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1 rite grown at 10-fold lower Asp concentration, yet 2-fold less in the crystal, spontaneously transfor
3 w-resident, long-lived plasma cell population, yet absence of this kinase led to increased rates of I
5 tivity-dependent forms of synaptic plasticity, yet activity-independent processes might also play som
6 for HIV-infected (HIV+) persons are excellent, yet acute rejection (AR) is common and optimal immunos
7 reduce the burden of HCMV-associated disease, yet after nearly a half-century of research and develo
8 sponse was not different between these groups, yet alphaPD-1 treatment resulted in significantly high
9 ble to high-throughput drug screening studies, yet animals eventually reject tumors and cannot be rai
11 s can detect the existence and concentrations, yet are not capable of locating the dental lesion site
13 hat a single CaM sufficed for Ca(2+) feedback, yet biochemical, FRET, and structural studies showed t
18 extrachromosomal DNA fragments in tumor cells, yet comprehensive examination of their structure and f
19 patients with breast cancer is generally poor, yet considerable differences in clinical outcomes betw
20 s an important strategy for their preparation, yet current methods are limited in their alkene-types
21 response to neurotrauma is an urgent priority, yet current models of traumatic brain injury (TBI) ina
22 D) is a leading cause of disability worldwide, yet current treatment strategies remain limited in the
23 ding cause of viral gastroenteritis worldwide; yet currently, no vaccines or FDA-approved antiviral d
24 is devastating for the mother and her family, yet data regarding incidence and contemporary trends a
26 ase ecology rarely track organisms past death, yet death from infection can alter important ecosystem
27 alian systems, such as ISG15, IFIT1, and OAS3, yet demonstrate a remarkable lack of significant induc
28 uitous functional groups in organic chemistry, yet despite their obvious appeal as surface-binding li
29 and synthesized molecules where two isomeric, yet, different, 8pai antiaromatic subunits, a benzocyc
30 entiation of CD4(+) T cells at the epithelium, yet differentiated IELs are able to preserve an effect
32 creased Abeta42:40 ratio relative to controls, yet displayed varied signatures for Abeta43, Abeta38,
33 oorly treated conditions in developed nations, yet effective therapeutics are not identified for many
34 agnosis of ATTR-CM using cardiac scintigraphy, yet emphasize its use in the appropriate clinical cont
35 ) include increasing age and immunodeficiency, yet estimates of HZ risk by immunocompromising conditi
36 liminated using CRISPR-mediated RNA targeting, yet evidence of its in vivo efficacy and durability is
37 e 2 diabetes (T2D) and cardiovascular disease, yet exhibit considerable inter-individual variation.
38 remains intact interictally in Scn1a+/- mice, yet exhibits decreased synchrony immediately before se
39 luenza virus form coherent global populations, yet exist at the level of single infections in individ
40 ous land management and avoided deforestation, yet few have accounted for forest degradation and natu
41 factors for accelerated fibrosis progression, yet few randomized controlled trials have tested clini
43 precipitation regimes and nitrogen deposition, yet few studies evaluate interactions among these chan
44 anded estimation of background mutation rates, yet fewer computational tools exist for specific inter
45 shed FGF-induced signal transduction pathways, yet FGF functions such as cell-matrix and cell-cell ad
46 dentify hundreds of differentially active TFs, yet find very little transcriptomic changes in steady-
47 (35%), selenium (70%), and vitamin B-12 (0.1%), yet for maternal intakes only a positive association
48 cy in photovoltaic and optoelectronic devices, yet fundamental understanding of film formation, key t
49 e of resilience in the face of climate change, yet future challenges include rising temperatures and
50 ly 0.2% of ingested eggs survived gut passage, yet, given the abundance, diet, and movements of ducks
51 duced ODE model that captures spatial effects, yet has the same dimension as commonly used well-mixed
52 with one successful clonal lineage (ST258/512) yet have been mobilized among diverse plasmids within
53 tant enterocytes, that are hyperproliferative, yet have regenerative deficits and are shifted towards
55 non-reproductive organs is poorly understood, yet highly relevant to health given the sex-biased inc
56 or for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progress
57 re and select actions for specific situations, yet how exactly rules shape actions toward specific se
58 nosis of colorectal cancer metastatic disease, yet how RAS-ERK signaling regulates colorectal cancer
59 d has operated for at least 3.4 billion years, yet how the ancient field was produced is still unknow
60 T Social connection is critical to well-being, yet how the brain reflects our attachment to people re
61 ronmental, occupational and clinical settings, yet how the brain tolerates these multi-stressor envir
62 tenuation of transcription on chromosome arms, yet how the cell regulates nuclear and chromatin-assoc
63 ar to the immunosuppressive B7 family members, yet how they regulate and coordinate alphabeta and gam
64 egrate inputs from distal regulatory elements, yet how this is achieved remains poorly understood.
