ライフサイエンスコーパス: role of @2 in

1 Our aim was to analyze the role of B cells in a house dust mite (HDM)-based murine

2 The critical role of blood lipids in a broad range of health and dise

3 rice (Oryza sativa) in order to explore the role of cytokinin in a monocot species.

4 poorly to antibiotic therapy, supporting the role of NETs in a late stage of TB pathogenesis.

5 Here, we investigated the role of PAG1 in a preclinical mouse model of house dust

6 longstanding Federal mandate to minimize the role of geography in access to transplant in the United

7 as provided molecular-level insight into the role of TMEDA in achieving effective catalysis.

8 atients from China, emphasizing an important role of 5hmC in AD pathogenesis and highlighting both et

9 To elucidate the precise role of iNKT cells in AD development of NC mice, we empl

10 ing colonoscopies to further investigate the role of diabetes in adenoma detection.

11 lying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affecting autophagy and

12 uality control enzymes will help unravel the role of mitochondrial plasticity in aging and disease.

13 Our study thus reveals a new regulatory role of PML bodies in Aire function, and highlights the

14 periostin in CKD, we discovered a protective role of periostin in AKI.

15 ted icIL-1Ra1(-/-) mice and investigated the role of icIL-1Ra1 in Aldara (5% imiquimod)-induced psori

16 might present new opportunities to study the role of PRs in AMD pathogenesis.

17 on recent findings and discuss the multiple roles of kinases in amyotrophic lateral sclerosis pathog

18 These findings shed light on the role of higher education in an era of political polariza

19 This article is a review of the role of imaging in answering specific questions to help

20 iciency and primary HLH, we investigated the role of perforin in anti-CD19 CAR T cell efficacy and HL

21 1 activation were applied to investigate the role of this inflammasome in asthma at the molecular lev

22 With the increasing understanding of the roles of macrophage immunometabolism in atherosclerosis,

23 To investigate the role of plasmodesmata in auxin patterning, we developed

24 ilencing approaches confirmed the regulatory role of HIF-1alpha in BACE1-AS/BACE1 in Tat-mediated amy

25 Due to the significant role of sigma factors in bacterial metabolism, their rat

26 ive than previously considered, and that the role of viruses in bloom formation and decline may be go

27 Given the prominent role of this mechanism in both herpesvirus biology and c

28 rowing body of evidence supporting an active role of astrocytes in brain information processing.SIGNI

29 e valuable knowledge to further decipher the role of phytohormones in BS induction and BS symptom dev

30 wide expression analyses to study a possible role of Rme1 in C. albicans morphogenesis.

31 d the cardiology community to reconsider the role of T2DM in CAD.

32 ken together this manuscript defines a novel role of E2F2 in cancer progression beyond cell cycle and

33 al inhibition of NMT1 to further dissect the role of this enzyme in cancer, and found an unexpected e

34 However, a detailed understanding of the role of this organism in cancer progression is limited,

35 e organic carbon, thus pointing out that the role of FSa in carbon sequestration in agricultural soil

36 ary breaching and boundary building; and the role of empathy in caring.

37 we applied genetic approaches to dissect the roles of caspase-8 in cell death and inflammation.

38 Here, we review the role of LIS1 in cellular dynein function and discuss rec

39 As such, the relevance of OXPHOS status and role of CI mutations in chRCC remain unknown.

40 s, to our knowledge, the first to define the role of IRF-7 in chronic virus infection.

41 In contrast to the detrimental role of periostin in CKD, we discovered a protective rol

42 ced reinstatement of cocaine seeking but the role of the DH in cocaine seeking during prolonged absti

43 Our data establish an essential role of FMRP in codon optimality-dependent mRNA stabilit

44 Little is known regarding the role of CFH in controlling complement activation within

45 However, despite the important role of IL-1beta in controlling local and systemic infla

46 es three key aspects of this hypothesis: the role of NAAA in controlling the signaling activity of PE

47 we have discovered a previously unrecognized role of Pdcd4 in controlling BDNF mRNA translation, and

48 Here, we investigate the role of primary cilia in controlling the decision betwee

49 time an unbiased and global analysis of the role of Ubqln2 in controlling the composition of the pro

50 Our work uncovers an essential role of YTHDF3 in controlling the interaction between ca

51 Escherichia coli However, the physiological roles of TCP96 in controlling bacterial infections and r

52 mporal pattern of AP firing, emphasizing the role of temporal code in conveying key information about

53 ty and present a model that investigates the role of ethnic markers in coordination games.

