyond 1 y
214                                            A randomized trial should be performed to test DAT and DAE
215 ans and policymakers interpreting results of randomized trials should recognize that the significance
216                                              Randomized trials show that unmonitored NOAC therapy is
217 eveloped in the 1980s, and recently, 5 major randomized trials showed an overwhelming superior benefi
218                                              Randomized trials showed significantly longer hospital s
219                           2-group, parallel, randomized trial stratified by initial weight loss (<10
220                                         This randomized trial suggests that the use of a pelvic drain
221                                              Randomized trials support the use of transcatheter aorti
222                                              Randomized trials support use of procalcitonin (PCT)-bas
223                                          One randomized trial supports the use of objective clinical
224                               The 3 eligible randomized trials (TAPAS [Thrombus Aspiration During Per
225 h were substantially less common among the 3 randomized trials than in contemporaneous cohort studies
226 ND DATA: We recently completed a prospective randomized trial that demonstrated an 11.7% absolute ris
227 ERA trial was an international, multicenter, randomized trial that included 5099 patients with early-
228          English-language cohort studies and randomized trials that compared different doses of nalox
229                  METHODS AND We searched for randomized trials that compared longer than 1-year DAPT
230                                              Randomized trials that incorporate this regimen are need
231 f FCR for patients with CLL and identified 5 randomized trials that met our inclusion criteria.
232                  It has been demonstrated in randomized trials that optimism can be learned.
233                            Data from 2 large randomized trials that randomly allocated hypertensive p
234                                              Randomized trials that reported pain, function, or harms
235 ivity to standard therapies in two phase III randomized trials that represent the development of the
236                                      In this randomized trial, the routine use of pasireotide signifi
237                                     A recent randomized trial, the Survey of Inhibitors in Plasma-Pro
238                                           In randomized trials, the efficacy and safety of the potent
239 d overweight/obesity has been established in randomized trials, the feasibility and effect of a globa
240         Conclusion: Consistent with previous randomized trials, this study found no association betwe
241                     Consistent with previous randomized trials, this study found no association betwe
242 enges of transporting a causal effect from a randomized trial to a specific target population.
243                                  A Phase III randomized trial to assess impact on neurologic outcome
244                               We conducted a randomized trial to assess the incidence of factor VIII
245      We performed an investigator-initiated, randomized trial to compare an everolimus-eluting biores
246                 We conducted a single-center randomized trial to compare the efficacy of 8 mm Fluency
247         To our knowledge, this was the first randomized trial to evaluate addition of an oncolytic vi
248                               We conducted a randomized trial to evaluate cognitive outcomes after ET
249                       Methods We performed a randomized trial to evaluate treatment adaptation on the
250 ARY BACKGROUND DATA: EVAR-2 remains the sole randomized trial to identify whether EVAR reduces mortal
251  I-SPY 2, a phase 2, multicenter, adaptively randomized trial to screen multiple experimental regimen
252 be applied to sequential multiple-assignment randomized trials to develop personalized adaptive treat
253            These findings support conducting randomized trials to explore risks and benefits of OAT r
254 rapy following BCS have been demonstrated in randomized trials to reduce the risk of both invasive an
255                       We conducted the first randomized trial, to our knowledge, to evaluate ERCC1 pr
256 ter can only be verified through prospective randomized trials using hormonal replacement therapy.
257                            This is the first randomized trial utilizing an accurate and validated bio
258 rticipants: In this pragmatic, double-blind, randomized trial, VLBW infants were recruited from 4 neo
259 line gastric cancer incidence, study design (randomized trial vs observational study), clinical scena
260                                    A cluster randomized trial was conducted in 18 centers for primary
261                                    A cluster-randomized trial was conducted in 75 villages in Kampong
262               A three-arm placebo-controlled randomized trial was conducted in homes with wood-burnin
263                                    A cluster randomized trial was conducted in Sudan with pyrethroid-
264                                A multicenter randomized trial was conducted on patients undergoing el
265             A prospective, international 1:1 randomized trial was conducted to evaluate in a noninfer
266                                         This randomized trial was done to assess effectiveness of PRF
267                The primary objective of this randomized trial was to compare thoracic epidural analge
268       Patients and Methods In this phase III randomized trial, we assessed the noninferiority of cisp
269                          In this multicenter randomized trial, we assigned patients with severe acute
270                             In a 3-y cluster-randomized trial, we developed an OHP INT with Navajo in
271   In a prospective, open-label, multicenter, randomized trial, we enrolled patients presenting with s
272              Based on a large-scale, cluster-randomized trial, we find that increasing instruction ti
273                     In a placebo-controlled, randomized trial, we found a prebiotic (OI) to selective
274                                         In a randomized trial, we found covered stents for TIPS to in
275             In light of evidence from recent randomized trials, we assessed whether percutaneous coro
276 fat composition and general overfeeding in a randomized trial.We studied the effects of 7 wk of exces
277 women from the Women's Health Initiative CaD randomized trial were included.
278 hest risk of bias were excluded or when only randomized trials were considered.
279           Funders and regulators (n = 39) of randomized trials were contacted and the literature was
280 tic reviews, 3 observational studies, and no randomized trials were found.
281 thods By June 2013, 102 completed or ongoing randomized trials were identified and individual patient
282                                  No relevant randomized trials were identified.
283                   Seven RCTs and three quasi-randomized trials were included.
284 ous double-blind, placebo-controlled cluster-randomized trials were revisited at age 8 y between Febr
285                               Ongoing larger randomized trials will clarify whether monitoring and su
286                             This multicenter randomized trial with 2 parallel arms (drain vs no drain
287                                      Cluster randomized trial with assignment to patient, provider, a
288           A double-blind, placebo-controlled randomized trial with capsaicin nasal spray was performe
289                                            A randomized trial with long-term outcomes is needed to de
290                               We performed a randomized trial with magnetic resonance imaging (MRI) a
291  knee replacements over 3 y.The design was a randomized trial with participants aged >50 y who had kn
292 collected during the course of a 3-y cluster-randomized trial with the aim of estimating the associat
293                                              Randomized trials with >/=50 patients, that had exclusiv
294                         Our meta-analysis of randomized trials with a follow-up of >/=2 years demonst
295 ssions abstracts, and relevant Web sites for randomized trials with a follow-up of >/=2 years investi
296                      (Danish Organization on Randomized Trials With Clinical Outcome II [SORT OUT II]
297                                     All were randomized trials with low or medium risk of bias.
298 sed measures should be routinely reported in randomized trials with time-to-event outcomes.
299 ulmonary Air Leakage study was a multicenter randomized trial, with blinded evaluation of endpoints.
300 oated balloon has differed greatly among the randomized trials, with better outcomes observed with hi

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