ライフサイエンスコーパス: -deficient

1 r1(-/-)) bitten by the virus-infected AaVA-1-deficient mosquitoes present a lower viremia and prolong

2 e and transfer of IL-10-proficient and IL-10-deficient B cells to muMT mice.

3 ld-type ILC2 rescued RSV-driven AHR in IL-13-deficient mice.

4 Colon tumors from IL-17RD-deficient mice are characterized by a strong enrichment

5 at in contrast to WT mice, diabetic 4E-BP1/2-deficient mice did not exhibit enhanced retinal Cd40 mRN

6 Remarkably, almost all IFB-2- and IFC-2-deficient animals develop to fertile adults.

7 of YAP-driven cancer cells, such as Lats1/2-deficient cancer cells as well as Galpha(q/11) mutated u

8 /6(-/-) pmLF and ROCE was similar in STIM1/2-deficient pmLF compared to Wt cells.

9 Myeloid-specific, IL-33-deficient or ST2-deficient mice were employed to examine

10 lycolytic responses were amplified in LXA(4)-deficient mice, which correlated with more severe pathol

11 Additionally, IL-6-deficient asthmatic mice exhibited reduced goblet cell h

12 the persistence of intact N4BP1 in caspase-8-deficient macrophages impairs their ability to mount rob

13 IL-8R2-deficient mice had fewer neutrophils in infected lungs t

14 s than controls, but unexpectedly the IL-8R2-deficient mice had fewer organisms in their lungs than t

15 pe, PARP-1 activation is undetectable in AAG-deficient cells.

16 fied previously, but only aba4 exhibited ABA-deficient phenotypes.

17 d as a regulatory motif, and the acetylation-deficient Lys258Arg mutant was enzymatically inactive an

18 Some of the salicylic acid-deficient Arabidopsis eds5 mutants have an unnoticed fah

19 inactive and failed to rescue growth of ACO2-deficient cells.

20 Intriguingly, ADA-deficient patients have been reported to have bilateral

21 in pathology, mirroring that observed in Ahr-deficient mice.

22 HR-competent Hepa1-GFP hepatoma cells or AHR-deficient LLC lung cancer cells.

23 imilar to the biochemical picture in ALDH7A1-deficient patients.

24 stinal bleeding and anemia in inducible ALK1-deficient adult mice.

25 eased apoptosis were observed in alpha3beta1-deficient tumor cells, these changes followed a robust i

26 clinical samples, E-cadherin-expressing and -deficient tumours both invade collectively and metastasi

27 In beta-Arr2-deficient mice, bile duct ligation injury (BDL) led to s

28 ression of beta-Arr2 in injured or beta-Arr2-deficient SECs rescued eNOS function by increasing eNOS

29 ligonucleotide to young-adult aspartoacylase-deficient mice reverses their pre-existing ataxia and di

30 ATGL-deficient INS1 cells and human pseudoislets showed reduc

31 itro, leading to selective cell death in ATM-deficient cells.

32 -directed agents, we created a series of ATM-deficient preclinical prostate cancer models and tested

33 nerated a mouse model that harbors an ATPase-deficient allele and demonstrates that mutant CHD7 retai

34 Autophagy-deficient cells secreted increased amounts of type I int

35 Also, autophagy-deficient ILC2s were adoptively transferred into Rag(-/-

36 ult of Tfap2a hyperactivity, where kctd15a/b-deficient embryos exhibited increased abundance of this

37 is abolished in C18orf8-, Ccz1- and Mon1A/B-deficient cells and restored by a constitutively active

38 /B cell-deficient B6.BTg.muMT mice, and BAFF-deficient/B cell-deficient B6.Baff(-/-) muMT mice demons

39 Experiments with BAFF-deficient B6.Baff(-/-) Bcl2(Tg) mice, B cell-deficient B

40 BAP1-deficient tumors exhibit deregulation of the Hippo pathw

41 Rapid growth of BAP1-deficient tumors indicates that these patients should be

42 In mice with Bcl6-deficient Treg cells, twice as many ST2(+) (IL-33R(+)) T

43 A-binding function of MEF2C, and DNA binding-deficient Mef2c global heterozygous mice display numerou

44 Notably, the expression of the DNA-binding-deficient mutant of NuMA affects chromatin decondensatio

45 nge activity is resuscitated in heme binding-deficient Sfh5 mutants.

