ライフサイエンスコーパス: -binding site

1 rminal region comprising ARL8- and kinesin-1-binding sites.

2 that the 3'UTR of CPSF6 contains a miR-125b-binding site that is conserved across several mammalian

3 ppa with DNA sequences containing HIF-1alpha-binding sites.

4 rformed mutagenesis to compromise the Zn(2+)-binding site and observed that this change severely hamp

5 within its CDR3 loop, which harbors a Zn(2+)-binding site that substitutes for a loop-stabilizing dis

6 transmembrane helices forming the two Ca(2+)-binding sites and the cytosolic headpiece mediating ATP

7 of a beta-sandwich and displays four Ca(2+)-binding sites at the tip of the domain.

8 g affinities associated with the four Ca(2+)-binding sites per heterodimer.

9 the four regions of hCP that serve as Ca(2+)-binding sites, (ii) determine the binding stoichiometry

10 This led us to search for potential Zn(2+)-binding sites outside of the dimer interface.

11 he single canonical conserved 3' UTR miR-290-binding site of Pfn2 or overexpression of the Pfn2 open

12 d in the primary sequence occupies the IP(3)-binding site and competitively inhibits IP(3) binding.

13 ntified and characterized a canonical 14-3-3-binding site (site 1) within the flexible, structurally

14 step, we sought to identify potential 14-3-3-binding sites in the APN sequence.

15 eas a reporter carrying a mutated miR-144-3p-binding site exhibited less sensitivity toward endogenou

16 covered an evolutionarily conserved let-7-5p-binding site within the chicken Chd7 gene and its human

17 In all cases, the m(6)A-binding site of ECT proteins is required for in vivo fun

18 These findings suggest that the Abeta-binding site of TTR may be hidden in its tetrameric form

19 the angiotensin I converting enzyme 2 (ACE2)-binding site.

20 an sulfate-binding site adjacent to the ACE2-binding site.

21 rthosteric site, a putative second bile acid-binding site with allosteric properties and structural f

22 suggested that ExoY possesses only one actin-binding site.

23 In the proposed model, the N-terminal actin-binding site of leiomodin can act as a "swinging gate" a

24 Bundling is known to require multiple actin-binding sites, yet small-angle X-ray scattering experime

25 We further uncover an Aft1-binding site in the MMT1 promoter sufficient for inducin

26 hat the correct positioning of a single AggR-binding site is sufficient to confer AggR-dependence.

27 acts between the NTD and classic LBD agonist-binding sites.

28 occur at the level of loop C-at the agonist-binding sites-and the loops at the interface between the

29 the "aromatic box" that define the aldehyde-binding site.

30 dominantly located at five reported antibody-binding sites, and within or close to the HA receptor bi

31 nged epitope residues confirmed the antibody-binding sites and revealed strongly reduced IgE reactivi

32 ression of mgrA and identify a probable ArlR-binding site (TTTTCTCAT-N(4) -TTTTAATAA).

33 Finally, ChIP assays verified an ATF4-binding site in the LAMP3 gene promoter, and a dual-luci

34 al-luciferase assay confirmed that this ATF4-binding site is indeed required for transcriptional up-r

35 A linked BchL dimer with one defective ATP-binding site does not support protochlorophyllide reduct

36 49A drastic shift of Walker A encroached ATP-binding site, whereas the site remained occupied by ADP

37 served cysteine residue within the FGFR4 ATP-binding site at position 552, two positions beyond the g

38 rs has been extremely challenging as its ATP-binding site shares high similarity with CDK1, a related

39 ribed RecBCD mutants altered in the RecB ATP-binding site also have this property, but uninhibited wi

40 ; computation docks NSAC1003 into RecB's ATP-binding site, suggesting NSAC1003 acts directly on RecB.

41 cluding residue Arg 3, which is near the ATP-binding site in sequence, is critical for degradation by

42 inhibitor that binds selectively to the ATP-binding site of the D2 domain, although both the D1 and

43 ed to delete critical amino acids in the ATP-binding site.

44 nd XPD while capping the DNA-binding and ATP-binding sites of XPD.

45 are predicted to have reduced numbers of ATP-binding sites, which potentially alters receptor functio

46 However, due to conservation of their ATP-binding sites, development of selective agents has remai

47 is, suggesting a potential role for this BH3-binding site in BAK activation.

