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1 ant formed puncta but failed to recruit Orai1, thereby preventing.
2 isrupt the generation of a chemokine gradient, thereby preventing a chemokine from properly performin
3 icipate in this resetting process in the worm, thereby preventing a decline in germ cell epigenetic s
4 forming growth factor-beta-activated kinase 1, thereby preventing a metabolic switch toward glycolysi
5 sk G(D2) or cross-reactive epitopes on nerves, thereby preventing a subsequent dose of unmodified 3F8
6 tects telomeres from being recognized as DSBs, thereby preventing a Tel1(ATM) checkpoint response.
7 of HDL binding to cell-surface proteoglycans, thereby preventing access of HDL to the plasma membran
8 ttached to 13 potential N-glycosylation sites, thereby preventing access to bound peptide and associa
9 creatitis maintains VAMP8-dependent secretion, thereby preventing accumulation of activated trypsin.
10 nt blocks to cell proliferation and apoptosis, thereby preventing accumulation of NO/RNS-generated mu
11 izes the membrane association of beta-catenin, thereby preventing accumulation of nuclear beta-cateni
12 ctively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic i
13 es activity of compartment-resident proteases, thereby preventing activation in other regions of the
14 at PMCs control BC fate by sequestering VEGF3, thereby preventing activation of alx1 and the downstre
16 ne or cell surface (e.g. flagella) structures, thereby preventing adhesion, disrupting specific virul
18 n distorts the receptor G-protein association, thereby preventing agonist-induced guanine nucleotide
19 motor deficit by removing early dying neurons, thereby preventing amplification of neuronal death fro
20 l morphologies in living reptiles and mammals, thereby preventing an accurate ecosystem reconstructio
21 revent a wasteful drain on cellular resources, thereby preventing an energetic crisis during stress.
24 colon epithelium in an EGFR-dependent manner, thereby preventing and treating DSS-induced intestinal
26 II-induced integrin activation in leukocytes, thereby preventing Ang II-induced recruitment of leuko
29 K1 ubiquitylation and proteasomal degradation, thereby preventing attenuation of S-phase checkpoint f
32 n of the immune system to be tolerant of self, thereby preventing autoimmunity, is facilitated by the
34 yrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of (2)b
35 Bcl6, inhibits T(FH) differentiation and help, thereby preventing B cell germinal center and antibody
37 the complex of VDAC1 and hexokinase II (HKII), thereby preventing Bax recruitment to VDAC1 and the r
41 ces persistent ssDNA-RPA overhangs in M phase, thereby preventing both classical NHEJ and Rad51-depen
42 ogenitor proliferation after genotoxic injury, thereby preventing both IR- and cyclophosphamide-induc
43 gomeric species and form long-lived complexes, thereby preventing both their further growth into fibr
44 maintain cellular ATP and thus PMCA activity, thereby preventing Ca(2+) overload, even in the face o
47 eferentially binds MurA liganded with UDP-NAG, thereby preventing catalysis by occluding PEP from acc
48 lopment during adolescence or early adulthood, thereby preventing catch-up from earlier acquired defi
49 esponsible for regulating hemichannel opening, thereby preventing cell damage through excessive flux
51 sary and sufficient to confer immunity to CDI, thereby preventing cells expressing the cdiBA genes fr
52 alterations in afferents to dopamine neurons, thereby preventing changes in dopaminergic activity un
54 ity for reducing the ClO3- intermediate to Cl-, thereby preventing ClOx- buildup and lowering Re comp
58 rm a hydrogen bond to the mutant R223 residue, thereby preventing competition between R223 and R152.