46 analogous to CFSs, fragile telomeres in BLM-deficient cells involved double-strand break (DSB) forma

47 antiproliferative profiles against both BRCA-deficient and BRCA-proficient cancer cells in cellular a

48 otein that promotes fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replicati

49 f how RAD52 contributes to viability of BRCA-deficient cells remains unknown.

50 The exquisite sensitivity of BRCA-deficient cells to 3' blocks indicates that they represe

51 is poorly understood, it is unclear why BRCA-deficient cells require APE2 for viability.

52 beled surrogate of PEG~TLZ in the MX-1 BRCA1-deficient tumor.

53 RP inhibitor combination therapies for BRCA1-deficient cancers than would be identified by traditiona

54 , such as diminished PARPi efficacy in BRCA1-deficient cells and altered repair of damaged telomeres,

55 modulator of stalled fork stability in BRCA2-deficient cells and show that codepletion of RFWD3 rescu

56 TET2 knockdown in BRCA2-deficient cells protected stalled replication forks (RFs

57 novel pathways of PARPi resistance in BRCA2-deficient cells.

58 performed a genome-wide RNAi screen in BRCA2-deficient mouse embryonic stem cells and validation in K

59 T cell receptor (TCR) transductants and BTN3-deficient human 293T cells reconstituted with alpaca or

60 C18orf8-deficient cells lack Rab7 activation and show severe def

61 els demonstrating end-organ protection in C3-deficient mice and evidence of complement activation in

62 We previously showed that calnexin (Canx)-deficient mice are desensitized to experimental autoimmu

63 In contrast, aging (18-24-month-old) Carns1-deficient mice exhibited olfactory sensitivity impairmen

64 n vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone

65 ection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures.

66 hat pathologic microvascular leakage in CD31-deficient mice can be corrected by enhancing the glycoly

67 lls from PIV-vaccinated WT mice to naive CD4-deficient (CD4 KO) mice demonstrated that antigen-experi

68 Sensitized wild-type and CD8-deficient (CD8(-/-)) mice were challenged with allergen.

69 y, DCs from BALB/c mice cocultured with CD83-deficient CD4(+) conventional T cells showed enhanced CD

70 B6.BTg.muMT mice, and BAFF-deficient/B cell-deficient B6.Baff(-/-) muMT mice demonstrated that, in a

71 ent B6.muMT mice, BAFF-overexpressing/B cell-deficient B6.BTg.muMT mice, and BAFF-deficient/B cell-de

72 deficient B6.Baff(-/-) Bcl2(Tg) mice, B cell-deficient B6.muMT mice, BAFF-overexpressing/B cell-defic

73 onstrate here that PLP(ECD)-immunized B cell-deficient mice failed to exhibit EAE.

74 were analyzed by using wild-type and B-cell-deficient (muMT) mice and transfer of IL-10-proficient a

75 tion in Ptgs2 (Ptgs2(Y385F) mice), mast cell-deficient (W/W(V)) mice, and W/W(V) mice given injection

76 Engraftment of mast cell-deficient mice with Tph1(-/-) mast cells or selective ma

77 uced a response in both wild-type and T cell-deficient mice, suggesting that it maintains a T-indepen

78 CFAP45-deficient cilia and flagella show normal morphology and

79 mice were subjected to a methionine-choline-deficient diet causing nonalcoholic fatty liver disease

80 at diet and in mice fed a methionine-choline-deficient diet.

81 at shock but was nearly eliminated in a ClpB-deficient E. coli strain, which demonstrates a significa

82 In enhancer cluster-deficient animals, Nppa was induced but remained low in

83 RNA RsaD is overexpressed >20-fold in a CodY-deficient strain in three S. aureus clinical isolates an

84 Mechanistically, Cosmc-deficient B cells have normal rolling and firm arrest on

85 the protein transport protein Sec31A in CRT-deficient cells.

