ライフサイエンスコーパス: spreading depression

1 ortex (possibly as a consequence of cortical spreading depression).

2 round 30-fold smaller than that of a wave of spreading depression).

3 thermia may be due to a reduced incidence of spreading depression.

4 e feedback in the generation of seizures and spreading depression.

5 time scale of 3 min may have been caused by spreading depression.

6 rea of the brain surface is known to trigger spreading depression.

7 l as during pathological conditions, such as spreading depression.

8 f neurons that showed activation by cortical spreading depression.

9 er loss of function, and higher incidence of spreading depression.

10 h as an increased susceptibility to cortical spreading depression.

11 op severe and prolonged motor deficits after spreading depression.

12 he trigemino-vascular system and in cortical spreading depression.

13 neuronal excitability that leads to cortical spreading depression.

14 ding hearing, vision, epilepsy, and cortical spreading depression.

15 centration of glutamine (2-5 mM) resulted in spreading-depression.

16 Minocycline had no effect on astrogliosis or spreading depression, a wave of ionic transients thought

17 rst time it has been shown that the cortical spreading depression activated the trigeminovascular sys

18 Spreading depression activates neurophysiological pathwa

19 neurovascular dysfunction and evoke cortical spreading depression, an event that is widely thought to

20 cance to migraine of events such as cortical spreading depression and activation of the trigeminovasc

21 ical hypoperfusion responses during cortical spreading depression and alpha-chloralose anaesthesia.

22 tic glutamate receptors, which occurs during spreading depression and ischemic depolarization.

23 e for the occurrence of spontaneous cortical spreading depression and peri-infarct depolarizations in

24 ited increased susceptibility to subcortical spreading depression and reverberating spreading depress

25 flurane anesthesia showed that both cortical spreading depression and terminal anoxic depolarization

26 te MCA occlusion is caused by either or both spreading depression and transient ischemic depolarizati

27 We argue that the dynamics of seizures, spreading depression, and anoxic depolarization lie alon

28 le of glial K buffering against seizures and spreading depression, and provides novel insights into a

29 n other slices, APC was emulated by inducing spreading depression (as determined by a negative DC shi

30 ological ceiling that separates seizure from spreading depression, as well as predicted a second ceil

31 se gain-of-function effects lead to cortical spreading depression, aura, and potentially migraine.

32 ntral) trigeminovascular neurons by cortical spreading depression, but not their activation from the

33 s are the first to demonstrate that cortical spreading depression can be blocked in vivo using single

34 Leao's spreading depression can be observed in clinically stand

35 Cortical spreading depression caused long-lasting blood-flow enha

36 Migrainous aura is caused by cortical spreading depression (CSD) - a slowly advancing wave of

37 However, the relationship between cortical spreading depression (CSD) and headache has not been ful

38 ow (rCBF) changes that occur during cortical spreading depression (CSD) are considered to be an exper

39 , although, animal models highlight cortical spreading depression (CSD) as a potential candidate.

40 ing has confirmed the importance of cortical spreading depression (CSD) as the pathophysiological mec

41 t and characterize complex waves of cortical spreading depression (CSD) evoked with KCL placed upon t

42 Cortical spreading depression (CSD) has been documented to confer

43 Cortical spreading depression (CSD) has been implicated in migrai

44 Cortical spreading depression (CSD) has been suggested to underli

45 Cortical spreading depression (CSD) has long been implicated in m

46 Animal studies of cortical spreading depression (CSD) have benefited greatly from t

47 tensive care and were classified as cortical spreading depression (CSD) if they took place in spontan

48 Cortical spreading depression (CSD) is a key pathogenetic step in

49 Cortical spreading depression (CSD) is a propagating event of neu

50 Cortical spreading depression (CSD) is a propagating wave of neur

51 Cortical spreading depression (CSD) is a self-propagating wave of

52 Cortical spreading depression (CSD) is a transient propagating ex

53 Cortical spreading depression (CSD) is a wave of neuronal depolar

54 Cortical spreading depression (CSD) is associated with release of

55 Cortical spreading depression (CSD) is characterized by slowly pr

56 Cortical spreading depression (CSD) is likely the underlying phen

57 Cortical spreading depression (CSD) is thought to be a fundamenta

58 Cortical spreading depression (CSD) may be the underlying mechani

59 Cortical spreading depression (CSD) was induced by transient (10

60 d, if so, the threshold for evoking cortical spreading depression (CSD), a process sharing characteri

