ライフサイエンスコーパス: the known

1 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 x 10(-1

2 These data are consistent with the known 3- to 6-month lag in recovery of specific immu

3 een the two datasets, with 24.7% or 42.5% of the known 49.0 kbp of LGT sequence predicted correctly,

4 All observed density can be attributed to the known 80 subunits of the individual complexes, inclu

5 ntiOxCINs, these molecules take advantage of the known ability of the triphenylphosphonium cation to

6 anches at their 6-positions, consistent with the known acceptor chain specificity of GlgE.

7 Thus all the known actin-like polymers are likely to be the desce

8 e in the intramolecular rotation, increasing the known activation energy to rotation from 8.5 to 10.6

9 Despite the small sample size, the known AD risk variant APOE4 reached genome-wide sign

10 The high frequency of this procedure and the known adverse effects of repetitive pain in neonates

11 up into the skin and contributes to many of the known adverse side effects of ATRA treatment, includ

12 widespread zoonotic transmission and adds to the known aetiologies of infectious diseases for this re

13 to an extent comparable to that attained by the known AKR inhibitor epalrestat.

14 ng two weakly mutagenic aromatic amines, and the known alkaloid comutagen norharman along with two re

15 Most of the known allergens that were dominant at the T cell lev

16 rature further stabilizes it with respect to the known alpha-B6O structure.

17 ociated with major TAL effectors that target the known alternative S genes OsSWEET14 and OsSWEET13.

18 review, we provide an up to date overview of the known AMPylating enzymes, the regulation of these en

19 e produced several simple models inspired by the known anatomical structures and neuronal responses w

20 A model based on the known anatomy of layer 4 demonstrates that the known

21 However, this view is at odds with the known anatomy of layer 4 interneurons in visual cort

22 various algorithms and to benchmark against the known ancestral genotypes and ancestral phenotypes.

23 Here, we test the function of all the known and candidate KDMs in myoblast and osteoblast

24 Leveraging the known and high-affinity interaction between CB[7] an

25 s review focuses on our current knowledge of the known and potential interaction of the microbiome in

26 ld be used judiciously and with awareness of the known and unknown or potential side effects.

27 conformation is a novel mechanism to explain the known anti-inflammatory effects of this compound, in

28 D4.2 lacks epitopes associated with half of the known antigenic sites, which significantly impacts o

29 gainst P. falciparum parasites comparable to the known antimalarials, chloroquine and mefloquine.

30 Using this pipeline, we have widened the known antimicrobial spectrum for V. odorata cyclotid

31 The known ASD risk genes were ranked on average in the 7

32 ly, this peptide motif is sequestered within the known ASF1-H3-H4 interface, raising the question of

33 sease has been relatively neglected, despite the known association between severe tricuspid regurgita

34 Our work is the first to demonstrate that the known association between WT1 expression in breast c

35 Overall, 26% of the known associations in studies of individuals of Euro

36 he associations with EA are far smaller than the known associations with the biologically proximal en

37 It is different from the known asteroid binaries in its combination of wide s

38 Structural modifications of the known autotaxin inhibitor lead compound 1, to attenu

39 ed with BBS did not identify any mutation in the known BBS genes.

40 ially for small groups of cells, emerge from the known behaviors of individual cells.

41 Intergenerational conflict combined with the known benefits conveyed to kin by post-reproductive

42 ndings from during the past decade expand on the known benefits of breastfeeding for women and childr

43 throughput screening hit anthranilic acid 4, the known benzofuran analogue 5, and the benzothiadiazin

44 Including the known bias of transformation toward the acquisition

45 As proof-of-principle, the known binding interaction of Cyclosporine A with cyc

46 The MBM in MKK3 is distinct from the known binding sites for p38 or upstream kinases.

47 luate the role of these RNA molecules within the known biochemical framework of SLE.

48 While cataloguing the profiles based on the known biotypes, all the employed RNA-Seq methods gen

49 The reaction of (C5Me5)3Th, 3, with H2 forms the known (C5Me5)3ThH as the sole thorium-containing pro

50 Despite the known cardiotoxic effects of doxorubicin and other a

51 la virus genomes, which represent over 5% of the known cases.