86 ggested that defective accumulation of CRTH2-deficient ILC2s in response to IL-33 was due to altered

87 In GM-CSF-deficient (Csf2(-/-)) mice, inflammation resolution is d

88 We further demonstrated that juvenile csf1r-deficient zebrafish exhibit systemic macrophage depletio

89 Hematopoietic Cx43-deficient chimeric mice show reduced mitochondria transf

90 Primary tumors from Cyp2c44-deficient mice contained higher numbers of tumor-associa

91 HFD feeding of CysC-deficient (CysC knockout [KO]) mice worsened obesity-ass

92 The aims were to determine, in vitamin D-deficient overweight and obese children, whether supplem

93 nservation voids for Caprinae and other data-deficient species inhabiting rugged or heavily vegetated

94 phenotypes were unaffected in Notch1/2 dimer-deficient mice, a subset of tissues proved highly sensit

95 lum (ER)-targeted mRNA translation in DIS3L2-deficient cells.

96 based transduction of Dnase1l3 into Dnase1l3-deficient mice restored the end motif profiles to those

97 id cell (ILC) number and function in a Dock8-deficient mouse model.

98 The migration of DOCK8-deficient T cells to the skin and their survival there h

99 ein were markedly reduced in Src-1/-2 double-deficient (Src-1/-2(d/d) ) fetal lungs, compared to WT.

100 ApoE/CD163 double-deficient mice displayed a more unstable plaque phenotyp

101 cterized the immune cell functions of DUSP11-deficient mice.

102 The oxidized Pol gamma becomes editing-deficient, displaying a 20-fold elevated mutations than

103 Administration of peptide YY to EEC-deficient mice restores normal electrophysiology, improv

104 l activities of the compounds against efflux-deficient Escherichia coli are mediated by LpxA inhibiti

105 ed L,X-type directing group with an electron-deficient 2-pyridone ligand to enable the beta-methylene

106 The use of an electron-deficient pyridone ligand is crucial for the observed en

107 activated (hetero)aryl bromides and electron-deficient (hetero)aryl chlorides, and significantly redu

108 gands such as dimethyl fumarate and electron-deficient styrenes afford primarily beta-hydride elimina

109 m the electron-rich pyrene (Py) and electron-deficient thiazolo[5,4-d]thiazole (Tz).

110 catalysts were evaluated with four electron-deficient alkenes to develop a three-parameter statistic

111 Distinctly, the most electron-deficient superoxo adduct is observed to react the faste

112 actical benzylic dehydrogenation of electron-deficient heteroarenes, including pyridines, pyrazines,

113 Herein we show that electron-deficient Grignard monomers readily polymerize under vis

114 ai stacking interaction between the electron-deficient pentafluorophenyl ring and electron-rich napht

115 es alkyl radicals for coupling with electron-deficient olefins for the generation of unnatural gamma-

116 oal was to knock out Gys1 in laforin (Epm2a)-deficient LD mice after disease onset to determine wheth

117 Reduction of IP3R1 in epsin-deficient mice restores atherosclerotic progression.

118 The secretome of ERK3-deficient cells is defective in chemotaxis of neutrophil

119 m ranelate (625 mg/kg/d) (strontium/estrogen-deficient).

120 RAP-stained cells was higher in the estrogen-deficient group than in estrogen-sufficient group at 30

121 gen-sufficient); ovariectomy+water (estrogen-deficient), sham-surgery+strontium ranelate (625 mg/kg/d

122 ion with a skeletal muscle signature in etv2-deficient embryos.

123 An APE1 exonuclease-deficient mutant identified in somatic tissue from a can

124 chieved by in trans rescue with a Nod factor-deficient S. meliloti mutant.

125 pproaches, and plasma LCB profiling in FADS3-deficient mice confirmed that FADS3 is a bona fide LCB d

126 s FXII- or FXI-deficient plasma, but not FIX-deficient plasma.

