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2 after ten generations (chi(2) = 6.6; P = 0.01) suggesting a reversal of P450-based resistance in the
4 time interaction (F((8,245)) = 2.02, p = 0.04), suggesting a prolongation of the antidepressant effec
5 ethered to DNA, could also open undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion
7 with many major Phanerozoic mass extinctions, suggesting a cause-effect relationship where volcanic
8 teins from unrelated animal-infecting viruses, suggesting a common ancestor for these accompanying pr
10 rger enhancements during spectral degradation, suggesting a condition-specific facilitation effect dr
11 ct inter-subunit interactions around the ring, suggesting a coordinated and directional GTP-hydrolysi
12 lated to mitochondrial Ca(2+) efflux pathways, suggesting a counteracting effect to avoid Ca(2+) over
13 c mAL neurons remain active during copulation, suggesting a countervailing role of mAL in opposing P1
14 napses, but enhanced in the nucleus accumbens, suggesting a dichotomous role of BDNF signaling in str
16 y increased with LAC2-dependent lignification, suggesting a direct relationship between these process
17 ation and promotes physiological angiogenesis, suggesting a dual effect on vascular repair upon FECH
19 state of diminished corticomotor excitability, suggesting a maladaptive supraspinal pain modulatory s
20 imilar across individuals but remains plastic, suggesting a means through which the olfactory system
21 cell apoptosis in gastric cancer pathogenesis, suggesting a mechanism for prolonged epithelioid tumor
22 CL) 2/TM3 at the G-protein-coupling interface, suggesting a mechanism of engaging G-proteins that may
23 currents in the PVN following AngII infusion, suggesting a mechanism whereby TNFR1 activation contri
26 utively elevated without activating mutations, suggesting a non-genetic basis for enhanced activity.
27 ic response to the circulating hormone leptin, suggesting a novel way to regulate brain entry through
29 populations contain lineage-labeled particles, suggesting a phagocytic role in the clearance of AMFs.
31 this mutant can induce early gene expression, suggesting a possible defect at the level of viral rep
32 ctivated unconventional T cells were detected, suggesting a potential contribution in the regulation
33 D1, the changes were more pronounced at PND21, suggesting a potential role of postnatal nutrition in
34 89R variant in a family with bipolar disorder, suggesting a potential role of this variant in disease
35 icient mice incapable of secreting antibodies, suggesting a predominant antigen presentation role.
37 previously only observed in human development, suggesting a reactivation of developmental programs.
39 robust replication in cells expressing mSTING, suggesting a role for 2C in recruiting STING to RV-A r
40 ) exhibit TDP-43 positive neuronal inclusions, suggesting a role for this protein in disease pathogen
41 synthesis and had increased DNA damage levels, suggesting a role for zinc in maintaining genome integ
45 CNAs in the NAT tissue and the adjacent tumor, suggesting a shared clonal origin, as well as instance
46 obo condition versus the Chimpanzee condition, suggesting a significant effect of feeding competition
48 d aggregation following proteasome inhibition, suggesting a switch in NUB1 function from targeted pro
49 s-changes rapidly with the control parameters, suggesting a tipping point in barrier response to exte
50 eased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by
54 DPP cannot rescue the anterior fate formation, suggesting additional targets of PNT participate in th
55 ient to induce intracellular protease release, suggesting altered membrane integrity after the field
56 ent in a diverse array of eukaryotic lineages, suggesting an ancestral EPR-1 was a component of a pri
57 an essential role in heterochromatin function, suggesting an ancestral role of this mark in transposo
58 onse to LPS by regulating macrophage function, suggesting an essential role of this pathway in macrop
59 ral similarity to the scaffold domain of TBK1, suggesting an evolutionary similarity between the auto
60 and restored responsiveness to immune therapy, suggesting an indirect stromally targeted avenue for t
61 rculating HCV-specific CD4+ T cell repertoire, suggesting antigen-independent survival of this subset
62 hanges encountered during endocytic recycling, suggesting APOL1 forms a cytotoxic cation channel in t
63 ed pineapple juice with immobilized pectinase, suggesting applicability of this system in juice and f
66 accessibility genome-wide at cellularization, suggesting both are pioneer factors with common as wel
67 ompetitively inhibited by mannose 6-phosphate, suggesting cation-independent, mannose 6-phosphate rec
68 ion led to worsening of the Mdr2 KO phenotype, suggesting caution in targeting beta-catenin globally
69 of cell and molecular events was not absolute, suggesting cell programmes reach the same end using di
70 ids and an increase in membrane phospholipids, suggesting changes in the Kennedy pathway of lipid bio
71 sitive for SARS-CoV-2 RNA by quantitative PCR, suggesting community transmission of SARS-CoV2 in Wuha
72 le Notch1 target genes in hepatic vasculature, suggesting constitutive functional importance in vivo.
