ライフサイエンスコーパス: -lead

1 up substitutions on the quinone ring at R(1)-lead to significant impacts on the Michaelis constant (K

2 Resting 10-lead electrocardiogram measured the R wave of the aVL le

3 12-lead ECG was performed at admission, after 7 and 14 days

4 In in-vivo swine studies (N = 17), 12-lead ECG signals were recorded at baseline and following

5 During in-vivo swine studies (n = 6), 12-lead ECG signals were recorded at baseline and following

6 h system, we trained a DNN with 1,169,662 12-lead resting ECGs obtained from 253,397 patients, in whi

7 econds) at 12 months of follow-up using a 12-lead ECG and Holter monitoring at 3, 6, and 12 months.

8 As a first step, participants recorded a 12-lead ECG and reported their relevant medical history.

9 T-wave inversion on a 12-lead ECG is usually dismissed in young people as normal

10 ace-mapping at these sites can generate a 12-lead ECG morphological match to a targeted ventricular t

11 V(3) is a relatively common finding in a 12-lead ECG of children and adolescents and is infrequently

12 mm.s is a relatively common finding in a 12-lead ECG of middle-aged subjects.

13 Our DLA successfully detected MI using a 12-lead ECG or a 6-lead ECG.

14 A 12-lead electrocardiogram (ECG) was obtained at these times

15 with baseline heart rate documented by a 12-lead electrocardiogram without pacing or atrial fibrilla

16 rance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid i

17 We developed a 12-lead smartphone-based electrocardiogram (ECG) acquisitio

18 The accuracy of ECGI versus a 12-lead surface ECG algorithm was compared.

19 We developed a 12-lead, blue-tooth/Smart-Phone (Android) based electrocard

20 Additionally, 12-lead ECGs were collected at diagnosis, before initiation

21 We screened all 12-lead ECGs over 6 months at 2 large hospital systems and

22 Original analog 12-lead ECG signals can be reconstructed from digital data

23 We analysed 12-lead ECGs from 45 haemodialysis and 12 LQT2 patients.

24 We analyzed 12-lead ECGs of 401 first-degree relatives of individuals w

25 d procedures involving both a resting and 12-lead ambulatory ECG, an exercise stress test, and geneti

26 The history, physical examination, and 12-lead ECG are each critical to the diagnosis and evaluati

27 CG) monitoring during hospitalization and 12-lead ECG was performed daily until hospital discharge.

28 questionnaire, physical examination, and 12-lead ECG.

29 ants completed both baseline 5-minute and 12-lead electrocardiogram recordings on a nondialysis day.

30 vital signs, a physical examination, and 12-lead electrocardiograph.

31 exposure, blood pressure, heart rate, and 12-lead electrocardiography were monitored throughout the 2

32 The corrected baseline 12-lead ECG QT interval duration (QTcorr) was determined by

33 dy stratified by QRS duration on baseline 12-lead ECG.

34 Baseline 12-lead ECGs were evaluated with regard to QRS morphology.

35 er when AF recurrence was not captured by 12-lead ECG.

36 We also evaluated AF recurrence by 12-lead electrocardiogram (ECG) at 3, 6, and 12 months.

37 without symptoms, AFib may be detected by 12-lead electrocardiogram (ECG), single-lead monitors (such

38 Continuous 12-lead ECG of 5 episodes of long-lasting VF occurring in 3

39 Compared to conventional 12-lead ECG, more detailed ECG lead configurations may prov

40 Conventional 12-lead electrocardiogram, a widely used noninvasive tool i

41 Clinical data, 12-lead ECG, 12-hour Holter recordings, coronary angiograph

42 ) was trained and validated using digital 12-lead ECG from 2,448 patients with a verified HCM diagnos

43 RSp measured from high-resolution digital 12-lead ECGs independently predicts ventricular tachyarrhyt

44 High-resolution (1024 Hz) digital 12-lead ECGs were recorded during intrinsic rhythm.

45 mpared original and post-DAC re-digitized 12-lead ECG data files ( approximately 5-minutes long) in t

46 ed symptom-limited cycle ergometry during 12-lead ECG monitoring.

47 We evaluated 12-lead ECGs of 10 899 Finnish middle-aged subjects (52% me

48 were evaluated with history, examination, 12-lead ECG, and further investigations as appropriate.

49 GMs usually are an accurate surrogate for 12-lead ECGs for differentiating clinical VTs from other VT

50 ere measured at baseline (1987-1989) from 12-lead ECGs.

