ライフサイエンスコーパス: -activated channel

1 ber increased cytosolic ATP-, lumenal Ca(2+)-activated channel activities to a nearly maximum level.

2 The density of the small-conductance Ca(2+)-activated channel decreased along the apical dendrite, w

3 e voltage-gated channel Kv1.3 and the Ca(2+)-activated channel IKCa1.

4 The Ca(2+)-activated channel of intermediate-conductance (KCa3.1) i

5 This study thus identifies a Ca(2+)-activated channel permeable to Ca(2+) and critical for C

6 st, the pore of the ATP, caffeine and Ca(2+)-activated channel remains open in the presence of Ca(2+)

7 2) revealed new proteins, including a Ca(2+)-activated channel TRPM5, for MUC5AC secretion.

8 ting in pore closure of the PCB95 and Ca(2+)-activated channel.

9 levels over time, involving extrinsic Ca(2+)-activated channels late during activation.

10 icles (GUVs), forms voltage-gated and Ca(2+)-activated channels with the key features of mPTP.

11 The absence of Zn(2+)-activated channels in rats and mice may explain why this

12 e, a rare feature only reported for the acid-activated channel ASIC3.

13 nel recordings show that capsaicin- and acid-activated channels have the same conductance, that the t

14 K 293 cells, which showed pH-dependent (acid-activated) channel activity.

15 ltered the activity of either class of L-Arg-activated channels, which were blocked by micromolar con

16 On the contrary, cytosolic ATP-activated channel activities were decreased as lumenal C

17 r-derived cGAMP into macrophages via the ATP-activated channel P2X7R.

18 oncentration dependent and the Po of the ATP-activated channel was unaffected by membrane voltage, re

19 f either beta- or gamma-ENaC block the basal-activated channel in a concentration-dependent fashion.

20 c side of the bilayer increased lumenal Ca2+-activated channel activities, suggesting that it lowered

21 the conformational transitions of a calcium-activated channel with real cryo-EM particles.

22 indicating that calcium channels and calcium-activated channels do not participate in shaping the pre

23 ctions between calcium-permeable and calcium-activated channels.

24 membrane proteins, which encompasses calcium-activated channels for ions and lipids.

25 ted channels is lower than that of capsaicin-activated channels.

26 Tg- and CCh-activated channels were permeable to Na(+) and Ba(2+), b

27 factor required for Ca2+ to inhibit the cGMP-activated channel.

28 inked to the control of a G-protein and cGMP-activated channels which functions to generate high syna

29 dephosphorylation of 'on' bipolar cell cGMP-activated channels, resulting in a rise in the sensitivi

30 tion by CaMKII is the 'on' bipolar cell cGMP-activated channels.

31 nsistent with CaMKII phosphorylation of cGMP-activated channels leading to a voltage-dependent reduct

32 ed via a cGMP cascade to the control of cGMP-activated channels.

33 igate the action of cytoplasmic Ca2+ on cGMP-activated channels in the outer segment.

34 has recently been demonstrated for rod cGMP-activated channels.

35 The increased affinity of the cGMP-activated channels in response to a fall in [Ca2+] has t

36 of rhodopsin and to transitions in the cGMP-activated channels.

37 cribe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature co

38 TRPC2,3,6 and 7 are widely accepted as DAG-activated channels, although TRPC3 can also be regulated

39 lcium signals in T cells occur via depletion-activated channels.

40 on 0.5 microM gamma-aminobutyric acid (GABA)-activated channels (10 +/- 1 pS) in inside-out or outsid

41 tches had the same chord conductance as GABA-activated channels and were gabazine-resistant.

42 ately 70 000) did not pass through the gamma-activated channel, indicating an upper limit to the pore

43 Two classes of glutamate-activated channels mediate excitation at central synapse

44 dynamic behaviour of post-synaptic glutamate-activated channels.

45 receptor-mediated currents or forms glycine-activated channels with the NR1 subunit alone.