48 teraction, we localized the TGFbeta- and BMP-binding site in MAGP-1 to a 19-amino acid-long, highly a

49 in live B. burgdorferi, and a specific BpuR-binding site was mapped 5' of the sodA open reading fram

50 sites were lost, whereas new pS22-Lamin A/C-binding sites emerged in normally quiescent loci.

51 ient fibroblasts, a subset of pS22-Lamin A/C-binding sites were lost, whereas new pS22-Lamin A/C-bind

52 ively spliced linker and a conserved calcium-binding site.

53 signaling, while mutagenesis of the calcium-binding site abolishes Gpr126 function in vivo.

54 We identified a carbenoxolone-binding site embraced by W74 in the extracellular entran

55 ues of the galectin-8N extended carbohydrate-binding site.

56 nine (Arg45) located across the carbohydrate-binding site.

57 vergence in the residues at its carbohydrate-binding sites, which makes it a promising candidate for

58 le glycan arms with the primary carbohydrate-binding sites.

59 stent with general beta-trefoil carbohydrate-binding sites (alpha, beta), and also a unique PMT2-subf

60 re fully functional despite their carotenoid-binding sites being occupied by astaxanthin instead of b

61 difications of FHL1- or both FHL1- and CD2AP-binding sites remain viable and develop spreading infect

62 V-1-infected humanized mice but elicited CD4-binding site mutations that reduced viral fitness.

63 tivities can be developed from the chemokine-binding site of an evasin.

64 lar recognition of cognate DNA and chromatin-binding sites, suggesting underlying cis-element cluster

65 w seconds on their specific DNA or chromatin-binding sites.

66 oxicity include its Spc42-, Spc29-, and Cmd1-binding sites.

67 , we are able to accurately predict HOXA2 co-binding sites.

68 s an ADP backbone this may extend beyond CoA-binding sites and include abundant Rossmann-fold motifs

69 nalysis of the data allowed pinpointing CodY-binding sites at close to single-nucleotide resolution.

70 d the presence and locations of several CodY-binding sites.

71 Based on the sequences of the CodY-binding sites, a model of CodY interaction with DNA is p

72 he matured cofactor at an analogous cofactor-binding site.

73 logue to occupy both substrate- and cofactor-binding sites of NTMT1, but the bisubstrate analogue wit

74 CH-3-8 binding to the colchicine-binding site in tubulin protein was confirmed by tubulin

75 -invariant domain boundary-containing a CTCF-binding site (CBS) and a transcription start site (TSS)-

76 well as loss of RUNX1 binding at RUNX1/CTCF-binding sites.

77 tides ('msR4Ms') designed to mimic the CXCR4-binding site to MIF, selectively bind MIF with nanomolar

78 Strikingly, we reveal a second CypA-binding site formed by the hydrophobic sequence (47) GVV

79 Mutagenesis of putative DAZL-binding sites in these mRNAs mimics the effect of DAZL d

80 involving resolvase NTDs at all three dimer-binding sites in res.

81 on strategy, we determined the preferred DNA-binding site for CDA-KLF1.

82 d by histones H2A and H2B via its second DNA-binding site(19).

83 ing the homologous strand at a secondary DNA-binding site, which frees the complementary strand to sa

84 C4 and mutagenesis studies show that the DNA-binding site and the histone/ATPase binding site of CW a

85 e steps result in the interconversion of DNA-binding sites in the catalytic core of condensin, formin

86 the transposon end and the generation of DNA-binding sites.

87 YY1 responsive element mapped not to YY1 DNA-binding sites in the HTLV-1 LTR but to the R region.

88 ues 22-31 that ultimately broadened the drug-binding site of AM2 S31N inhibitor 4, which spans residu

89 eport a 2.1- angstrom structure and the drug-binding site of E's transmembrane domain (ETM), determin

90 These compounds bind to seven drug-binding sites on SA.

91 but ibuprofen binds to both SAs in two drug-binding sites, only one of which is common.

92 When associated, the two strands form a dye-binding site, followed by an increase in fluorescence of

93 not by variants with mutations in its dynein-binding site.

94 ional EBNA3C, BMI1 was sequestered to EBNA3C-binding sites after EBNA3C activation.

95 tial expression is due to an extra C/EBPbeta-binding site in the PRMT1 promoter of individuals carryi

96 d thereby enhance affinity with the effector-binding site in Ras compared with WT RBD.

