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1 cipants could perform monthly home monitoring, though 1 participant stopped after 4 months (adherence
2 6 days, the overall case fatality rate was 33%, though 25% remain admitted.
3 ients' satisfaction nor their quality of life, though a certain patient reluctance to undergo future
4 d levels varied significantly among locations, though a consistent stepwise decrease from healthy tis
5 port were independent of RSLD phosphorylation, though a hyperphosphorylated mimetic mutant failed to
6 ible for the observed yjbIH mutant phenotypes, though a minor role exists for the putative truncated
7  under control and disease progression at bay, though a small subset of HIV-infected subjects can con
8 mylation (AHF) of alkenes to chiral aldehydes, though a topic of high interest, the contemporary deve
9 reatment at teaching hospitals also increased, though accompanied by marginally higher cost.
10 d that most parameters are minimally affected, though activation energy is impacted quite substantial
11                                 In conclusion, though AE-related study drug discontinuation was highe
12 ally beneficial by reducing cord inflammation, though after rewarming these benefits are lost due to
13 tients demonstrated low-level ADA at baseline, though all children tolerated IV-ERT well.
14 his doctoral advisor William Henry Perkin, Jr., though all but two appeared after Robinson had taken
15 frequently pursued for optical communications, though also for other specialized applications such as
16 chanism driving these changes remains unknown, though altered expression of ubiquitin proteasome syst
17 myocardium in larger organisms is challenging, though, and remains to be established for models of ch
18 d distinct networks of HGT across individuals, though AR and mobile genes are associated with more di
19 al bioluminescent probes are limited in scope, though, as they cannot be easily distinguished in biol
20 om these three simulants at even trace levels, though attention should be paid to some specific analy
21 egative fitness outcomes in response to HIREC, though beneficial fitness outcomes may occur in some c
22 have potential as functional food ingredients, though benefits may not be simply due to flavonols.
23                          Only gamma is active, though both gamma and delta' functionally influence an
24 RE11A (p.W210C) tended to show slower mitosis, though by far not as significant as RAD50-deficient ce
25 esponse to anthropogenic habitat modification, though caribou data were limited.
26 l factors were generally of lesser importance, though catchment slope and habitat size constraints we
27 ure to radiation in their natural environment, though causal attribution of gene responses remains un
28 omodulatory role through complex interactions, though causality has not yet been fully demonstrated.
29 prescribing (RR, 0.4; 95% CI 0.2-0.8; P = .01), though collinearity between viral testing and clinica
30 wed better contractility with coarse graining, though connectivity was still markedly reduced for thi
31  a viable alternative treatment option for CL, though cost and lack of local availability may limit i
32  across teaching and nonteaching environments, though costs were higher at teaching hospitals.
33 r synchronous discharges in the temporal lobe, though critical microcircuit-level detail is missing f
34 cating that they are part of a core mycobiome, though crop management influenced richness and diversi
35  difference in average total hospital charges, though daily hospital charges were significantly lower
36 ealth Organisation guidelines recommend fixed (though disease-specific) waiting times for end-of-epid
37 e a significant effect on aggressive behavior, though dominant females had elongated estrus cycles (d
38                 Injections of siRNA into skin, though effective, are painful and cover small surface
39 TV sequence led to apparent cure of infection, though effects on worm health or behavior were not obs
40 g reduced seedling emergence of all genotypes, though emergence of AG1 + AG2 introgression lines was
41                 Enamel density was unaffected, though enamel volume was significantly reduced in Hyp
42 and MSH2-MSH3 bind to Z-DNA-forming sequences, though ERCC1-XPF recruitment to Z-DNA is dependent on
43 in open savanna versus acacia thicket habitat, though escape success was consistently underestimated.
44 ified reliably using NIR images in many cases, though eyes with a thin choroid resulting in isoreflec
45 s have been investigated as vaccine adjuvants, though few direct comparisons exist.
46 alyzed C(sp(3))-H functionalization reactions, though few examples of Pd(IV) complexes containing cyc
47 inating process, even in lesions <2 weeks old, though fibrosis was more evident after 6 weeks.
48                                   Her account, though, focuses narrowly on internal cognitive mechani
49  better in reducing C(free) PAHs than biochar, though for 2- and 3-ring PAHs, the differences in AC a
50 ificant improvement of 1.2% (p < 0.05) for HS, though for keloids this was 0.4% (p = 0.26).