127 The flavonol-deficient tt4 mutant has elevated ROS in trichoblasts an

128 ive in vivo inhibition of miR-128-3p in FMRP-deficient astroglia sufficiently rescues decreased mGluR

129 1)-receptor and A(1)R-Y288A(7.53) (a folding-deficient variant used as a reference), respectively.

130 this study, we generated a BP180 functional-deficient mouse strain by deleting its extracellular dom

131 Briefly, FVIII-deficient mice received IV emicizumab 24 hours before ta

132 ormal pooled plasma, as well as FXII- or FXI-deficient plasma, but not FIX-deficient plasma.

133 her studies, using adult liver-specific G6pc-deficient mice at both pre-tumor and tumor stages, hepat

134 During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impair

135 ivation in wild-type (Col-0) or rescue of GA-deficient dwarf mutants.

136 not occur efficiently in vivo and that Galc-deficient Schwann cells autonomously produce psychosine.

137 AMP1 fully rescues the phenotype of the GALC-deficient mouse (Twitcher), and widespread deletion of G

138 h compared to those injected with gingipain-deficient OMVs or controls.

139 the observed Golgi localization of O-glycan-deficient cargos is due to their slow Golgi export.

140 d by the lack of circadian rhythmicity in GR-deficient B cell counts normally associated with diurnal

141 s that can reverse microglial defects in Grn-deficient mouse microglia, we performed a compound scree

142 Hdac3-deficient osteoclasts demonstrate increased K310 NF-kapp

143 Single-cell transcriptome analysis of Hh-deficient mesoderm revealed selective deficits in anteri

144 Reciprocally, Hhex-deficient MBCs exhibited increased Bcl6 expression and r

145 Importantly, HLTF-deficient cells also exhibit reduced double-strand break

146 Here, we demonstrate that HLTF-deficient cells fail to undergo fork reversal in vivo an

147 We show here that Hmces-deficient mice display normal hematopoiesis without glob

148 rests cardiac differentiation, whereas Hoxb1-deficient mouse embryos display premature cardiac differ

149 xpression of interferon response genes in HR-deficient cancers.

150 Notably, HRI-deficient mice display normal Bcl11a levels, suggesting

151 as relatively unchanged, forming diffuse, HS-deficient deposits in both the Prnp180Q/196Q and WT mice

152 nic mouse system using otherwise MHC class I-deficient C57BL/6 mice, thereby conditionally ablating M

153 toration of endothelial MHC I rendered MHC I-deficient mice susceptible to lung injury.

154 (OVA)-expressing E.G-7 tumor-bearing immune-deficient mice, intravenously injected Cy5.5-CTLs were c

155 er when xenografted subcutaneously in immune-deficient NSG mice.

156 These IRF5-deficient cells exhibited impaired influenza virus-induc

157 ISG15-deficient humans exhibit permanent, low-level expression

158 nd reveal the therapeutic potential of ISG15-deficient porcine and rhesus models.

159 The ITCH-deficient macrophages had increased levels of the mature

160 al PDAC samples that exhibit the HNF1A/KDM6A-deficient molecular phenotype.

161 We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhi

162 r in vivo studies revealed that myeloid-KLF6-deficient mice were highly resistant to endotoxin-induce

163 absent or, possibly, compromised in laforin-deficient murine LD.

164 Taz prevented growth of PDA cells in leucine-deficient medium, but not in complete medium.

165 formed at the interface of Pt NPs and linker-deficient Zr(6)O(8) nodes resting on the Pt NP surface.

166 Using LITAF-deficient cells, a second, subsequent whole-genome CRISP

167 Lmo4-deficient mice (Lmo4gt/+) consumed significantly more an

168 ted the infection of C3H 5-lipoxygenase (LO)-deficient mice with Borrelia burgdorferi results in prol

169 ression levels return to near baseline, LSD1-deficient CD8 T cells failed to remethylate the Pdcd1 lo

170 otypic and transcriptomic profiling of c-Maf-deficient CCR6(-) ILC3s revealed a hyper type 1 differen

171 nding in the head is mostly intact in Magel2-deficient mice, although it is reduced in the lateral pe

172 teral periodontium (gums) of neonatal Magel2-deficient mice compared to wild-type controls.