97 s bound with high affinity with the effector-binding site of Ras in an active conformation.

98 that promotes accessibility of the effector-binding site.

99 0 bps of Klotho promoter and one of the Egr1-binding sites.

100 hosphorylation, contains the secondary eIF4E-binding site and three other phospho-sites, whose mechan

101 SNPs within functional transcription factor-binding sites (TFBSs) genome-wide.

102 f NAD(+) MS-based mapping identified an Fdx1-binding site at the junction of HoxE and HoxF, adjacent

103 Elimination of the FHL1-binding site in the nsP3 HVD can be used for the develop

104 , 88 contained or were located next to Foxf2-binding sites.

105 1-to-2 stoichiometry with two distinct FtsX-binding sites located within an antiparallel coiled coil

106 is187 coordinate a Zn2+ adjacent to the FXII-binding site, and a comparison with the ligand-free gC1q

107 ng substrate DNA strand containing five GAL4-binding sites revealed that GAL4-VVD randomly moved on t

108 Computational models predicted a GAT1508-binding site validated by experimental mutagenesis exper

109 ccupancy of GATA-1, OGT, and OGA at the GATA-binding site of the lysosomal protein transmembrane 5 (L

110 membrane helix 6 (TM6) alter the glutathione-binding site and the associated substrate-binding cavity

111 nd is only partially dependent on the glycan-binding site of CRT, which is generally relevant to subs

112 ture.ORG for further investigation of glycan-binding sites and glycan structures.

113 While alternating access of sugar- and H(+)-binding sites to either side of the membrane is driven b

114 mutants targeting the substrate- and NAD(H)-binding sites identifies key residues in the active site

115 q, together with NMR analysis of the H3K4me3-binding sites of the PHD fingers from PHF23, KDM5A and B

116 ent effort to recognize nucleotide- and heme-binding sites with a comparable accuracy to highly speci

117 chrome reductases also possess atypical heme-binding sites, the NrfA nitrite reductase (CXXCK) and th

118 eling and mutagenesis, we mapped its heparin-binding site.

119 sible to predict the location of the heparin-binding site.

120 agating to opening of the intracellular G(i)-binding site.

121 helices from each monomer, with three Zn(II)-binding sites, two of which occupy the active sites, whe

122 this article, we describe that the integrin-binding site of human CD40L is predicted to be located i

123 search for additional alphav-class integrin-binding sites.

124 ence identity, the NHE9 architecture and ion-binding site are remarkably similar to distantly related

125 al the conserved architecture of the NHE ion-binding site, their elevator-like structural transitions

126 r latent or reactivation-specific RBP-Jkappa-binding sites.

127 To this end, we identified an NF-kB-binding site in USP7, ubiquitin-like domain 2, that sele

128 interact with LC8, many contain multiple LC8-binding sites.

129 also discover a distant (25 angstrom) ligand-binding site unique to SARS-CoV-2, which can alternative

130 The extracellular ligand-binding site of DRD2 is remodelled in response to agonis

131 ing mode in the orthosteric PPARgamma ligand-binding site.

132 entric and scalable method to predict ligand-binding site residues.

133 These motifs define the ligand-binding site and make up the most structurally divergent

134 n allosteric network encompassing the ligand-binding site and the G protein-binding site.

135 find that the base pairs close to the ligand-binding site become stronger upon ligand binding, wherea

136 cribe how structural changes from the ligand-binding site can be transmitted to the central ion-condu

137 mation on the chemical structure, the ligand-binding site, the direction of modulation, the potency,

138 decreasing in both stem 1 and at the ligand-binding site.

139 ormational flexibility, together with ligand-binding site and interaction mechanisms.

140 rification, and possess deeply buried ligand-binding sites.

141 Fast and accurate classification of ligand-binding sites in proteins with respect to the class of b

142 ransforms the molecular structures of ligand-binding sites to 2D Voronoi diagrams, which are then use

143 calculations identified two potential ligand-binding sites.

144 Detecting protein-ligand-binding sites experimentally is time-consuming and expen

145 The discovery of protein-ligand-binding sites is a major step for elucidating protein fu

146 icularly to the NBDs and its putative ligand-binding sites face the transporter to likely modulate AT

147 lpha are generally distal to putative ligand-binding sites.