51 All had 12-lead electrocardiogram recordings available for cardiac

52 lthcare-practitioners (N = 31) skilled in 12-lead ECG interpretation took part in a repeated-measures

53 Arrhythmia monitoring included 12-lead electrocardiography conducted at baseline and at 1,

54 econd opinions for difficult-to-interpret 12-lead ECGs, either locally or remotely through the use of

55 ansplantation must include an interpreted 12-lead electrocardiogram (ECG).

56 ed using VMHDVCG extracted from intra-MRI 12-lead ECGs, providing a means to enhance patient monitori

57 e trained CNNs using 10-second samples of 12-lead ECG signals from 499 727 patients to predict sex an

58 nd expertly labeled dataset consisting of 12-lead ECGs from 40,258 patients with four arrhythmia clas

59 og conversion (DAC) and reconstruction of 12-lead ECGs.

60 Inclusion of 12-lead electrocardiography (ECG) in preparticipation scree

61 fore participating in sports, the role of 12-lead electrocardiography (ECG) remains uncertain.

62 f the 2-dimensional PCA representation of 12-lead QRS waveforms identified 2 patient subgroups (QRS P

63 stic information to the interpretation of 12-lead resting ECGs, even in cases that are interpreted as

64 acterized as right-sided or left-sided on 12-lead ECG recordings at baseline and during isoproterenol

65 Those with sinus rhythm on 12-lead ECG, no history of AF, and >/=2 risk factors accord

66 Sinus rhythm was recorded on 12-lead electrocardiograms at 1 year in 61/83 ablation pati

67 pproach for the detection of HCM based on 12-lead electrocardiography (ECG).

68 arrhythmia classification scheme based on 12-lead surface ECGs that attains the accuracy performance

69 on's age and self-reported sex using only 12-lead ECG signals.

70 nalysis, orthostatic vital signs, WSF, or 12-lead ECG parameters.

71 nds duration confirmed by rhythm strip or 12-lead ECG.

72 ischarge records or death certificates or 12-lead ECGs performed during 3 triennial follow-up visits.

73 Using paired 12-lead ECG and echocardiogram data, including the left ven

74 cardial infarction diagnosed on paramedic 12-lead ECG.

75 oximately 16 h predose to 24 h postdose); 12-lead electrocardiograms (ECGs); clinical chemistry, hema

76 a 2-dimensional representation of preCRT 12-lead QRS waveforms.

77 eview will summarize all of the published 12-lead ECG algorithms used to guide localization of OT ven

78 0 (1%) among 848 individuals who recorded 12-lead ECG.

79 ight was directly measured, and a resting 12-lead ECG obtained under standardized conditions.

80 Limited studies have assessed the resting 12-lead electrocardiogram (ECG) as a screening test in inte

81 r suggested by abnormalities on a resting 12-lead electrocardiogram (ECG).

82 Half the cohort (26/52) had resting 12-lead electrocardiogram abnormalities: 25/26 had repolari

83 ans younger than 56 years who had resting 12-lead electrocardiography, 90.5% of whom were men.

84 n of data collected on one manufacturer's 12-lead ECG hardware/software into that of any other.

85 ters were determined from a baseline 10-s 12-lead ECG.

86 normal sinus rhythm, standard 10-second, 12-lead ECG acquired in the supine position at the Mayo Cli

87 al sinus rhythm using standard 10-second, 12-lead ECGs.

88 We decomposed 10 seconds, 12-lead electrocardiograms from 34 668 multi-ethnic partici

89 ile pacing the His lead with simultaneous 12-lead ECG rhythm strips.

90 acement of the electrodes in the standard 12-lead and a more detailed 64-lead ECG configuration were

91 ncluded if they had at least one standard 12-lead ECG acquired on the date of the ED visit and an ech

92 n on atrial activation using the standard 12-lead ECG alone.

93 Higher prevalence of ER in a standard 12-lead ECG in victims of SCD than in survivors of an acute

94 Compared with standard 12-lead ECG, CineECG at baseline had a 100% positive predic

95 oninvasive CineECG, based on the standard 12-lead ECG, opens new prospective for diagnosing patients

96 val, as measured by the resting, standard 12-lead ECG, reflects the duration of atrial/atrioventricul

97 rse electrocardiogram (ECG) from standard 12-lead ECG, to localize the electrical activity pathway in

98 an temporospatial isochrone from standard 12-lead ECG.

