ライフサイエンスコーパス: (broadly|widely) applicable

1 tumors are needed to make these living drugs widely applicable.

2 es limitations of previous approaches and is widely applicable.

3 s more closely, ensuring any conclusions are widely applicable.

4 ing patients in specialized stroke wards-are widely applicable.

5 platform, these antibody-testing methods are broadly applicable.

6 of cells, indicating this approach could be broadly applicable.

7 ulations and ensure that genetic research is broadly applicable.

8 onate-containing N-heterocyclic carbene, are broadly applicable.

9 etic manipulation we describe here should be broadly applicable.

10 focused on minimizing alcohol intake may be broadly applicable.

11 nsive, enabling features that make CANs more broadly applicable.

12 target anti-cancer ILC2s and T cells may be broadly applicable.

13 age size and quality, and makes the software broadly applicable.

14 onjunction with existing Cre lines making it broadly applicable.

15 super-resolution imaging protocols, and are broadly applicable across biology.

16 x of the dogs, resulting in a method that is broadly applicable across canid species' morphologies.

17 ed analysis and visualization techniques are broadly applicable across developmental and systems biol

18 ry events and population effects and is thus broadly applicable across eukaryotic species.

19 ting that the parameters determined here are broadly applicable across highly conserved cyclophilins

20 Our method is broadly applicable across microbial life, opening possib

21 rotein complex mapping studies and should be broadly applicable across organisms as more CF-MS datase

22 te and robust correction technique, which is widely applicable across challenging biological samples.

23 within-host pathogen evolution that will be widely applicable across organisms.

24 ctivation is chemically challenging, and few broadly applicable activation strategies for signaling e

25 echanisms of inactivation and the absence of broadly applicable allosteric sites.

26 A widely applicable analytical LC/HRMS method based on ion

27 ne or more nitrogen-containing moieties, and broadly applicable and efficient catalytic transformatio

28 of this unified representation (UniRep) are broadly applicable and generalize to unseen regions of s

29 particular imaging targets, the approach is broadly applicable and is expected to improve resolution

30 reening and rational engineering approach is broadly applicable and suggests that greater potential o

31 We expect the model to be broadly applicable and useful in coarse-grained models o

32 The PAA method is widely applicable and can be easily implemented with com

33 to native antibody cysteine residues, it is widely applicable and enables high drug loading for impr

34 This technique is widely applicable and is not limited to crystal growth p

35 the welfare benefits of tunnel handling are widely applicable and not diminished by the use of other

36 Our approach is widely applicable and offers an opportunity to quantitat

37 al autonomy of coordinated neural systems is broadly applicable, and our findings provide evidence of

38 ror estimation approaches described here are broadly applicable, and the provided tools work with oth

39 In summary, we present a novel, broadly applicable, and versatile therapeutic modality f

40 ts, make insights gleaned from model systems widely applicable, and explain circuit performance and f

41 y correlated oxide interfaces and lays out a broadly applicable approach for depth-resolving band hyb

42 ntrol over its function, we have developed a broadly applicable approach for the optical activation o

43 targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-

44 esulting complex, providing an efficient and broadly applicable approach to early fragment developmen

45 specific CD4(+) Th cells may be a useful and broadly applicable approach to generating improved vacci

46 Here we present a broadly applicable approach to quantification and classi

47 These results describe a potentially broadly applicable approach to understanding the interac

48 lin aptamer-TAP siRNA conjugate represents a broadly-applicable approach to increase the antigenicity

49 We introduce a powerful, widely applicable approach to characterizing polymer con

50 Our results not only validate our widely-applicable approach for inferring directed genoty

51 erefore there is tremendous need for new and broadly applicable approaches to site-specific conjugati

52 These nanoparticle-supported liposomes are broadly applicable as membrane antigen vehicles for indu

53 es and their usage as mechanistic tools in a broadly applicable assay platform.

54 f materials design, this approach provides a broadly applicable, automated tool to understand atomic

55 ity, robustness and economy of Flura-seq are broadly applicable beyond cancer research.

