ライフサイエンスコーパス: -step

1 Incremental cost to the NHS per 1,000-step increase per day was pound 96 and to society was po

2 (CADO) approach described here results in 1-step conversion of wet ethanol vapor (40 wt% in water) t

3 f RNA-seq data sets, we developed a novel '1-Step' approach named Pooling RNA-seq and Assembling Mode

4 onstrate in a computational benchmark that 1-Step outperforms 2-Step approaches in predicting overall

5 Individuals were more successful in the 1-step conditions, if they participated in more trials, sh

6 es toward these molecules, resulting in a 10-step total synthesis of (-)-curvulamine, a dimeric membe

7 ion/rearrangement strategy resulting in a 10-step total synthesis of garsubellin A, an enhancer of ch

8 the primary outcomes of fast-pace 5- and 10-step stair ascent power.

9 Despite a recent 10-step approach to identify such benchmark values, a stand

10 lenging Pauson-Khand reaction, afforded a 17-step synthesis of the molecule in enantioenriched form.

11 on of vancomycin aglycon, this provides a 19-step total synthesis of vancomycin.

12 A 2-step hierarchic approach first evaluated ipi3 versus HDI

13 ation of ATT in TBU were generated using a 2-step modified Delphi technique.

14 ethods for transcript discovery rely on a '2-Step' approach where the first step encompasses building

15 ased radiosynthesis of [(18)F]FGlc-FAPI by 2-step (18)F-fluoroglycosylation.

16 CG normalization was the primary endpoint (2-step Simon design).

17 yperopia is an independent risk factor for 2-step and 3-step DR progression and PDR.

18 Progression was defined as a >=2-step increase in DR severity scale score or development

19 Multivariate 2-step cluster analysis was used to identify clusters of e

20 ropia was associated with a higher risk of 2-step progression (hazard ratio [HR], 1.29; 95% confidenc

21 tational benchmark that 1-Step outperforms 2-Step approaches in predicting overall transcript structu

22 ranscriptomics study reveals an unexpected 2-step process of biotransformation.

23 models and only marginally associated with 2-step progression (HR, 1.11; 95% CI, 1.00-1.24) in the ad

24 access to a 100-mer polysaccharide via a 201-step synthesis within 188 h.

25 Here, we describe a concise, 22-step synthetic strategy for the production of avenolide.

26 95% confidence interval [CI], 1.05-1.59), 3-step progression (HR, 1.35; 95% CI, 1.05-1.73), and PDR

27 foAmmonium Betaine (TBSAB), we developed a 3-step procedure using tributylamine as the novel solubili

28 an independent risk factor for 2-step and 3-step DR progression and PDR.

29 reas prior work toward this end focused on 3-step processes featuring dehydration, oligomerization, a

30 ralizes the validity and robustness of the 3-step map alignment algorithm as a predictive tool and co

31 Here, using the 3-step map alignment computational model, we predict and v

32 ne linkages (MHP-P5Q), which show a unique 3-step N(2) adsorption isotherm.

33 Methods: A 5-step optimization schema was developed.

34 + MFMD experienced greater improvements in 5-step regular-pace stair descent time [net difference (95

35 d pack size targets were developed using a 6-step process informed by the UK sugar and salt reduction

36 We report a 6-step synthesis of (-)-finerenone, which features an enan

37 Using a step-by-step approach, we identified IGFBP7, a protein secreted

38 We include step-by-step commented R code (R Foundation for Statistical Comp

39 A step-by-step fitting procedure is presented, which enables the d

40 We also give step-by-step guidance on the execution of individual analysis ty

41 uencing data and present a practical step-by-step guide to help implement the protocol.

42 e of open-source analysis tools with step-by-step instructions and code and details our recommendatio

43 ia a computational method called the step-by-step linearization method (SSLM).

44 to product evolution in a controlled step-by-step manner.

45 ors and mouse mutants, we define the step-by-step mechanisms that control stretch-mediated tissue exp

46 e-positive risk, it contains several step-by-step operation processes.

47 We provide a step-by-step overview, a tailored set of consensus criteria for

48 This protocol describes the step-by-step procedures for construction of a custom-made marmos

49 s are presented, providing a robust, step-by-step process for countries to follow.

50 Here, we provide a step-by-step protocol for using LIGER to jointly define cell typ

51 in our methods sections and to share step-by-step protocols in protocol repositories or journals.

52 ges and their annotations, and offer step-by-step recommendations for future studies.

53 Herein, a step-by-step self-assembly strategy is developed to allocate nic

54 Quick start and step-by-step tutorials as well as tutorial data are fully incorp

55 ory, and audiovisual distractors in a double-step saccade task to investigate if this stability mecha

56 electron microscopy, we directly show a dual-step twinning nucleation mechanism in HCP rhenium nanocr

57 An eight-step linear synthesis that starts with commercially avai

58 es is necessary and sufficient for the eight-step conversion of cholic acid to DCA.