46 ull-length Caenorhabditis elegans cyclic GMP-activated channel TAX-4, reconstituted in lipid nanodisc

47 EK293 cells exhibit increased basal and GPCR-activated channel currents, and increased Ca(2+) fluores

48 Detection of thermal IR requires the heat-activated channel TRPA1, which is expressed in neurons a

49 The calcium permeability of heat-activated channels is lower than that of capsaicin-activ

50 The homogenate-activated channels were Ca2+ sensitive, selective for Ca

51 is a major determinant for hyperpolarization-activated channel gating.

52 molecular determinant for hyperpolarization-activated channel gating.

53 The role of hyperpolarization-activated channel 1 (HCN1) in stress responses to witnes

54 alter gating of the plant hyperpolarization-activated channel, KAT1.

55 r residue conserved in all hyperpolarization-activated channels, by Ala substitution produced a depol

56 etween depolarization- and hyperpolarization-activated channels.

57 tials and distal dendritic hyperpolarization-activated channels that mediated site independence of so

58 InsP3-activated channels invariably inactivated, with average

59 spines through voltage-sensitive and ligand-activated channels, as well as through Ca(2+) release fr

60 ns BKCa channels primarily operate as ligand-activated channels gated by intracellular Ca(2+) and tha

61 Channelrhodopsin-2 (ChR2) is a light-activated channel that can conduct cations of multiple v

62 mediated transmission, and, by using a light-activated channel to excite the network, we demonstrate

63 using Cre-dependent expression of the light-activated channel Channelrhodopsin-2.

64 Like the light-activated channel of the cell, it is non-selective among

65 Light-activated channels exhibited similar unitary currents, r

66 r potassium channels and two different light-activated channels, all of which have an effect on Vmem

67 ion transport as ion pumps or directly light-activated channels.

68 ity using layer-specific expression of light-activated channels and indicator dyes.

69 of a highly Ca(2+)-permeable class of light-activated channels of Drosophila photoreceptors.

70 sembled those ascribed to one class of light-activated channels, TRP.

71 subunit of a class of Ca(2+)-selective light-activated channels that carry the bulk of the phototrans

72 alcium influx through the TRP and TRPL light-activated channels triggers a complex regulatory hierarc

73 Mallotoxin-activated channels remain incrementally sensitive to Ca2

74 tive, tetrodotoxin-resistant, sodium (Na(+))-activated channel involved in regulating Na(+) homeostas

75 lar Mg2+ stabilized the open state of NAD(+)-activated channels.

76 +) on the single N-methyl-D-aspartate (NMDA)-activated channel burst duration and frequency and on th

77 -1592, -1460 and -1754) block the open NMDA-activated channel were studied at membrane voltages (Vm)

78 provides evidence that occupancy of the NMDA-activated channel by Mgi2+ destabilizes the closed state

79 urrent, a four-state model in which the NMDA-activated channel can close while blocked by Mgi2+ is pr

80 ng sites at different depths within the NMDA-activated channel.

81 FA reduces the mean open time of single NMDA-activated channels in a concentration-dependent manner w

82 se presynaptic terminals reveals single NMDA-activated channels, showing multiple conductance levels,

83 of both the Ca(2+)- and the Ca2+/nucleotide-activated channels, suggest a mechanism for channel open

84 ors, hyperpolarization and cyclic nucleotide-activated channels (HCNCs) and a separate target that ha

85 ls with the same property (cyclic nucleotide-activated channels) have been reported that are involved

86 ing able to form homomeric cyclic-nucleotide-activated channels.

87 Oxidant-activated channels were observed to display two gating m

88 cation channel, zTrpa1b, coupled with photo-activated channel ligands, such as optovin and 4g6.

89 The L-Pro-activated channels were not affected by either L- or D-A

90 In heart, G-protein-activated channels are complexes of two homologous prote

91 Acid-sensing ion channels (ASICs) are proton-activated channels expressed in neurons of the central a

92 between 6.0 and 6.5, as expected for proton-activated channels, and current-voltage dependence did n

93 caused by RANTES, indicating that the RANTES-activated channel was the Ca2+ -activated K+ channel.