56 PET imaging is a widely applicable but a very expensive technology.

57 Our highly customizable pipeline is widely applicable, capable of detecting filopodia in fou

58 Herein, we demonstrate a general and broadly applicable catalytic cross coupling of methylene

59 amenable to high throughput screens and as a broadly applicable cellular tool to interrogate the temp

60 sion-weighted or diffusion-weighted MRI is a widely applicable clinical tool, and the "mismatch" betw

61 tic objectives are defined, based on which a broadly applicable combination therapy is proposed to co

62 uide to leukaemia cell line selection, and a broadly applicable computational approach for quantifyin

63 Our methods are widely applicable, computationally tractable for many co

64 We believe that our synthesis provides a broadly applicable conceptual framework to understand an

65 The development of broadly-applicable, core microsatellite panels has the p

66 derstood on the basis of a simple and rather widely applicable Coulomb model based on the characteris

67 We applied novel, quantitative, and widely applicable cytogenetic strategies to elucidate th

68 Here, we report an accurate and broadly applicable data-driven algorithm for dimensional

69 Here, we present a widely applicable deep learning neural network approach

70 Thus, we demonstrate a broadly applicable device-based methodology to probe the

71 ove SDM predictions by explicitly modeling a widely applicable direct physiological effect: climate-i

72 ghlight how data sharing efforts can provide broadly applicable discoveries.

73 The development of a broadly applicable dispersion quantification method will

74 These characteristics make aptamers broadly applicable (e.g., as an analytical, diagnostic,

75 This broadly applicable E2 delivery platform shows promise as

76 Thus, inverse vulcanization becomes more widely applicable, efficient, eco-friendly and productiv

77 Here, we disclose a broadly applicable enantioselective [2 + 2]-cycloadditio

78 However, widely applicable enantioselective Suzuki-Miyaura variat

79 ell as sharing of such large-scale models, a broadly applicable, flexible, and high-performance data

80 This approach may be broadly applicable for designing effective and enduring

81 Our approach is broadly applicable for determining structures of undisco

82 gp120 inner-outer domain interface and were broadly applicable for engineering Env from diverse stra

83 ational removal of ssDNA exonucleases may be broadly applicable for enhancing the efficacy and ease o

84 This protocol is broadly applicable for filling structural gaps of many t

85 These methods are broadly applicable for high throughput single cell chemi

86 SAFIRe should be broadly applicable for imaging live cell dynamics with c

87 karyotic cells, we expect this assay will be broadly applicable for investigating mechanisms of MMR i

88 n contact for free-ranging hosts, and may be broadly applicable for investigations in wildlife diseas

89 the Cre-switchable PET reporter mice will be broadly applicable for non-invasive long-term tracking o

90 r)oxides makes this electrochemical approach broadly applicable for studying changes in iron oxide re

91 Overall, GxEMM is broadly applicable for testing and quantifying polygenic

92 or loop structures should make this approach broadly applicable for the atomic-level study of large R

93 Our method may be broadly applicable for the derivation of analogous stem

94 covery and validation that is accessible and broadly applicable for the progression of efforts toward

95 Cryoreduction-EPR is broadly applicable for the study of electron transfer in

96 nds were tested in vitro, making this method broadly applicable for tool compound development.

97 This framework is broadly applicable for understanding the mechanisms of s

98 on regulates cell signalling, which might be broadly applicable for understanding the signalling func

99 ric transcription factors (aTFs) have proven widely applicable for biotechnology and synthetic biolog

100 This marker development strategy should be widely applicable for genetic studies in many taxa, part

101 This method is widely applicable for hydrazide linkers containing vario

102 Our method should be widely applicable for investigations of tRNA charging as

103 essential for initiation and our approach is widely applicable for mapping interactions in other sign

104 in differentiated human RPE cells should be widely applicable for other studies aimed at understandi

105 otransduction and contributes tools that are widely applicable for studying receptor mechanics at dyn

106 FKF1/GI- and CRY2/CIB1-based systems will be widely applicable for the light-dependent control of tra

107 nteractions) approach described here will be widely applicable for the study of combinatorial phenoty

108 This innovative methodology is widely applicable for the study of phonotaxis and spatia

109 utic recombinant fusion proteins become more widely applicable for the treatment of various types of

110 indings establish habituation as a possible, widely applicable functional readout and target for phar

111 These findings bring us closer to a widely applicable gene therapy for hemoglobin disorders.

112 ogether, this presents CellTag Indexing as a broadly applicable genetic multiplexing tool that is com

113 enhanced ascorbate peroxidase 2 (APEX2) as a broadly applicable genetic tag that generates EM contras

114 Our findings may be broadly applicable given that transcription on topologic

115 te simple stewardship interventions that are widely applicable globally.

116 There remains a need for a broadly applicable, hernia-specific tool that incorporat

117 This work demonstrates LAMIMS as a broadly applicable high-throughput operando screening me

118 for such materials and paving the way for a broadly applicable high-throughput-discovery and materia

119 Together, these data establish a widely applicable high-throughput and high-resolution me

120 The method is broadly applicable, highly regio-, chemo-, and enantiose

121 anoPOTS top-down proteomics platform will be broadly applicable in biomedical research, particularly

122 aches for cholinergic modulation that may be broadly applicable in dystonia.