99 mplexity parameters derived from standard 12-lead ECGs for AF termination and long-term success of ca

100 s TPE were measured from digital standard 12-lead ECGs in 5618 adults (46% men; mean age 50.9+/-12.5

101 ll voltage criteria derived from standard 12-lead ECGs recorded at baseline and biannually were compa

102 nd SVG azimuth) were measured on standard 12-lead ECGs.

103 The standard 12-lead electrocardiogram (ECG) provides a method for non-i

104 referred for cardiac evaluation (standard 12-lead electrocardiogram and transthoracic echocardiograph

105 arameters were measured from the standard 12-lead electrocardiogram.

106 QT interval was measured using a standard 12-lead electrocardiogram.

107 l assessments, echocardiographic studies, 12-lead electrocardiograms, 24-hour Holter monitoring, bloo

108 The surface 12-lead ECG is routinely used to localize the anatomic site

109 The only useful diagnostic tests were the 12-lead and exercise electrocardiograms and ajmaline provoc

110 The 12-lead ECG is considered the gold standard to differentiat

111 n machine learning methods can extend the 12-lead ECG to quantitative applications well beyond its cu

112 t ventricular ejection fraction using the 12-lead ECG varies by race/ethnicity and to (2) determine w

113 ricular activation in real time using the 12-lead ECG was developed.

114 sing 554 temporal-spatial features of the 12-lead ECG, we train and test multiple classifiers on two

115 l as the presence of ST-depression on the 12-lead ECG.

116 tricular ejection fraction <=35% from the 12-lead ECG.

117 associations with maximum PWD across the 12-lead ECG.

118 The 12-lead ECGs are interpreted via telemedicine.

119 The 12-lead ECGs of the clinical VTs were compared with 64 diff

120 The 12-lead electrocardiogram (ECG) is readily available during

121 nce endpoint, biventricular pacing on the 12-lead electrocardiogram at 1 month, was achieved in 33 of

122 In 18 patients, the 12-lead electrocardiographic morphology was left bundle bra

123 T wave quantitative analysis on the 12-lead surface ECG provides an effective, novel tool to di

124 , 288 females) in whom drug-free day-time 12-lead ECG Holters were available.

125 cene </=10 minutes, ambulance on scene to 12-lead ECG acquisition </=8 minutes, on-scene time </=15 m

126 F screening pathways using the ubiquitous 12-lead ECG to detect asymptomatic paroxysmal AF in at-risk

127 ent with higher accuracy than a validated 12-lead ECG algorithm (83.3% versus 38.9%; P=0.015).

128 d 532 survivors of such an event, in whom 12-lead ECGs recorded before and unrelated to the event cou

129 Screening young athletes with 12-lead ECG plus cardiovascular-focused history and physica

130 Clinical VT had been documented with 12-lead ECGs in 15 of 21 patients.

131 linical VT was defined by comparison with 12-lead electrocardiograms and stored implantable cardiover

132 ected by pre-participation screening with 12-lead electrocardiograms.

133 ial catheter mapping and ablation of VT, 120-lead body surface potential mappings were obtained durin

134 m baseline to 24 weeks between FIX-HF-5C2 (2-lead system) subjects relative to control subjects from

135 A new 2-lead system eliminated the need for an atrial lead.

136 83.1% of 2-lead subjects compared with 42.7% of controls experience

137 All subjects received an Optimizer 2-lead implant.

138 1.02-2.42) mL/kg per minute greater in the 2-lead device group versus controls.

139 Optimizer-related adverse events with the 2-lead system compared with the 3-lead system (0% versus 8

140 The 2-lead system effectively delivers comparable amount of CC

141 -related adverse effects are less with the 2-lead system.

142 ested the safety and effectiveness of this 2-lead system compared with the 3-lead system.

143 control subjects from the prior FIX-HF-5C (3-lead system) study.

144 contractility modulation (CCM) employed a 3-lead Optimizer system.

145 id not differ significantly between 2- and 3-lead systems (19 892+/-3472 versus 19 583+/-4998 CCM sig

146 s with the 2-lead system compared with the 3-lead system (0% versus 8%; P=0.03).

147 subjects with atrial fibrillation) as the 3-lead system, is equally safe and improves peak VO(2) and

148 ss of this 2-lead system compared with the 3-lead system.