52 response enhancement effect did not require the known catalytic activity of CheR, but did involve a

53 Sensory deprivation is the known causal mechanism for acquired synaesthesia and

54 breeds to characterize mapping precision of the known causal mutations.

55 ely 15% of resolved cases, respectively) are the known causes of ADPKD.

56 n among HAdV-Ds in a region overlapping with the known CD46 binding site in HAdV-B.

57 Given the known clinical relevance of the CD73/adenosine pathw

58 accomplished computationally in reference to the known "closed" apo-PBP2a X-ray crystal structure sta

59 inding to CPSF6, is largely independent from the known cofactors for nuclear entry, and alters integr

60 ulin interacted with the peptides containing the known collagen cross-linking sites and the MMP-1 cle

61 ndent from and have larger effect sizes than the known common variation in these regions.

62 hich Ub adopts a dynamic equilibrium between the known, common Ub conformation and a distinct, second

63 of the BCR signaling network, which captured the known complex cross-talk between the NFkappaB, ERK,

64 %), successfully identifying the majority of the known components of the canonical glycoprotein ERAD

65 micropollutants was within a factor of 2 of the known concentration.

66 that the phenylalanine clamp (varphi-clamp), the known conductance bottleneck in the PA translocase,

67 Its absolute configuration was assigned by the known configurations of the starting compounds and b

68 by prior phosphorylation at Ser204, fitting the known consensus sequence for GSK3 substrates.

69 The known consensus sequence is observed to have the hig

70 study provides new mechanistic insight into the known contribution of myeloid cells to muscular dyst

71 In addition to the known contributions from electric-field and chemical

72 Due to the known contributions of N-linked glycosylation to pro

73 A substantial part of the known correlation between the recombination rate and

74 gent delta power response is consistent with the known cortical degeneration in CLN5(-/-) sheep.

75 Among the known custom DNA-binding modules, the nuclease-dead

76 This Perspective reviews the known CXCR3 antagonists and considers future opportu

77 fungus, Phomopsis sp. (CMB-M0042F), yielded the known cytochalasins J (1) and H (2), together with f

78 Thus, despite the known cytotoxicity of cobalt and zinc ions, these re

79 ll review the historical data for D4, review the known D4 ligands, and then highlight new data suppor

80 receptor blockade, a finding consistent with the known dependence of this response on the innate cyto

81 ite predictions in ccmB transcripts based on the known determinants of nucleotide base recognition by

82 terial and archaeal DGR lineages that expand the known DGR range by 120% and reveal a history of hori

83 Particularly given the known difficulties involved in this type of transfor

84 the other sibling pair, targeted testing of the known disease gene for Roifman syndrome (RNU4ATAC) p

85 ons in patients who lack exonic mutations in the known disease genes.

86 Their number matches the known distinct meteorite parent bodies.

87 ibrary of recombinant CBMs representative of the known diversity of type A modules.

88 ling has only been observed in Ni3TeO6 among the known double corundum compounds to date.

89 We revealed that 23 loci, including the known Dt1, E2, E1, Ln, Dt2, Fan, and Fap loci, as we

90 Here we review the known ecological and evolutionary implications of sy

91 ExoU is the most cytotoxic of the known effector proteins and has been associated with

92 Here, we summarize the known effectors, their modes of action, and RNA targ

93 hich suggests that the CFIm complex mediates the known effects of CPSF6 in HIV-1 infection.

94 demonstrate that our methodology can detect the known effects of drug-induced neuronal inactivity an

95 alyses in smokers and non-smokers because of the known effects of smoking on FEV1 decline.

96 eveal binding sites that are consistent with the known effects of these molecules on beta2m amyloid f

97 Despite the known effects that TMP-SMX has in reducing clinical

98 fore suggest that a mechanism in addition to the known electron carrier function of ubiquinone is req

99 hey had improved safety profiles compared to the known electrophilic Nrf2 inducers.