51  sensation from the hand, can be debilitating, though functional recovery does occur.
52                                       However, though fungicides have greatly contributed to substant
53 SM as a predictive marker for redox therapies, though further in vivo work is needed.
54 preference for an in-person training workshop, though further investigation is needed to determine wh
55 an be elucidated from the structural proteome, though future experimental work is needed to validate
56 ptomatic individuals who were later diagnosed, though future longitudinal studies are required to con
57                  All patients were discharged, though &gt;50% had persistent hepatitis up to 1 month aft
58 ing risk (RR 1.31; 95% CI 0.78-2.18; p = 0.31), though had higher risk of CRNMB (RR 1.60; 95% CI 1.13
59 tion assay (CSA) can overcome this limitation, though has mostly been used for detection of relativel
60 ention that was less than Alzheimer's disease, though higher than age-matched, cognitively normal con
61 ved to contribute to flexible decision making, though how their relative contributions differ remains
62 ion to evade CD8(+) T cell immunosurveillance, though how this is accomplished is not always well def
63 ders of magnitude higher than in brain tissue, though how this might impact NO signaling dynamics is
64               We also show that the microglia, though important for the initiation of neuroinflammati
65  years of delivery of the PopART intervention, though important gaps remained among men and young peo
66 g underrepresented minority 11th-12th graders, though in both cases adjustment for multiple compariso
67 ssors on species and ecosystems independently, though in reality, stressors often interact in ways th
68 populations, consistent with the 3M phase-out, though in sharp contrast to overall increasing trends
69 of sieve elements; they represent a conundrum, though, in the context of the widely accepted pressure
70  could be reactivated in both culture systems; though, in contrast to 2D cultures, it appeared to be
71 tion and neuroinflammation were significantly, though incompletely, prevented.
72 heir walking patterns more slowly than adults, though individual children ranged from slow to adult-l
73  [95% confidence interval, .24-1.69]; P = .37), though individuals who reported OPS were more likely
74 havior, morphology of mouth parts, and saliva, though information on the specific composition of the
75                                   Their scope, though, is still limited to date by the requirement fo
76 kinase (OR 3.79; 95% CI 1.06, 13.51; p = 0.04), though it was strongly associated with a decreased ri
77               These findings suggest that CEM, though it achieves good covariate balance, may not be
78 ersing both repetitive and non-repetitive DNA, though it becomes crucial at long CAG repeat lengths.
79 s in a rodent model has not yet been achieved, though it could provide a means of studying the human
80 ut failed to show efficacy in clinical trials, though it has been suggested that it may be effective
81 and the least elongated shape of the vesicles, though it is related to fast ejection of a low viscosi
82      This pattern affects the market fairness, though it may be helpful to incentivise emission abate
83 typically developing (TD) and ASD individuals, though it remains unclear whether the microbiome contr
84 t on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue
85 tcomes in multivessel coronary artery disease, though its impact in diabetic patients has never been
86 ave poorer prognosis than normal-flow (NF) AS, though its pathophysiology remained unclear.
87 ing activation by pathogen-associated stimuli, though its role during virus infection is largely unkn
88 emographic and admixture analyses showed that, though Jeju horse is genetically the closest to the Mo
89 past 10 years have been particularly fruitful, though key aspects about V- and Fe-nitrogenases remain
90                                           And, though known to be anisotropic, there is a limited und
91 ied but no obvious loss of function mutations, though large heterozygous deletions are known to be co
92 an visual inputs can support grid cell firing, though less accurately, in complete darkness.
93 er sensory integration sites that also differ, though less extensively, between the male morphs.
94 s also play important roles after development, though less is understood about their functions in the
95 R) as proposed sites of molecular recognition, though limited biochemical evidence exists regarding t
96 ng healthcare outcomes over the past 30 years, though limited power source access and user wearabilit
97 hin all major primate groups examined to date, though little is known about introgression deeper in t
98 scussion focuses primarily on ex vivo tissues, though many considerations are relevant in vivo as wel
99 dry cycles atop a general aridification trend, though may underestimate the impact of local-scale con
100 ated with higher driving simulator crash risk, though mechanisms explaining this relationship remain
101 aturia (and hypercalciuria) in both genotypes, though mice remained normophosphataemic.