123 Consequently, information on BCO2 becomes broadly applicable in human biology with important impli

124 ination of HDX stability fingerprints may be broadly applicable in many applications for understandin

125 In conclusion, this versatile method is broadly applicable in screening and characterisation of

126 roughput manner, and has the potential to be widely applicable in achieving more predictable and dele

127 ss of degrons for acute protein depletion is widely applicable in various developmental contexts.

128 h ratios (UVVR) suggesting these metrics are broadly applicable indicators of microtidal marsh vulner

129 nvestigated whether these molecules are more broadly applicable inhibitors of beta2m amyloid formatio

130 ing widely studied classes of MOFs, provides broadly applicable insight into the rigidity and compres

131 validity of this assumption, or consider how broadly applicable it may be to all genes that are in th

132 technique can provide this information in a broadly applicable manner and thus structural studies of

133 ts has not been studied in a prospective and broadly applicable manner.

134 nonequilibrium thermodynamics, we present a widely applicable mechanism for a similar effect, the Ma

135 Here, we present dStruct which is the first broadly applicable method for differential analysis acco

136 Overall, we provide a broadly applicable method for evaluating the selectivity

137 Here, we describe a broadly applicable method for labeling and imaging pili

138 Herein, we report a mild and broadly applicable method for the construction of comple

139 se insights exemplify spliceosome iCLIP as a broadly applicable method for transcriptomic studies of

140 e force response of helicases and provides a widely applicable method for inferring the underlying he

141 ng requires the development of efficient and broadly applicable methods for delivering programmable n

142 extensive research, but highly effective and broadly applicable methods remain elusive.

143 in looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromat

144 Nowadays, several widely applicable methods exist for non-destructive whol

145 We apply and compare three widely applicable methods for estimating ecosystem trans

146 p of the cancer-immunity cycle and propose a broadly applicable 'minimal combination' of therapies de

147 guide and wall plasticizer into a simple but widely applicable model of tip growth.

148 shown promise in the field, but accurate and broadly applicable models are still lacking.

149 warrants further studies that may lead to a broadly applicable molecular imaging tool to examine abn

150 This work highlights a broadly applicable nanoscale structure-refinement method

151 are provided open access; they constitute a broadly applicable neuroscience toolbox resource for res

152 Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenol

153 uanidine prodrug 11, 8a will serve as a most widely applicable, pharmacological tool to target DDAH-1

154 Taken together, this work provides a broadly applicable platform for high-throughput function

155 ty within a single disease and establishes a widely applicable platform for genotype-phenotype correl

156 A broadly applicable, practical, scalable, efficient and h

157 A widely applicable, practical, and scalable strategy for

158 table for large-scale production and enables widely applicable, preliminary yet accurate screening of

159 tion process that should serve as useful and broadly applicable principles for future design of more

160 A set of two broadly applicable procedures for the N-arylation of hyd

161 omparisons with a potential for establishing broadly applicable quantitative BKV DNA load cutoffs for

162 To address this, we have developed a widely applicable recruitment assay system through which

163 The MGRB provides a broadly applicable reference cohort for clinical genetic

164 elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts.

165 We demonstrate sPREs as a practical, widely applicable, robust, and very sensitive technique

166 necessary to show whether this technique is widely applicable, safe in the long-term, and effective

167 supports the potential of this antibody as a broadly applicable scaffold for the development of selec

168 ealing recognition principles and of raising broadly applicable strategies, including functional assa

169 These data reveal a broadly applicable strategy across tumor types for repro

170 P is a powerful, experimentally concise, and broadly applicable strategy for directly visualizing RNA

171 However, development of a broadly applicable strategy for stable and functional va

172 This broadly applicable strategy may lead to decreased pestic

173 ene capping is introduced as a practical and broadly applicable strategy that can expand the scope of

174 of targeted therapy and Quisinostat may be a broadly applicable strategy to induce a prolonged respon

175 Here, we describe a broadly applicable strategy, based on llama-derived sing

176 henotype-associated enhancer and establish a widely applicable strategy for systematic in vivo evalua

177 er models or datasets, making it unclear how widely applicable such models are.

178 Here we describe a broadly applicable technique called 'Ligation in situ Hy

179 We introduce a new, broadly applicable technique for the precisely controlle

180 approach to controlled assembly represents a widely applicable technique for creating new classes of

181 Inception loops represent a widely applicable technique for dissecting the neural me

182 which aim towards rendering it a general and widely applicable technique that combines the highest po

183 tes that IDLV-mediated HDR is a powerful and broadly applicable technology to carry out site-specific

184 PIC-seq provides a direct and broadly applicable technology to characterize intercellu

185 ible and customizable and are therefore more broadly applicable than the examples presented.