149 64-pole basket catheters and simultaneous 57-lead body surface ECGs.

150 eristic curves of the DLA with VAE using a 6-lead ECG were 0.880 and 0.854, respectively, and the per

151 fully detected MI using a 12-lead ECG or a 6-lead ECG.

152 ting MI and is difficulty to apply to limb 6-lead ECG based life type or wearable devices.

153 nstructed precordial 6-lead ECG using limb 6-lead ECG.

154 ncoder (VAE) that reconstructed precordial 6-lead ECG using limb 6-lead ECG.

155 essments included orthostatic vital signs; 6-lead continuous telemetry monitoring (approximately 16 h

156 onal 12 lead ECG but also with a life type 6-lead ECG device that employs our DLA.

157 nce algorithm (DLA) for detecting MI using 6-lead ECG.

158 btain the location of the stimulus from a 64-lead ECG system was developed.

159 the morphology of the ECG signals from a 64-lead vest and the location of the origin of rapid atrial

160 the ECG signals in multiple leads (e.g. a 64-lead vest) may provide a viable approach.

161 the standard 12-lead and a more detailed 64-lead ECG configuration were selected.

162 From 4 other anesthetized pigs, 64-lead body surface potential maps were recorded during si

163 bserved experimentally (obtained from the 64-lead ECG system), showing a strong agreement between the

164 Using 64-lead EEG recorded from human subjects receiving computer

165 In 14 patients with a history of AF, 67-lead body surface recordings were simultaneously registe

166 lten salt electrolyte, and a liquid antimony-lead alloy positive electrode, which self-segregate by d

167 Here we describe a lithium-antimony-lead liquid metal battery that potentially meets the per

168 , ventricle (3), or both chambers (4; atrial-lead threshold, 4.7+/-4.3 versus 0.7+/-0.3 V; ventricula

169 ffects, with trials proceeded by an auditory-lead needing more auditory-lead to seem simultaneous, an

170 ed by an auditory-lead needing more auditory-lead to seem simultaneous, and vice versa.

171 rony over a wide range, from 512 ms auditory-lead to 512 ms auditory-lag, and judged whether they see

172 Ms) is a rapidly developing approach in drug-lead discovery.

173 investigate the safety and efficacy of dual-lead thalamic DBS (one targeting the ventralis intermedi

174 paramagnet under an external magnetic field)-lead to three kinds of thermoelectromagnetic effect: cha

175 oepitaxy (NHE) of high-quality formamidinium-lead-tri-iodide (FAPbI(3)) perovskite films.

176 -Hutchinson Gilford Progeria Syndrome (HGPS)-lead to reduced ITL formation and telomere loss.

177 nger negative associations of living in high-lead-risk census tracts in children from lower- versus h

178 itro and in vivo analyses of HTS-derived hit-lead compounds, we identified a novel anticancer compoun

179 We use marginal linear models and lag-lead analysis to measure ecological associations between

180 ages that were previously determined by lead-lead dating of CAIs, which may be overestimated by sever

181 itic materials using the high-precision lead-lead (Pb-Pb) chronometer.

182 is a cornerstone of the high-precision lead-lead dates that define the absolute age of the solar sys

183 onstrate the potential use of ENSO as a long-lead prediction tool for childhood diarrhea in southern

184 pring and summer, potentially providing long-lead predictability of the SAM and its associated surfac

185 ns, implying the possibility of reduced long-lead predictability of the SAM and associated surface cl

186 We prospectively studied manganese-lead interactions in early childhood to examine whether

187 early childhood to examine whether manganese-lead coexposure is associated with neurodevelopmental de

188 Met-lead 1.44 M1 has an apparent dissociation constant (K(d)

189 transfer (FRET)-based Pb(2+) biosensor, 'Met-lead 1.44 M1', with excellent performance.

190 We deployed Met-lead 1.44 M1 to measure Pb(2+) concentrations in differe

191 The 10 nM sensitivity of Met-lead 1.44 M1 is five times below the World Health Organi

192 esults show that the accuracy of the 1-month-lead Nino 3.4 index prediction was the highest, the 12-m

193 ndex and SOI in the 1-, 3-, 6-, and 12-month-lead predictions among all the methods considered.

194 dex prediction was the highest, the 12-month-lead SOI prediction was the slowest, and the correlation

195 approach allows its application to any multi-lead ECG system.

196 ved a general approach relevant to any multi-lead ECG system.