61 icient to cause infarcts, triggered cortical spreading depression (CSD), a propagating slow depolariz

62 on exhibit increased propensity for cortical spreading depression (CSD), a propagating wave of neurog

63 Cortical spreading depression (CSD), a wave of neuronal depolariz

64 mice, we show that a single wave of cortical spreading depression (CSD), an animal model of migraine

65 nnels and are highly susceptible to cortical spreading depression (CSD), the electrophysiologic event

66 Here, we report that cortical spreading depression (CSD), the electrophysiological sub

67 We evaluated the ability of cortical spreading depression (CSD), the proposed mechanism of th

68 ring somatosensory stimulations and cortical spreading depression (CSD), the putative mechanism of th

69 n damage and ischemia often trigger cortical spreading depression (CSD), which aggravates brain damag

70 this study was to determine whether cortical spreading depression (CSD)--an event believed to underli

71 us and evoked activity in naive and cortical spreading depression (CSD)-sensitized trigeminovascular

72 range trigeminovascular neurons by cortical spreading depression (CSD).

73 s (with [n=7] or without [n=7] HH), cortical spreading depressions (CSD) were elicited to ascertain t

74 Recurrent spreading depression episodes were induced by applicatio

75 ecovery rate for [K+]o, and interval between spreading depression episodes were measured before and a

76 ection analysis) and in vivo (i.e., during a spreading depression event in an anesthetized rat).

77 factor in the clinical response to cortical spreading depression events.

78 d the effect of fremanezumab on the cortical spreading depression-evoked activation of mechanosensiti

79 s predicted a second ceiling that demarcates spreading depression from anoxic depolarization.

80 Although spreading depression has been known for over 50 years, r

81 velength optical intrinsic imaging, cortical spreading depression has been shown to have a triphasic

82 Upstream events such as cortical spreading depression have also been modeled recently and

83 The pathological phenomena of seizures and spreading depression have long been considered separate

84 Pathological conditions, such as spreading depression, have been linked to abnormal range

85 Hyperthermic spreading depression (HSD) in immature rat hippocampal s

86 and headache by demonstrating that cortical spreading depression, implicated in migraine visual aura

87 cerebral ischaemia, and blocking of cortical spreading depression improved stroke outcome in these mi

88 provides evidence for an integrative role of spreading depression in brain pathophysiology.

89 ound, global cerebral ischemia, and cortical spreading depression in C57BL6 mice; 1 day after probe d

90 ge, but it is unknown whether TNF influences spreading depression in cerebral cortex in vivo.

91 signals evoked by stimulation, seizures and spreading depression in intact brain differ from those o

92 ole in the return of [K+]o to baseline after spreading depression in the cortex in vivo.

93 urovascular changes associated with cortical spreading depression in the mouse.

94 mulation blocked the propagation of cortical spreading depression in two of eight animals.

95 Enhanced susceptibility to cortical spreading depression increased sensitivity to focal cere

96 ity in reducing the total number of cortical spreading depressions induced by potassium chloride.

97 mechanism for the susceptibility of cortical spreading depression initiation in migraine disorders.

98 Cortical spreading depression is a propagating wave of depolariza

99 The findings indicate that cortical spreading depression is accompanied by transient neurobe

100 Our understanding of cortical spreading depression is also advancing.

101 These findings indicate that cortical spreading depression is associated with a multiphasic al

102 Cortical spreading depression is associated with profound vascula

103 Hypoxia-induced spreading depression-like depolarization (hypoxic SD, or

104 larizations (PIDs) are seemingly spontaneous spreading depression-like waves that negatively impact t

105 Results support a spreading, depression-like neuroelectric event occurring

106 Vascular/metabolic uncoupling with cortical spreading depression may have important clinical consequ

107 strated significant activity in the cortical spreading depression model of migraine as we reported pr

108 atine for 3 h failed to prevent hyperthermic spreading depression occurrence; and (2) intracellular A

109 utic targets in the disorders where cortical spreading depression occurs.