173 Interestingly, the C-mannosyltransferase-deficient Deltadpy19 parasites were strongly attenuated

174 We show that in MAX-deficient cells, MNT binds to MLX, but also forms homodi

175 oliferation of intestinal stem cells in MCL1-deficient mice required WNT signaling and was associated

176 Gene expression analysis of mirn23a-deficient myeloid progenitors revealed a decrease in TLR

177 ed motility and chemotactic response by MKL1-deficient neutrophils.

178 than their wild-type counterparts, and Mmp14-deficient Mphis showed a reduced ability to induce EndMT

179 Rh-PPO as a chemotherapeutic targeted to MMR-deficient cancers.

180 Patients with MMR-deficient colorectal cancer were excluded.

181 d selectively induce cytotoxicity within MMR-deficient cells.

182 introduced mtDNA is stably retained in mtDNA-deficient (rho0) recipient cells following uridine-free

183 More importantly, microglial mTOR-deficient mice displayed increased neuronal loss and dev

184 classifiers revealed that half of the mTORC2-deficient NK cells belongs to the least mature NK cluste

185 AP) sites abolishes higher survival of Mutyh-deficient (Mutyh (-/-)) MEFs, but this blockade had no a

186 In agreement, immature cDC1s in Mycl (-/-) -deficient mice exhibited reduced expression of genes tha

187 ubtypes (i.e., BRAF-mutant, NRAS-mutant, NF1-deficient, and triple wild-type).

188 erostructure composed of strongly coupled Ni-deficient Li(x)NiO nanoclusters and polycrystalline Ni n

189 NIPP1-deficient keratinocytes massively expressed proinflammat

190 We generated a new Nlrc4-deficient mouse line and mice with S533D phosphomimetic

191 PCP signaling is partially active in Nodal-deficient embryos and its inhibition exacerbates their C

192 he helicase-nuclease Cas3(4,5), but nuclease-deficient type I systems lacking Cas3 have been repurpos

193 the expression of genes with wide nucleosome-deficient regions (e.g., ribosomal protein genes), known

194 ing, hypoxic/quiescent and necrotic/nutrient-deficient).

195 Cultured Olfml3-deficient pericytes exhibited aberrant motility and alte

196 Of note, an outer-membrane porin (omp)-deficient strain of Escherichia coli expressing heterolo

197 AM-sufficient (ADM(+/+)) or -deficient (ADM(+/-)) mice were exposed to normoxia or hy

198 ermal, fibroblast, and immune cells of Ovol1-deficient skin that reflect an altered course of epiderm

199 e (aKG) esters elicits rapid death of OXPHOS-deficient cancer cells by elevating intracellular aKG co

200 om the eastern tropical North Pacific oxygen-deficient zone and that some microbially produced sulfid

201 Generation of the oxygen-deficient vanadium oxide, [V(6)O(6)(OC(2)H(5))(12)](1-),

202 at heat-induced DV destabilization in PI(3)P-deficient P. falciparum precedes cell death and is rever

203 nd PI3K signaling pathways are delayed in P2-deficient mouse bone marrow-derived macrophages, mouse e

204 Supporting this, P2X4-deficient (KO) mice were protected against ischemic AKI

205 co-targeting MK2 and XPA to pre-existing p53-deficient tumors in a highly aggressive, immunocompetent

206 pathway was essential for the growth of p53-deficient tumor organoids.

207 nt to enhance the therapeutic effects on p53-deficient neuroblastoma.

208 ogical and morphological properties of Pcdhg-deficient and wild-type cINs during the period of cIN ce

209 in irradiated wild-type recipients of PDIA6-deficient bone marrow cells, both in the absence or pres

210 Thus, a murine model of perforin-deficient CAR T cells recapitulated late-onset inflammat

211 Interestingly, pGP3-deficient Chlamydia sp. was able to colonize the colon f

212 However, the small intestinal pGP3-deficient Chlamydia sp. failed to reach the large intest

213 intestine, explaining the lack of live pGP3-deficient Chlamydia sp. in rectal swabs following an ora

214 intracolon inoculation, suggesting that pGP3-deficient Chlamydia sp. might be prevented from spreadin

215 nt enrichment in an oligotrophic, phosphorus-deficient pond in Cuatro Cienegas, Mexico.