54 Our data also highlight the role of biofilms in creating spatially distinct geochemi

55 d stimulate an improved understanding of the role of O-GlcNAc in cytoplasmic protein quality control

56 l areas of current debate, including (i) the role of molecular assays in defining the duration of iso

57 presented here conclusively demonstrate the role of electric charge in detection sensitivity as well

58 Next, we discuss the roles of BRs in development and stress responses.

59 This argues for a key role of positional fluctuations in dictating stem cell n

60 t discoveries in this field, emphasizing the role of TLRs in different diseases and the therapeutic e

61 ith bipolar disorder, suggesting a potential role of this variant in disease.

62 and corresponding cell lines establishes the role of driver genes in diverse contexts and enables mec

63 is increased activity on the strand-specific role of Pole in DNA replication and the action of extrin

64 ades following forest establishment, but the role of climate in driving these trends has not been exp

65 The goal of this study was to uncover the role of FIR in ECFCs function and to reveal potential bi

66 tia and mathematical models to elucidate the role of interaction variability in ecosystem succession

67 sion on human Th cells and also examined the role of IL-3 in effector functions of these cells.

68 This role of the microbiota in eliciting protective antibodie

69 gulation of ghrelin function in vivo and the role of MRAP2 in energy homeostasis.

70 However, the role of autophagy in epidermal proliferation, particular

71 studies indicate a potential chemopreventive role of statins in epithelial ovarian cancer risk.

72 The expression pattern and biological role of ITGAV expression in esophageal adenocarcinoma (E

73 amisyn is not sufficient to account for the role of amisyn in exocytosis: Both the pleckstrin homolo

74 However, the role of cDC1s in expansion of tumor-specific CD8(+) T ce

75 We investigated the role of sleep in experience-dependent dendritic spine el

76 Our results highlight the computational role of these regions in exploration and suggest that do

77 pronounced at PND21, suggesting a potential role of postnatal nutrition in facilitating the sex-spec

78 Finally, the physiological role of CT-1 in fasting is confirmed by the impaired foo

79 teins reported here more clearly defines the role of NFU1 in Fe-S client protein maturation in Arabid

80 This study revealed a predominant role of Tregs in female mice in promoting adipocyte beig

81 Finally, a practical role of NC in FETs is to save the subthreshold and overd

82 reduces DUX4 expression suggesting potential role of GQs in FSHD pathogenesis.

83 Unlike BRD4L, the role of BRD4S in gene transcription remains unclear.

84 This provides unique direct evidence for the role of submesoscale fronts in generating lateral mixing

85 spin Hall angle values and reveal the unique role of TSS in generating SOT.

86 These results reveal the role of H3K9me3 in genome organization could be partiall

87 The aim of this study was to investigate the role of fructose in glucose and lipid metabolism in the

88 trin as a tool to describe the physiological role of cholesterol in glutamatergic synaptic transmissi

89 The sex-specific role of murine Dusp8 in governing hypothalamic Jnk signa

90 lure and to investigate potential functional role of MVs in graft occlusion.

91 Here, we investigated the role of SpxA1 in growth and virulence by identifying gen

92 populations is central to understanding the role of genetic factors in health and disease.

93 We assessed here the role of Lsh in hematopoiesis using conditional Lsh knock

94 age between coral bleaching and disease, the roles of symbiotic bacteria in holobiont resistance and

95 ltogether our findings support a profibrotic role of PDGFR-alpha in HSCs during chronic liver injury

96 However, the exact role of CD80 in HSV-1 immune pathology is not clear.

97 debate outlined opposing views regarding the role of animal products in human diets.

