ライフサイエンスコーパス: -binding

1 rminal region comprising ARL8- and kinesin-1-binding sites.

2 with PM via a polybasic cluster and a Ca(2+)-binding loop.

3 ucture revealed an EF domain with two Ca(2+)-binding motifs inserted within the catalytic domain.

4 with a peripheral membrane-associated Ca(2+)-binding protein, likely ANXA1.

5 binding restricts the dynamics in the Ca(2+)-binding region.

6 step, we sought to identify potential 14-3-3-binding sites in the APN sequence.

7 AAV6-binding antibodies were highly prevalent in SPF cats (83

8 etic perturbation that cellular nucleic acid-binding protein (CNBP) and La-related protein 1 (LARP1),

9 nd that PRC2 interacts with the nucleic acid-binding protein Ybx1.

10 cellular proteins, particularly nucleic-acid-binding proteins.

11 ity and 1-anilinonaphthalene-8-sulfonic acid-binding experiments, comparing original BEAT, mutated BE

12 and the interaction between actin and actin-binding proteins.

13 Filaments are regulated by actin-binding proteins, but the nucleotide state of actin is a

14 ce for the critical role of the Tarp F-actin-binding domains in host cell invasion and for the Tarp e

15 ducing conformational flexibility of F-actin-binding domains via interdomain cross-talk and consequen

16 n's interactions with myosin and other actin-binding proteins are essential for cellular viability in

17 ing regions of myosin assures a proper actin-binding interface and active site have formed before pro

18 tin monomers directly, formins use the actin-binding protein profilin to dynamically load actin monom

19 Targeting the actin-binding proteins LIMK1 and LIMK2 significantly diminishe

20 that increase the surface area of the actin-binding regions promoting myosin interaction with actin,

21 with functional assays to identify the actin-binding residues in FL villin that regulate its filament

22 inds to iNOS, and selective ligands for AGRP-binding melanocortin (MC) receptors.

23 llustrate the benefits of linking an albumin-binding domain to the single-domain ADCs.

24 lation in tumors compared to in situ albumin-binding prodrugs.

25 and is dependent on expression of the AMPAR-binding protein GRIP1.

26 resent the synthesis and evaluation of anion-binding properties of 12 new receptors from the unclosed

27 Functional studies including antigen-binding and neonatal fragment crystallizable (Fc) recept

28 ns, such as poly-reactivity and long antigen-binding loops, which are usually under negative selectio

29 m target clustering and higher-order antigen-binding valency.

30 ure of the DNA-binding domain of a model ASO-binding protein PC4, in complex with a full PS 2'-OMe DN

31 aiP exposes a mimic of an eukaryotic ATG16L1-binding motif that binds to ATG16L1's WD40 domain.

32 ATP-binding cassette (ABC) transporters constitute one of th

33 ndidate genes, glycogen synthase (glys), atp-binding cassette transporter (atp), and low-density lipo

34 etion was not a consequence of increased ATP-binding cassette subfamily G member 5/8 activity given t

35 n the microtubule-bound state by slowing ATP-binding, resulting in high-force production at both homo

36 In this system, the ATP-binding cassette (ABC) transporter LptB(2) FGC extracts

37 tif V controls communication between the ATP-binding pocket and the helical gate.

38 an irreversible bond with Cys 215 in the ATP-binding pocket, a residue that is not present in human C

39 lular levels of anticancer drugs through ATP-binding cassette (ABC) pumps.

40 volution of chlorosis, describe a biliverdin-binding protein in vertebrates, and introduce a function

41 Loss of MGP or its BMP4-binding capacity disrupted the retinal vasculature, resu

42 cent subunit Spt8 interact with the TATA box-binding protein (TBP)(2,7,15-17).

43 for calcium management (calmodulin, calcium-binding proteins), pH regulation (V-type proton ATPase),

44 ogin (SCGN) is a recently discovered calcium-binding protein belonging to the group of EF-hand calciu

45 in belonging to the group of EF-hand calcium-binding proteins.

46 signaling, while mutagenesis of the calcium-binding site abolishes Gpr126 function in vivo.

47 The Arabidopsis thaliana Calmodulin-binding Transcription Activator (CAMTA) transcription fa

48 Cap-binding protein (CBP)20 and its binding partner CBP80 ha

49 Here, we found that the noncanonical 5' cap-binding protein eIF3d was activated in response to metab

50 Srrt interacts with the nuclear cap-binding complex and facilitates recruitment of the splic

51 ly been challenged by studies of nuclear cap-binding protein 3 (NCBP3).