65 T (iNKT) cells are self-reactive lymphocytes, yet how this lineage attains self-tolerance remains un
66 ong the main drivers of behavioral plasticity, yet, how animals evolve and modulate functional respon
67 e this first NLCB estimate to less productive, yet hydrologically dynamic regions of the wet-dry trop
68 st separated from the surrounding environment, yet in intimate contact with the solution phase and re
70 ons form the framework for the highly diverse, yet increasingly threatened, coral reef ecosystem.
71 re associated with adverse pregnancy outcomes, yet iron homeostatic mechanisms during pregnancy are p
73 r may strongly affect the impact of stressors, yet is largely ignored for the frequently occurring co
74 mily as high-fidelity replicative polymerases, yet is specialized for the extension reaction in trans
75 , WAVE1 and WAVE2, reside at the leading edge, yet it has remained unclear whether they perform simil
77 probably somewhere in-between these extremes, yet it is clear that AI is providing new challenges no
78 disease results in sphingolipid accumulation, yet it is unique among the sphingolipidoses because of
79 s is fundamental to many biological processes, yet it remains challenging to predictively design this
80 CCMs catalyze ~50% of global photosynthesis, yet it remains unclear which genes and proteins are re
81 nded intervention in Ebola virus disease (EVD), yet its impact on patient outcomes remains unclear.
82 opular high school sport in the United States, yet its association with health in adulthood has not b
85 olved in transcription and chromatin dynamics, yet its general in vivo requirement for these function
86 stics for engulfing NPs and other large cargo, yet its molecular machinery and involvement in NP upta
88 ge-related disorders including osteoarthritis, yet its relative contribution to pathogenesis remains
89 tress plays a major role in tissue remodeling, yet its role in diverticulosis has not been studied.
91 SK3beta) plays a key role in memory formation, yet its role in mood regulation remains controversial.
92 means of dissecting biological heterogeneity, yet its sensitivity, specificity, and validity in asse
94 The SZ genotype is also considered severe; yet, its effect on lung health remains unclear.Objecti
95 n fascinated by the human brain for centuries, yet knowledge of the cellular and molecular events tha
97 ies such as mass, maintenance, and senescence, yet leaving reaction-level behavior unconstrainted.
98 g CD8+ TRM cells are reactivated more quickly, yet less efficiently, than their counterparts in the d
99 es that infect Escherichia coli or Salmonella, yet, less is known about the packaging motor of Pseudo
100 growth for most if not all of the life cycle, yet light enough (approximately 21 kg when filled with
101 rrhosis patients are higher risk for sedation, yet limited data are available describing anesthesia c
103 n the US are performed in outpatient settings, yet little is known about facility-level variation in
104 ndensed states are formed by phase separation, yet little is known about how material properties are
105 to sequester C for climate change mitigation, yet little is known about how reactive Fe and Al miner
106 nificantly to chemical fluxes in the deep sea, yet little is known about the microbial communities in
107 bition can lead to neuropsychiatric disorders, yet little is known about the molecular basis underlyi
108 f viral large T antigen (TAg), and malignancy, yet little is known about the specific integration mec
109 nic development have been extensively studied, yet little is known about their functions during larva
110 eductase activity in cholesterol biosynthesis, yet little is known about their post-translational reg
111 most clinically-effective therapeutic targets, yet low consensus of RNA-Seq fusion prediction algorit
112 vidity T cells provide superior tumor control, yet low-avidity T cells can promote tumor regression.