98 ubiquitous expression on human NK cells the role of CD56 (NCAM) in human NK cell cytotoxic function

99 he last developments regarding the potential role of hsTYR in human pathologies, the advances in reco

100 vascular occlusion is crucial to assess the role of inflammation in human stroke and for the develop

101 We explored the role of intrahepatic LCN2 in human alcoholic hepatitis (

102 targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis.

103 xpansion, and a framework for evaluating the roles of VNTRs in human evolution and disease.

104 Here, we investigate the role of IL-31 in IBH of horses and developed a therapeut

105 Current guidelines addressing the role of multimodality imaging in IE are discussed.

106 However, the role of sex in immune system aging is not well understoo

107 Consistent with the known roles of ILF3 in immune response, epithelial-mesenchymal

108 This essay describes the role of community pharmacists in implementing the system

109 Thus, we sought to determine the role of dicarbonyl electrophiles in inflammation-associa

110 Together, these data support a critical role of SIRT1 in inflammation and insulin resistance in

111 Here we determine the role of mammalian EIPR1 in insulinoma cells.

112 tributed to our current understanding of the role of this pathway in intestinal organogenesis, which

113 tissue and provides unique insights into the roles of Piezo in invasive cell behavior.

114 d yeast crd1Delta cells, indicating that the role of CL in iron-sulfur biogenesis is highly conserved

115 opment of the ancient DNA discipline and the role of plant research in its progress and refinement.

116 This study describes an important role of YAP in KCs for regulation of liver inflammation

117 Our data demonstrate a role of for in larval nociceptive behavior.

118 TOPHAGY-RELATED8 (NoATG8) protein and show a role of microlipophagy in LD turnover in N. oceanica CCM

119 However, the role of K3 in leukemic stem cell (LSC) retention and gro

120 These data support earlier findings on the role of GORASPs in linking stacks, and we suggest that u

121 ity and related metabolic disorders, but the role of sleep in long-term weight loss maintenance (WLM)

122 These findings support a causal role of pulmonary impairment in lung cancer etiology.

123 macrophage function, suggesting an essential role of this pathway in macrophage inflammatory response

124 Here, we investigate the role of UCP2 in macrophage activation in the context of

125 adhesion is actin-dependent, but the precise role of actin in maintaining cell-cell adhesion is not f

126 ondrial genes, suggesting towards a specific role of AtPam16L in maintaining mitochondrial homeostasi

127 Numerous studies support a role of the microenvironment in maintenance of the leuke

128 fers an ideal cell model to study the active role of YAP1 in maintenance of the adult epithelial phen

129 Supported by evidence for an essential role of the PfELC in malaria pathogenesis, these structu

130 However, the possible role of PHB in mammalian spermatogenesis has not been in

131 for m3C formation as well as the biological role of m3C in mammals is unknown.

132 Here, we examined the role of Wnt6 in MeCP2 T158A mouse model of RTT.

133 However, the role of host factors in mediating autophagy to suppress

134 sed site-specific mutagenesis to examine the role of NEMO in mediating RANKL-induced signaling in mou

135 Given the central role of ovBNST in mediating maladaptive behaviors associ

136 change on migratory species and the critical role of plant phenology in mediating the ability of ungu

137 dependent mechanisms of ADE overlap with the role of these receptors in mediating antiviral protectio

138 We review the roles of pathogens in mediating ecosystem services provi

139 he developing, complex, and under-recognized role of engineering in medicine to address the multitude

140 about the rules for building the SC and the roles of the SC in meiotic processes.

141 o circumvent these limitations and study the role of patrolling monocytes in melanoma metastasis to l

142 vidence has emerged to support the etiologic role of MCPyV in Merkel cell carcinoma (MCC), an extreme

143 However, the central role of alpha-klotho in metabolism remains largely unexp

144 These findings support a critical role of DBP in migraine susceptibility and shared biolog

145 spite increasing recognition of the critical role of coastal wetlands in mitigating climate change, s

146 shed literature across disciplines about the role of masks in mitigating severe acute respiratory syn

147 asts bearing the CHCHD10(S59L) mutation, the role of CHCHD10 variants in mitofilin-associated protein