77 re selectively engaged by chemosensory blends, suggesting different roles for EGCs than analogous int
78 the calpain-2 isoform but not with calpain-1, suggesting differential roles for both calpain isoform
80 tially, but not in step with binding affinity, suggesting distinct modes of interactions in these com
81 r being admissible as evidence in most courts, suggesting eDNA method reliability is not the problem.
82 than dissolved and particulate organic carbon, suggesting emissions were primarily fuelled by contemp
83 )ppGpp target, the purine salvage enzyme HPRT, suggesting evolutionary conservation in different enzy
84 isms that have structural cell wall cellulose, suggesting expansins evolved in ancient marine microor
85 lectively for unexpected highly similar foils, suggesting expectation violation does not enhance memo
86 ophyte genomes and vascular plants is limited, suggesting extensive rearrangements since divergence.
87 oskeleton linkage are reduced in MHD patients, suggesting for the first time that integrin-associated
88 de, within which sequences cluster by species, suggesting frequent duplication and/or gene conversion
89 F orthologs but lack the associated receptors, suggesting functional diversification across kingdoms.
90 a-TCRs using strikingly diverse binding modes, suggesting fundamental differences in gammadelta T cel
93 , models 1 to 4 all showed similar O:E ratios, suggesting high accuracy in risk prediction using curr
94 f inoculation method on gametocyte production, suggesting higher gametocyte commitment following IBSM
96 es (PFSAs) were enriched in dosed mouse serum, suggesting in vivo transformation of sulfonamide precu
97 s independently associated with elevated FeNO, suggesting increased eosinophilic airway inflammation.
99 eural patterns differed between both subjects, suggesting individual variability in the correlates of
100 or the Fls3-sustained reactive oxygen species, suggesting involvement of multiple structural features
101 cation perturbation and DNA damage in S phase, suggesting it acts as a post-replicative resolvase.
102 ral and species-specific 6 mA site prediction, suggesting it can provide a useful resource for furthe
103 ble CVD risk is similar to those risk factors, suggesting it is a particularly potent contributor.
104 etic bacteria lack the C-terminal prosequence, suggesting it is a recent functional adaptation in pla
105 ot find that SI variability changed over time, suggesting it might be trait-like, at least over 2 yea
106 without augmenting adaptive immune responses, suggesting it might offer a novel adjunctive therapeut
108 nd lacked cardiac and behavioral side effects, suggesting its potential for use in pharmacotherapy fo
110 ade of Kcnn2 improves these learning deficits, suggesting Kcnn2 blockers as a new intervention for le
111 s demonstrate lower levels of Cd19 expression, suggesting limitations in preclinical animal models of
112 g differential roles in insulin sensitization, suggesting mechanisms bridging the association of thei
115 main glycans affect N1 stability more than N2, suggesting N2 is more accommodating to glycan addition
116 terferon beta-1 abrogated the viral infection, suggesting one potential mechanism for more severe vir
117 y p38, Erk1/2 and PI3K-Akt pathway inhibition, suggesting p38, Erk1/2 and PI3K-Akt pathways as signal
119 ke cells in human fibrotic lungs was observed, suggesting persistence of the transitional state in fi
120 ial-independent spontaneous glutamate release, suggesting plumes are a consequence of inefficient cle
122 minent expression of alpha7 nAChRs in rat SOC, suggesting possible engagement of ACh-mediated modulat
123 s common to conventional sapphire preparation, suggesting potential industrial application both on st
125 (i)) resulted in increased cementum formation, suggesting PP(i) metabolism may be a target for period
126 mportant topological positions in the network, suggesting relationships between the bloom dominant sp
127 s were recorded together in September-October, suggesting reproductive activity at this time of year.
