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1 re indicating clear or almost clear plus a 2-grade improvement in the IGA score for the intertriginou
2 ase activity thanks to a semi-quantitative 4-grade scale, named respectively PGA (Physician Global As
4 rade IDH differentiation syndrome (17%), all-grade electrocardiogram QT prolongation (26%), and grade
5 , hyperphosphataemia was the most common all-grade adverse event irrespective of cause (88 [60%] of 1
8 erse events of special interest included all-grade IDH differentiation syndrome (17%), all-grade elec
9 robaileyales together form the so-called ANA-grade of angiosperms, which are extant representatives o
11 ion mechanisms in polycrystalline biomedical-grade superelastic NiTi are spatially mapped using in si
13 cking the RSPO3-LGR4 interaction by clinical-grade anti-RSPO3 antibody (OMP-131R10/rosmantuzumab) imp
15 eatly increase capacity to generate clinical-grade peptides on demand, which is a key step in reachin
16 ect manager to facilitate obtaining clinical-grade biomarkers (blood/tissue NGS, specific immunohisto
17 w have been guided by biomarkers or clinical-grade assays developed to predict patient response and,
18 lockade of the NRG1/HER3 axis using clinical-grade blocking antibodies re-sensitizes tumors to hormon
19 The methodology was validated using clinical-grade induced pluripotent stem cell-derived retinal pigm
21 rations currently measured on two commercial-grade cell-free tumour DNA platforms, despite the use of
23 by conducting aerial surveys with a consumer-grade quadcopter (DJI Phantom 3), while concurrently rec
24 modules for a unified outcome of diagnostic-grade reliability: A 4-minute, parent-report questionnai
26 study included 5,193 kindergarten and first-grade students enrolled from 13 communities in 2002-2003
28 ent study developed novel highly active food-grade antimicrobial peptides affecting a wide range of b
29 immobilized and commercially available food-grade Candida antarctica lipase B, Lipozyme(R) 435, was
30 nd bromelain were selected out of eight food-grade enzymes for the kinetic analysis of peanut protein
46 >=3 s electrical pause or asystole; (2) high-grade Mobitz type II atrioventricular block or complete
47 grade glioma (n = 93), ependymoma (32), high-grade glioma (25), medulloblastoma (22), ganglioglioma (
48 with cerebral gliomas (9 low-grade, 34 high-grade; 9 primary tumors, 34 recurrent tumors) who had pr
50 nt study, we report the production of a high-grade spinal cord glioma model in pigs using lentiviral
51 th carcinoma in situ (with or without a high-grade Ta or T1 tumour) had a complete response within 3
54 p developed response criteria for adult high-grade glioma, but these were not created to meet the uni
55 mmendations for the management of adult high-grade glioma, for paediatrics there is inclusion of diff
57 quently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated wi
58 fectiveness of qHPV vaccination against high-grade cervical precancerous lesions, among women vaccina
60 lomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence r
61 sis were conducted with histologic anal high-grade squamous intraepithelial lesion (A-HSIL) as the de
63 uman papillomavirus (HPV) genotypes-and high-grade anal intraepithelial neoplasia (HGAIN) in men who
64 t can also efficiently bind B cells and high-grade B cell lymphoma (diffuse large B cell lymphoma) ce
65 R 4.53, 95%CI 1.34-15.26; P = 0.02) and high-grade dysplasia (HGD) in the original resection (HR 3.60
66 nomas, adenomas >=20 mm in diameter and high-grade dysplasia were associated with increased risk of c
68 static cancers, including low-grade and high-grade gliomas and brain metastases (BrMs) originating fr