197 We use the strontium-neodymium-lead isotopic composition of proglacial sediment dischar

198 highly piezoelectric lead magnesium niobate-lead titanate (PMN-PT) layer 8mum in thickness thinly co

199 We found the use of non-lead ammunition significantly reduced lead exposure in e

200 agnostics and clinical data as an LSE or non-lead system event by 2 physicians after reviewing the el

201 009 and 2010 hunting seasons we provided non-lead rifle ammunition to local hunters and recorded that

202 The non-lead system event detection rate was different among lea

203 t 24% and 31% of successful hunters used non-lead ammunition, respectively.

204 posed to lead, and the efficacy of using non-lead rifle ammunition to reduce lead in eagles.

205 were LSEs (including 65 LFs) and 95 were non-lead system events.

206 starting in the morning with ambulatory one-lead ECG monitors.

207 Organo-lead halide perovskite solar cells have emerged as one o

208 Organo-lead halide perovskite solar cells have gained enormous

209 Organo-lead halide perovskite solar cells represent a revolutio

210 ing exposures to opioids through a physician-lead response.

211 We report on a class of platinum-lead/platinum (PtPb/Pt) core/shell nanoplate catalysts t

212 assify 12 rhythm classes using 91,232 single-lead ECGs from 53,549 patients who used a single-lead am

213 ECGs from 53,549 patients who used a single-lead ambulatory ECG monitoring device.

214 ulse palpate, record, and interpret a single-lead ECG (SLECG).

215 Ten methods to compute single-lead ECG-derived respiration (EDR) were compared under m

216 d by 12-lead electrocardiogram (ECG), single-lead monitors (such as ambulatory blood pressure monitor

217 ction/phenotyping) and data fidelity (single-lead ECG/22-channel EEG).

218 g model for arrhythmia detection from single-lead ECG(6) is vulnerable to this type of attack.

219 ad range of distinct arrhythmias from single-lead ECGs with high diagnostic performance similar to th

220 is, involving a total 59 482 one-min, single-lead ECG segments recorded from 156 subjects.

221 1:1) to receive 3 months of optimised single-lead DBS-either VIM or VO.

222 e available, historical and prolonged single-lead electrocardiogram recordings during electrocardiogr

223 Screening with twice-weekly single-lead iECG with remote interpretation in ambulatory patie

224 ecordings from the human cortex, with single-lead and time-resolved decoding, using a wide range of t

225 A three-lead ECG was recorded throughout and the final 5 min of

226 he lack of high-efficiency, low-band gap tin-lead (Sn-Pb) mixed-perovskite solar cells (PSCs).

227 the number of recent successful fragment-to-lead (F2L) publications.

228 in an annual series, summarizes fragment-to-lead (F2L) success stories published during 2018.

229 ides a tabulated overview of the fragment-to-lead literature published in the year 2015, together wit

230 Subsequently, structure-guided fragment-to-lead optimization led to the identification of a >100-fo

231 the third in a series reviewing fragment-to-lead publications from a given year.

232 erspective summarizes successful fragment-to-lead stories published in 2019.

233 atural amino acid structures found in hit-to-lead and lead optimization campaigns and clinical stage

234 Successful SAR exploration in Hit-to-Lead and Lead Optimization efforts leading to the select

235 and cost of drug discovery within the hit-to-lead and lead optimization phases.

236 ctional group can be found in various hit-to-lead and lead optimization studies in early stages and i

237 ly encountered in medicinal chemistry hit-to-lead and lead optimization.

238 ghput screen for NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound that is str

239 n ideal starting point for subsequent hit-to-lead campaigns providing evident target-binding, suitabl

240 the triage of candidate compounds in hit-to-lead campaigns.

241 We describe the hit-to-lead development of selective Bcl-XL inhibitors originat

242 strategies for fragment screening and hit-to-lead development.

243 hem as a promising starting point for hit-to-lead development.

244 excellent starting point for further hit-to-lead development.

245 iral drugs, overlooked in traditional hit-to-lead discovery efforts, may be responsible for these poo

246 A comprehensive hit-to-lead effort culminated in the discovery of 45h as a pote

247 -receptor, we herein report a de novo hit-to-lead effort on the identification of subnanomolar purine

248 We now describe a hit-to-lead effort resulting in the discovery of a potent and s

249 Systematic hit-to-lead efforts significantly improved potency and efficacy

250 We describe the hit-to-lead exploration of a [1,2,4]triazolo[1,5-a]pyrimidine p

251 und screening campaign and a rigorous hit-to-lead flowchart combining biochemical and biophysical app

252 represents a promising candidate for hit-to-lead follow-up in the drug-discovery process against Alz

253 obust starting point for initiating a hit-to-lead medicinal chemistry effort.