52 BP80 have been thought to constitute the cap-binding complex (CBC) that is acquired co-transcriptiona

53 e initiation stage by competing with the cap-binding initiation factor complex, eIF4F, restricting in

54 Insulators also gain H3K27ac and CCCTC-binding factor (CTCF) in anaphase/telophase.

55 eracts with androgen receptor (AR) and CCCTC-binding factor (CTCF), and modulates AR-dependent gene e

56 n this report, we demonstrate that the CCCTC-binding factor (CTCF), a crucial chromatin organizer, is

57 f A, which we previously identified as a CDK-binding motif.

58 ith an atypical chemokine receptor chemokine-binding protein 2 variant V41A (ACKR2-V41A; rs2228467).

59 cation and characterization of the chemokine-binding interface of evasins could thus inspire the deve

60 arrangements, disorder within the chromatin-binding proteins facilitates promiscuous binding to a wi

61 oxicity include its Spc42-, Spc29-, and Cmd1-binding sites.

62 that show well-known TRMs and related TF co-binding events.

63 nalysis of the data allowed pinpointing CodY-binding sites at close to single-nucleotide resolution.

64 CH-3-8 binding to the colchicine-binding site in tubulin protein was confirmed by tubulin

65 owever, the clinical relevance of complement-binding anti-HLA antibodies remains unclear.

66 ntaining polyglutamine tracts including core-binding factor alpha1, mediator subunit 12, transcriptio

67 In particular, the methyl-CpG-binding domain of MeCP2 shows preferential interactions

68 t the promoter, recruits the C/EBPbeta (CREB-binding protein) and CBP transcription factors and activ

69 well as loss of RUNX1 binding at RUNX1/CTCF-binding sites.

70 tides ('msR4Ms') designed to mimic the CXCR4-binding site to MIF, selectively bind MIF with nanomolar

71 DNA-binding results and cellular activity confirm that Omomy

72 hanced phosphorylation (Ser73), and AP-1/DNA-binding in response to S. mansoni infection.

73 B-dependent phosphorylation of the SAF-A DNA-binding domain; failure to execute this pathway leads to

74 if1 stimulated its helicase, ATPase, and DNA-binding activities, whereas maintaining its substrate pr

75 ranscriptional regulation is mediated by DNA-binding transcription factors that bind to regulatory ge

76 Cys2His2 zinc finger is the most common DNA-binding domain expanding in metazoans since the fungi hu

77 mall changes outside of highly conserved DNA-binding regions can lead to profound changes in protein

78 ious DNA motifs are mediated by its flat DNA-binding surface, which is centered on a short loop spann

79 cRNAs with high affinity through its HMG DNA-binding domain in vitro.

80 and anti-obesity drugs by inhibiting its DNA-binding activities.

81 The large DNA-binding surface on FACT appears to be protected by the c

82 ructurally unrelated to the E. coli McrB DNA-binding domain.

83 s demonstrate that YaaA is a new type of DNA-binding protein associated with the oxidative stress res

84 Missense mutations in cancers in the p53 DNA-binding and tetramerization domains cement the importanc

85 Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer ca

86 on strategy, we determined the preferred DNA-binding site for CDA-KLF1.

87 NA sequences containing their respective DNA-binding motifs and identify preferential motif arrangeme

88 ur findings show that even though UAF1's DNA-binding activity is redundant with that of RAD51AP1 in F

89 This sequence-specific DNA-binding protein can disrupt EBV latency by driving the t

90 pressing ALS-linked gene mutants for TAR DNA-binding protein (TDP-43) and superoxide dismutase 1 (SOD

91 ns of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and

92 TAR DNA-binding protein 43 (TDP-43) has emerged as a key player

93 Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central nervou

94 ocks MRE11 degradation in vitro, and the DNA-binding ability of CST is required for blocking MRE11-me

95 PCH1 and PCHL also inhibit the DNA-binding ability of PIF1 to negatively regulate the expre

96 re, we report a crystal structure of the DNA-binding domain of a model ASO-binding protein PC4, in co

97 which requires its interaction with the DNA-binding domain of PARP1.

98 rsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site.