148 This review will focus on the role of CoV receptors in modulating immune responses.

149 or (p75NTR) is an important receptor for the role of neurotrophins in modulating brain plasticity and

150 Our study demonstrates the distinct roles of K612 ubiquitination in mRIPK1/K627 ubiquitinati

151 The role of B cells in MS was selected as the topic of the 2

152 er organize approaches for disentangling the roles of glycans in multicellular interactions using new

153 e findings highlight previously unrecognized roles of PAR1 in myelin regeneration, including integrat

154 M) is an important factor in determining the role of DOM in natural and engineered systems, yet there

155 (TrkC-OE) mice were generated to dissect the role of TrkC in nephron development and maintenance.

156 These observations indicate a role of CG4266 in nervous system development and functio

157 It then examines the extended role of autophagy in neuronal function, plasticity, and

158 Together, these results highlight the unique role of eRNAs in neuronal gene regulation and demonstrat

159 t mouse blastocysts as a tool to investigate roles of CHD7 in neuronal and glial differentiation.

160 We aimed to investigate the role of ATP in neutrophil response to pneumococcal infec

161 To assess the role of Asc in NPQ in green algae, which are known to co

162 f CARM1-Pontin-FOXO3a and further expand the role of CARM1 in nuclear regulation of autophagy.

163 high meibum delivery, indicating the pivotal role of meibum secretion in ocular surface health that s

164 Fam20C knockdown not only confirmed the role of Fam20C itself in OPN phosphorylation, but also r

165 ring copulation, suggesting a countervailing role of mAL in opposing P1 activity during mating.

166 f high-order mutants of RAFs reveal critical roles of the RAFs in osmotic stress tolerance and ABA re

167 t the novel context-specific, pro-metastatic role of SIRT3 in ovarian cancer.

168 The role of TET2 in PAH is unknown.

169 R knockout mice (SXRKO) and to elucidate the role of SXR in PCB-153 metabolism and promotion of its h

170 To address the role of NK cells in PD pathogenesis, NK cell function wa

171 To investigate the role of mesenchymal plasticity in PDAC progression, we g

172 advances have occurred in understanding the role of these oxidants in physiology and disease, includ

173 this review advance our understanding of the role of this channel in physiology and pathophysiology a

174 Although the central role of NAD in plant metabolism and its regulatory role

175 duction in rosette size, thus confirming the role of these genes in plant growth.

176 tolerance, indicating conserved and positive roles of PTPN in plant drought tolerance.

177 For investigation of the physiological role of amylin signaling in POMC neurons, the core compo

178 Future work will define the role of pMRI in predicting kidney graft and patient's su

179 Evidence for a causal role of variants in presbycusis was provided by pathogen

180 Our results indicate a critical role of force in promoting axon growth by facilitating m

181 VX) females were also included to assess the role of ovarian hormones in promoting nicotine reinforce

182 However, little is known about the role of calcineurin in promyelinating SCs after birth.

183 To define the role of ATM loss in prostate tumor DDR function and sens

184 The role of antibodies in protection against a primary Chlam

185 The model also highlights the role of membrane tension in providing the long-range mec

186 These results shed new light on the roles of NAs in PrP misfolding and TSEs.

187 However, the potential role of circRNAs in psychiatric diseases, particularly m

188 The role of coherence in quantum thermodynamics has been ext

189 ic vessels; however, less is known about the role of axial stretch in regulating contraction.

190 These findings reveal a cell-intrinsic role of Batf3 in regulating CD8 T cell memory developmen

191 d BCKA content and highlights the biological role of BCKAs in regulating muscle insulin signaling and

192 GA application and present evidence for the role of GA in regulating reduced LRD in bmr12.

193 Our results indicate an important role of GRASLND in regulating stem cell chondrogenesis,

194 educed ZIKV replication, indicating a direct role of Hippo pathway in regulating ZIKV infection.

195 e live and fixed cell imaging to uncover the role of Nek8445 in regulating Giardia cell division.