59 mplement regulatory protein factor H directly, thereby, preventing complement factor C3 deposition on
60 14-3-3sigma enhanced COP1 self-ubiquitination, thereby preventing COP1-mediated p53 ubiquitination, d
61 ion was inhibited at the membrane fusion step, thereby preventing core entry into the cytoplasm and e
62 main 1 of EspD as a key compound-binding site, thereby preventing correct assembly of the T3SS comple
63 cytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleteriou
66 comprising VEGFR2, PlexinD1, and neuropilin-1, thereby preventing degradation of internalized VEGFR2,
68 ponents control TLR3-mediated innate immunity, thereby preventing development of immunodeficiency and
70 d enhanced mitochondrial fatty acid oxidation, thereby preventing diet-induced obesity and insulin re
71 on gene MITF and the proapoptotic factor SOX9, thereby preventing differentiation, inhibiting cell de
73 a encapsulates mycobacterium-containing cells, thereby preventing dissemination and further infection
74 bits procaspase-8 activation at the CD95 DISC, thereby preventing downstream activation of the caspas
76 f HER3 heterodimerization and phosphorylation, thereby preventing downstream AKT phosphorylation.
79 ape being destroyed by the host immune system, thereby preventing effective immune control of infecti
82 ket encode a catalytically incompetent kinase, thereby preventing emergence of resistant variants.
83 s autophagy and maintains endosomal recycling, thereby preventing endosomes and autophagosomes from r
84 ion of multiple cell cycle-promoting proteins, thereby preventing epithelial cells from exiting the c
85 sitize" aged microglia to an immune challenge, thereby preventing exaggerated behavioral and neuroinf
86 egulate gene expression by counteracting SWR1, thereby preventing excessive accumulation of H2A.Z.
87 d angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.
88 he oxidized, aggregated material leaves cells, thereby preventing export of apoB-lipoproteins contain
91 s bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress,
93 fering with the binding of Groucho/TLE to TCF, thereby preventing formation of transcription represso
95 rium in favor of the non-slipped conformation, thereby preventing frameshifting and potentially enhan
96 uestrin depolymerization will limit depletion, thereby preventing full disassembly of the polymeric c
97 apical leaves and, once embolized, were shed, thereby preventing further water loss and protecting t
98 ithin 30 seconds after fusion with a sperm [3], thereby preventing further fertilization events, it i
99 izes GP and triggers premature release of GP2, thereby preventing fusion between the viral and endoso
100 phorylated G-protein-coupled receptors (GPCRs), thereby preventing G-protein coupling, triggering rec
101 of their cognate G protein-coupled receptors, thereby preventing G protein coupling and often switch
102 as wedges between the transmembrane segments, thereby preventing gating rearrangements that are nece
104 DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of i
106 ll expansion in lymphopenic hosts after aHSCT, thereby preventing GVHD without global immunosuppressi
107 ulted in CD8+ T cell exhaustion and apoptosis, thereby preventing GVHD, whereas PD-L1 interactions wi
109 distant from the dermal papilla are unscathed, thereby preventing hair greying typical of melanocyte
110 ssion of chemoattractant proteins (chemokines), thereby preventing harmful immune cells from penetrat
111 stemic metabolic homeostasis and inflammation, thereby preventing HCC by a non-cell-autonomous mechan
112 ecule drug that inhibits retroviral integrase, thereby preventing HIV DNA from inserting itself into
113 variations that interfere with immunogenicity, thereby preventing HLA-B 57-mediated immune pressure.
114 e factor(s) from attenuated transgenic arrays, thereby preventing HLB formation and gene expression o
119 electively inhibits allergen-IgE interactions, thereby preventing IgE clustering and mast cell degran
120 SDMD processing, but abrogates pore formation, thereby preventing IL-1beta release and pyroptosis.
121 ression dampens presentation of self antigens, thereby preventing inappropriate T cell activation tha
125 the virulence of pathogenic bacterial strains, thereby preventing infections caused by Staphylococcus
127 serted between ARM repeat 10 helices H1-H2-H3, thereby preventing intramolecular helical stacking ess
128 und trp RNA-binding attenuation protein (TRAP), thereby preventing it from binding RNA, and allowing
129 glycoprotein UL148 retains CD58 within the ER, thereby preventing it from reaching the cell surface,
130 ein Axin targets beta-catenin for destruction, thereby preventing it from transducing inappropriate s
131 retains Chs2 at the endoplasmic reticulum (ER), thereby preventing its translocation to the neck.
132 y bind and stabilize a nontoxic form of Abeta, thereby preventing its aggregation into toxic forms.