102                                       Notably, though, ML-265-treatment did reduce entrance into the
103 ethylmercury (MeHg) in dried blood spots (DBS) though more research is required to evaluate mercury (
104 ration cards (PSCs) have become available and, though more expensive, have lower total misclassificat
105 al interference with a novel pandemic vaccine, though more studies are needed to determine if this is
106 olitinib and 8.8 for the crossover population), though most anaemia events were mild to moderate in s
107  have originated in the primitive environment, though most contemporary biomonomers don't spontaneous
108 ateau, southwestern USA, are strongly debated, though most hypotheses acknowledge the importance of n
109 es in this experiment were more heterogeneous, though most participants adopted an asymmetric gait.
110 genes associated with hibernation are present, though most significantly, that gene ontology categori
111 ucose homeostasis in obesogenic animal models, though much of the evidence supporting this premise is
112 en manure, compost, etc.) in crops is low (27%), though N recovery in subsequent years (10%) was grea
113 f phosphate only in jejunum of wild-type mice, though NaPi-IIb protein expression was upregulated in
114 racterized the ecosystem as highly threatened, though natural processes such as erosion can also play
115 es can be utilized in flow battery technology, though naturally occurring quinones have not yet been
116 near infrared wavelengths to disable subjects, though near infrared sources remain attractive given t
117  baseline acuity vs 13.4 lines lost; P = .031), though no difference was observed at 6 months after t
118 ibited an increased occurrence of bradycardia, though no changes in stroke volume or cardiac output w
119 and had been at the correct, first time point, though no stimulus had occurred at that location.
120 py, particularly with impaired renal function, though no studies have reported ceftaroline-associated
121  date, many serology LFAs have been developed, though none meet the performance requirements necessar
122 te complaints than those in the placebo group, though none were judged to be serious.
123  beta-cell-specific knockout mice (NOX4betaKO) (though not from NOX2 knockout mice) and from NOX4-sil
124 with the presence of microinfarcts (P = 0.025), though not microbleeds (P = 0.973).
125 associated facies (e.g., turbidites, debrites), though not without controversy.
126 T(VM)) has been described that possesses many, though not all, features of "true memory" T cells, wit
127                     Our finding suggests that, though not an independent risk factor, COex could pote
128          We show that imputation can mitigate, though not eliminate reference bias in ultra-low cover
129                These findings show a critical, though not exclusive, rEPN role in cocaine's aversive
130 he full-length gB protein and mRNA-LNP groups, though not in ectodomain-vaccinated rabbits.
131 ic CO(2) abundance and ensuing climate change, though not proportionately.
132 onse is required for changes in PIN1 polarity, though not sufficient.
133 rature of 160 degrees C led to PAHs formation, though not the heavy ones.
134 fferent contexts to compartmentalized "states." Though not often framed this way, the maladaptive beh
135 064 deaths) the findings were broadly similar, though obese individuals with high mMED retained a mod
136 mble the evolutionary diversification of bats, though on a smaller scale.
137                                         Often, though, one can access additional information regardin
138             Most studies performed genotyping, though only 5 studies performed genome-wide associatio
139 and C termini to inhibit GPCR phosphorylation, though only the C domain interaction disrupts GRK5 mem
140 ced brainwide dFC but increased brainwide eFC, though only the former effect survived multiple compar
141                                        So far, though, only DNA microarrays for the authentication of
142 eologically diverse audiences converge online, though our analysis also reveals that more than half o
143 be present in active gel filtration fractions, though OZ1 and ORRM1 were mainly found in low-MW inact
144 tion rates vary widely (0.001 to 5.39 cm h(-1)), though parcels are generally well-vegetated and gent
145                                  Additionally, though past experience can sometimes make simulations
146              The cohorts were largely similar, though patients with higher tumors (69.9% vs 47.5%, P
147 olutionary dynamics between host and parasite, though patterns of phylogenetic community structure of
148 LDL cholesterol and have good safety profiles, though PCSK9 inhibitors remain costly.
149 s is an important cause of mortality globally, though population incidence estimates from low income
150 er in subjects vaccinated with prior-year IIV, though postimmunization titers were generally high.
151                                  The proteins, though present, do not contribute to the measured sign
152 timulate subcortical arousal-promoting nuclei, though previous studies yielded inconsistent results.
