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1 or 8 weeks induced extensive hepatic fibrosis, whereupon 1D11 dosing was initiated and maintained for
2 adication is frequently not achieved with MTD, whereupon a de facto goal of longer-term tumor control
3 icase E1 to an A/T-rich origin of replication, whereupon a dihexamer forms, resulting in DNA replicat
4 ptors on the cell surface and is internalized, whereupon a pH drop in the endosome (pH approximately
5 ble migration of the endo oxo out of the cone, whereupon a second silylation affords the stable U(IV)
7 pond by triggering RIPK3-mediated necroptosis, whereupon a third T3SS effector, EspL, acts to inactiv
8 KC to relatively common anionic phospholipids, whereupon a two-dimensional search is initiated by the
9 )O, little change was observed until ~15 mass% whereupon an exponential increase in rate occurred unt
10 sylceramide in live cells or in mouse tissues, whereupon an HPLC assay enabled detection and quantifi
12 the membrane to the inner part of the cytosol, whereupon another diffusion-trapping mechanism involvi
13 +/-6 days until the development of TIC and MR, whereupon biplane videofluoroscopy and transesophageal
15 Uniform stimuli trigger a symmetric response, whereupon cells stop and round up; then localized patc
16 oplasmic reticulum to the trans-Golgi network, whereupon Cer is converted to sphingomyelin (SM) and o
17 bjected to non-surgical periodontal treatment, whereupon changes in salivary CSF-1, IL-34, and MMP-8
20 papillomavirus virion uncoats in the endosome, whereupon conformational changes result in a dissociat
21 ied strategy is described for their synthesis, whereupon cross-conjugated ketones are dibromo-olefina
22 toxin internalization into acidified vesicles, whereupon cryptic segments from within the 1,050-aa tr
23 5 for ACKR3, was confirmed by binding studies, whereupon CXCR3, CXCR4, and ACKR3 small-molecule ligan
24 P, until replacement of the final alpha-helix, whereupon cyclopropanation and branching activity comp
25 sed of the peptide cation and reagent dianion, whereupon dehydration of the complex via collision-ind
26 a domain-general decision-making architecture, whereupon domain-specific information is converted int
27 a domain-general decision-making architecture, whereupon domain-specific information is likely conver
28 lasm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along microtubu
29 d ability of mitotic kinetochores to biorient, whereupon each sister kinetochore forms microtubule (M
30 tural specificity to DNA junctions as a dimer, whereupon each subunit cleaves a phosphodiester bond o
31 n urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversi
33 critical role in bringing Gab2 to FcepsilonRI, whereupon Gab2 becomes tyrosyl-phosphorylated in a Syk
34 habitat lead to extinction of the specialists, whereupon generalists invade from the uniform habitat,
35 ting of the human papillomavirus (HPV) capsid, whereupon host cyclophilins facilitate the release of
36 This run-down was prevented by okadaic acid, whereupon ICl,CaMK remained near its maximum value for
37 osomes of hematopoietic and parenchymal cells, whereupon IgG is diverted from degradation in lysosome
38 SMLM) images NPCs at protein-level resolution, whereupon image analysis software studies NPC variabil
39 S. aureus to facilitate bacterial attachment, whereupon infected or sterile catheters were stereotac
40 ere then exposed to an N-heterocyclic carbene, whereupon intramolecular Stetter reaction proceeded sm
41 g mice unless the mice were stratified by age, whereupon inverse correlations between memory and Abet
42 samine, and N-glycolylglucosamine 6-phosphate, whereupon irreversible de-N-glycolylation of the latte
44 s recruited by DNA-binding activator proteins, whereupon it alters chromatin structure to increase pr
45 ct water from humid air to a saturation point, whereupon it automatically and continually releases fr
46 ocalize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits
47 omes phosphorylated in a lck-dependent manner, whereupon it can directly recruit p85 adaptor subunits
50 ses the star to evolve back into a cool giant, whereupon it experiences renewed mass ejection before
51 activation by post-translational modification, whereupon it facilitates translation of specific subse
52 ed by increases in the cellular AMP:ATP ratio, whereupon it functions to help preserve cellular energ
53 or after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse gene fa
54 cells and released from apoptotic tumor cells, whereupon it interacts with the complement C5a recepto
55 s, consumption may peak between 2015 and 2020, whereupon it is likely to drop by up to 40% until 2050
57 ates in the nucleus after rapamycin treatment, whereupon it primes the phosphorylation of the RNA pol
58 se DC subsets efficiently internalize CLEC12A, whereupon it quickly translocates to the early endosom
59 elium or H2 as the sample was heated to 523 K, whereupon it reacted with oxygen of the support to giv
61 rod/hook-type proteins before hook completion, whereupon it switches specificity to recognize filamen
62 tion with receptor I, which phosphorylates it, whereupon it translocates into the nucleus presumably
63 r solar irradiation during an induction phase, whereupon it undergoes an in-situ restructuring proces
64 to damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to m
65 00) generated an average charge state of 5.88+; whereupon, liquid chromatography/electrospray ionizat
66 mination removes the repressive DNA structure, whereupon long K48-linked ubiquitin chains are conjuga
67 the transcription factor IRF3 to the promoter, whereupon MafB acted as a transcriptional antagonist,
68 t-bridges (as many as 18 for specific binding) whereupon many of the unmasked charged groups hydrate
72 uch as angiotensin II into cellular responses, whereupon Na(+) and Ca(2+) influx and depolarization o
73 ates, NHP-O-B-glucoside and NHP glucose ester, whereupon only NHP-O-B-glucoside formation requires a
74 ncidents of discordance between the two tests, whereupon PCR shows positive results when culture indi
