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2 O(2) affinity, which we attribute to an O(2)-independent antisickling activity, in addition to the O(
3 that mimics both the O(2)-dependent and O(2)-independent antisickling properties of fetal hemoglobin.
5 ibrosis, our results highlight that the O(2)-independent UQ biosynthetic pathway may represent a targ
9 ve been conflicting reports about the Arp2/3-independent biochemical activities of WAVE1 on actin fil
10 conventional caspase-dependent but caspase 3-independent cell death and that the mechanism of cell de
11 ng chronic filarial infection and that IL-4R-independent/IL-5- and CCR3-dependent pathways are suffic
14 , SnRK2.6, SnRK2.7, and SnRK2.8, and the ABA-independent subclass 1 protein kinases SnRK2.1, SnRK2.4,
16 3 and ASC into a novel RIPK1 kinase activity-independent cell death complex to drive pyroptosis and a
17 found fully functional RIPK1 kinase activity-independent necroptosis driven by the RIPK3-MLKL pathway
19 at this diversity is the product of activity-independent size fluctuations, which are sufficient to g
21 Notably, adhesion-dependent and adhesion-independent migration are not mutually exclusive, but ra
24 n mitochondrial function were UCP1- or AKAP1-independent, suggesting compound effects on multiple nod
31 of tumor cells on HR signaling for anchorage-independent growth and highlights how the metastatic mic
32 independence and HT resistance in anchorage-independent cells revealed distinct context-dependent me
34 knockdown of which diminished the anchorage-independent growth of ILC cell lines through cell cycle
35 cancer cell lines increased their anchorage-independent growth and inhibited TGFB signaling to a gre
37 A modest increase in Cas9-dependent and -independent DNA off-target editing, and in transcriptome
39 unoblotting with conformation-dependent and -independent mAbs, which confirmed it to be both pure and
41 ins, suggesting that Pol zeta-dependent and -independent roles of Rev7 are relevant to cisplatin resp
46 tions have demonstrated a chlamydial antigen-independent immune mechanism for regulating chlamydial p
49 ence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate cancer (NEPC) after
51 pathogen interactions and suggest a new Arf1-independent role for components of the COPI coatomer com
53 nd Haemophilus influenzae use tripartite ATP-independent periplasmic transporters (TRAPs) to scavenge
56 in vivo and in vitro and complemented biotin-independent growth of the M. smegmatis tam deletion muta
61 -targets present were characteristic of Cas9-independent off-targeting and point to TC motifs as acti
62 induces a low frequency of genome-wide Cas9-independent off-target C*G-to-T*A mutation in mouse embr
63 sufficient to induce necroptosis, a caspase-independent mechanism of host cell death that failed to
67 ed by mannose 6-phosphate, suggesting cation-independent, mannose 6-phosphate receptor-mediated endoc
68 /DREB binding factor (CBF)-dependent and CBF-independent cold signaling pathways to tolerate cold.
73 identification of a cDC-dependent but T cell-independent modality that naturally adjuvants plasma cel
74 B cell differentiation in response to T cell-independent type 2 Ags (TI-2 Ags) has been understudied.
76 ts PLK4 from self-assembling into centrosome-independent condensates that serve as ectopic microtubul
77 ambda1 production was also induced in a cGAS-independent and DNA-protein kinase (DNA-PK)-dependent ma
78 tility of serum sphingolipids as cholesterol-independent markers of risk and even future targets for
79 nt decRiPPter (Data-driven Exploratory Class-independent RiPP TrackER), a RiPP genome mining algorith
80 ta show that DNA-PK has RNA-dependent, cNHEJ-independent functions during ribosome biogenesis that re
82 at lacks gC was more sensitive to complement-independent neutralization by a panel of gB monoclonal a
83 findings, we uncovered similar concentration-independent behavior from a control compound, strongly s
88 ll studied from isolate genomes, but culture-independent metagenomics provide a new window into their
89 opments in methodologies, especially culture-independent approaches, have accelerated and driven this
90 n has been given to hypothesis-free, culture-independent tests that can be performed directly on prim
93 e, we apply Hi-C, a high-throughput, culture-independent method, to surveil the bacterial carriage of
96 as been proposed in the past; and (2) a Cx36-independent rod pathway(s) (e.g., direct rod to OFF cone
101 n-shotgun proteome analysis (DI-SPA) by data-independent acquisition mass spectrometry (DIA-MS), we d
103 ection strategies for the processing of data-independent acquisition (DIA) proteomics experiments.
105 of concept, we applied FLEXIQuant-LF to data-independent-acquisition (DIA) data of the anaphase promo
108 nds that the skyrmion Hall angle is diameter-independent for skyrmions with diameters ranging from 35
109 integration of siRNA sequences into a Dicer-independent RNA stem-loop based on pre-miR-451 microRNA-
110 R-1 modulates both Dicer-dependent and Dicer-independent Argonaute pathways and provide insight into
111 line ones, such as nearly optimal, direction-independent properties and robustness against defects.