186 RM or their binding motifs, and is thus more widely applicable than motif-based methods for predictin

187 In this review, we discuss general and broadly applicable themes that have emerged from this co

188 Broadly applicable, these predictive models can use stan

189 of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for the management of BKV

190 cation-based band gap tuning we describe are broadly applicable to 3D metal halide perovskites and wi

191 tform for solid-state protein studies and is broadly applicable to a variety of systems and experimen

192 me indicates that the correction strategy is broadly applicable to a wide range of microduplication l

193 Our modeling assumptions are broadly applicable to adherent, monolayer cell cultures,

194 ods validated here are general and should be broadly applicable to allow the direct and rapid detecti

195 imaging pathophysiology research system), is broadly applicable to analyses of other respiratory path

196 nd show that the optimized masking domain is broadly applicable to antibodies of interest.

197 surfactants in multiple environments and are broadly applicable to any discipline where finite volume

198 introduces a novel analysis method, which is broadly applicable to any LPTV networks, and validates i

199 oach for connecting genotype to phenotype is broadly applicable to any sample that is phenotypically

200 As a computational methodology, WIF is broadly applicable to any SMLM dataset, imaging system,

201 ich to study human in situ adaptive immunity broadly applicable to autoimmunity, infection, and cance

202 annotate novel sphingolipid species make LDA broadly applicable to automated sphingolipid analysis, e

203 anisotropy and hence biofilm morphology, are broadly applicable to bacterial biofilms with similar mo

204 integrative analysis, which we expect to be broadly applicable to bacterial epigenomic studies.

205 lymer systems, suggesting that the method is broadly applicable to block copolymer materials assemble

206 y immunogenic antigens in principle could be broadly applicable to cancers and other diseases.

207 s with high impact for further study, and is broadly applicable to complex human diseases.

208 Our approach is broadly applicable to complex multimetallic systems and

209 This report describes chemistry that is broadly applicable to cysteine-rich peptides and the inf

210 abled selection of CID (COMBINES-CID) method broadly applicable to different ligands.

211 ic cross-link design is highly versatile and broadly applicable to different polymer architectures as

212 Furthermore, our technique is broadly applicable to earlier image-based detection of m

213 tiochelin system; therefore, our results are broadly applicable to emerging clinical isolates of S. m

214 roach and mechanism of action that should be broadly applicable to functional RNA targeting.

215 Our allele balance framework is broadly applicable to genotype analysis of any variant t

216 microbe-phenotype triangulation may be more broadly applicable to human microbiome studies.

217 The implications of this work are broadly applicable to hydrogenation and dehydrogenation

218 Rapid conductance measurements will be broadly applicable to IC-based sensors that undergo anal

219 tor functions, while our network approach is broadly applicable to identifying regulators in other in

220 tinase inhibitors and may be a strategy more broadly applicable to inhibiting proteins that require u

221 from vertebrates, although the concepts are broadly applicable to invertebrates.

222 The method should be broadly applicable to many bosonic and fermionic species

223 This new insight is broadly applicable to many types of molecular threading

224 The resulting potential is broadly applicable to materials science, biology, and ch

225 resent an oligonucleotide MS method which is broadly applicable to monitor in vitro RNA (de-)modifica

226 lts suggest that the underlying chemistry is broadly applicable to nucleic acid sensing.

227 als, this mRNA delivery technology should be broadly applicable to numerous research and therapeutic

228 ligands, and a small-molecule agonist may be broadly applicable to other aGPCR family members.

229 Our strategy is broadly applicable to other aptamers, enabling the devel

230 etween monomers and dimers is expected to be broadly applicable to other biogenic and anthropogenic S

231 ent loading in the Mississippi Basin and are broadly applicable to other coupled human-natural system

232 ticles or semiconductors, are believed to be broadly applicable to other heterostructures with novel

233 W-type materials, which may prove to be more broadly applicable to other layered zeolites.

234 strategy to prevent synapse loss that may be broadly applicable to other neurodegenerative diseases.

235 The conceptual framework we describe is broadly applicable to other novel disease systems.

236 We expect that the methods developed are broadly applicable to other obligates, particularly to r

237 s for N- and O-glycosylation that are likely broadly applicable to other plant cell-wall-degrading en

238 ds of RNA-seq described in this protocol are broadly applicable to other sample types beyond whole or

239 vity are shown, but the PIE-FLIM approach is broadly applicable to other signaling pathways.