99 Another motif, DPHK, is in the DNA-binding domain.

100 ently suggests that the knowledge of the DNA-binding properties of the proteins is in itself not suff

101 directly, using as the primary probe the DNA-binding species with the binding site inactivated and eG

102 en by favorable interactions between the DNA-binding surface of the DBD and the multiple phosphorylat

103 Notably, the expression of the DNA-binding-deficient mutant of NuMA affects chromatin decon

104 nding to the same consensus motif, their DNA-binding syntax is different, suggesting discriminatory f

105 DNA polymerase beta has two DNA-binding domains that interact with the opposite sides of

106 rminal region a previously unappreciated DNA-binding domain that exhibits specific binding to G-quadr

107 In vitro DNA-binding experiments and structural prediction show that

108 we show that variant PRC1 complexes with DNA-binding activities occupy target sites independently of

109 through YAP association with the TEA domain-binding motif in the promoter region of inflammatory cyt

110 Moreover, other Sirtuins share some DSB-binding capacity and DDR activation.

111 upies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and sterically prevents cGAS fro

112 iciently and selectively captured known CS-E-binding proteins in vitro and in cells.

113 a-interface, mapped to Switch I and effector-binding regions, (ii) alpha-interface at the allosteric

114 Surprisingly, we found that the eIF4E-binding domain of eIF4GI increases not only the binding

115 s is maintained by sterol regulatory element-binding proteins (SREBPs), membrane-bound transcription

116 e transcription factor cAMP response element-binding protein (CREB) to enhance the expression of prot

117 found that loss of the cAMP response element-binding protein (CREB) transcription factor significantl

118 eramide-induced RIP of cAMP response element-binding protein 3-like 1 (CREB3L1) also involves RAT.

119 Here, we tracked the microtubule end-binding activity of yeast kinesin-8, Kip3, under varying

120 d by recruitment of the microtubule plus end-binding protein EB1/EBP-2 around the wound and actin rin

121 the G allele interacted with CCAAT/enhancer-binding protein beta transcription factor (TF), while th

122 lls revealing upregulation of CCAAT/enhancer-binding protein homologous protein and immunoglobulin he

123 that NRARP interacts with lymphoid enhancer-binding factor 1 (LEF1) and potentiates Wnt signaling in

124 in stress marker insulin-like growth factor-binding protein 1 (IGFBP-1), were observed with 12-D(3)N

125 oproteinase-2 and insulin-like growth factor-binding protein 7 was measured at H0, H6, H12, and H24.

126 te assembly uncovered a transcription factor-binding motif for ZNF263, a C2H2 zinc finger protein.

127 n(s) within Periostin responsible for FAM20C-binding.

128 red nonessential either by their high fibrin-binding parameters and short lifetimes or their initial

129 Mutagenesis studies of the galabiose-binding domain of type P(N) SadP adhesin showed that the

130 experiments, and inhibition analysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjug

131 inder threshold followed by a list of glycan-binding motifs.

132 des a way to expand the repertoire of glycan-binding proteins for further study.

133 ture.ORG for further investigation of glycan-binding sites and glycan structures.

134 shorter and the bilobed cleft of the glycine-binding domain in GluN1 is more closed when bound to gly

135 We first demonstrate, via a [(35)S]GTPgammaS-binding assay, that drug activity is retained after conj

136 , which upregulates genes encoding guanylate-binding proteins (GBPs) and inducible nitric oxide synth

137 nd therapeutic interventions such as heparin-binding peptides (HBPs), which are used for other cases,

138 cterized one of the newly-discovered heparin-binding proteins, C-type lectin 14a (CLEC14A), a member

139 bstrate selectivity of ADAM17 toward Heparin-binding epidermal growth factor like growth factor (HB-E

140 We used pan-genomic HIF-binding and transcriptomic data to identify a novel long

141 m these additional factors together with HLA-binding properties by using machine-learning algorithms

142 mine the binding selectivities of several HS-binding proteins.

143 IgE-binding to fish tropomyosins and TPIs was demonstrated f

144 and glucose-6-phosphate isomerase showed IgE-binding for 6%-13% of patients.

145 Three IgE-binding proteins were identified: legumin (Pru du 6), al

146 in-like growth factor (IGF)-1 as well as IGF-binding protein (IGFBP)-3.

147 er that covalently binds with FMN and Cu(II)-binding pocket is located at the interface of the NfoR d

148 ay-based platform yields high-quality MHC-II-binding peptide datasets that can be used to improve the

149 IP-seq reveals that global effects on Pol II-binding are mutually rescued by prp5-GAR and spt8Delta.

150 ires the ATR activator, topoisomerase IIbeta-binding protein 1 (TopBP1).

151 ion between RGD structure and their integrin-binding capacity.