115 crucial to the fidelity of signaling pathways, yet many pathways use the same kinases to achieve wide
116 ived much attention over the past few decades, yet many questions remain unanswered regarding pattern
117 ecurrent in systemic lupus erythematosus (SLE), yet mechanisms that drive cutaneous inflammation in S
118 ellular structures are important for function, yet mechanisms underlying subcellular size control are
120 ich are analogous to vertebrate myeloid cells, yet molecular underpinnings of the lymph gland hemocyt
121 y in a pyridinic Fe-N(4) ligation environment, yet, molecular model catalysts generally feature pyrro
122 e of disability-adjusted life years worldwide, yet most attention has focused on acute care and the i
123 cess does not improve with pair-bond duration, yet multi-year pair bonds are common, could be explain
124 were speculated to target cellular membranes, yet no plausible mechanism emerged to explain a membra
125 of alcoholism-related brain damage in adults, yet no study has prospectively tracked deviations from
127 cytidine dinucleotide near the catalytic Zn(2+), yet not in the catalytic position, where the interac
128 dentify biases during sequencing or alignment, yet not many tools exist to interpret biases due to ou
131 analytics of polyP, a molecule with prominent, yet often incompletely understood, contributions to ce
132 CD8+ T cells expressing "exhaustion" markers, yet oHSV infection led to a reduction in PD-1+ CD8+ T
133 dently colonised cycads from angiosperm hosts, yet only a few clades appear to have radiated followin
134 lar amylin, Abeta40, or Abeta42 were detected, yet only supernatant from VZV-infected cells induced a
135 induced by physiological receptor activation, yet ORAI1 is dispensable in generation of oscillations
136 more efficiently when O-GlcNAc levels are low, yet other alternative splicing pathways change minimal
137 ort telomeres have been linked to cancer risk, yet other evidence supports them being tumor suppressi
139 n promoted in China to mitigate air pollution, yet our measurements and analyses show that NGV growth
140 t the movement of goods and ancient economies, yet our understanding of critical aspects of the ancie
141 dentity is a core feature of human experience, yet our understanding of gender identity is shifting w
142 nd arid/semi-arid ecosystems around the world, yet our understanding of the belowground impacts of th
143 the most common childhood soft-tissue sarcoma, yet patients with metastatic or recurrent disease cont
144 an recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses requi
145 redominantly phosphorylated at multiple sites, yet phosphorylation at specific tyrosines is variable
146 eiving durable MCS after ECLS remains limited, yet preoperative factors may allow differentiating fut
147 ries are one of the most frequently occurring, yet preventable hospital-acquired adverse events.
148 ly highly aggressive and treatment-refractory, yet RAS mutation itself is insufficient for tumorigene
149 is generally neglected in evolutionary models, yet recent work suggests that it may be more common th
150 stimuli presented to aquatic animals in water, yet refraction has often been ignored in the design an
151 e to snagging DFG, providing an opportunistic, yet regular, reporting mechanism by longline fishery o
152 aggeration and loss of nutritional plasticity, yet reject a major role of taxon-restricted genes in t
153 iverse tumour phenotypes driven by individual, yet related, variants and reveal how glioblastoma alte
154 cRNAs) are crucial in many cellular processes, yet relatively few have been shown to regulate human c
155 ecies are close relatives of Escherichia coli, yet relatively few previously described phages appear
156 iscussions of social and cognitive complexity, yet relatively little is known of their social organiz
157 esults described from 2007 to the end of 2019, yet relevant pioneering transformations are eventually
158 hat nevertheless undergo retrograde migration, yet remain durably committed to the residency program
159 ned to play a critical role in carbon removal, yet remains under paced in deployment efforts, mainly
160 us health concern for children, in particular, yet remains understudied compared to influenza A virus
161 f viral genomic DNA into the host chromosomes, yet remarkably, the timing and cellular location of un
162 en the basis of the design of numerous alloys, yet research on metastable high-entropy alloys is stil
163 nificant differences in orthonasal perception, yet retronasal results showed that 0% lager was percei
164 nships strongly deviate from scale invariance, yet reveal a common motif-they are all accounted for b
166 ulates important aspects of animal physiology, yet roles in regulating innate immunity are relatively
167 fects of wildfire are relatively well studied, yet sediment transport models remain unable to account
168 al changes that are robust on the group level, yet show substantial inter-individual variability.