148 Our results suggest that the two ligand-binding sites are potentially controlled by each other d

149 dinate allosteric coupling of the two ligand-binding sites.

150 subpockets and compare them to whole ligand-binding sites.

151 hic alpha-helices h1 and h3 comprise a lipid-binding site that is partially pre-formed in solution, i

152 the membrane through the canonical CRD lipid-binding site (CRD beta7-8), as well as an alternative in

153 mitoylation that directly occupies its lipid-binding site and inhibits TEAD-mediated transcription in

154 AR surfaces are sequestered and the PX lipid-binding sites are occluded.

155 In spite of these shared lipid-binding sites, we observe significant differences in myo

156 ller and pore domains located close to lipid-binding sites.

157 selectively coordinates the putative lithium-binding site results in a dramatic 100-fold reduction in

158 use intact proteins to show that the lysine-binding site of K2(hPg) is a major determinant of the ac

159 The binding of PAM to the lysine-binding site of K2(hPg) relaxes the conformation of hPg,

160 mall-molecule inhibitor targeting the lysine-binding site of KIV-10 can combat the pathophysiological

161 been proposed to be mediated by their lysine-binding sites.

162 tructures and identify two conserved mannose-binding sites, which are consistent with general beta-tr

163 ionalized the scaffold by installing a metal-binding site consisting of four glutamate residues close

164 ic characterization of a tri-aspartate metal-binding site previously identified on the three-fold sym

165 have previously identified a putative metal-binding site on the inner surface of the Rhodospirillum

166 turbations of His(232), just below the metal-binding site along the proton exit route, differentially

167 ant in which aspartate residues in the metal-binding site of the polymerase domain were replaced by a

168 required for alternating access of the metal-binding site to the external or cytosolic environment.

169 nt functions: one conserved transition metal-binding site acts as the transport site essential for ac

170 ial for activity, whereas the variable metal-binding site is required for hZIP4's optimal activity pr

171 ded that the two physically associated metal-binding sites in the BMC of human ZIP4 (hZIP4) zinc tran

172 The results indicate three critical metal-binding sites: two Mn and one Ca, with occupation of the

173 plied not only for MT2 but to identify metal-binding sites in other Cys-containing proteins.

174 upon sensing copper at the interfacial metal-binding sites in CusS's periplasmic sensor domains, prio

175 he efficiency of the method by mapping metal-binding sites of Zn(7-x)MT species using a bottom-up MS

176 talytic site and neighboring secondary metal-binding sites.

177 etal complexes offers insight into the metal-binding sites.

178 uirement of correct occupancy of these metal-binding sites coupled to a slow restructuring of the pro

179 ular dynamics simulations identify two metal-binding sites within the N and C domains of ferroportin.

180 eractions by disrupting each predicted miRNA-binding site by CRISPR-Cas9 genome editing in C. elegans

181 p of pairwise interactions between 171 miRNA-binding sites and identified synergistic and redundant e

182 X-ray crystal structure revealed a monobody-binding site centered on the alpha4 helix of the MLKL 4H

183 imited to a region extending from the mtClpX-binding site to the active site.

184 ly associated with bHLH motifs, strong Myod1-binding sites were co-enriched with non-bHLH motifs, pos

185 ion of Ca(2+) to regulate exposure of myosin-binding sites and, thus, myosin cross-bridge recruitment

186 Disruption of the NAD(+)-binding site or the ARM-TIR interaction caused constitut

187 se to DNA damage and occupancy of the NAD(+)-binding site, the interaction of HPF1 with PARP1 or PARP

188 Although mutating one or two NC-binding sites caused only mild defects in packaging, mut

189 and efficacy at three discrete neurosteroid-binding sites determine whether a neurosteroid has poten

190 fic binding to three identified neurosteroid-binding sites in the alpha(1)beta(3) GABA(A) receptor (G

191 the CAST gene is a target of NFI and has NFI-binding sites in its intron 3 region.

192 ystallography uncovered an additional nickel-binding site at the dimer interface, which binds Ni(II)

193 iver, we show that proximity to a nucleotide-binding site increases the risk of N-acetylation and ide

194 apping it with the Sec7d from ARF nucleotide-binding site opener (ARNO)/cytohesin-2, a plasma membran

195 ily of enzymes shares an atypical nucleotide-binding site known as the ATP-grasp fold.