216 phosphorylation in vivo, new phosphorylation-deficient p53-S180A knock-in mice were generated.

217 In sensory-specific Piezo2-deficient mice, the distribution of corneal neurons disp

218 CfrA overexpression is also observed in PII-deficient strains; however, it is lethal in this genetic

219 re and puncture), adoptive transfer of Pink1-deficient bone marrow or pharmacological inhibition of m

220 n that bypasses the gastric barrier, plasmid-deficient Chlamydia produced infectious progenies in sma

221 However, to our surprise, plasmid-deficient Chlamydia failed to produce infectious progeni

222 Both PRAP1-deficient and E85V knock-in mutant mice fed a chow diet

223 K27me3 by 50% each time DNA replicates, PRC2-deficient ISCs initially retain sufficient H3K27me3 to a

224 demonstrate that growth inhibition in PRDM10-deficient mESCs is in part mediated through EIF3B-depend

225 and immunostimulatory reprogramming of Prox1-deficient tumors, destroyed tumor fibrosis, and unleashe

226 observations, BRF1 overexpression in a Pten-deficient mouse (Pten(Delta/Delta) BRF1(Tg)) prostate ca

227 of NHEJ-DDR proteins in autophagy- and PTEN-deficient cells.

228 tion 5B (STAT5B), and STAT6 in p53- and PTEN-deficient TNBC cells.

229 prostate and skin cancer initiation of Pten-deficient mice.

230 emoglobin processing remains unaffected, PV5-deficient parasites generate less hemozoin.

231 ulates skull development, we generated Rab23-deficient mice that survive to an age where skeletal dev

232 factor Spt4/Spt5 suppresses TC-NER in Rad26-deficient cells.

233 We show here that RAD50-deficient fibroblasts exhibit a marked delay in mitotic

234 istently, depletion of NK1.1(+) cells in Rag-deficient mice both prevented IFN-gamma production and r

235 hlight a downstream actionable target in RB1-deficient cancers, for which there are currently no targ

236 not led to effective strategies to treat RB1-deficient tumors, as it is challenging to develop target

237 s as a top enriched class of genes in Rbfox2-deficient retinas.

238 vehicle, TSLPR(-/-) mice, and IL-33 receptor-deficient (ST2(-/-) ) mice were challenged intranasally

239 after ZIKV challenge in type I IFN receptor-deficient mice and wildtype mice administered neutralizi

240 BALB/c WT and TSLP receptor-deficient (TSLPR(-/-) ) mice were challenged intranasall

241 cers, especially in homologous recombination-deficient cancers, which display a distinctive mutationa

242 cancer therapies in homologous recombination-deficient cancers.

243 ubstitutions in the homologous recombination-deficient Rad51 mutant, specifically dependent on the Po

244 le vulnerability in homologous recombination-deficient tumor cells.

245 al therapy to treat homologous recombination-deficient tumors.

246 f2 activity is absent in the retina of REDD1-deficient mice compared with WT.

247 to reveal that genetic rescue of DNA repair-deficient germ cells (Fancm(-/-) ) leads to increased mu

248 ost of them were generated using replication-deficient lentiviruses, a technique that presents divers

249 utcompete near-cognate suppression in an RF1-deficient expression host and therefore could not produc

250 RIN-deficient fruit never ripened completely, even when supp

251 The reduced ET production by RIN-deficient tomatoes was due to an inability to induce aut

252 Nonetheless, RIP-deficient strains have over an order of magnitude fewer

253 genes are differentially expressed in the SA-deficient mutant plant line compared to the wild type an

254 blocked anti-insulin vaccine response in SAP-deficient NOD mice.