100 r outer shells could also exist, but none of the known elements have filled g-orbitals.

101 seudorotaxane stereoisomer in agreement with the known "endo-alkyl rule".

102 ent inhibitor of NMDAR-induced currents than the known endogenous neurosteroid, pregnanolone sulfate

103 of a constitutively active Mek1 (Mek1(DD)), the known ERK activator, restores the tectal stem zone a

104 In addition to the known ERK deactivation, retinoschisin treatment of r

105 On the basis of the known esophageal past medical history as well as the

106 vesicle priming process that they control to the known etiological mechanisms of psychiatric and neur

107 tsuokella multacida (PhyAmm) in complex with the known eukaryotic second messengers Ins(1,3,4,5)P4 an

108 termitophile so far discovered, pushing back the known evolutionary history of termitophily by approx

109 stent with previously established trends for the known families of tetrahedral CdSe frameworks.

110 e provides a personal recollection (with all the known faults of self-reporting and retrospective mem

111 species due to multiple protomers, including the known fluoroquinolone protomers and the new finding

112 c progression of male germ cells, similar to the known function of boule in invertebrates.

113 Given the known function of mindin, its early expression in th

114 Despite the known function of viral envelope glycoproteins in ca

115 These observations reflect the known functional properties of the PE and PEc, with

116 These results, together with the known functional relevance of the three genes to LMI

117 In line with the known functions of c-Jun, LT also inhibited cell pro

118 f cellular protein levels, which goes beyond the known functions of PRMT5 as a transcription and spli

119 In the years since, the known functions of Reelin signaling in the brain hav

120 reover, these data also significantly expand the known functions of smORF-encoded microproteins.

121 addition to confirming oncogenic activity of the known fusion oncogenes engineered by our constructio

122 Using this strategy, we engineered the known fusion oncogenes, BCR-ABL1, EML4-ALK, and ETV6

123 -proteins that cannot be easily explained by the known G-protein signaling pathways.

124 Besides the known GAPs in the malaria parasite, the complex incl

125 The known gas-phase spectrum, including its vibronic str

126 nown Usher genes or in extra-exonic parts of the known genes - to date a largely unexplored possibili

127 revalence of 50% by the age of 50; however, the known genes explain little of the heritability.

128 er syndrome caused by recessive mutations in the known genes.

129 There remains a large discrepancy between the known genetic contributions to cancer and that which

130 At present, the known genetic risk loci are largely uncharacterized

131 orrelations represent enzymatic reactions in the known glycosylation pathway, and then predict new bi

132 This review will summarize the known health effects of PEDs but will also focus on

133 To determine the frequency of the known heritable meningioma- or schwannoma-predisposi

134 patients will be highly variable because of the known heterogeneities in signaling pathways among th

135 jor crossover pathways in plants and some of the known homeostatic mechanisms that act during meiotic

136 entify additional residues in the network of the known hotspot residues of different anti-Ebola antib

137 to play a role distinct from that of Pro in the known HP1beta CSD-PXVXL complexes.

138 We found that the known hSOD1 mutations G93A and A4V increased the cap

139 s have been isolated from humans, increasing the known human bacterial repertoire by 29%.

140 We recovered the known immune evasion molecules PD-L1 and CD47, and c

141 sociated with HIV-1 outcome, consistent with the known impact of classical HLA alleles.

142 Based on these results, and the known importance of E73 in VDAC physiology, VDAC dim

143 Despite the known importance of phospholipids in regulating prot

144 Despite the known importance of TGF-betas in promoting disease p

145 This is not accounted for by the known incidence of chromosomal aneuploidy in miscarr

146 ified 87 cancers in different quadrants than the known index cancer, constituting the basis of this r

147 R imaging-detected multicentric cancers than the known index lesion, and 18 of 73 (25%) (95% CI: 15,

148 eutic and imaging protein conjugates despite the known instability of the resulting products that und

149 Our results reveal a paradigm that the known interaction of many proteins with PARP1 under

150 The overall structure confirms the known interactions, including some that were not pre

151 We extend the known inventory of planktonic archaeal lipids to inc

152 in cerebellum appears to be consistent with the known involvement of this brain region in auditory f

153 be related to their known precursors and to the known kinetic isotope effects of enzymes involved in

154 fic lupeol synthases and does not group with the known L. clavatum alpha-onocerin cyclases.