196 WEW, which encodes a coiled-coil, nucleotide-binding site and leucine-rich repeat protein (CNL).

197 Additional nucleotide-binding sites were found on the face of the protein oppo

198 erized by structurally asymmetric nucleotide-binding sites.

199 ation by acyl-CoAs is enhanced by nucleotide-binding sites and may contribute to higher stoichiometry

200 -malonylation by malonyl-CoA near nucleotide-binding sites which overlaps with in vivo N-acetylation

201 f the takinib scaffold within the nucleotide-binding sites of each respective kinase.

202 iminish N-malonylation near their nucleotide-binding sites, but not at distant lysine residues.

203 Furthermore, an additional oligosaccharide-binding site 20 angstrom away from the catalytic pocket

204 More strikingly, we found an oligosaccharide-binding site at the surface of domain A, distant from th

205 ns, and is nearby but not directly in the OM-binding site.

206 hieved by ColN having multiple distinct OmpF-binding sites, one located within its central globular d

207 ccupies both the macrolide- and orthosomycin-binding sites on the 70S ribosome.

208 OsHOX24-binding sites in each sample and differential binding si

209 ecise global distinction between p53-and p63-binding sites, recognition motifs, and potential co-fact

210 nal repression of Wapl through a single Pax5-binding site by recruiting the polycomb repressive compl

211 We located the Br-PBTC-binding site through mutagenesis and docking in alpha4.

212 the unexpected discovery of a second peptide-binding site in Hsp70s.

213 owever, this well-established single peptide-binding site alone has made it difficult to explain the

214 while increasing flexibility of the peptide-binding site turret loop.

215 the N-terminal alpha-helix near the peptide-binding site while increasing flexibility of the peptide

216 riant leads to the exposure of a plasminogen-binding site that is cryptic in FXII-WT.

217 experiments indicated that the canonical PLB-binding site (comprising transmembrane helices M2, M4, a

218 c genomic locations that correspond to PRDM9-binding sites.

219 ng the ligand-binding site and the G protein-binding site.

220 the ligand-binding pocket and the G-protein-binding site in the G-protein-coupled receptor superfami

221 d by more than 20 angstrom and the G-protein-binding site is a shallow groove rather than a cleft.

222 orting of membrane lipids around the protein-binding site to prepare it for viral assembly.

223 peak calling correspond to annotated protein-binding sites and/or have stable predicted secondary str

224 r recognition and the flexibility of protein-binding sites.

225 Asp(22) is part of the proton-binding site of GlcP(Se) and crucial for the glucose/H(+

226 in blocking the canonically proximal quinone-binding site.

227 ydrogen-bond networks connecting the quinone-binding site to the transmembrane subunits are found to

228 We also identified two distal quinone-binding sites with bound quinones.

229 We recently identified an additional Rap1-binding site in the talin-1 F1 domain that makes a great

230 Previous work identified a low-affinity Rap1-binding site in the talin-1 F0 domain that makes a small

231 n (F1) contains a previously undetected Rap1-binding site of similar affinity to that in F0.

232 clear how SHP2 selectively recognizes RasGAP-binding sites on EGFR and HER2.

233 ve charge around the haemagglutinin receptor-binding site show increases and decreases in avidity, re

234 ility: it modulates exposure of its receptor-binding site and subsequently undergoes complete structu

235 to open conformations to expose its receptor-binding site and, subsequently, from prefusion to postfu

236 omain B and overlaps with the Mxra8 receptor-binding site.

237 ed accessibility of epitopes in the receptor-binding site (RBS) for neutralizing mAbs, resulting in e

238 ysis of both RBDs suggests that the receptor-binding site for QX is located at a different location o

239 A/6B via a region homologous to the receptor-binding site in Clostridioides difficile toxin B (TcdB),

240 ominant site, which may overlap the receptor-binding site.

241 at a site that is distinct from the receptor-binding site.

242 d preserves steric accessibility to receptor-binding sites, likely influencing antigen binding and ef

243 ic peptides containing the HPV16 L2 retromer-binding site and a cell-penetrating sequence enter cells

244 REVERBalpha-binding sites are highly enriched for consensus RORE or

245 demonstrate that RBP, with a tunable ribose-binding site and further engineered to bind xenon, enabl

246 CTD of P stalk proteins because the ribosome-binding site is exposed.

247 ctures that otherwise sequester the ribosome-binding site of the 3'gene.