128 antly related parasites comprise an infection, suggesting sequential transmission of complex infectio
129 al PB-projecting neurons regulated male sleep, suggesting several groups of PB-projecting neurons act
130 ing mycorrhizal association and leaf venation, suggesting substantial modifications in fine-root morp
131 to-Ags are fundamental to disease development, suggesting T1D etiology is heterogeneous and may limit
132 imal inhibitory concentration [IC50] = 1-2 uM), suggesting that BCH070 acts via a novel mechanism of
133 tegrity (|r(nodes)| = .420; |r(edges)| = .583), suggesting that connectome aging occurs on broad dime
134 liferator-activated receptor alpha (PPARalpha), suggesting that FATP2 activity is linked to a PPARalp
135 cits in mouse models of Kennedy's disease (KD), suggesting that restoring muscle BDNF might restore f
136 deformational and Earth rotational effects(8), suggesting that the response of AIS grounding lines t
137 rse LDI performance in individuals (>60 years), suggesting that this higher activation may be an indi
138 showed an index of replication (iRep) of 1.32, suggesting that 32% of this population was actively re
139 neous release without altering evoked release, suggesting that aberrant spontaneous release is suffic
140 s of various AKT inhibitors remain suboptimal, suggesting that AKT-driven tumor metastasis needs to b
141 ardless of the presence of the leader peptide, suggesting that although the PEP domain serves for rec
142 vity of HR(+) 59-2-HI tumor to PD-L1 blockade, suggesting that antiprogestins may improve immunothera
143 on of cell death or loss of insulin secretion, suggesting that appropriate levels of Myc could have t
144 cl1 yielded a similar delay in neuronal birth, suggesting that Ascl1 cannot rescue the loss of Neurog
145 nificantly different from those of WT vessels, suggesting that basal K(ATP) channel activity in LSM i
146 in improved visual function in diabetic mice, suggesting that chromophore deficiency plays a causati
147 sformation at premalignant/preinvasive stages, suggesting that circulating messengers, intercepted in
148 by increased numbers of HIF-1alpha+ monocytes, suggesting that CMH enhances monocyte removal by ampli
149 ansect from the control site towards the seep, suggesting that CO(2) exerts a strong control on isoto
150 evealed asymmetric effects of effort and pain, suggesting that cognitive effort may not share the sam
151 hymal renal injury in patients with cirrhosis, suggesting that concurrent mechanisms, including those
152 ZC and inflammatory markers were inconsistent, suggesting that correlation and decile analyses should
153 r PIP into PA-rich membrane bilayers in vitro, suggesting that CPSFL1 potentially facilitates vesicle
154 ive beta-catenin, alpha-fetoprotein, and SOX9, suggesting that DCLK1 overexpression induces clonogeni
155 ss information redundancy) during task states, suggesting that decreased correlations increased infor
156 other hand, can cope without functional CWC15, suggesting that developing pollen might be more tolera
157 that differs from gradual precessional pacing, suggesting that direct rainfall forcing effects were p
158 gnificantly affected in the presence of DMNDC, suggesting that DMNDC does not inhibit insulin aggrega
159 zymatic activity compared with healthy donors, suggesting that dysregulation of the AHR/CYP1A1 axis m
160 ed the activities of pyramidal neurons in PrL, suggesting that EA treatments seem to perform it benef
161 ond to known vibrational modes of chlorophyll, suggesting that electronic-vibrational mixing facilita
162 ecially at dopamine receptor promoter regions, suggesting that epigenetic modification of germ cell D