255 SENP3-deficient cells exhibit hypersumoylation of E2F1 and are

256 similar to that observed in Notch-signaling-deficient epithelia.

257 functional analysis of human primary SMARCD2-deficient cells.

258 SMCHD1-deficient cells displayed reduced ATM S1981 phosphorylat

259 In SOD3-deficient mice, hypoxia increased lung hyaluronidase exp

260 SPEG-deficient skeletal muscles contained fewer myogenic cell

261 Myeloid-specific, IL-33-deficient or ST2-deficient mice were employed to examine the role of IL-3

262 Furthermore, human STAT5b-deficient NK cells had low cytolytic capacity, and fixed

263 In the presence of co-stimulation-deficient T cell activation, anergy is a dominant hallma

264 or the treatment of MCC and many other STING-deficient cancers.

265 esses using a model of TLR priming in a TAK1-deficient setting to mimic pathogen-induced priming and

266 0c-2* and miR-497 as underexpressed in TAp63-deficient cuSCC.

267 Using Tbet-deficient (Tbet KO) mice, we showed a partial role for T

268 In Tbx1-deficient mice, the spheno-occipital synchondrosis was c

269 sregulated CD86 expression in Tet2- and Tet3-deficient B cells was further demonstrated by the restri

270 ehaviors or SAA1 and SAA2 production in Th17-deficient mice after stress.

271 MTCH2 read-through-deficient cells, generated using CRISPR-Cas9, showed inc

272 TIPE-deficient T lymphocytes are completely pilot-less: they

273 stering near the nucleus as seen in TMEM106B-deficient cells.

274 are significantly decreased in the TMEM106B-deficient Oli-neu oligodendroglial precursor cell line.

275 reviously characterized phenotype of Tmem189-deficient mice may be caused by a lack of plasmalogens.

276 21, and a reduction of mature NPCs in Torsin-deficient cells lead us to conclude that the hallmark ph

277 Ames wild-type strain or the isogenic toxin-deficient mutants DeltaEF, DeltaLF, and DeltaPA.

278 The PTEN/TP53-deficient tumor demonstrates treatment resistance, selec

279 d ClC-6 ion transport, as shown by transport-deficient double mutants, and depended on Cl(-)/H(+) exc

280 transport system was verified in transporter-deficient rats as a secondary model organism, and transl

281 illar Abeta oligomers were elevated in Trem2-deficient brains.

282 Analysis of tryptophan-deficient states as compared to control in both germ-fre

283 an overcome the H(2)O(2) sensitivity of Tsa1-deficient cells.

284 t, and AKT or ERK1/2 signaling in human TSC2-deficient cells treated with GLPG1690.

285 highlighting critical roles for ATX in TSC2-deficient cell fitness and in TSC tumorigenesis.

286 e studies increase our understanding of TSC2-deficient cell metabolism, leading to novel potential th

287 In upf1-deficient mutants, NMD-susceptible transcripts of riboso

288 increased post-injury scarring in collagen-V-deficient mice.

289 elayed replenishment of Treg cells in Vbeta5-deficient mice compromises suppression of microbiota-dep

290 Moreover, FTO expression is increased in VHL-deficient ccRCC tumors compared to normal adjacent tissu

291 metabolic reprogramming and survival of VHL-deficient ccRCC cells.

292 ively reduces the growth and survival of VHL-deficient cells in vitro and in vivo.

293 therapeutic target for the treatment of VHL-deficient renal cell carcinoma.

294 Compared with wild-type, VHL-deficient Th17 cells had elevated glycolysis and glycoly

295 vICA-deficient mutants, lacking either UL36 or M36, exhibit g

296 ry and viral progeny are reduced in vimentin-deficient fibroblasts, compared with control cells.

297 Many bacteria can form wall-deficient variants, or L-forms, that divide by a simple

298 Despite this, migration defects of WNK1-deficient thymocytes do not account for the developmenta

299 XRN2-deficient cells also showed enhanced PARP1 activity.

300 seminiferous tubules of the testis in ZFP628-deficient mice that results in male infertility.