248 n constraints, including promoters, ribosome-binding sites and terminators.

249 te that Mn(2+) competes with Fe(2+) for rRNA-binding sites and that protection of ribosomes from Fe(2

250 We identified a RUR-binding site near helix S1 that may stabilize this helix

251 ivergent cluster adjacent to the SEC31/SEC23-binding site was critical for this SAR1B function.

252 he Tsr homodimer (pTsr) has an intact serine-binding site.

253 RBS, using the general design of 9-O-Ac-Sia-binding sites as blueprint, backed-up by automated ligan

254 ka virus SLA and NS5, and identified the SLA-binding site on NS5.

255 ndicating that they each are part of the SLA-binding site.

256 k in the receptor core, which forms a sodium-binding site in most GPCRs.

257 in immunoprecipitation-sequencing to map SRF-binding sites in human coronary artery SMC, showing that

258 R beta(+)-alpha(-) subunit interface steroid-binding site and identify several steroid PAMs that act

259 Here, we identified steroid-binding sites in purified human alpha1beta3 and alpha1be

260 ce for intersubunit and intrasubunit steroid-binding sites in the GABA(A)R transmembrane domain, but

261 tant role in defining the acceptor substrate-binding site.

262 presence of a putative allosteric substrate-binding site in a hydrophobic pocket on the enzyme surfa

263 its analogues bind to the central substrate-binding site of SERT, stabilize the outward-open conform

264 rger than expected for a localized substrate-binding site.

265 port pathway extends from the MlaE substrate-binding site, through the channel of MlaD, and into the

266 structural alteration of the NAA10 substrate-binding site.

267 structural alteration of the NatE substrate-binding site.

268 ecause DapF (Ct) utilizes a shared substrate-binding site for both racemase and epimerase activities,

269 They all have a single substrate-binding site and two gates, which are present on either

270 structures have revealed a single substrate-binding site in the SBD that binds a single segment of a

271 tom linker only interacts with the substrate-binding site and functions as a substrate.

272 that occur upon occupation of the substrate-binding site by an active site-directed inhibitor.

273 the cysteinylglycine region of the substrate-binding site occupied.

274 Although buried near the substrate-binding site, S267X substitutions were easily accommodat

275 te, involving rearrangement of the substrate-binding site-associated re-entrant hairpin loops.

276 a large rigid body movement of the substrate-binding site.

277 didate molecules to homology models of sugar-binding site.

278 ng studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site.

279 We named this site surface-binding site (SBS) A1.

280 3c subdomain orientation obscures the target-binding site.

281 den from nuclease attack, whereas the target-binding sites are exposed to allow delivery to the cance

282 ar the entrance of the (6S)-tetrahydrofolate-binding site.

283 the contribution of genetic variation in TF-binding sites to disease heritability is challenging, as

284 " mechanism to design two cooperative, three-binding-site receptors starting from a single-site-and t

285 ith voltage-shifting mutations and the toxin-binding site of human Na(V)1.7, an attractive pain targe

286 eractions that extend into the peptidyl tRNA-binding site and towards synergistic binders that occupy

287 he binding interface between the tropomyosin-binding site of cardiac leiomodin and the N-terminus of

288 C-terminal subdomain containing the Ube2D~Ub-binding site.

289 cover a method for identifying unexpected Ub-binding sites.

290 injury) and their effects on the ubiquinone-binding site and a connected cavity in ND1.

291 analog of the VA isoflurane to identify a VA-binding site in the TREK1 K2P channel.

292 ty of regulatory sequences, as ErfA- and Vfr-binding sites were found to have evolved specifically in

293 should enable the identification of vimentin-binding sites and compound moieties for binding.

294 ; 2) the M1 domain that harbors the vinculin-binding site is unfolded at ~6 pN; and 3) unfolding of t

295 th UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustain

296 lung adenocarcinoma risk by creating an YY1-binding site to suppress DCBLD1 expression, which may se

297 n the DNA-binding domain, distal to the zinc-binding site.

298 ese studies reveal a previously unknown zinc-binding site on the surface of the ADAR1 deaminase domai

299 u(2+) We also demonstrate that multiple zinc-binding sites on tau are involved in the LLPS-promoting

300 ormational changes in the region of the Zn2+-binding site reveal an allosteric basis for Zn2+ modulat