112 Ubqln4 engages the J proteins in a J-domain-independent manner, in contrast to the previously report
113 r photoproduct yields are explained by donor-independent, fast charge recombination with rates of ~0.
116 zation, the behavioral signature of effector-independent representations, to address this crucial gap
117 nt NSCLC models with EGFR-dependent and EGFR-independent resistance mechanisms, IACS-13909, administe
120 es that flu-produced (1)O(2) triggers an EX1-independent signaling pathway and proves that SAFE1 supp
122 hese results advance our understanding of FA-independent ICL repair and establish a role for the RecQ
123 8-FADD (FADDosome) complex and reveal a FADD-independent inflammatory role of caspase-8 that involves
124 itions can be converted into potent FcgammaR-independent agonists with remarkable antitumor activity
126 nculin association, our data show that force-independent relief of autoinhibition is sufficient to me
127 affect Treg suppressive function via a FOXP3-independent mechanism, thus sustaining the clinical impr
128 consequence of both fuel-dependent and fuel-independent mechanisms; they undergo slower decompositio
129 ty-six (ETS) fusion-dependent and ETS fusion-independent cancer cell lines revealed improved ETS fusi
130 ncer cell lines revealed improved ETS fusion-independent/dependent selectivity indices for select 2'-
131 disease status and used the G-SCI (Genotype-independent Signal Correlation and Imbalance) test(1) to
133 Recent data have revealed glutathione/GPX4-independent axes for suppressing ferroptosis, and insigh
136 ese findings identify FTO as a potential HIF-independent therapeutic target for the treatment of VHL-
137 inib targeted both Hippo-dependent and Hippo-independent regulation of YAP1, ablating rhabdomyosarcom
138 ld domain and the hairpin, exhibited hormone-independent interactions with PhMAX2A and PhD53A, respec
139 and represents a novel mechanism for hormone-independent pathogenesis of endometrial adenocarcinoma.
141 se data characterize the pleiotropic hormone-independent mechanisms underlying acquisition and restor
142 t is essential for both the prenatal hormone-independent as well as the pubertal hormone-dependent br
143 1(+)CD16/32(+) hematopoietic-stem-cell (HSC)-independent erythro-myeloid progenitors (EMPs) present i
144 our data indicate that CHP-1 plays an HSP90-independent function in controlling EGFR trafficking thr
145 cognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp that no longer recog
148 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective
151 hat mammalian STING possesses widespread IFN-independent activities that are important for restrictin
156 both inflammation-dependent and inflammation-independent functions, such as NF-kappaB-mediated cell s
158 ient cells leading to an increase in insulin-independent glucose transporter levels, enhanced cellula
159 imaging (FLIM) is a quantitative, intensity-independent microscopical method for measurement of dive
160 onical gp130 signaling, SarA function is JAK-independent but requires GSK-3, a key regulator of metab
162 rf2 function: a tonic effect through a Keap1-independent mechanism under basal conditions and an indu
165 l regulation of tankyrase serves as a ligand-independent developmental mechanism for post-translation
167 mulate bICP0 E promoter activity in a ligand-independent manner in mouse neuroblastoma cells (Neuro-2
169 f the embryo, is dispensable for both ligand-independent signaling pathway activation and ligand-resp
171 es that CXCR4 exhibits some degree of ligand-independent activity, a relevant feature for drug develo
173 results underscore the importance of ligand-independent TNFR1 dimerization in NF-kappaB signaling.
174 tion requirement, resulting in robust ligand-independent induction of proinflammatory genes and oncog
178 owing APC mutations, resulting in Wnt ligand-independent stabilization and nuclear accumulation of be
179 Therefore, femoral dP/dtmax is not a load-independent marker of left ventricular contractility and
180 ere we report the first high-precision, mass-independent Ru isotope compositions for Eoarchaean ultra
185 results suggest that a loss of NOD-LNSC MHC-independent suppressive mechanisms may contribute to dia
186 is promoted by oocyte-specific, microtubule-independent enrichment of the antiparallel microtubule c
188 that pestiviruses, although capable of miRNA-independent replication, took advantage of miRNAs as ess
193 a direct quantification of sensory modality-independent brain activity, revealing fast activation of
195 tination results in DNA2-dependent but MRE11-independent nucleolytic degradation of nascent DNA at st
196 ontrast, MPs activate translation in an mTOR-independent manner due, at least in part, to proteasomal
200 ant defense response in addition to COI1/MYC-independent functions in plant growth and development, s
205 onstrate that both NLRP3-dependent and NLRP3-independent inflammasome activation mechanisms induce CN
206 n CNV occurs via NLRP3 or also through NLRP3-independent mechanisms, and (3) whether complement activ
207 ition (with negative or neutral results), NO-independent soluble guanylate cyclase (sGC) activation,
209 illator model of aromaticity), NICS (nucleus-independent chemical shift), ACID (anisotropy of the ind
211 esonance scans using a reproducible operator-independent fully automatic open-source end-to-end pipel
212 faces are aligned to a view- and orientation-independent face template encoded in a face-centered ref
213 Our newly discovered bifunctional oxygen-independent pathway, widespread in bacteria, salvages at
215 here is less information available about p53-independent roles of MDMX or the MDM2-MDMX complex.