94 of membrane ionic conductances and receptor-activated channels in CNS neurons and, via these mechani

95 e identified critical functions for receptor-activated channels in the endoplasmic reticulum that all

96 els were blocked by gadolinium; the receptor-activated channels formed upon expression of higher leve

97 ), capacitative Ca2+ entry, and Ca2+ release-activated channel opening (CRAC), and often underlies th

98 tes the cooperation with the calcium release-activated channel Orai1 in directing localized cytoskele

99 ng, whereas treatment with a calcium-release-activated channel inhibitor rescues the ligand-activated

100 lowed by Ca(2+) entry through Ca(2+) release-activated channels (CRACs).

101 mobilization independent of calcium release-activated channels.

102 f plasma membrane-associated calcium release-activated channels.

103 lular calcium influx through calcium-release-activated channels.

104 ker) and gadolinium(III) chloride (a stretch-activated channel blocker) did not alter the level of ac

105 sis by adding gadolinium chloride (a stretch-activated channel blocker) to the saline (0.008 g.mL-1)

106 Piezo1 is a stretch-activated channel important to muscle contractile dynami

107 ure-dependent gating properties of a stretch-activated channel with a current/voltage plot indicating

108 ntial vanilloid isoform 4 (TRPV4), a stretch-activated channel, is required to maintain ocular hypert

109 Moreover, disruption of a stretch-activated channel, Piezo1, in zebrafish prevents extrusi

110 MscL, a stretch-activated channel, saves bacteria experiencing hypo-osmo

111 how that hypotonic shock generates a stretch-activated channel-dependent calcium pulse in yeast.

112 indicates its possible identity as a stretch-activated channel.

113 ctivated K(+) channel that is also a stretch-activated channel.

114 hlin with the cell surface bound and stretch-activated channel TREK-1.

115 nels may contribute to the increased stretch-activated channel activity observed in mdx myofibers.

116 Neither stretch-activated channel was detected in the grain protoplasts

117 describes a physiologically relevant stretch-activated channel, at both the single-channel and whole-

118 anodine receptor (RyR) and (iii) the stretch-activated channel (SAC) in both single myocytes and mult

119 ased proliferation is induced by the stretch-activated channel Piezo1 and involves calcium-triggered

120 ecome too crowded, they activate the stretch-activated channel Piezo1 to trigger extrusion of cells t

121 Stretch-activated channels (SACs) have been found in myocardial

122 Stretch-activated channels (SACs) have been found in smooth musc

123 Stretch-activated channels (SACs) have been shown in other prepa

124 integrated changes in caveolin-3 and stretch-activated channels (SACs).

125 Binding of alpha2beta1 integrin and stretch-activated channels mediate M migration and mechanosensin

126 cell-attached patches (i.e. they are stretch-activated channels), they differ in their ability to tra

127 spider venom that is known to block stretch-activated channels in animal cells, but the spontaneous

128 We tested the hypothesis that both stretch-activated channels (SACs) and intracellular calcium ([Ca

129 lipid-mediated modifier of cationic stretch-activated channels, eliminated the voltage and divalent

130 ane, Ca2+-permeable cation channels (stretch-activated channels) opened and a global increase in [Ca2

131 block voltage-gated Ca(2+) channels, stretch-activated channels (SACs), or the Na(+)-Ca(2+) exchanger

132 th TEA, Tris or choline, eliminating stretch-activated channels but suggesting that if transmembrane

133 Unitary ionic currents from stretch-activated channels and [Ca2+]i images were recorded simu

134 ting mechanism and pharmacology from stretch-activated channels described previously.