153 jecture in the context of function prediction, though questions about the evolution of function remai
154 g and complex responses for each anion tested, though reaction between the anion and receptors was ob
155 galovirus, Epstein-Barr virus, and adenovirus, though recent published studies have successfully targ
156 or CAD were higher in patients with LVEF <=40% though remained low.
157                       How it breaks membranes, though, remains unknown.
158 on chemists' ability to interpret NMR spectra, though research demonstrates that cultivating such pro
159 ed to play roles in breast cancer development; though, results are inconsistent.
160 ity itself may be developmentally constrained, though rigorously testing this hypothesis requires mor
161 he adult brain, mainly in the mushroom bodies, though sema1a.2 was expressed most robustly.
162 r in Flublok and Fluzone High-Dose recipients, though seroconversion rates trended higher in Flublok
163 r in Flublok and Fluzone High-Dose recipients, though seroconversion rates trended higher in Flublok
164 relatively small differences in feature value, though several features were highly sensitive to these
165 alth effects of terpenes are not widely known, though several studies have suggested that they may pr
166 cally significant (P = 0.71) Further analysis, though, showed that SLT had a significantly lower IOP
167 tivation for visiting nature was high for all, though slightly lower for those with CMDs.
168 natural losses declined between 2000 and 2016, though slower declines in natural loss caused an incre
169 nd non-synaptic mitochondrial sub-populations, though small brain regions cannot be assayed due to lo
170 ia is a next-generation sequencing gene panel, though some conditions necessitate specific types of t
171 dividuals at-risk for Alzheimer's disease (AD), though standard cognitive assessments typically study
172 he least basic of the six lipid types studied, though still more basic than alanine.
173 nge (IPCC) has proposed EFs of 0.25% and 0.75%, though studies have suggested that both these values
174  failed to report the duration of home visits, though studies which started prenatally showed the mos
175 are associated with P2Y12 inhibitor selection, though substantial hospital variation exists.
176 roteinuria are the cornerstone of the disease, though systemic organ dysfunction may ensue.
177 es where mutations are known to accelerate PD (though the target sequences, in this study, were wild-
178 easing on bringing radical fragments together (though the total energy change is substantially stabil
179  are toxic to most animals - including humans - though the larvae of many moths and butterflies (orde
180 mpact survival (case fatality rate, 34% vs 35%), though the BTKi was held during the COVID-19 course
181 /- 3.7 %ID/g vs. 3.0 +/- 0.8 %ID/g, P = 0.006), though the efficiency of cardiomyocyte suppression wa
182 ess than the reference diet ($1.03/kg tilapia), though the median feed cost ($0.68/kg feed) was sligh
183 isk of oedema (RR: 2.21, 95% CI: 1.48 to 3.31), though the risk of hypoglycaemia was absolutely lower
184 o capture all nationalities of UAMs in Greece, though the 2 most common nationalities, Afghan and Pak
185 pes may also be prevented by prompt treatment, though the association was not as strong, which may be
186 l life years compared to very unhealthy score, though the association was not significant, whilst a h
187  altered brain function and pathological mood, though the cellular and molecular mechanisms of this p
188  of the symbiont cell cycle in the G(1) phase, though the cellular mechanisms involved remain unknown
189 ellar vermis may regulate aggressive behavior, though the cerebellar circuits and patterns of activit
190 ould address the limitations of these methods, though the complex problem of classifying variable beh
191 singly recognized as groundwater contaminants, though the composition and distribution of AFFF-derive
192 extreme rainfall and water limited conditions, though the degree to which these weather impacts are r
193 esponded almost instantaneously to subdaily D, though the direction of this response depended on ante
194  Members of the Ascomycota were most dominant, though the exact function of most taxa remains unclear
195 disruption in intrauterine immune homeostasis, though the exact origins are incompletely defined.