155 has been modeled using DFT calculations from the known LGO precursors levoglucosan and 1,4:3,6-dianhy

156 than 10-fold higher than predicted based on the known ligand affinities.

157 de were found in diverse proteins, including the known ligand high-molecular-weight kininogen (HK), a

158 In addition to the known light chain myosin tail interacting protein (M

159 openic phenotype of TIEG1 KO mice as well as the known links between TIEG1 expression levels/allelic

160 Chip), combined with conditional analysis in the known lipid loci.

161 In view of the known long-term safety profile of PPI, they can be a

162 ain three important elements: in addition to the known (main) binding site, we identified a linker re

163 on coefficients show the maximum value among the known MAX phases, to date and to the author's knowle

164 and although carboxylation of acetyl-CoA is the known mechanism for generating the distinct plastidi

165 aims of this Review Article are to summarize the known mechanisms of protein translational fidelity a

166 describe how this process is consistent with the known mechanisms of TRAP transporters and consider h

167 ialylated cell adhesion molecules, including the known megakaryocytic markers integrinbeta3 and CD44,

168 The identification of the known MET TKIs, glesatinib and foretinib, as negativ

169 The results substantially expand the known metabolic potential of CPR bacteria, although

170 ts the chemical transformation that converts the known metabolites into the unknown one.

171 However, approximately 90% of the known metabolites reported in metabolomic databases

172 this enhanced IBC migration effect, and that the known metastatic oncogene, RhoC GTPase, is necessary

173 icular emphasis is placed on improvements to the known methodologies and recent advances in the field

174 accumulated to levels equivalent to that of the known MIE transcript later in infection.

175 hat Cys-119 or Cys-162 of p38alpha, close to the known MKK3 docking domain, were relevant for these r

176 consanguineous families with no variants in the known MMIHS-associated genes.

177 e renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, a

178 unprecedented polyphosphanes in addition to the known monoinserted product LGaP4 (1) are observed.

179 In addition to increasing the known morphological disparity of extinct lampreys, a

180 mRNA was isoform 2, which is the ortholog of the known mouse IL-36beta mRNA.

181 way for RER in RNase HII-deficient cells and the known mutagenic profile of DnaE, we propose that mis

182 A488P and R655C mutations were compared with the known mutation V883M.

183 r locations and residue charge profiles with the known native binding proteins.

184 P. anaerolimi, but it appears to lack any of the known natural carbon fixation pathways.

185 d the NRP1 cytoplasmic domain (NCD), but not the known NCD interactor GIPC1.

186 how that it does not bind directly to any of the known netrin-1 receptors.

187 ation in the Drosophila model, we can expand the known network of genes involved in disease pathogene

188 ological organization would reliably reflect the known neurobiology of individual amygdaloid nuclei,

189 tors (TF) associated with gene signatures of the known neuroendocrine/epithelial (NE) and non-neuroen

190 A combination of the known neuroprotective molecule, pigment epithelium-d

191 crucial for this transformation, unlike for the known nitrogen-directed arylations.

192 AOB phylotypes predominantly from the known Nitrosomonas group were distributed across the

193 n (residues 1-4) of NCC differs from that of the known NOP antagonists, as being slightly slipped dee

194 As the known number of AHR-mediated processes grows, so too

195 4 histone Kbhb sites, a figure comparable to the known number of histone acetylation sites.

196 A at five new sites, thus more than doubling the known number of sites.

197 ted PPy-PFOS was adjusted by polarization to the known open-circuit potential of the solid contact in

198 became markedly activated by cyanide (CN) or the known opener P1075 with a current density that was ~

199 We are summarizing some of the known or reported consequences of such infection dur

200 isolated from whole blood and cultured with the known OSM inducers GM-CSF and follistatin-like 1, an

201 and hence resulting in an underestimation of the known particle height.