152 etween M6A, an intrinsically disordered iron-binding domain, and an iron oxide particle was visualize

153 endoplasmic reticulum localization, kinesin-binding or phosphoinositide-binding properties abrogated

154 bled monolayers (SAMs) of helical lanthanide-binding peptides.

155 he protein's structure, dynamics, and ligand-binding activity in both its soluble and membrane-anchor

156 also discover a distant (25 angstrom) ligand-binding site unique to SARS-CoV-2, which can alternative

157 We conclude that both ligand-binding and activity-based assays under optimized deterg

158 -directed mutagenesis and competitive ligand-binding analyses revealed that DPO and Ala-AA occupy the

159 y the presence of large extracellular ligand-binding domains (LBDs) and constitutive homo/heterodimer

160 eta11-12 linker in the extracellular, ligand-binding domain is an integral component of the desensiti

161 ing small molecule binding, measuring ligand-binding affinity, monitoring protein folding and unfoldi

162 For MN4, ligand-binding results in the reduction of dynamics that are lo

163 suggests the existence of an optimal ligand-binding pocket conformation for capsaicin-mediated TRPV1

164 ormation and occupies the orthosteric ligand-binding pocket enabled by a conformational change that d

165 calculations identified two potential ligand-binding sites.

166 icularly to the NBDs and its putative ligand-binding sites face the transporter to likely modulate AT

167 form of TNFR1 with a mutation in the ligand-binding CRD2 subdomain retained the monomer-to-dimer rat

168 ormational flexibility, together with ligand-binding site and interaction mechanisms.

169 ed that Fabp5, an abundant cytoplasmic lipid-binding protein found in brain endothelial cells, makes

170 gest how changes in the association of lipid-binding caveolar proteins upon flattening of caveolae co

171 contemporary view of how proteolysis, lipid-binding activity and interactions with polysaccharides a

172 AR surfaces are sequestered and the PX lipid-binding sites are occluded.

173 report that, in mammalian cells, NF2's lipid-binding ability is critical for its function in activati

174 teracting with lipid membranes (termed lipid-binding loop [LBL]).

175 nstrate that SWG directly binds to the lipid-binding cavity of OSBP.

176 d physiological membranes in both a liposome-binding assay and MIN6 cells.

177 These findings characterize hGBP1 as an LPS-binding surfactant that destabilizes the rigidity of the

178 ved through a hydrophobic trimethyl-L-lysine-binding 'cage' formed by BAHCC1(BAH), mediating colocali

179 been proposed to be mediated by their lysine-binding sites.

180 ave shown that 5-HT(3A)-ICD fused to maltose-binding protein (MBP) directly interacts with RIC-3, wit

181 The collectins mannose-binding lectin (MBL) and surfactant protein D (SP-D) are

182 Additionally, high-mannose-binding lectins possess a broad capacity to neutralize a

183 The relative levels of membrane-binding of recombinant alphaA(N101D)- and WTalphaA prote

184 However, current MHC-binding prediction methods lack an analysis of the major

185 Kinesin is part of the microtubule-binding motor protein superfamily, which serves importan

186 diated by lysine residues in the microtubule-binding repeat region of tau.

187 The microtubule-binding taxanes, docetaxel and cabazitaxel, are administ

188 p of pairwise interactions between 171 miRNA-binding sites and identified synergistic and redundant e

189 eractions by disrupting each predicted miRNA-binding site by CRISPR-Cas9 genome editing in C. elegans

190 igh-throughput engineering of small-molecule-binding aptamers to acquire those with improved binding

191 target of Myb protein 1 (Stm1; SERPINE1 mRNA-binding protein 1 [SERBP1] in mammals), and recently, la

192 riguingly, Cep63 fused to a microtubule (MT)-binding domain of Cep57 functioned in concert with Cep15

193 Disruption of the NAD(+)-binding site or the ARM-TIR interaction caused constitut

194 However, STEAP1 lacks an intracellular NADPH-binding domain and does not exhibit cellular ferric redu

195 rvation and structural similarity in the NES-binding cleft region, (Sc)CRM1 exhibits 16-fold lower bi

196 The nucleosome-binding interface exclusively occupies the strong double

197 R, protease-activated receptor 2, nucleotide-binding domain, leucine-rich-containing family, pyrin do

198 munication between the actin- and nucleotide-binding regions of myosin assures a proper actin-binding

199 WEW, which encodes a coiled-coil, nucleotide-binding site and leucine-rich repeat protein (CNL).

200 iated by the intracellular cyclic nucleotide-binding domain (CNBD) connected to the pore-forming S6 t