169 shuttling into LECs from breast cancer cells, yet showed other [Formula: see text] signals in LECs s
170 n gene expression profiles across vertebrates, yet social status and reproductive state are often con
171 pplied to a wide taxonomic range of organisms, yet some of these models have poor fits to empirical d
173 ining agricultural economies and biodiversity, yet stands to lose both from present exposure to natur
174 operties have attracted attention for decades, yet stiff materials that can resiliently tolerate extr
175 ased signal amplification are highly relevant, yet still plagued by diverse drawbacks including erron
176 ved shell that displays an apparently mundane, yet striking feature from a developmental point of vie
177 heteroternary complexes were used as dynamic, yet strong, cross-linkers in the fabrication of supram
178 allow one to perform online sequence searches, yet, such a feature would be highly useful to investig
181 liably produces benign nevi (pigmented 'moles'), yet the same change is the most common driver mutati
182 has been explored for more than two decades(1), yet the origins of TAA-specific T cells remain unclea
183 caC) was accompanied by a drop in TET2 levels, yet the analysis of KO cells suggested that TET2 is re
184 conditions with high morbidity and mortality, yet the basic mechanisms underlying these conditions a
185 e areas of research in biology and biophysics, yet the basic physical origins of their different morp
186 ogy displays large variability and complexity, yet the canonical regularities of the cortex suggest t
187 mmune cell function to evade immune responses, yet the complex mechanisms driving immune evasion rema
188 tissues, secondary cell wall (SCW) deposition, yet the coordination of these processes remains elusiv
189 ty intactness declined in all three scenarios, yet the decline was smaller in the sustainability scen
190 ys a major role in environmental interactions, yet the development of the cellular components of the
191 subjects receiving dapagliflozin and placebo, yet the difference in EGP between dapagliflozin and pl
192 has previously been proposed as a drug target, yet the effectiveness of the first and only known inhi
193 que composition of lipids within the membrane, yet the effects of lipid mixing on the membrane biophy
194 mitted stages develop from the asexual stages, yet the factors behind this transition are not complet
195 ogression of glycemia after onset of diabetes, yet the factors that influence glycemic progression ar
196 he CTD is crucial to eukaryotic transcription, yet the functional and evolutionary relevance of this
197 hypoxia-inducible factor 1 (HIF-1) and c-Myc, yet the impact of hypoxia on negative regulators of an
198 ers require prior authorization (PA) for OPAT, yet the impact of the inpatient PA process is not know
199 ersity as naturally occurring coding variants, yet the impact of these variants on protein function a
200 environmental microbiome) on disease dynamics, yet the importance of the host-host microbiome-pathoge
201 en that secretes c-di-AMP and activates STING, yet the in vivo role of the STING pathway during bacte
202 vantage of multipartitism has been identified, yet the maintenance of genomic integrity appears probl
203 composed of multiple environmental stressors, yet the majority of research in environmental physiolo
204 is critical for the emergence of hypertension, yet the mechanisms by which inflammatory mediators con
205 multaneously occurring features of a stimulus, yet the mechanisms by which this integration occurs ar
206 ion exerts a high demand on protein synthesis, yet the mechanisms coupling the two processes are not
207 chromatin regulators modulate these networks, yet the mechanisms governing how tissue specificity of
208 nt for the motile behavior of many cell types, yet the mechanisms governing PKA activity during cell
209 d transporter cause microcephaly and seizures, yet the mechanisms responsible for these phenotypes ar
210 hromatin methylation to altered SAM abundance, yet the mechanisms that allow organisms to adapt and p
211 fined time window results in B cell apoptosis, yet the mechanisms that enforce dependence on co-stimu
212 ple, in chronic obstructive pulmonary disease, yet the mechanisms that retain neutrophils within tiss
213 stases account for most cancer-related deaths, yet the mechanisms underlying metastatic spread remain
214 hown to coordinate with nutrient availability, yet the mechanisms underlying this coordination remain
215 nce factor responsible for cleaving host IgA1, yet the molecular mechanism has remained unknown since
216 forks are main sources of genomic instability, yet the molecular mechanisms for protecting forks from
217 onse compared with their younger counterparts, yet the molecular mechanisms responsible for the discr
218 tic coronaviruses represent an ongoing threat, yet the myriads of circulating animal viruses complica
219 been used to treat major depressive disorder, yet the neural circuit mechanisms underlying this ther
221 n brain disorder affecting millions of people, yet the neuronal mechanisms underlying this prevalent
222 Tregs) have been shown to be atheroprotective, yet the numbers of these immunosuppressive cells decre
223 ion is a known hallmark of cancer progression, yet the oncogenic signals that promote metabolic adapt
224 accumulate at the exterior of senile plaques, yet the protofibril-fibril interplay is not well under
225 irst step of most analyses of gene expression, yet the quantitative biases it introduces are largely
226 , nanocrystals have size-dependent properties, yet the question remains whether nanocrystal propertie
227 ponse upon stimulation with bacteria or fungi, yet the reasons for this dominant T-helper 17 (Th17) r
228 ponse upon stimulation with bacteria or fungi, yet the reasons for this dominant TH17 response in PSC
229 ences on child behavior and brain development, yet the relationships among prenatal depression, child
230 and inflammatory influences on blood pressure, yet the role played by each of these processes in the
231 stem differs when compared with other mammals, yet the role that virus-derived endogenous elements ma
232 ing cell cycle, proliferation, and metabolism, yet the roles of specific modifiers in different cance
234 the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transi
235 race elements sustain biological productivity, yet the significance of trace element mobilization and
236 tion methods result in a trimeric form of PSI, yet the SMA-PSI complexes display a heterogenous kinet
237 are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd
238 cted persons are susceptible to HAV infection, yet the susceptibility in the US population is not wel
240 ce of noise is an important cellular function, yet the underlying computational mechanisms are not we
243 which can enhance or repress gene expression, yet the underlying molecular mechanism remains uncerta
244 remes is the existence of spatial dependences, yet the vast majority of studies to date have analyzed
245 ersist within the gastrointestinal tract (GIT); yet, the underlying mechanisms that enable sanctuary
246 tive value that they assign to future rewards, yet, the components feeding into this appraisal of val
247 ucial for the normal function of mitochondria, yet, the molecular mechanisms underlying IRGM-mediated
248 D. savignyi overlap in the Indo-West Pacific, yet their bindins show no evidence of positive selecti
249 ms in modulating global biogeochemical cycles, yet their biological communities and related carbon dy
250 orm the backbone of biodiversity conservation, yet their effectiveness is often not known nor even ev
251 hypotheses in psychology are verbal in nature, yet their evaluation overwhelmingly relies on inferent
252 (3)) skeletons support entire reef ecosystems, yet their formation mechanism is poorly understood.