196 xpresses two T cell receptor (TCR) clonotypes, though the extent and functional significance of this
197 s, including progeria, myopathy, and dystonia, though the extent to which endogenous mechanical stres
198                         Our results show that, though the four specimens represent extinct wolf linea
199 SPCs were associated with cell death pathways, though the high-importance gene sets were found to be
200 t associated with worse disease-free survival, though the HR for >=Q3 was 2.32 (95% CI 0.90-5.97, P =
201 duction and post-harvest challenges in carrot, though the identity of these microbes as well as facto
202 petition for land if applied at a large scale, though the impact is scale and context specific, highl
203 sitive) charges to ATP enhance reaction rates, though the impact of these contributions on nucleotide
204 ed little support for the ortholog conjecture, though the incomplete nature of the data cast doubt on
205 products inhibited growth of Escherichia coli, though the inhibition was mitigated by the presence of
206 ignal using [3H] CP-55,940 and [3H] SR141716A, though the latter exhibited a lower signal to noise ra
207 iated burst firing of thalamocortical neurons, though the latter is not essential for seizure express
208 e immediately recruited to the site of damage, though the local enrichment of PCNA persisted longer t
209 rate reductions in disease risk, respectively, though the magnitude of these changes depends on paras
210 its CXXC domain, TET1 also binds to enhancers, though the mechanism involved is unknown.
211 hancer activation during cell differentiation, though the mechanism is incompletely understood.
212 ctive proteins are good electronic conductors, though the mechanism of conduction is not yet understo
213 d aggregation are implicated in ALS pathology, though the mechanism(s) of TDP-43 and FUS cytoplasmic
214  in cannabis, causes fetal growth restriction, though the mechanisms are not well understood.
215 on and low-level expression of viral proteins, though the mechanisms involved in synaptic damage are
216 hotspots of diversity, biomass, and abundance, though the mechanisms responsible are poorly understoo
217 th greater weight gain among persons with HIV, though the metabolic consequences, such as diabetes me
218 ttributed to its secreted toxin, candidalysin, though the molecular mechanisms are poorly understood.
219  to efficiently determine individual identity, though the neural mechanisms underlying this process a
220 tly surfaced as promising strategies for PTSD, though the neurobiological mechanisms underlying their
221 en LN cells were challenged with Ova in vitro, though the number of regulatory T cells (Treg) in the
222 ession in follicular fluid has been described, though the number of studies remains small.
223 st current-driven dynamics have been reported, though the origin of this DMI is unclear.
224 y angiography in states with public reporting, though the point estimate suggested decreased utilizat
225 tute a first-line antidepressant intervention, though the precise cognitive and computational mechani
226 , involves pathological alpha-syn aggregation, though the process is centred around oligodendrocytes
227 ternatives remain less hazardous than decaBDE, though the range of hazard of the five alternatives wa
228 hemical features suggestive of Lynch Syndrome, though the rapid progression to cancer within the surv
229 declined significantly over the past 10 years, though the rate was slow at some sites.
230 this family is divided into three classes and, though the regulated transporter activity of class I p
231                                       However, though the relative abundance of ecosystem areas with
232                                       However, though the relevance of these studies depends upon hum
233  the cystathionine-beta-synthase (CBS) domain, though the role of this domain is not fully understood
234 el biomass fraction of ectomycorrhizal plants, though the strength of this relationship varies across
235 s also been proposed to suppress tumor growth, though the underlying mechanism is unknown.
236 endosome maturation, Rab5 is replaced by Rab7, though the underlying mechanism remains poorly underst
237 cryo-EM structure of the bovine CLC-K channel, though the volume of the intracellular (inner) region
238 are thought to be involved in causing disease, though, the exact mechanism by which EAEC causes diarr
239 n the conventional artificial neural networks, though their full computational capabilities are yet t
240  that are also used in public health research, though their performance has not been assessed in many
241 oles in cell division control and development, though their precise molecular functions are not fully
242 ins (LICs) 1 and 2 are cargo-binding subunits, though their relative roles are not well understood.
243 ved in response to faces vs. non-face stimuli, though there were no drug effects at any dose.
244 irst and second sampling moment, respectively), though these differences were not significant.
245 pared to raltegravir (3.4 kg) and PIs (4.1 kg), though these differences were not statistically signi
246 ix and cell-cell adhesion remained unaffected, though these activities did require FGFR kinase activi
247 so far to undergo head-to-tail polymerization, though these are widespread among all living kingdoms.