163 tested by the reduction of mMCP-1/7 in plasma, suggesting that EPIT specifically decrease IgE-mediate
164 n their levels in the diacylglycerol fraction, suggesting that erucic acid was preferentially incorpo
165 al forebrain and striatal cholinergic neurons, suggesting that falls reflect disruption of the cortic
166 d abilities to dissociate alphaSyn aggregates, suggesting that fibril disassembly is linked to the in
167 ociated with lower ART concentrations in hair, suggesting that food insecurity may be associated with
168 n innate lung immunity to bacterial infection, suggesting that FSTL-1 influences type-17 pulmonary ba
169 ogical patterns that are also present in ARDS, suggesting that generalizable patterns exist in divers
170 g practices preferentially talk to each other, suggesting that greater steps are needed for informati
171 ly associated with ascending aorta dilatation, suggesting that hemodynamic factors influence aortopat
172 coupling between the two structures were low, suggesting that HFOs are generated locally within the
173 acterial killing in opsonophagocytosis assays, suggesting that HN13 LTA is an attractive target for f
174 al contamination in the private wells studied, suggesting that household septic systems are the sourc
175 fusion and is associated with PGD development, suggesting that ILCs may be involved in regulating lun
176 ontents subjectively mimic perceived contents, suggesting that imagery and perception share common ne
177 poprotein lipase (LPL) activity was increased, suggesting that increased blood TG clearance contribut
178 cells in culture and xenografts of HCC tumors, suggesting that inhibition of PJA1 may be beneficial i
179 oters-are enriched for lineage-specific genes, suggesting that interactions at these loci contribute
180 tophagy that is observed in the IRGM KD cells, suggesting that IRGM regulates mitophagy through the i
183 ith the compounds' physicochemical properties, suggesting that it may be mediated by differential com
184 1 replication forks and replicating viral DNA, suggesting that it may play a direct role in viral rep
185 to antagonism by the glycoGag protein of MLV, suggesting that its virologic role is Nef specific.
186 us Pip partially restored SAR in jmj14 plants, suggesting that JMJ14 regulated Pip biosynthesis and o
187 equally likely to result in language deficits, suggesting that language is distributed symmetrically
188 nfiltrated the TG and were retained long term, suggesting that latent epitope expression is sufficien
189 ed both cognitive and P50 inhibition deficits, suggesting that longer term treatment with alpha7 nACh
190 onged RA exposure phenocopies LSD1 inhibition, suggesting that LSD1 regulates endocrine cell differen
191 but not CD4+ T cell-specific (CD3) antibodies, suggesting that M-tropic viruses had a macrophage orig
192 a behavior that wild-type males never display, suggesting that male mosquitoes possess the central or
193 depression when under stress than at baseline, suggesting that MDD-PRS adds unique predictive power i
194 filter drastically increased the IC(50) value, suggesting that MDIMP binds to the extracellular side
196 tedly, two phospholipids are bound to MlaFEDB, suggesting that multiple lipid substrates may be trans
197 urons carried information about image content, suggesting that neurons in the entorhinal cortex carry
198 , is synthesized by chlorinating nitromethane, suggesting that nitromethane may be the immediate prec
199 d surrounding the vascular tissues of anthers, suggesting that OsNLA1 is important throughout the dev
200 ly failed to preserve muscle mass in cachexia, suggesting that other mechanisms might be involved.