201 g a detailed multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoire involved

202 identify epigenetic regulation of nucleotide-binding leucine rich repeat or Nod-Like Receptor (NLR) g

203 ivate innate immune cells through nucleotide-binding oligomerization domain (NOD) 1 and/or NOD2 recep

204 Furthermore, an additional oligosaccharide-binding site 20 angstrom away from the catalytic pocket

205 OSBPL1 encodes the full-length oxysterol-binding protein-related protein ORP1L, which transports

206 the opposing functions of BRCA1 and the p53-binding protein 1 (53BP1)-associated complex in DNA rese

207 nal repression of Wapl through a single Pax5-binding site by recruiting the polycomb repressive compl

208 rands and crosslink them: class A penicillin-binding proteins (aPBPs) and complexes of SEDS proteins

209 role of the bifunctional class A penicillin-binding proteins (aPBPs) as well as the L,D-transpeptida

210 or peptidoglycan crosslinking by penicillin-binding protein 2 (PBP2) are unable to initiate polarize

211 ent peptidoglycan crosslinking by penicillin-binding protein 3 (PBP3/FtsI) initiate polarized divisio

212 between adjacent wall peptides by penicillin-binding proteins to confer robustness and flexibility.

213 single amino acid replacements in penicillin-binding protein 2X (PBP2X), a major target of beta-lacta

214 single amino acid substitution in penicillin-binding protein PBP2X that conferred a 2-fold increased

215 DNA while its CIP (Ctf4-interacting peptide)-binding helical domains remain available to recruit part

216 positions are component parts of the peptide-binding pocket 7 (P7) of the HLA-DR heterodimer, suggest

217 vel its details, we identified all phosphate-binding protein lineages in the Evolutionary Classificat

218 ization, kinesin-binding or phosphoinositide-binding properties abrogated the regenerative effects.

219 tent with adipogenesis, and the phospholipid-binding protein annexin A3 (AnxA3), a negative regulator

220 (7)S-) were found to be critical to the PI5P-binding ability.

221 Chlamydomonas reinhardtii, the LHCSR pigment-binding proteins are essential for NPQ.

222 c genomic locations that correspond to PRDM9-binding sites.

223 h is regulated by hypoxia via HIF-1 promoter-binding in multiple cell types.

224 This structure revealed a protease-binding mode for EapH1 with cathepsin-G that was globall

225 ften function as molecular decoys of protein-binding partners or nucleic acid targets, while enzymati

226 Knowledge of protein-binding residues (PBRs) improves our understanding of pr

227 terference of biomolecular interactions, PSA-binding ligands have important implications for both bio

228 We also identified two distal quinone-binding sites with bound quinones.

229 ydrogen-bond networks connecting the quinone-binding site to the transmembrane subunits are found to

230 se (NOX2) subunit, p67(phox), and to the RAC-binding domain of p21-activated kinase, consistent with

231 chromatin architecture and genome-wide RALY-binding pattern reveal insights into its cooperative int

232 Whereas its RAS-binding domain (RBD) contains the main binding interface

233 The Ras-binding domain of the protein kinase c-Raf (c-Raf-RBD) i

234 IgM, A, and G Ab responses against receptor-binding domain are significantly correlated to the disea

235 sorbent assay utilizing recombinant receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was

236 an extended loop in the C-terminal receptor-binding domain (HC) of BoNT/B (HC/B) has been proposed t

237 between those directed against the receptor-binding domain (RBD) and those directed against the N-te

238 The receptor-binding domain (RBD) is immunodominant and the target of

239 rotein (GFP), siderocalin (Scn), and retinol-binding protein 4 (RBP4) as model proteins and screened

240 ritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, folate, and

241 The FinO-domain-protein ProQ is an RNA-binding protein that has been known to play a role in os

242 ffold with basic patches constituting an RNA-binding surface exhibiting a preference for binding doub

243 ting elements, alternative splicing, and RNA-binding factors.

244 strained, and enriched for cis-eQTLs and RNA-binding protein (RBP) interactions.

245 (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via liquid-liquid phase

246 DZIP3/hRUL138 is a poorly characterized RNA-binding RING E3-ubiquitin ligase with functions in embry

247 Consequently, RNA-binding proteins and mRNA-encoded sequence elements serv

248 could validate RBMS1, a barely described RNA-binding protein, as a new target gene for oncogenic miR-

249 PEP activity, composed of genes encoding RNA-binding proteins.

250 h, revealed significant changes only for RNA-binding motif 3 (Rbm3).