253 instem regions support vital bodily functions, yet their genetic architectures and involvement in com
254 ies protect newborns from early-onset disease, yet their impact on GI colonization and LO disease is
255 , capable of large and catastrophic eruptions, yet their low eruptive frequency makes it challenging
256 nistically regulate these life history traits, yet their mechanism of action, antagonism and targets
257 -catalysts represent an appealing alternative, yet their use remains sparse due to undesired side-pro
258 RNAs) are key regulators of the immune system, yet their variation and contribution to intra- and int
259 1R targeting requires receptor downregulation, yet therapy-mediated removal from the cell surface act
260 nd in vivo characterization of radioligands(2), yet there exist few radiolabelling protocols for the
261 jected to rise as populations continue to age, yet there are no current therapeutic approaches that d
262 s the transmission of disease and information, yet there has been less focus on how networks influenc
263 izophrenia and related psychoses in offspring, yet there has been limited research focused on materna
264 role of DOM in natural and engineered systems, yet there is still considerable uncertainty regarding
265 United States have increased in recent years, yet there remains little attention on liposuction, or
266 research fields where MSI is commonly applied; yet, there is no standardized protocol for analyzing t
267 espiratory syndrome coronavirus 2 (SARS-CoV-2), yet these measures are already having similar effects
269 is the most frequently mutated gene in cancer, yet these mutations remain therapeutically non-actiona
270 species translocations across the Quaternary, yet these techniques are often used in isolation, rath
271 are often not examined in refugee populations, yet they are critical to understand granular health tr
272 he ears simultaneously or in close succession, yet they are effortlessly segregated into distinct per
273 as "co-benefits" of mitigating climate change, yet they are rarely considered when designing or imple
274 hey should easily evade whale-sized predators, yet they are regularly hunted by some species of rorqu
275 owth and modified growth occur simultaneously, yet they are usually studied separately and assessed u
277 frequently associated with chronic infection, yet they lack expression of many virulence determinant
279 periodontal disease in different populations; yet they have not being tested in Spanish population.
280 ute to safely achieving high energy densities, yet this architecture faces challenges arising from in
281 o as one of the most flexible limbs in nature, yet this assumption requires detailed inspection given
282 ique strategy for tuning molecular properties, yet this atom is rarely found in Nature and approaches
283 5-5p expression to suppress VEGF-C expression, yet this miR-185-5p effect on VEGF-A was reversed via
284 or patients who have pneumonia with tachypnea, yet trial data indicate that not using amoxicillin to
285 NAP) is crucial in cellular energy production, yet understanding of mitochondrial DNA transcription i
286 are significantly affecting stream ecosystems, yet understanding of their long-term impacts is hinder
290 these patterns display impressive consistency, yet variability inevitably exists within pattern-formi
291 ches intracellular cytokinin content in roots, yet we also find cytokinins in extracellular fluid, po
292 Temperature governs most biotic processes, yet we know little about how warming affects whole eco
293 d growing authority over refugee resettlement, yet we know little about their attitudes toward refuge
294 canonical translation initiation is inhibited; yet we find that inflammatory genes are highly transla
295 rctic terrestrial and freshwater environments; yet we still know little about their biodiversity.
296 ep disturbances are statistically significant, yet weak, risk factors for suicidal thoughts and behav
297 ave several SUN- and KASH-containing proteins, yet what governs their proper engagement is poorly und
298 ss the gap junction protein connexin-43 (Cx43), yet whether Cx43 regulates collective invasion remain
299 sticity in response to changes in temperature, yet wild animals often experience multiple environment
300 ns are evolutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, ho