69 n distinction between the low-grade and high-grade intraepithelial melanocytic proliferations and nee
70 Family history of pancreatic cancer and high-grade IPMN was identified as risk factors for recurrence
71 ent in distinction between the low- and high-grade lesions was 76% for PAM, 67% for conjunctival mela
72 ritability (h(g)(2)) of EOC overall and high-grade serous ovarian cancer (HGSOCs) were estimated to b
74 e percentage of (Gleason pattern-based) high-grade cancers (PHG) is demonstrated in EAs (p < 0.01) bu
75 udy Group database with primary central high-grade osteosarcoma of the extremities, treated between 1
77 rmediate (non-metastatic R0 or R1 >5 cm high-grade, or unresected tumour of any size or grade); or hi
79 tection rate of 100% (8/8) in detecting high-grade dysplasias and carcinomas over white-light detecti
80 age-matched Pten littermates developed high-grade prostatic intraepithelial neoplasia and prostate c
81 y (PET/CT), is often used to assess for high-grade coronary artery disease (CAD) requiring revascular
84 erentiate low-grade (Fuhrman I-II) from high-grade (Fuhrman III-IV) renal cell carcinoma using radiom
85 -P could further be differentiated from high-grade prostatic intraepithelial neoplasia (HGPIN), a pre
88 rates of lesions suspected of harboring high-grade dysplasia or early adenocarcinoma, a novel grasp a
89 phy (3.4% versus 10.2%, P<0.0001), have high-grade CAD (0.5% versus 6.5%, P<0.0001), and receive reva
90 tifies PET/CT patients unlikely to have high-grade CAD or require revascularization within 90 days an
91 functionally silenced, HR+, CARM1-high, high-grade serous ovarian cancer cells become PARPi sensitive
92 in well characterized cohorts of human high-grade astrocytomas, mostly glioblastomas, compared to he
93 nd Obstetrics (FIGO; 1988) stage IC-IIA high-grade serous, clear cell, or any poorly differentiated o
100 , gammaH2AX expression was increased in high-grade PanINs but not in PDAC, corroborating earlier resu
101 SOX9 is significantly overexpressed in high-grade PC tumors (P < 0.05) and in chemotherapy-treated p
103 tein convertase, is highly expressed in high-grade serous carcinoma of ovarian cancer patients, and i
104 ring neoadjuvant chemotherapy (NACT) in high-grade serous ovarian cancer (HGSOC), we performed immuno
105 (CRISPR)-mediated knockout of FABP4 in high-grade serous ovarian cancer cells reduced metastatic tum
109 ed 18 years and older with stage III/IV high-grade serous, endometrioid, or clear cell ovarian cancer
110 included diffuse large B-cell lymphoma, high-grade B-cell lymphoma with rearrangements of MYC and eit
112 is an emerging precursor to neoplastic high-grade B-cell lymphoproliferation among people with HIV,
114 ty tables that include the incidence of high-grade adverse events, defined by the Common Terminology
115 S); 20 LBCL-IRF4 cases; and 12 cases of high-grade B-cell lymphoma (HGBCL), NOS in patients <=25 year
117 sion of advanced adenomas, diagnosis of high-grade dysplasia in the rectum or pouch, or progression o
121 odel, the parameters most predictive of high-grade melanocytic intraepithelial lesion/melanoma in sit
122 reatic cancer involves visualization of high-grade pancreatic intraepithelial neoplasias (PanIN-3s),
126 e prevailing paradigm in the genesis of high-grade serous carcinoma (HGSC), the most common ovarian c
127 n glycosylation in the heterogeneity of high-grade serous ovarian carcinoma (HGSC), we perform mass s
128 ve identified transcriptome subtypes of high-grade serous ovarian carcinoma (HGSOC), but their interp
129 lentiviral vector induced pig model of high-grade spinal cord glioma and may potentially be used in
130 ium 68 DOTATATE PET/CT, and in cases of high-grade tumors, they were also evaluated with fluorine 18