135 ation of both ERK1/2 and p38 kinase, stretch-activated channels, small GTPase proteins, and extracell

136 ed MSHA, whereas other inhibitors of stretch-activated channels (Gd(3+), ruthenium red, SKF96365) did

137 results suggest that the opening of stretch-activated channels allows ions, including Ca2+, to enter

138 ese data highlight the importance of stretch-activated channels in pregnancy maintenance and parturit

139 anical distention-induced opening of stretch-activated channels in smooth muscle cells.

140 s not useful in the investigation of stretch-activated channels which may underlie the myogenic respo

141 nium (III) chloride (an inhibitor of stretch-activated channels) only blocked the activation of ERK1/

142 y gadolinium (Gd3+), an inhibitor of stretch-activated channels, but is independent of extracellular

143 Consistent with the presence of stretch-activated channels, we show that Ca2+ influx is triggere

144 iminated by gadolinium, a blocker of stretch-activated channels.

145 ated channels was similar to that of stretch-activated channels.

146 ished by gadolinium, an inhibitor of stretch-activated channels.

147 in creating these signal: Rho/ROCK, stretch-activated channels, and 'Molecular Strain Gauges.' We al

148 at Gd3+-sensitive, poorly selective, stretch-activated channels were not involved.

149 This mechanical strain suggests that stretch-activated channels may constitute a mechanism to explain

150 The stretch-activated channels were inhibited by a spider venom that

151 at the MEF effects, depending on the stretch-activated channels' conductances and reversal potentials

152 The entry of Ca2+ through stretch-activated channels is also amplified by Ca2+ release fro

153 that inhibiting Ca2+ influx through stretch-activated channels using various compounds, including a

154 distinguished by signalling through stretch-activated channels.

155 echanoelectrical feedback (MEF), via stretch-activated channels.

156 s mechanosensitive (ie, swelling- or stretch-activated) channels was tested.

157 ing nor identical to the endogenous swelling-activated channel.

158 m with the properties of endogenous swelling-activated channels.

159 g on the subunit composition, these swelling-activated channels conduct chloride, amino acids, organi

160 ed channels and inositol 1,4,5-trisphosphate-activated channels.

161 The dendritic arborization and voltage-activated channel complement of rat neocortical pyramida

162 Cardiac mitoBK(Ca) is a calcium- and voltage-activated channel that is sensitive to paxilline with a

163 for the pore-forming subunit of low voltage-activated channel proteins has not been unequivocally id

164 l tissues, whereas KCNQ1 function as voltage-activated channels with very slow kinetics in cardiac ti

165 alpha1G and alpha1H and to the high voltage-activated channels formed by alpha1Ebeta3.

166 R-type high voltage-activated channels inactivate fully in a few hundred mil

167 , P/Q- and R-type channels, the high voltage-activated channels most intimately associated with presy

168 be classified as either low or high voltage-activated channels.

169 endent inhibition of non-L-type high-voltage-activated channels of the Ca(v)2 family.

170 of these otherwise long-lasting high-voltage-activated channels.

171 sually permit Ca influx through high-voltage-activated channels.

172 ction with the external potential in voltage-activated channels.

173 lpha1A, alpha1B, and alpha1E) or low voltage-activated channels (alpha1G).

174 d its function to maintain these low voltage-activated channels closed at resting membrane potentials

175 tion of channels did not gate as low voltage-activated channels, requiring stronger depolarizations t

176 Low-voltage-activated channels are called 'T' type because their cur

177 o the postsynaptic calyx through low-voltage-activated channels driven by changes in cleft [K(+)] as

178 7-P9) type I hair cells acquired low-voltage-activated channels that shortened the rise time of the r

179 chanisms (transducer adaptation, low-voltage-activated channels, nonquantal transmission, and spike t

180 that MDIMP preferentially blocks low-voltage-activated channels.

181 standing related mechanisms in other voltage-activated channels.

182 between the N-cadherin JMD and these voltage-activated channels.

183 Ca2+ influx through L-type voltage-activated channels (LTCs) is particularly effective at a

184 c L-type voltage-gated calcium (high voltage-activated) channel with accessory proteins beta and alph