135 ter RD and associated with phosphorylated Akt, thereby preventing its dephosphorylation and further a
138 (LDL) receptor at the surface of hepatocytes, thereby preventing its recycling and enhancing its deg
139 mpairs the essential GTPase activity of EF-Tu, thereby preventing its release from the ribosome.
140 r, we show that ZCL278 also functions in vivo, thereby preventing Junin virus replication in a mouse
141 e and consequently disrupts LasR dimerization, thereby preventing LasR from binding to its target DNA
144 strains interfere with the activation of RecA, thereby preventing LexA cleavage and SOS induction.
146 pstream hepatocytes to downstream hepatocytes, thereby preventing local saturation of further detoxif
148 ed protein kinase restored sirtuin-3 activity, thereby preventing LPS and ethanol from stimulating th
150 ficiently blocked kidney cystine accumulation, thereby preventing lysosomal deformations and crystal
151 NPXY motif in beta integrin cytoplasmic tails, thereby preventing lysosomal degradation of beta integ
153 n and trapped the receptor in early endosomes, thereby preventing lysosomal trafficking and degradati
155 spermatogonial differentiation factor Sohlh1, thereby preventing meiosis and promoting spermatogonia
157 lization and down-regulate energy expenditure, thereby preventing metabolically beneficial adaptation
158 ART who are at high risk of transmitting HIV, thereby preventing morbidity and onward transmission.
160 e progression and promote repair or apoptosis, thereby preventing mutation accumulation and suppressi
161 maintain a stable level of uncomplexed HDAC3, thereby preventing mutual interference in the assembly
162 dation of myocardial Ca(2+)-handling proteins, thereby preventing myocardial apoptosis and necrosis.
164 can potently inhibit Nedd8 activating enzymes, thereby preventing neddylation of Cullin proteins and
165 tinuing or discontinuing exposure to artworks, thereby preventing negative emotions from becoming out
166 epare to respond to public health emergencies, thereby preventing negative impacts through planning a
167 ouples pericytes to the endothelial cell wall, thereby preventing neonatal intraventricular hemorrhag
169 quadrupole bender that deflects the ion beam, thereby preventing neutral contaminants from impinging
171 T2 attenuates the uptake of muramyl dipeptide, thereby preventing NOD2-dependent activation of NF-kap
172 uclein when the protein concentration is high, thereby preventing non-membrane-bound monomers from ag
173 e signals control the initiation of catalysis, thereby preventing non-productive double-strand breaks
174 d acts as a chaperone of the nucleoprotein (N), thereby preventing nonspecific encapsidation of cellu
175 tents, which permanently cage the vessel wall, thereby preventing normal coronary vasomotion, preclud
176 roduction, and decreased fatty acid synthesis, thereby preventing obesity-induced metabolic complicat
177 d shift of PCCs, are not expressed in the SCN, thereby preventing on RF a shift of the master SCN CC
179 entiated osteoblasts maintains bone formation, thereby preventing osteoporotic bone loss induced by o
180 1 and Aco-2 in preserving AEC mtDNA integrity, thereby preventing oxidant-induced mitochondrial dysfu
181 2alpha degradation and restored SOD2 activity, thereby preventing oxidative stress and hypertension.
182 g that inhibits ataxia telangiectasia mutated, thereby preventing p53 phosphorylation, inhibited DFO-
184 B1 "desensitized" microglia in the aged brain, thereby preventing pathological infection-elicited neu
185 isk is frequently low and misconceptions high, thereby preventing patients from seeking treatment ear
186 PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and al
187 rt of HLA class I (HLA-I) to the cell surface, thereby preventing peptide presentation to CD8(+) T ce
188 due to ATP elevation by increased glycolysis, thereby preventing phosphorylation and inactivation of
189 tail tip to push against the vertical surface, thereby preventing pitch-back of the head and upper bo
190 ambient concentrations of splicing activators, thereby preventing poisoning of key transcripts and di
194 ion and activity of meiotic Polo-like kinases, thereby preventing premature interaction with stage-in
196 rogates injury-induced externalization of TG2, thereby preventing profibrotic crosslinking of extrace
197 cells die as a consequence of Stk2 activation, thereby preventing propagation of the phage to the res
198 ior to a surge in collagen synthesis at night, thereby preventing protein misfolding and ER stress.