254 zolopyridines as a starting point for hit-to-lead medicinal chemistry.

255 eliminary results, we report herein a hit-to-lead optimization and multidimensional structure-activit

256 Hit-to-lead optimization and structure-activity relationship st

257 Traditional hit-to-lead optimization assumes that upon elaboration of chemi

258 an be considered as hit compounds for hit-to-lead optimization campaigns in drug discovery programs.

259 A hit-to-lead optimization effort was then initiated on derivativ

260 The hit-to-lead optimization led to the discovery of a novel chemot

261 Hit-to-lead optimization of a new series of thienopyrimidine-ba

262 n, we describe the identification and hit-to-lead optimization of a novel class of tricyclic sulfonam

263 structure-activity relationships and hit-to-lead optimization of dual Top1-TDP1 inhibitors in the in

264 that provided robust guidance in the hit-to-lead optimization of small molecule LRRK2 inhibitors.

265 assess their applications in the EED hit-to-lead optimization process, large amount of thermodynamic

266 the attention on hit identification, hit-to-lead optimization, ADME profile evaluation, and the stru

267 based screening of compounds library, hit-to-lead optimization, computational and structure-based des

268 Subsequent hit-to-lead optimization, using cocrystal structures of inhibit

269 Through a process of hit-to-lead optimization, we report here the discovery of compo

270 ing antischistosomal hits for further hit-to-lead optimization.

271 gands from high throughput assays and hit-to-lead optimizations.

272 re-activity relationship (SAR) on the hit-to-lead path using in-house libraries and/or commercially a

273 ements existing methodologies for the hit-to-lead phase in fragment-based drug discovery.

274 SKR, we were able to re-evaluate the hit-to-lead process of cyclopentylamines as CCR2 antagonists.

275 was also based on residence time, the hit-to-lead process yielded compound 22a, a new high-affinity C

276 int for a structure-based drug design hit-to-lead program.

277 describe the identification process, hit-to-lead progression, and binding profiles of these selectiv

278 a chemical library, it showed a good hit-to-lead ratio and is an efficient early stage screening for

279 identification of the inhibitors, the hit-to-lead studies, and the emerged structure-activity relatio

280 HTS can significantly reduce cost and hit-to-lead time while yielding novel compounds with promising

281 f SMYD2 contributed significantly to "hit-to-lead" design efforts, culminating in the creation of pot

282 Twelve-lead ECGs during left bundle branch block and cardiac re

283 Twelve-lead ECGs were recorded and analyzed at years 0, 7, and

284 Twelve-lead electrocardiogram matched in 15 of 19 VTs between d

285 Twelve-lead electrocardiograms (ECG) of spontaneous VT often ar

286 Twelve-lead electrocardiograms were normal in 10 (53%) of the g

287 Twelve-lead electrocardiograms were recorded before study drug,

288 Uranium-lead chronology of carbonate deposits (speleothems) in a

289 Uranium-lead geochronology in detrital zircons and provenance an

290 lian speleothem record anchored by a uranium-lead chronology with North Atlantic ocean data to show t

291 Here we apply uranium-lead (U-Pb) zircon geochronology to Deccan rocks and sho

292 tio has fundamental implications for uranium-lead geochronology and cosmochronology.

293 However, uranium-lead (U-Pb) analyses of horizontally bedded layers of ca

294 lithosphere cooling with the use of uranium-lead (U-Pb) thermochronology on volcanically exhumed low

295 of the existing chronology based on uranium-lead dating and palaeomagnetic stratigraphy has recently

296 ic composition of zircons, for which uranium-lead and hafnium isotopic data provide age constraints,

297 estimated Deccan eruption rates with uranium-lead (U-Pb) zircon geochronology and resolved four high-

298 pilation of ~120,000 detrital zircon uranium-lead (U-Pb) ages from global sedimentary deposits as a p

299 Here, we present new zircon uranium-lead (U-Pb) geochronologic constraints on the age and du

300 d, 4.7+/-4.3 versus 0.7+/-0.3 V; ventricular-lead, 3.0+/-3.3 versus 0.7+/-0.3 V).