201 fectively in azithromycin-treated neutrophils, suggesting that pathogen-specific factors may interact
203 ostin during the late stages of tendon repair, suggesting that persistent NF-kappaB signaling may fac
204 the colon following an intracolon inoculation, suggesting that pGP3-deficient Chlamydia sp. might be
205 small kinetic difference with respect to SLG, suggesting that photothermal processes, in contrast to
206 e tumor, while did not increase in the spleen, suggesting that PnV-activated macrophages were led pre
207 etheless stabilize the polymerase-DNA complex, suggesting that Pol beta, when bound to a lesion, has
208 in and E-cadherin genes in DRA-KO mouse colon, suggesting that posttranscriptional mechanisms play a
209 ularine also did not disrupt editing in vitro, suggesting that PPR65 cannot bind modified bases due t
210 ty was dominated by sulfur oxidising bacteria, suggesting that primary production in the sediment was
211 ated TM7, while absent from environmental TM7, suggesting that prophages may have played a role in ad
212 served than that indicated by the 2D-MSI data, suggesting that quantitative analysis of molecularly d
213 antage at initial steps of metastatic seeding, suggesting that Rab27a may alter cell-autonomous invas
214 erformance improvements over reference models, suggesting that register data could be leveraged to sy
215 y and increased hypoxia versus pre-resistance, suggesting that resistance occurs despite effective th
216 rose and increases in ethanol and lactic acid, suggesting that resource competition shapes organismal
217 istics that resemble those of unilateral BKAs, suggesting that restoring somatosensation may improve
218 expression and confers Enz resistance in CRPC, suggesting that SE-mediated expression of downstream e
219 plant iron stress triggers immune activation, suggesting that sensing of iron depletion is a mechani
220 ent sgn3 Casparian strip formation phenotypes, suggesting that SERK proteins also mediate GSO1/SGN3 r
221 s clones independent of intercellular bridges, suggesting that shared intrinsic properties are apopto
222 A-1 expression in the entire non-gonadal soma, suggesting that somatic sexual differentiation may be
223 specificity, and class-wide cross-reactivity, suggesting that some conserved epitopes, including two
224 cell numbers and impaired NK cell maturation, suggesting that STAT5b is involved in terminal NK cell
225 ool of some patients for greater than 4 weeks, suggesting that stool may hold utility as an additiona
226 associated with PR interval and QRS duration, suggesting that subtle changes in TBX3 expression affe
227 me instability in a wild-type (WT) background, suggesting that such mutants have the potential to pro
228 This effect was not retinotopically specific, suggesting that suppression of PM altered sensory inte
229 s blocked by reciprocal allosteric inhibition, suggesting that the 2 receptors exert distinct roles i
230 ave little or no effect on CKD-associated MCI, suggesting that the accumulation of uraemic neurotoxin
231 at develops independently of peripheral input, suggesting that the AL is initially pre-patterned and
232 tes maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from
233 F made the cells permissible to MNV infection, suggesting that the cause of resistance lies in the en
234 scription initiation element (TIE) of Klk1b21, suggesting that the cooperative function of EBE and TI
235 tion norm slopes at high ambient temperatures, suggesting that the current level of thermal plasticit
236 tween the short-term and long-term treatments, suggesting that the effects were largely if not entire
237 rogression, which enables crossover formation, suggesting that the establishment of MSCI permits the
238 y present in primary cultures but not in situ, suggesting that the expression of these receptors migh
239 tion between knowledge and social relatedness, suggesting that the farther scientists move from their
240 tivation by the NfsA and NfsB nitroreductases, suggesting that the formation of highly reactive nitro
241 e initially downregulated by PRMT5 inhibition, suggesting that the increased H3K27me3 could directly
242 e to cyclin D1 deficiency and CDK4 inhibition, suggesting that the obese/diabetic environment confers
243 10-fold improvement of intrinsic OER activity, suggesting that the observed activity increase is domi
244 images), and less affected by the sample size, suggesting that the optimal network structure is data-
245 to input transcription factor concentrations, suggesting that the stripe is shaped by the interplay
246 f pathology and toxicity in cells and in mice, suggesting that the structural differences may play im
247 PC4 in these fibroblasts restored trafficking, suggesting that the trafficking defect was due to redu
248 , impact cell competition-based host defences, suggesting that their effect on tumour risk may in par
249 o not overlap with results from other species, suggesting that there are multiple ways to generate va