110 oelectric and metabolic event likened to the spreading depression of Leao.

111 tibility to ischemic depolarizations akin to spreading depression predisposes migraineurs to infarcti

112 Altogether, these data show that spreading depression propagates between cortex, basal ga

113 ing, and c-fos immunohistochemistry to trace spreading depression propagation into subcortical struct

114 e showed that unlike the wild type, cortical spreading depression readily propagated into subcortical

115 t astrocytes normally extrude calcium during spreading depression, resulting in rapid recovery of the

116 Although intercellular Ca2+ waves resemble spreading depression (SD) and occur in hippocampal organ

117 spontaneous, recurring episodes of cortical spreading depression (SD) as early as 20 min post-inject

118 Spreading depression (SD) has been demonstrated followin

119 occlusion, as well as the effects of induced spreading depression (SD) in intact animals.

120 We have developed an in vitro model of spreading depression (SD) in rat neocortex.

121 We examined characteristics of spreading depression (SD) induced on the rat cortex 1 da

122 Spreading depression (SD) involves current flow through

123 Spreading depression (SD) is a propagating wave of neuro

124 Spreading depression (SD) is a wave of cellular depolari

125 Spreading depression (SD) is wave of profound depolariza

126 The possibility that spreading depression (SD) of cortical activity, a phenom

127 stigated the role of spontaneous and induced spreading depression (SD) on the evolution of focal isch

128 Spontaneous episodes of spreading depression (SD) originating in multiple source

129 Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanis

130 ant, on fluid shifts, cerebral perfusion and spreading depression (SD) using diffusion- (DWI) and per

131 Spreading depression (SD), a slow diffusion-mediated sel

132 Spreading depression (SD), a slowly propagating neuronal

133 This study used spreading depression (SD), which is characterized by red

134 In the ischemic periphery, spreading depression (SD)-like waves of depolarization w

135 , I(Na,P), in the generation of seizures and spreading depression (SD).

136 expression following unilateral neocortical spreading depression (SD).

137 receded by an aura likely caused by cortical spreading depression (SD).

138 ous transition between epileptic seizure and spreading depression states as the cell swells and contr

139 ssium or hypoxia induced), mixed seizure and spreading depression states, and the terminal anoxic "wa

140 mone levels in these mice modulated cortical spreading depression susceptibility in much the same way

141 smooth muscle Notch 3 mutations to enhanced spreading depression susceptibility, implicating the neu

142 mutation are highly susceptible to cortical spreading depression, the electrophysiological surrogate

143 During spreading depression, the evoked increase in cytosolic C

144 Amiloride was shown to block cortical spreading depression, the experimental correlate of aura

145 We tested the susceptibility of cortical spreading depression, the experimental correlate of migr

146 This paper shows that cortical spreading depression, the neural correlate of migraine a

147 at cortices, when administered post-cortical spreading depression, transcranial magnetic stimulation

148 unction, one during the propagating cortical spreading depression wave and a second much longer phase

149 t current shift associated with the cortical spreading depression wave was accompanied by marked arte

150 concentration increased during the cortical spreading depression wave, but recovered and remained at

151 After recovery from the initial cortical spreading depression wave, we observed a second phase of

152 istinct from the initial propagated cortical spreading depression wave.

153 tical spreading depression and reverberating spreading depression waves.

154 h mechanical and chemically-induced cortical spreading depression when administered immediately post-

155 euronal activities, from spikes to seizures, spreading depression (whether high potassium or hypoxia

156 ion and c-fos expression are associated with spreading depression, which is believed to contribute to

157 ity, and enhanced susceptibility to cortical spreading depression, which is the electrophysiological

158 TAC-Red-stained brain cortex in mice during spreading depression, with velocity 4.4 +/- 0.5 mm/min,

159 and transient ischaemia can trigger cortical spreading depression without an enduring tissue signatur