196 cytes, iCOS-iCOSL in T helper cells, and the role of NFAT in regulating the immune response, were aff

197 Unlike the critical role of O-GlcNAc in regulating the animal circadian cloc

198 duration is impaired in rLG, confirming the role of reflex feedback in regulating force duration in

199 The role of soil biodiversity in regulating multiple ecosyst

200 actor PIF4 fails to accumulate, indicating a role of SPAs in regulating the phyB-PIF4 module at high

201 However, the role of such proteins in regulating cellular processes i

202 The functional role of the microbiota in regulating not only mucosal bu

203 study of hepatocellular carcinoma (HCC), the role of the proteasome in regulating cross talk between

204 export events and highlight an unappreciated role of viruses in regulating diatom life cycle transiti

205 e and sextuple mutants confirmed the crucial roles of ALA proteins in regulating plant development as

206 To enhance our understanding of the role of lipids in regulation of lifespan and healthspan

207 These results demonstrate an important role of NBCn1 in regulation of alcohol consumption and s

208 This review will focus on the role of S1P in renal cells and how aberrant extracellula

209 Our results reveal the role of Vps29 in retromer localization and function, hig

210 ynamics of episodic memory and highlight the role of alpha rhythms in revealing when and where differ

211 studies have presented mixed results on the role of margin status in risk of recurrence after surgic

212 way for future investigation of the specific roles of these proteins in SA signalling and their poten

213 esults provide a potential mechanism for the role of N in SARS-CoV-2 viral genome packing and in host

214 Directly regulated targets reflect the role of ABI3 in seed maturation, desiccation tolerance,

215 We describe the roles of RGC subclasses in shaping unique developmental

216 The role of oxytocin in social cognition has attracted treme

217 A dominant role of fru in specifying sex-specific aggressive behavi

218 l cell carcinoma), little is known about the role of this variant in specifying risk for other cancer

219 neurons (MSNs) in the NAc and determined the role of GSK3beta in spike timing-dependent long-term pot

220 mechanical basis for future studies into the role of mechanosensing in spinal cord repair.

221 ously overlooked, but potentially important, role of stochastic processes in stabilising population d

222 of trans-histone cross-talk and the dynamic role of H2B ubiquitination in stimulating histone methyl

223 challenge of isolating and interpreting the roles of proteins in stress-activated signaling networks

224 nucleus accumbens, suggesting a dichotomous role of BDNF signaling in striatal regions.

225 mixing processes, which suggests a potential role of vertical transport in structuring mesopelagic NC

226 together, these data establish an unforeseen role of GLS2 in sustaining tumor proliferation and under

227 The role of microbes in sustaining agricultural plant growth

228 habitat function and highlighting the vital role of stopover habitats in sustaining migratory commun

229 a follow-on 24-hour vEEG to investigate the role of AMPARs in Syngap1 haploinsufficiency.

230 While previous studies have described a role of TAGAP in T cells, much less is known about its f

231 Herein we present a balanced review of the role of exocytosis proteins in T2D, with thoughts on nov

232 However, the genome-wide role of CSB/Rad26 in TC-NER, particularly in the context

233 To examine the role of TGFbeta signaling in tenocyte function the TGFbe

234 We established a possible role of PrimPol in tenofovir-induced toxicity in vitro a

235 as been increased awareness of the potential role of alternative splicing in the etiology of cancer.

236 enhancers but do not consider the endogenous role of an enhancer in the context of native chromatin.

237 c marine and limnic waters has redefined the role of aquatic environments in the regional CH(4) cycle

238 In particular, the central role of B cells in the disease has been demonstrated by

239 The role of betaCA3 in the high CO(2) -mediated response in

240 To investigate the role of C19MC in the regulation of EMT genes, we employe

241 stribution data also suggest an accelerating role of climate change in the range expansion of M. sole

242 We investigated the role of CRBN in the angiogenic process and in propagatin

243 In summary, our results identify a critical role of CXCR6 in the development of inflammation and fib

244 The results suggest an important role of DNA methylation in the normal homeostasis of car

245 This demonstrates the important role of ECC remodeling in the cardiac dysfunction second

246 xercise in health, little is known about the role of ET-1 in the cardiovascular response to exercise

247 hows that EZH1 could partially safeguard the role of EZH2 in the formation of H3K27me2.