250 ns is 31%, at Pasadena and 14% at Centreville, suggesting that there may be a larger reservoir of unm
251 nding pocket 7 (P7) of the HLA-DR heterodimer, suggesting that these alterations might account for th
252 and ManNAc instead of ManN in the core region, suggesting that these differences may contribute to th
253 h suppressed compared to those in the cytosol, suggesting that these kinases are regulated differentl
254 with putative endocrine pancreatic enhancers, suggesting that these SNPs modulate enhancer activity
255 lyzed adsorbates and particle-adhesion forces, suggesting that these species mediate adhesion by chem
256 in regressing plaques lacked Nrp1 expression, suggesting that they are induced in the periphery duri
257 nificantly weaker than those at telomere ends, suggesting that they are located in different regions
258 rm treatment with the NMDAR antagonist MK-801, suggesting that they arise from acute effects of compr
259 predominantly found on medium-sized vesicles, suggesting that they may be specific to microvesicles
260 lls manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a common appr
261 rsibly swellable walls found in various algae, suggesting that they may function in turgor buffering,
262 ing TDMD, miRNAs undergo tailing and trimming, suggesting that this is an important step in the decay
263 plant tissue are as virulent as the wild type, suggesting that this is due to alterations in the init
264 associated with the mouse segmentation clock, suggesting that this oscillator might be conserved in
266 at 24 h post inoculation in med15b.D mutants, suggesting that transcriptional reprogramming at this
267 lux, cell polarization, and ERK1/2 activation, suggesting that TrkA is an important player in the sig
268 ensity at the leading edge of polarized cells, suggesting that tubulin binding may play a role in MEK
269 illimeters squared of the immunostained tumor, suggesting that tumor sampling may influence interpret
270 ms of their contribution to catalyst efficacy, suggesting that tuning individual electronic environme
271 vely associated with prognosis in GC patients, suggesting that UBE2T is a promising target for GC the
272 xplained liability is within common variation, suggesting that variation predating the human diaspora
273 ies are shown to exist during crystallization, suggesting that volatile exsolution, crystallization,
274 teau at the level of the best natural enzymes, suggesting that we have exhausted the potential of MtC
275 .1 cluster A(H3N2)v viruses in young children, suggesting that young children are still at high risk
277 y, with fast axes perpendicular to its strike, suggesting the development of lattice-preferred orient
278 ted decreased viral fitness in cultured cells, suggesting the feasibility of using this deletion in t
279 ble for Alix-mediated rescue of virus budding, suggesting the involvement of other regions of the Gag
280 e-back task (OBT), not during passive viewing, suggesting the involvement of task-related feedback si
281 th increased phosphorylation of H2AX and CHK1, suggesting the modulation of transcription and DNA dam
282 proficiently incorporates dGTP opposite oxoA, suggesting the nascent oxoA:dGTP overcomes the geometr
283 cells than from physically impeded particles, suggesting the possibility for alternate Fe-acquisitio
284 can upregulate VGluT2 in surviving DA neurons, suggesting the possibility of a role in cell survival,
285 st persisting A. varius populations in Panama, suggesting the potential for genetic rescue in this sy
286 ent in therapy naive or fully resistant cells, suggesting the potential for new therapeutic intervent
287 ns is sensitive to exogenous addition of IFNs, suggesting the potential of IFNs as therapeutics.
288 y diminishes glioblastoma invasion and spread, suggesting the potential value of these proteins as th
289 ral factors bypass this translational shutoff, suggesting the presence of additional regulatory mecha
290 se IFNs show a reduction in viral replication, suggesting the prophylactic effectiveness of IFNs agai
291 h region originates from a SCN-H-O-Al complex, suggesting the surface site specificity of these exper
293 concomitant loss of triphenylphosphine oxide, suggesting their possible role as intermediates in an
294 d changes in structural brain characteristics, suggesting their usefulness not only as screening and
295 esional and nonlesional AD and psoriasis skin, suggesting their utility as a minimally invasive alter
296 ateral sclerosis (ALS), as early as childhood, suggesting these pathways are involved in disease risk
297 on, and more closely aligned to NoGo activity, suggesting this activity contributes to withholding of
298 eased the number of registrations on the AODR, suggesting this is a strategy that could potentially i
299 index are also hotspots of ecological rarity, suggesting transboundary responsibility for their cons
300 ed unaltered upon manipulating Wnt signalling, suggesting Wnt-related genes to be downstream effector