251 excitement around ProQ as a novel global RNA-binding protein, and its potential to serve as a matchma

252 ndividual guide RNAs (gRNA), we identify RNA-binding proteins (RBPs) that influence the formation of

253 (dT) capture, and proteomics to identify RNA-binding proteomes.

254 ighly interconnected network enriched in RNA-binding proteins (RBPs) and EV cargoes.

255 Finally, we observed a DNV burden in RNA-binding-protein regulatory sites (OR = 1.13, 95% CI 1.1-

256 classical NLSs within the cold-inducible RNA-binding protein (CIRBP).

257 ated mRNA decay and associate with major RNA-binding proteins (RBPs) such as Hfq and ProQ.

258 our results showed increased binding of RNA-binding protein CUGBP1 with occludin and E-cadherin gene

259 s and are enriched with binding sites of RNA-binding proteins, RNA structure-changing variants and tr

260 ition for binding sites among protective RNA-binding proteins and decay factors, PTBP1 promotes displ

261 to investigate viral genome replication, RNA-binding affinity, ATP hydrolysis activity, and helicase-

262 ere, we report the identification of the RNA-binding protein HuR/ELAVL1 as a central oncogenic driver

263 s to functional neurons by depleting the RNA-binding protein PTB (also known as PTBP1).

264 s through experimental examples with the RNA-binding protein Puf4.

265 enome-scale collection of RBPs and their RNA-binding domains (RBDs) and assessed their specificities

266 ized livers through its interaction with RNA-binding protein HuR.

267 y a construct derived from the PRG:Galpha(s)-binding region, PRG-linker.

268 ion by NMR spectroscopy, we identify the SAM-binding region and observe changes in the dynamics of th

269 othelial growth factor (VEGF) and semaphorin-binding receptor Neuropilin-1 (Nrp-1) emerge as crucial

270 ompete identifies a GC-rich region as SERBP1-binding motif; subsequent genomic and functional analyse

271 Structural insights into setron-binding poses and their inhibitory mechanisms are just b

272 ty in a panel of variants of the Car9 silica-binding peptide (DSARGFKKPGKR) fused to the C-terminus o

273 -membrane interaction and fully map the site-binding energetics of Syt1 both in the absence and prese

274 utively inhibits I(Kv1.5) Disrupting the Src-binding motif of Kv1.5 through N-terminal truncation or

275 on protein A (RPA), a major eukaryotic ssDNA-binding protein, is essential for all metabolic processe

276 ealed a large, membrane-accessible substrate-binding pocket that alternately faced the ER lumen and c

277 partially collapsed inward-facing substrate-binding cavity.

278 ecause DapF (Ct) utilizes a shared substrate-binding site for both racemase and epimerase activities,

279 2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-

280 ariable structural features of the substrate-binding pocket that underlie the divergent evolution of

281 nly six substitutions occur at the substrate-binding surface, and the others change domain-domain int

282 We propose that sugar-binding pockets spatially closer to the catalytic domain

283 bitors of non-canonical IkappaB kinases TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKe

284 esigned two cyclic peptide mimics of the TAR-binding beta2-beta3 loop sequences present in two high-a

285 HOAP is a telomere-binding protein that has a conserved role in Drosophila,

286 network features such as network size and TF-binding affinities.

287 t-1 bind to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with

288 associated protein 1 (adenosine triphosphate-binding cassette subfamily C member 1 [ABCC1]) is abunda

289 why no relationship between exposure to TTR-binding compounds and circulating T4 levels in humans ha

290 e of this impurity, does not exhibit tubulin-binding activity.

291 Ablation of tubulin-binding cofactors (TBCs) further sensitizes cells and th

292 ence of a polymerization catalyst or tubulin-binding drugs.

293 injury) and their effects on the ubiquinone-binding site and a connected cavity in ND1.

294 ablishing UBA(Cez) as a functional ubiquitin-binding domain.

295 In addition to ubiquitin-binding and ubiquitin-like domains, they contain a conse

296 We found that folding-upon-binding primarily occurred through induced-folding pathw

297 The identified VA-binding region contains residues that play roles in the

298 Two predicted zinc-binding residues, Asp87 and His88, are required for MBLA

299 n of the E3 ligase complex, such as the zinc-binding motif and N- and C-terminal regions of the prote

300 n the DNA-binding domain, distal to the zinc-binding site.