199 inflammasome priming and caspase-1 activation, thereby preventing pyroptosis independent of GSDMD tar
200 heir pyrroline ring intermediate(s)/product(s), thereby preventing pyrroline tautomerisation from inh
201 onto the solid surface near the column inlet, thereby preventing QD attachment, whereas in the down-
202 minimize the formation of faulty proteasomes, thereby preventing recognition and inhibition by Ecm29
203 f PAR levels in the nucleus and the cytoplasm, thereby preventing release of AIF from mitochondria an
204 translocation stops specifically at XerCD-dif, thereby preventing removal of XerCD from dif and allow
206 ellular pool of deoxynucleoside triphosphates, thereby preventing reverse transcription of retroviral
207 li lactate dehydrogenase as an NADH scavenger, thereby preventing reversible formaldehyde reduction.
208 btype abolishes interaction of RFWD3 with RPA, thereby preventing RFWD3 recruitment to sites of ICL-i
209 -Papas syndrome, inhibits its kinase activity, thereby preventing RIPK4-mediated IRF6 activation and
212 kpoint inhibits mitotic entry upon DNA damage, thereby preventing segregation of broken chromosomes a
213 xia telangiectasia mutated in recipient cells, thereby preventing senescence and allowing blood vesse
216 ak2-mediated Hck activation is also inhibited, thereby preventing Stats serine phosphorylation, which
217 ponent YAP negatively regulates Wnt signaling, thereby preventing stem cell overpopulation after a re
218 nd-independent homotypic receptor preassembly, thereby preventing sTNF-induced, but not mTNF-induced,
219 mproving learning about the traumatic context, thereby preventing subsequent development of symptoms
221 hibitors physically trap the synaptic complex, thereby preventing target DNA binding and thus concert
222 of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic
223 P) only recognizes cultures as 'type material', thereby preventing the naming of uncultivated organis
224 ted amount of material (one to three colonies) thereby preventing the need for subculturing bacterial
225 te of alpha(IIb)/beta(3) integrin (GPIIb/IIIa), thereby preventing the activated integrin from reacti
226 hase-promoting complex/cyclosome (Cdc20-APC/C), thereby preventing the proteolytic destruction of sec
227 membrane (PM) to the trans-Golgi network (TGN), thereby preventing the recruitment of active Lck to t
228 tablishes a strong intramolecular interaction, thereby preventing the access of the cyclophilin domai
229 plexes and supports the ubiquitination of H2A, thereby preventing the accumulation of DNA/RNA-hybrids
230 n altered MHCII-bound self-peptide repertoire, thereby preventing the activation of diabetogenic T ce
231 is up-regulated to make LTD induction harder, thereby preventing the adverse effect of excessive LTD
232 ient cells ATF3 remains bound to the promoter, thereby preventing the arrival of polymerase II and th
233 ethane to methanol in methanotrophic bacteria, thereby preventing the atmospheric egress of approxima
234 population of inactive junction conformations, thereby preventing the binding of processing enzymes a
236 ofibrils and crosslinks other wall components, thereby preventing the collapse of conductive vessels,
237 edes the progression of cells through S phase, thereby preventing the completion of host DNA replicat
238 e relative abundance of Prevotella in the gut, thereby preventing the destruction of the intestinal b
239 asures to modulate the innate immune response, thereby preventing the detrimental effects of sepsis.