131 virus (HIV) plasma viral load (PVL) on high-grade cervical intraepithelial neoplasia (CIN2+) detecti
132 cation based on adenoma size >=20 mm or high-grade dysplasia (instead of the current high-risk classi
133 (<1cm, and without villous histology or high-grade dysplasia) and no neoplasia, respectively (log-ran
134 0mm, adenomas with villous histology or high-grade dysplasia, or colorectal cancer [CRC]) and assesse
136 Robust preclinical models of ovarian high-grade serous carcinoma (HGSC) are needed to advance our
142 rhabdoid tumors (n = 229) and pediatric high-grade gliomas (n = 401), we show significant association
143 pients receiving valganciclovir as PET, high-grade HHV-6 viremia was associated with increased age an
144 psy revealed a cytokeratin 20-positive, high-grade neuroendocrine neoplasm consistent with Merkel cel
147 , Frmd6/Pten double knockouts presented high-grade prostatic intraepithelial neoplasia (HG-PIN) and h
150 static R0 or R1 low-grade, or <=5 cm R1 high-grade tumour); intermediate (non-metastatic R0 or R1 >5
151 the tumor region, CMRO(2) was reduced (high-grade tumor CMRO(2), 0.23 mumol/g/min +/- 0.07; low-grad
152 ars) with recurrent, platinum-resistant high-grade serous ovarian cancer (determined histologically)
154 rs or older who had platinum-sensitive, high-grade serous or endometrioid ovarian, primary peritoneal
156 the following five histologic subtypes: high-grade myxoid liposarcoma (HG-MLPS); leiomyosarcoma (LMS)
159 with low-grade disease may progress to high-grade disease after immune modulation, which can be effe
160 atients at high risk for progression to high-grade dysplasia (HGD) or EAC are needed to improve outco
162 at baseline, the risk of progression to high-grade SILs (HSILs) and the clearance rate were estimated
166 mune surveillance of EBV, patients with high-grade disease may have a recurrence in the form of low-g
167 current colonic adenoma associated with high-grade dysplasia (HGD) colon polyps at baseline colonosco
168 BE samples collected from patients with high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC)
169 ion (ER) and ablation for patients with high-grade dysplasia (HGD) or intramucosal adenocarcinoma (IM
171 o [SIR] 2.07; 95% CI 1.40-2.93) or with high-grade dysplasia (SIR 0.79; 95% CI 0.39-1.41), whereas fo
172 on in plasma EV of the 11 patients with high-grade dysplasia alone, only 1 had high MUC5AC expression
173 uctal papillary mucinous neoplasms with high-grade dysplasia and some enlarged pancreatic intraepithe
176 -line, platinum-based chemotherapy with high-grade serous or endometrioid EOC should be offered PARPi
178 val among children and adolescents with high-grade, high-risk, mature B-cell non-Hodgkin's lymphoma a
179 ts efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.
181 ed with earlier year of diagnosis and higher-grade tumors (P < 0.05).The overall pCR rate was 8.6%, i
183 positive scans between patients with higher-grade and lower-grade primary tumors (Gleason score of >
190 umor CMRO(2), 0.23 mumol/g/min +/- 0.07; low-grade tumor CMRO(2), 0.39 mumol/g/min +/- 0.16; overall
191 ed (EL_INST: 17 patients, 17 lesions, 10 low-grade glioma, 3 cavernoma, 4 focal cortical dysplasia; N
192 l B-cell lymphoma (DLBCL/PMBCL; n = 28), low-grade B-cell lymphoma (n = 8), or chronic lymphocytic le
193 -three patients with cerebral gliomas (9 low-grade, 34 high-grade; 9 primary tumors, 34 recurrent tum
195 al features that are distinct from adult low-grade gliomas, and the developing paediatric brain is mo
196 Disturbances in glucose homeostasis and low-grade chronic inflammation culminate into metabolic synd
197 a from 335 adult patients with high- and low-grade glioma to form a replicable tumour frequency map.