202 t bacterial DNA and yielded fewer reads from the known pathogens.

203 Our studies reveal that beyond the known pathways, such as base excision repair, the pr

204 eroxisome division in a manner that requires the known peroxisome division factor PEROXISOME AND MITO

205 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine

206 nt a novel rodent model to reproduce much of the known phenotype of CTEPH, including the pivotal path

207 From sand flies, we isolated most of the known Phlebovirus strains that potentially cause hum

208 The known physiologic effects of EDN1 on the vasculature

209 pylori lacks a gene encoding a homologue of the known pimeloyl-ACP methyl ester cleavage enzymes sug

210 ts of volatile compounds, including CO2, and the known plant growth-promoting volatile 2,3-butanediol

211 which can occur with oral quinine because of the known poor adherence to 7-d regimens.

212 ved for MT-2 cells and provide evidence that the known poor infectivity of HTLV-1 particles may corre

213 fects on telomere length could contribute to the known poor performance of later-ovulated family memb

214 ed in the midbrain and hindbrain, increasing the known populations.

215 of strong similarity with the clip region of the known portal proteins.

216 Alongside the known postfusion conformation, a novel one was ident

217 endent, G-protein conformational change from the known prefusion conformation to an extended, monomer

218 ents observed were generally consistent with the known profile of lisdexamfetamine.

219 e safety profile of triple therapy reflected the known profiles of the components.

220 e known anatomy of layer 4 demonstrates that the known proportion and connectivity of inhibitory neur

221 Based on the known proportion of tree species in neotropical lowl

222 s due to pregnancy are sufficient to explain the known protective effect of full-term pregnancy in ea

223 l innate immune signaling, which complements the known PRRSV-mediated immune-evasion mechanisms.

224 Having reproduced the known Pten KO phenotype using the CRISPR-Cas9 system

225 This observation fundamentally expands the known range of gas-transport systems in extant arthr

226 ght into C-C-hydrolyzing enzymes and expands the known range of reactions catalyzed by the amidohydro

227 S1 mutations are functionally different from the known recessive Wolfram syndrome-causing mutations,

228 ion in Welwitschia mirabilis to test whether the known regulatory links between LEAFY and its MADS-bo

229 in layer 4 than in subplate, consistent with the known relay of thalamic information to layer 4 by su

230 isease, and correctly flagged all but one of the known repeat expansions.

231 Our results expand the known repertoire of 'eukaryote-specific' proteins in

232 superior resistance to that demonstrated by the known resistant cultivar Mace.

233 The structure explains the known restrictions of cis-interactions of some Pcdh

234 ction by MOV10 was unique and independent of the known retinoic acid-inducible gene I/mitochondrial a

235 hreat of hypoxia in the tropics, even though the known risk factors, including eutrophication and ele

236 have an evidence-based discussion regarding the known risk of cutaneous surgical procedures in the s

237 al lesions detected in peripheral fields and the known risks associated with H/Ma and peripheral lesi

238 countries, medical interventions to address the known risks associated with pregnancy and birth have

239 rthermore, OGA is physically associated with the known RNA polymerase II (pol II) pausing/elongation

240 hydroxyapatite (HA) crystals in vitro and on the known role mineralization inhibitors, like PPi, play

241 Because of the known role of glycolysis in biosynthesis, we tested

242 Given the known role of Mer in contact-dependent inhibition of

243 In contrast to the known role of NCR peptides as effectors of endosymbi

244 ffect of PDF on clock gene transcription and the known role of PDF in enhancing PER/TIM stability occ

245 e whether connexin phosphorylation regulates the known role of zonula occludens-1 protein (ZO-1) in g

246 These findings complement the known roles of CASPR2 in brain development, and warr

247 intrinsic antiviral immunity contrasts with the known roles of PIAS proteins as suppressors of innat

248 binding interface that has shifted away from the known RV P-genotype binding sites but is conserved a

249 profile of tremelimumab was consistent with the known safety profile of CTLA-4 inhibitors.