248 This reflects the indispensable role of FANCB protein in the enzymatic activation of FAN

249 nd genetics were used to confirm the central role of GLR3.3 in the amino acid-elicited cytosolic Ca(2

250 However, the precise role of GR in the pathophysiology of AD remains unclear.

251 Comparatively less is known about the role of histone PTMs in the cellular adaptive response t

252 However, the precise role of IL-2 in the maintenance and function of Treg cel

253 We lay a framework for understanding the role of IL-6 in the context of cancer research and COVID

254 conducted mediation analysis to examine the role of leptin in the associations of early-life nutriti

255 We aimed to investigate the role of leptin in the differential association between e

256 ct in the immune system, we investigated the role of osteopontin in the homeostasis of IEL.

257 These studies clarify the role of photoisomerization in the heptamethine cyanine s

258 Together, these data reveal the central role of secreted polysaccharides in the intricate behavi

259 Given the role of statins in the reduction of systemic and pancrea

260 The role of the intensivist in the care of patients on extra

261 function should account for the multifaceted role of the rTPJ in the representation of social inputs

262 these data indicate a fundamental regulatory role of the VDR in the regulation of myogenesis and musc

263 Then, to evaluate the role of these fields in the human cortex in large MRI da

264 ng, the current study aimed to elucidate the role of these neurotransmitters in the social learning p

265 These findings support a critical role of Tregs in the pathogenesis of persistence induced

266 me in this group, underscoring the important role of viruses in the early evolution of life on Earth.

267 Here we investigate the casual role of vmPFC in the acquisition of pavlovian threat con

268 Motivated by the widely accepted role of volatility in the emergence of persistence, we c

269 We describe the roles of Bhlhe40 in the circulating and tissue-resident

270 The key roles of cholesterol metabolism in the activation of inf

271 The roles of dopaminergic neurons in the modulation, structu

272 This study reveals unrecognized roles of LXR in the transcriptional control of the tumor

273 The in vivo roles of RAB39b in the brain remain unknown.

274 They have been described in wines and the role of yeast in their formation is clear.

275 Further research is needed to define the role of asymptomatic hyperuricaemia in these pro-inflamm

276 r of physiological and oncogenic events, the role of PKI proteins in these pathways has remained elus

277 However, the role of scaffold proteins in these processes is poorly u

278 definitive conclusions about the biological role of tau in these models.

279 resource allocation and acquisition, and the role of behavior in this process, will help to build mor

280 to prevent aberrant nuclease resection, the role of BRCA2 in this process has not been described.

281 ficacy of oncolytic viruses(2); however, the role of CAFs in this context remains unclear.

282 However, the role of the thalamus in this process is poorly understoo

283 To determine the roles of Akt isoforms in this model we crossed Akt1(-/-)

284 es that lack specificity due to the multiple roles of key kinases in this pathway.

285 human tissue types that suggests a potential role of 5hmC in tissue-specific development; as well as

286 The role of NIPP1 in tissue homeostasis is not fully underst

287 The role of S6K1 in TKI resistance was determined in in vitr

288 Future studies will further elucidate the role of DSIF in transcriptional dynamics and disentangle

289 ochromatin function, suggesting an ancestral role of this mark in transposon silencing.

290 To examine the role of peripheral ORs in triggering brain hypoxia, we u

291 However, the role of IL-17RD in tumor biology remains to be studied i

292 Our findings demonstrate the pivotal role of PERK in tumor-MDSC functionality and unveil stra

293 ng B-ALL an excellent model for studying the role of aneuploidy in tumorigenesis.

294 The crucial role of mtCa(2+) in tumorigenesis is highlighted by alte

295 transcriptional regulator aphB; however, the role of OmpR in V. cholerae biology outside virulence re

296 in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development

297 his study not only demonstrates the critical role of SFTSV NSs in viral pathogenesis but also suggest

298 This study reveals complex roles of antibodies in viral entry and can guide future

299 investigate the functions and physiological role of the OX1R in vivo and promising lead compounds fo

300 hese data provide compelling support for the role of statistical learning in vocal production learnin