240 proach for restoring the reparative potential, thereby preventing the development of ischemic vascula
241 of B lymphocyte-induced maturation protein-1, thereby preventing the down-regulation of transcriptio
242 -like lesions that later completely regressed, thereby preventing the emergence of mammary tumors in
243 ing: AKT phosphorylates TopBP1 at Serine 1159, thereby preventing the enhanced association of ATR wit
244 s assembled in a modular way via subcomplexes, thereby preventing the formation of a functional H(+)-
245 peroxidation in hypercholesterolaemia rabbit, thereby preventing the formation of atherosclerotic pl
246 s for occupancy of highly regulated promoters, thereby preventing the formation of repressive chromat
247 grees C for 1 hour resulted in E6 degradation, thereby preventing the formation of the E6-p53 complex
248 C activation while inhibiting TAFI activation, thereby preventing the generation of the antifibrinoly
249 tion that promotes interaction with arrestins, thereby preventing the interaction of GPCRs with heter
250 ntify subsets of the samples with low quality, thereby preventing the loss of complete samples when r
251 ning 3 while enhancing the expression of EZH2, thereby preventing the loss of H3K27Me3 in the irradia
252 rting cholesterol to inert cholesterol esters, thereby preventing the negative feedback elicited by u
253 ntains fluid-epithelial interface homeostasis, thereby preventing the onset of inflammatory condition
255 creates an iron(III)-hydroperoxo intermediate, thereby preventing the possible thiolate dioxygenation
256 s the probability of Ca(i) sinkhole formation, thereby preventing the post-shock reinitiation of vent
257 ATP binding to TAP and, thus, activity of TAP, thereby preventing the presentation of viral peptides
258 cells reduced p38MAPK and MAPK/ERK signaling, thereby preventing the progression of benign papilloma
259 inhibit the recruitment of the cyanobacteria, thereby preventing the reoccurrence of cyanobacterial
260 intermediate acceptors of cellular-derived UC, thereby preventing the saturation of HDL particles and
261 ctional groups allows for copper complexation, thereby preventing the separation of the copper cataly
262 alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is require
264 e incoming virion-associated minus-strand RNA, thereby preventing the synthesis of viral mRNAs, and c
265 would disrupt the ECM-integrin signaling axis, thereby preventing the transformation into the insulin
266 ent on the amount of (13)C label accumulation, thereby preventing the use of a common basis set.
267 ry dendritic cells to the adipose compartment, thereby preventing their accumulation in the mesenteri
268 ing their surface and binding phage particles, thereby preventing their attachment to the cell exteri
269 oid volatiles into noncleavable triglycosides, thereby preventing their deglycosylation and release f
270 (AB blastomere) several cell divisions later, thereby preventing their forced reprogramming by an en
272 and efficiently internalizes these chemokines, thereby preventing their interaction with other chemok
273 which HdeA stably binds substrates at low pH, thereby preventing their irreversible aggregation.
274 udding of peroxisomal importomer subcomplexes, thereby preventing their premature assembly at the ER.
275 me slit-dependent shape slivers were shuffled, thereby preventing their spatiotemporal integration, s
276 ty of broken DNA ends in G1-phase lymphocytes, thereby preventing these DNA ends from accessing repai
278 and inhibits its interaction with syntaxin17, thereby preventing these two host SNARE proteins from
280 iscrimination of microbial "foe" from "friend," thereby preventing tolerance to a common skin pathoge
281 6 (P6) and older, outer segments were absent, thereby preventing trafficking of outer segment protei
283 alciparum gametocytes in infected human hosts, thereby preventing transmission of malaria to mosquito
284 iparum and blockade of gametocyte development, thereby preventing transmission, and also showed paras
286 to the amino half of spectrin repeats of TRIO, thereby preventing TRIO's amino half of spectrin repea
287 UmodC147W/+ mice by reducing active caspase-3, thereby preventing tubule cell death and loss of epith
290 strain their growth by monitoring IL-2 levels, thereby preventing uncontrolled responses and autoimmu
291 ons can be avoided by tuning the contact time, thereby preventing unfavourable oxygen surface coverag
292 collectively preclude their final maturation, thereby preventing untimely tRNA and mRNA binding and
293 the aggregation in different protein systems, thereby preventing unwanted aggregation and enabling t
294 ails to appropriately traffic USP18 to IFNAR2, thereby preventing USP18 from negatively regulating re
295 by enabling VEC-related phosphatase activity, thereby preventing vascular leak during alveolar hypox
296 same binding site to interact with vIL-6 RNA, thereby preventing vIL-6 RNA from association with the
297 ng between the virus and cell-surface glycans, thereby preventing viral entry into the cells and, as
299 of the viral and cellular endosomal membranes, thereby preventing virus entry into the host cell.
300 L3 Delta403-459 targets KLHL3 for degradation, thereby preventing WNK degradation, whereas general lo