248 eobacteria became more dominant after 30 days, though these communities showed no evidence of methano
249                                       However, though these data sets have been widely utilized, thei
250 J, but BP (ND) was higher for (18)F-SynVesT-1, though these differences were not significant.
251 dder disease followed by death were increased, though these findings may primarily reflect single-out
252  signalling, such as behavior and habitat use, though these have substantial potential to alter signa
253 ed after SOT due to logistical considerations, though these may be overcome by novel methods to monit
254  used to measure neutrophil elastase activity, though these tools lack specificity and traceability.
255 ilure than those not at risk (odds ratio=0.51), though they were less likely to experience remission.
256 ent years and seasons, and at all local times, though they are generally small in magnitude relative
257 mentally undifferentiated states in adulthood, though they are generated before birth.
258  as regulators of smooth muscle contractility, though they display different sensitivities to signali
259 ibosomes to determine where initiation occurs, though they do affect how efficiently initiation occur
260  deaths from a low dose (10(3) PFU) challenge, though they experienced viremia and body weight loss.
261 st, typically based on Cu(2+), d(9) compounds, though they feature structural imperfections.
262     Over time, the rates slowed substantially, though they remained well above the bulk rate.
263 apentine-isoniazid was 0.53 (90% CI 0.49-0.56) though this ratio varied by day after rifapentine-ison
264 er stiffness than amputee subjects (p < 0.001), though this depended on the amputee subject (p < 0.00
265  0.182 +/- 0.114 to 0.486 +/- 0.139, P = .002), though this rise did not match pyruvate dehydrogenase
266 fibrosis as an indicator of organ involvement, though this approach is highly subjective and relies o
267 als, and 1D quantum anomalous Hall insulators, though this can be applied to similar systems.
268 emporal refugia for canopy-dwelling organisms, though this effect is temporary and confined to daylig
269  to be made useful in a point of care setting, though this half-strip LFA may serve as a useful start
270 rA), which is encoded by the 8.3 kb gene perA, though this has not been conclusively proven.
271 d Amazon tree is impeded by riverine barriers, though this has not yet resulted in speciation.
272 in and soft tissue infection (SSTI) incidence, though this is burdensome and costly.
273                                       However, though this marginally improved performance for bounda
274 en unable to discern between these two models, though this may be because of the relatively low spati
275 ses with increasing environmental variability, though this pattern was only significant for aridity,
276  motion has been to use shorter MRI protocols, though this reduces the reliability of results.
277 onstrated to be essential for Rv2509 function, though this region did not seem to play any role in pr
278 tly identifies patients at risk for mortality, though this risk is only increased in patients with se
279  it estimates a "lifetime effect" of exposure, though this term remains vaguely defined.
280 terial were also distinguishable from plastic, though to a lesser extent.
281 ought to promote emerging infectious diseases, though to date, evidence linking climate changes and s
282                           In Study 1 (N = 200), though total drinking time was equivalent, participan
283 (SSTR2)-expressing neuroendocrine tumour (NET) though tumour regression occurs in only a minority of
284 ts DD-mediated interaction and ubiquitination, though underlying mechanisms remain incompletely under
285 istance of metals, is a useful transformation, though understanding the mechanistic underpinning of s
286                                 This approach, though underutilized in psychiatric genetics, has seve
287    I propose that sodium also plays a central, though unheralded role in herbivore digestion, via its
288 egment-elevation myocardial infarction (STEMI), though use in recent practice is not well described.
289 1 overexpression also did not rescue myotonia, though variable rescue of Clcn1 splicing and other spl
290 ep earthquake in the 0.01-1 Hz frequency band, though waveform fidelity is low at high frequencies.
291 y prey which can be tracked to a final source, though we found no evidence to suggest that he had the
292 be equally economically viable at local level, though we note several ecological limitations to this
293 viously ignored 'dark proteome' is increasing, though we note that research in eukaryotes and bacteri
294                  Across the three populations, though, we find that targeted "salutary sheltering" by
295 associations with exercise and a healthy diet, though weaker than the association with body mass inde
296 l vertebrae also arise through resegmentation, though with a duplication of the number of vertebrae p
297 avioral phenotypes of single Gtf2ird1 mutants, though with the caveat that our Gtf2ird1 mutants, like
298 SUV(max) (6.6%-8.7%) and SUL(peak) (9.2%-11.3%), though without significant repeatability differences
299  is prevalent in S. mediterranea lab colonies, though without causing evident disease.
300 rRNA genes were often detected simultaneously, though without correlation as previously observed.

 
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