200 patients had a transient, asymptomatic, low-grade atrioventricular block that resolved spontaneously
201 icates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards
202 logical types of childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade gliom
203 o autoinflammatory diseases, which cause low-grade systemic inflammation and contribute to several co
204 encompasses genetic alterations, chronic low-grade inflammation and gut dysbiosis, has led to improve
208 stic of aging is the presence of chronic low-grade inflammation that is characterized by elevated con
209 lication of processes related to chronic low-grade inflammation, including a network involving methyl
211 insight into the development of chronic, low-grade inflammation and oxidative stress in age-related d
214 Aging is characterized by a chronic, low-grade inflammation, which is a major risk factor for car
219 normal follicle structures and developed low-grade serous ovarian carcinomas with 100% penetrance wit
222 s of Enterobacteriaceae that exacerbated low-grade mucosal inflammation, suggesting that remediating
223 LBCL/PMBCL, 63% (95% CI, 25% to 92%) for low-grade lymphoma, and 50% (95% CI, 16% to 84%) for CLL.
224 -years were 1.09 (95% CI, 0.85-1.33) for low-grade/high-grade dysplasia and 0.14 (95% CI, 0.06-0.22)
228 ated within phase 3 trials of the German Low-Grade Lymphoma Study Group, were comparatively analyzed.
229 lation between the increased survival in low-grade glioma (LGG) and complementarity of IDH1 mutants t
231 augmenting the immune response to EBV in low-grade LYG include treatment with interferon-alpha2b, whe
233 rimary and metastatic cancers, including low-grade and high-grade gliomas and brain metastases (BrMs)
234 llular and molecular processes including low-grade inflammation are major players in the pathogenesis
235 inib showed durable efficacy with mainly low-grade toxic effects in patients with medullary thyroid c
238 ase may have a recurrence in the form of low-grade disease after immunochemotherapy, and those with l
242 tudy presents a non-invasive analysis of low-grade gliomas using imaging features based on the update
244 ty is associated with a chronic state of low-grade inflammation and progressive tissue infiltration b
245 e network system as neural correlates of low-grade inflammation and stress exposure, and suggest that
254 une cell composition and likely promotes low-grade chronic inflammation, which has been proposed to b
255 with primary or recurrent biopsy-proven, low-grade upper tract urothelial cancer (measuring 5-15 mm i
256 roups were: low (non-metastatic R0 or R1 low-grade, or <=5 cm R1 high-grade tumour); intermediate (no
259 However, the implications of surviving low-grade ACLF in terms of risk of subsequent high-grade ACL
260 have hypothesized that chronic systemic low-grade inflammation may contribute to greater risk of dev
262 on and stress exposure, and suggest that low-grade inflammation, alongside with stress, may render in
263 limited value in distinction between the low-grade and high-grade intraepithelial melanocytic prolife
264 assification correctly graded 76% of the low-grade cancers and 71% of the high-grade cancers accordin
265 ectivity among brain networks related to low-grade inflammation and stress exposure using two large i
268 ice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it was the first to dem
270 after immunochemotherapy, and those with low-grade disease may progress to high-grade disease after i
274 between patients with higher-grade and lower-grade primary tumors (Gleason score of >=4 + 3 vs. <3 +
276 thods Data in patients with IDH-mutant lower-grade gliomas (World Health Organization grade II/III) a
277 godendroglioma is an important type of lower-grade glioma (LGG), which is a slowly progressing brain
278 0 patients from five institutions with lower-grade gliomas (World Health Organization grade II and II
281 perties and the long-term effects of machine-grading and subsequent restoration of ski runs so as to
284 strongly corroborate the efficacy of medical-grade masks and highlight the importance of regular wash
287 jury grade (adjusted odds ratio, 2.0 per one-grade increase [95% confidence interval {CI}: 1.6, 2.4];
289 trate that cells treated with pharmaceutical-grade rigosertib (>99.9% purity) or commercially obtaine
290 yne impurities for the production of polymer-grade lower olefins remains an important and challenging
293 , B, C, and AE), produced either as research-grade material in 293 and CHO cells or as two independen
295 gent-grade and affordable dietary supplement-grade ellagic acid was sourced from tree bark and pomegr
298 e significantly associated with higher tumor-grade while 3/5 lncRNAs were also associated with no tum
299 ma-ray data and are able to identify weapons-grade plutonium, masked by naturally-occurring radioacti
300 e, a sphere of 4.5 kg of alpha-phase weapons-grade plutonium known as the BeRP ball, a 6 kg sphere of