75 eive these chemicals until embryonic day 12.5, whereupon placental samples were collected and compare
76 loited to separate and purify target analytes, whereupon plutonium and neptunium were simultaneously
77 d by rnc) cleaves the pnp untranslated leader, whereupon PNPase represses its own translation by an u
78 ich MPO and PON1 interact during inflammation, whereupon PON1 binding partially inhibits MPO activity
79 f the intact propionic acid proved unworkable, whereupon protected propionate (-CO(2)(t)Bu) and sever
80 ze a GFP plasmid inside the PFC nanoemulsions, whereupon protein expression is achieved selectively w
82 2-(2-aminophenyl)naphthalene in CH(3)CN-D(2)O, whereupon regiospecific incorporation of deuterium tak
83 Sfp1's relocation to the nascent transcripts, whereupon Sfp1 accompanies these mRNAs to the cytoplas
84 promotes a spread AEC2 KRT17+ basaloid state, whereupon sFRP2 then activates a mature cytokeratin 5+
85 h FcgammaRIIb to promote SHIP phosphorylation, whereupon SHIP binds to Shc and dissociates from Fcgam
86 age sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1
87 boxylates, with 3-cyanochromones is described, whereupon spirochromenofuran derivatives 5 or 6 were o
88 ated with corticotropin releasing factor (CRF), whereupon SSTR2 exits the compartment on syntaxin-6-p
89 MI; n=50) or a severe AMI (anterior AMI; n=50), whereupon surviving animals (n=36 moderate, n=33 seve
90 stumpy forms" until entry into the tsetse fly, whereupon TbPTP1 is inactivated and major changes in p
92 by using the polarizable continuum model (PCM), whereupon the activation of the C-CN bond was found t
93 lt pattern by 96 hours postfertilization (hpf), whereupon the temporal pattern of neuroD expression i
94 nvolved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine
95 ic (TTF*+) or dicationic (TTF2+) counterparts, whereupon the alpha-CD ring, moves along the dumbbell
98 scent network that eventually fills the gland, whereupon the buds shrink in size and become mitotical
99 lysine, is then added to the reaction mixture, whereupon the DNA molecules bind electrostatically to
100 = 0.06), through the spin transition of iron, whereupon the elastic moduli exhibited up to 25% softe
101 the CE instrument and homogenizes the eluates, whereupon the eluted blood compounds are automatically
102 ce of an intrahelical, fully base-paired oxoG, whereupon the enzyme promotes extrusion of the target
103 Cdc42 localizes the exocyst to primary cilia, whereupon the exocyst targets and docks vesicles carry
104 2 localizes the exocyst to the primary cilium, whereupon the exocyst then targets and docks vesicles
106 cobalamin-colchicine prodrug by cancer cells, whereupon the hydrazone linker undergoes hydrolysis in
107 a plethora of real-world medical data exists, whereupon the increase in data volume comes at the exp
108 ecome fixed when environment variation is low, whereupon the mean fitness in the population is higher
109 re transiently translocated into the ER lumen, whereupon the NST domain is glycosylated to yield an i
110 e host plasma membrane and enters the cytosol, whereupon the P8 shell disassembles and the polymerase
111 olypeptide that is imported into mitochondria, whereupon the pre-sequence is proteolytically removed
112 unaffected until [Zn] increased to 20 microM, whereupon the radius of gyration, RG, values increased
113 ter specifically binds methyl epoxyfarnesoate, whereupon the receptor homodimerizes and changes terti
114 eciably deprotonated at physiological pH also, whereupon the resultant thiolate nucleophile may play
115 with a time constant of approximately 500 fs, whereupon the retinal rapidly twists and encounters a
116 rough the RAC1-NADPH oxidase 1 enzyme complex, whereupon the senescent cells express an antifibrosis
117 bular matrix of continuous or discrete values, whereupon the software is designed to rapidly visualis
118 he portal that is embedded in the capsid wall, whereupon the structure of the portal and its interact
119 ction by recruiting Csk to active Src kinases, whereupon their activities and consequent c-myc induct
120 required for maintaining the tumor phenotype, whereupon there is a switch from a gene expression pro
121 less activated to differentiate to adipocytes, whereupon these cells reduce expression of several pro
122 on until induced during regeneration or aging, whereupon they become Notch1-dependent and fail to ful
124 efficient at capturing microbes when immature, whereupon they can transform into potent antigen-prese
125 me activated by an associated tyrosine kinase, whereupon they dissociate from the receptor and dimeri
126 ced into a mammalian skin by a sandfly vector, whereupon they encounter increased temperature and tox
127 tment to the plasma membrane by GTP-bound RAS, whereupon they initiate signaling through the MAP kina
128 ced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cell
129 with temperature up to 15 C in E. verrucosus, whereupon they leveled off (except for lactate dehydro
131 il the chromosomes reached the cell periphery, whereupon they often somersaulted and returned to the
132 roken end until they encounter a chi sequence, whereupon they produce a 3' single-stranded DNA tail o
133 ved antigens in the CNS via molecular mimicry, whereupon they produce high levels of GM-CSF, IFNgamma
134 cteria until the insect tissues are exhausted, whereupon they reassociate and leave the cadaver in se
135 by activation of endogenous adenylyl cyclase, whereupon they receive stimulation from adjacent PE vi
136 por onto the biomolecule-containing particles, whereupon they were sampled into the inlet of our spec
137 ility to efficiently infect immature human DC, whereupon those DC were observed to undergo rapid acti
138 ed by piperidine and piperazine substitutions, whereupon three compounds were identified as promising
139 e cells are pivotal in the reaction to injury, whereupon, under ideal conditions, repair and resoluti
140 ctural descriptors updated from this analysis, whereupon we identified and confirmed the first intrin