250 Adverse events were consistent with the known safety profile of roflumilast.

251 Safety profiles were consistent with the known safety profiles of these agents.

252 using logistic regression and correcting for the known sampling fractions from stage 1 to stage 2, ov

253 Building on the known SAR of this compound series, we now describe a

254 o the control compound prostratin (1), while the known sesterterpenoid alotaketal C (2), isolated fro

255 itu autophosphorylated protein, we expand on the known set of CPK28 autophosphorylation sites, and we

256 Because of the known sex differences in neural and behavioral smoki

257 Finally, an examination of the known SHG active AMCO3F (A = alkali metal, M = alkal

258 This benefit must be weighed against the known side-effect profile of these antimicrobials.

259 In this assay, the compounds behave like the known sigma1 receptor antagonist haloperidol.

260 difference in Gibbs free energy compared to the known similar class of materials to date.

261 within the CPK28 J domain that overlaps with the known site of intramolecular interaction between the

262 lights key similarities and differences from the known solution-phase pathway.

263 e instrumentation system, or to any other of the known sources investigated.

264 olved in this representation overlapped with the known spatial cell types in the circuit, such as pla

265 nalysis were used together to reveal whether the known species of Fargesia represent discontinuous sa

266 d the confirmation of FRET measurements from the known standards.

267 nancy is unknown, but hepcidin regulation by the known stimuli (i.e., iron, erythropoietic activity,

268 also led to dephosphorylation at Ser-555 of the known STING regulator, UNC-51-like kinase 1 (ULK1).

269 e stoichiometry of complex I by reference to the known stoichiometries of complexes III and IV.

270 fied a region that could not be explained by the known stratigraphy.

271 RNA immunoprecipitation with the known stress granule aggregates TIAR and G3BP1 was p

272 The input patterns reveal boundaries between the known striatal domains.

273 Even deletions of one of the known structural protein genes that is present in al

274 ar activity to that of Pt(111), in line with the known structure insensitivity of the reaction.

275 structural models for a target protein from the known structure of its homologous template proteins

276 Provided with the known structures of a protein, our method uncovers a

277 bound pigments are discussed with respect to the known structures of LHCII and CP29.

278 hibitors involved in the pathway, along with the known substrate cleavages and peptidase-inhibitor in

279 ly explained by a microscopic model based on the known surface dynamic behavior under vacuum conditio

280 curs via a degenerative pathway unrelated to the known synapse function of these proteins and involvi

281 ted by the ability of LT-scanner to identify the known targets of FDA-approved kinase inhibitors base

282 these photochemical reactions different from the known thermal chemistry of 1, but the reversibility

283 sor surface were investigated, understanding the known TLR-PAMP interactions, through the exploitatio

284 It has been well-established that the known TMs can be classified by the dimensionality of

285 Only trace levels of the known toxic metabolite, thio-DMA, were observed, acr

286 Despite the known toxicity of some high-molecular-weight azaaren

287 sequence block 3 (CSBIII), just upstream of the known transcription-replication transition point, su

288 these functional data strongly contrast with the known transcriptional regulation of NRT1.1, which is

289 reefs are associated with more than half of the known tropical dead zones worldwide, with >10% of al

290 rmitilis, suggesting for the first time that the known tropism of RNA bacteriophages may include gram

291 d sandsheets were identified and compared to the known tsunami sandsheets.

292 BART miRNA cluster 2, new relationships with the known type 1/type 2 strains are demonstrated, and a

293 We show that the known tyrosine kinase inhibitor tyrphostinA23, which

294 Recurrent coding mutations were found in the known UM drivers GNAQ, GNA11, BAP1, EIF1AX, and SF3B

295 While emerging studies are greatly expanding the known universe of RNA-binding proteins, methods for

296 Given the known vascular effects of cannabis, this study exami

297 The known viral replication proteins, a telomere binding

298 Using the known water dimer interaction potential, we estimate

299 f deep evolutionary relationships(3-5) or on the known, well-classified diversity of life with an emp

300 0 gene loci predominantly at W-box elements, the known WRKY binding motif.