219 ng protein-1 (FUNDC1), an effector of Parkin-independent mitophagy, also participates in cellular pla
220 exo-HAV, infectivity of HAV particles is pH-independent and requires HAVCR1 or another as yet uniden
221 NHE module but not by those including the pH-independent CaV and BK module or proportionate mixed sce
224 ndependent role for Rac1 in mediating a PI3K-independent MET-to-mTOR pathway and suggest alternative
229 yglutamine-expanded (mHTT) and polyglutamine-independent HTT specific immunoassays for validation in
230 in a Tir-dependent but actin polymerisation-independent manner, which was enhanced by priming with i
231 erpene (-)-jiadifenolide on action potential-independent inhibitory currents at GABAergic synapses, u
232 events were consistent with action-potential-independent spontaneous glutamate release, suggesting pl
233 s; p = 0.005) and remained stable in preload-independent ones (mean change = 49.2 mm Hg.s; p = 0.114)
236 cells, which was accompanied by proteasomal-independent losses of the viral genome and integrase enz
240 e that osmotolerance is conferred through Q8-independent protection of respiration, not by altering p
241 nogenic DNA damage taking advantage of Rad51-independent single-strand annealing (SSA) assays in the
248 nts (EPSCs) are followed by GABA(A) receptor-independent outward currents, reflecting the hyperpolari
249 s result was consistent with increased renin-independent aldosterone production and hypertension.
250 d pressure category had a continuum of renin-independent aldosterone production, where greater severi
254 ost-assembly host species richness, richness-independent host phylogenetic diversity, and colonizatio
255 gen-activated protein kinase-dependent Ripk1-independent IL-1 and tumor necrosis factor production, a
256 DM as in the original model, there is an RNA-independent maintenance phase involving CMTs followed by
257 then based on a combination of RdDM and RNA-independent mechanisms involving DNA methyltransferase M
258 ope, and reference electrodes provide sample-independent reference potentials over a wide range of el
259 with a decreased likelihood of schizophrenia-independent of intelligence-and, hence, may be entangled
261 roups, indicating the existence of a sensory-independent knowledge coding system in both groups.
262 tructural complexity in mt tRNAs by sequence-independent induced-fit adaption to the cognate mitochon
264 episodes, children had short-lived, sequence-independent increases in average whole-protein seroreact
265 c force microscopy data support the sequence-independent nature of the Hfq-DNA interaction and a role
266 a high-throughput assay for assessing sgRNA-independent off-target effects of CBEs in rice protoplas
269 of DNA damage response genes is largely SOG1-independent in fbl17 In addition, through analyses of ro
270 RNA is determined to be universal and spacer-independent for enhancing the sensitivity and specificit
273 ing to demonstrate that NuMA plays a spindle-independent role in forming a single, round nucleus.
274 Overall, this work establishes the spindle-independent function of NuMA in choreographing proper ch
275 Here, we show that Stattic exerts many STAT3-independent effects on cancer cells, calling for reasses
276 ple fMRI paradigms, suggesting a brain-state-independent neural phenotype underlying individual genet
278 ly relevant tissue actions of TRPV4, stretch-independent responses, and underlying mechanisms are unk
279 QR4 in breast tumors was found to be subtype-independent and correlated with increased ceramidase act
281 MPH-220 provides a potential nervous-system-independent option to treat spasticity and muscle stiffn
283 nses to immunizations with T-dependent and T-independent (Type 1) Ags, but Ab responses to a multival
284 1) Ags, but Ab responses to a multivalent T-independent (Type 2) Ag were impaired, a surprise findin
285 ndent antigens, the conjugates also retain T-independent properties, leading to detrimental effects o
288 spacing, small Stokes shift, and temperature-independent PL linewidth and PL lifetime (between room t
289 ment, TfR1 was endocytosed in an AP2- and Tf-independent pathway and trafficked to the lysosome for d
293 s was found to be dependent on transcription-independent functions of IRF3 and also on Bax, a pro-apo
294 3) (+)) or, alternatively, a proton transfer-independent nucleophilic ferric peroxo anion (compound 0
297 on, 2) stimulate uncoupling protein 1 (UCP1)-independent respiration in subcutaneous white fat, 3) ch
299 ese results suggest that LSG may have weight-independent effects on metabolic disease and should be c
300 rom the previous Wnt-dependent view to a Wnt-independent one and unveil a previously unappreciated HI