240 emonstrated that the present approach may be broadly applicable to proteins undergoing relatively sma

241 We anticipate that sci-fate will be broadly applicable to quantitatively characterize transc

242 ral agents and diagnostic tests that are not broadly applicable to resource limited settings, includi

243 icacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to Staphylococcus aureus.

244 Our APE-based method is easily computed and broadly applicable to statistically similar models found

245 Our approach is broadly applicable to study human immunity and can help

246 This analytical method is broadly applicable to study membrane protein interaction

247 autodE is broadly applicable to study organic and organometallic r

248 dynamics and the approach presented here is broadly applicable to studying order in macromolecular s

249 paired with sample flexibility, makes HOTMAQ broadly applicable to targeted peptidomics, proteomics,

250 We also demonstrate how MEIRLOP is broadly applicable to the analysis of numerous types of

251 ma transcriptomic subtype classifier will be broadly applicable to the cancer research and clinical c

252 se as a surprising approach that is possibly broadly applicable to the challenge of designing biased

253 The approach may be broadly applicable to the kinetic stabilization and char

254 catalytic system is practical, scalable, and broadly applicable to the reductive coupling of a wide r

255 he NADH photo-activation coupled with EPR is broadly applicable to trap reactive intermediates at low

256 The approach is broadly applicable to type II fatty acid synthase system

257 This technology platform is broadly applicable to various diseases with well-known b

258 This approach will be widely applicable to all families of porous ions and rep

259 y of production and isolation should make it widely applicable to basic research of the eye.

260 aking advantage of new technology, making it widely applicable to diverse users, including those in s

261 -soldiers (S&S) effect, has been found to be widely applicable to dynamic covalent and supramolecular

262 The models we developed are widely applicable to evaluate the fitness consequences o

263 Our framework is widely applicable to integration challenges in other dom

264 RPAf is widely applicable to investigate its mechanism of action

265 lysis tools developed for this study will be widely applicable to investigations of clustering behavi

266 APEX-seq should be widely applicable to many systems, enabling comprehensiv

267 integrates growth and specification and are widely applicable to many tissues.

268 ermination of oligomeric structures would be widely applicable to membrane proteins where paramagneti

269 The PhABit platform is envisioned to be widely applicable to novel protein targets, identifying

270 xperimental and modeling strategies could be widely applicable to other biological systems.

271 over, the approach used to develop ThSSim is widely applicable to other fields of science and enginee

272 erved features of retroviruses and should be widely applicable to other LTR retrotransposons, endogen

273 Due to its generic character, the method is widely applicable to other types of data.

274 These methods should be widely applicable to research involving green algae.

275 challenges to address for the methods to be widely applicable to supplement high-throughput experime

276 increases stimulus response precision and is widely applicable to synaptically connected spiking neur

277 The method is widely applicable to the biophysical investigation of co

278 The use of ecological analysis is widely applicable to the field of surgical outcomes rese

279 ample of self-organization and could be more widely applicable to the modelling of other complex syst

280 We anticipate that this approach will be widely applicable to the study of small molecule binding

281 This platform is widely applicable to TPPs with complex structures and wi

282 es for size control are well established and widely applicable to various QD systems, the structural

283 We are expanding the package to be widely-applicable to other fusion algorithms and expect

284 e projects by presenting guidelines that are broadly applicable (to any species), sustainable over ti

285 CiBER-seq profiling provides a powerful and broadly applicable tool for dissecting genetic networks.

286 private databases as a specific in-house but broadly applicable tool for optimizing exome analysis.

287 troduced by Hofer, Wysocki, and Zehnder as a broadly applicable tool for regularizing moduli spaces o

288 ate parameters using FRAP recovery data is a broadly applicable tool for systems where intracellular

289 MALDI-HiTES is a broadly applicable tool for the discovery of cryptic pep

290 common, suggesting our SEM-FLM approach is a widely applicable tool for exploring the joint responses

291 Cellular volume perturbation is a widely applicable tool to detect transient protein inter

292 ed using dynamic pathway regulation, but few broadly applicable tools are available to achieve this.

293 iction to lose its PHL capacity, and provide broadly applicable tools for other jurisdictions to enha

294 Broadly applicable tools for the efficient delivery of m

295 advantages for the development of robust and broadly applicable tools.

296 ts that anti-CRISPR proteins should serve as widely applicable tools for synthetic systems regulating

297 echnology may therefore provide a practical, broadly applicable treatment that can generate anti-tumo

298 e bridging nitrogen should provide access to widely applicable tricyclic, photoswitchable pharmacopho

299 The D-loop Mapping Assay is widely applicable with different substrates and donor ty

300 repurposing ATO to target p53 mutations for widely applicable yet personalized cancer therapies.