59 ic burden, suggests its potential as a first-step screening tool in intermediate-risk patients to ide

60 tion of activated macrophages offers a first-step towards a multi-factorial amenable IBD platform tha

61 oplast, leaf and whole plant) and is a first-step towards representing mechanistically leaf ontogenet

62 the contingency of lineage outcome on first-step mutations and the ability for strains to escape fro

63 tly uncovered, allowing us to develop a five-step asymmetric synthesis of (-)-arborisidine, an enanti

64 rationally safer, scalable and offers a five-step reduction in the previously reported longest linear

65 The interferograms were analyzed by four-step phase shift algorithm to reconstruct the colony pro

66 trophic denitrification consists of the four-step sequential reduction of nitrate to dinitrogen gas o

67 We tracked the development of ground-stepping in 4- to 48-mo-old infants and found that, afte

68 igh coverage of antibodies on AuNPs is a key-step to build up a sensitive biosensor, but an ideal cov

69 ata show that HS17B3 acts as a rate-limiting-step for the maximum level of testosterone production by

70 system that synergistically develops in lock-step with physiological development of its host.

71 the need for numerical optimization in the M-step, the algorithm is easy to implement and computation

72 We previously described a multi-step algorithm, Iterative Clustering and Guide-gene Sele

73 e (nano-to milliseconds), reflecting a multi-step mechanism for binding Cdk2/Cyclin A.

74 This finding suggests a multi-step mechanism of kinase activation.

75 To this end, we performed a multi-step N-glycan analysis by HPLC and various exoglyosidase

76 MS with the aid of fractionation and a multi-step peptide search strategy to identify peptides genera

77 Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies an

78 activation at overgrowing tissue is a multi-step process requiring ROS- and JNK-mediated Mmp2 upregu

79 his suggests that protamine is using a multi-step process to loop the DNA rather than a one-step proc

80 RPo formation is a multi-step process with transient intermediates of unknown str

81 repeated exposure for two weeks via a multi-step resistance selection experiment.

82 lant specimens is a time-consuming and multi-step process, which requires well-equipped laboratories

83 processing, which is often complex and multi-step, thus requiring in-depth analysis.

84 platforms for multiplexed sensing are multi-step, time consuming, requiring expensive and bulky inst

85 germinal center reaction is a complex multi-step process controlled by transcription factors that in

86 S-layer biogenesis is a complex multi-step process, disruption of which has severe consequence

87 g-5.78Zn-0.44Zr subjected to a complex multi-step processing.

88 roduce mantis-ml, a multi-dimensional, multi-step machine-learning framework that allows objective as

89 cytosine (5hmC), starting an indirect, multi-step process that ends with reversion of 5mC to unmodifi

90 r structure determination that involve multi-step purification of a multi-subunit ubiquitin ligase an

91 AcrIIA1 fails to block Cas9 due to its multi-step inactivation mechanism.

92 e system and can be used uncover novel multi-step immune pathways, examine species-specific differenc

93 ve been proposed, generally relying on multi-step and PCR-based, time-consuming and cost-ineffective

94 nvolves high-temperature-high-pressure multi-step processes.

95 operate with KRAS mutations to promote multi-step tumorigenesis via the Wnt-Ras-p53 axis in human col

96 e control of regioselectivity requires multi-step synthetic procedures to prepare the desired tether

97 The various multi-step pathways of ORR are firstly reviewed and the rate-d

98 Limitations include the multi-stepped causal pathway from PDMP mandate implementation

99 of soy protein-based foods requires multiple-step, intensive processing and storage of soy ingredient

100 Instead of single/multiple-step single-type reactions commonly applied for on-surfa

101 DFT calculations revealed that the multiple-step reaction, being endergonic overall, is facilitated

102 Due to the complex multiple-steps protocols in data acquisition, extreme deviation o

103 One-step growth, reverse transcription-quantitative PCR, and

104 th rich edge sites are synthesized via a one-step approach by harnessing geometric constraints.

105 , this primer concept was developed as a one-step assay, driven by PCR-amplified DNAzymes, for FO-SPR

106 shell structures are synthesized using a one-step chemical vapor deposition process with rapid coolin

107 e enriched simultaneously, followed by a one-step denaturation, reduction, and alkylation.

108 gle cell capture efficiency, we employ a one-step FRET-based biosensor which monitors the single canc

109 microfluidic technology to demonstrate a one-step immunoassay for the detection of the cardiac marker

110 A one-step immunochromatographic strip test for LMG detection

111 We report a one-step procedure to directly reduce unactivated aryl ester

112 found that large-scale contraction is a one-step process, resulting in a median loss of ~60 triplet

113 ep process to loop the DNA rather than a one-step process.

114 ticals and PET radioligands, including a one-step radiosynthesis of the clinically used compounds [(1

115 We report a one-step route to [(18)F]CF(3)SO(2)NH(4) from [(18)F]fluorid

116 ic frameworks (sMOFs) are obtained via a one-step solvothermal approach rather than in a layer-by-lay

117 Here, a one-step strategy for fabricating core/shell poly(vinylidene

118 re simply immobilized on paper through a one-step surface modification process.

119 Now, a one-step synthesis of metal-inorganic frameworks Hf(4) N(20)

120 BLI-SELEX is a one-step technique for rapidly generating aptamers against p

121 Here we report a one-step three-component radical coupling of [1.1.1]propella

122 film electrode (GFE) are developed by a one-step, low-cost, straightforward, and mass-producible met

123 We also provide a one-step-method to achieve high quality predictions for prot

124 ated into a microfluidic chip, achieving one-step multiplex analysis within 40 min.

125 Here, a simple, cost-effective, and one-step approach that enables the control of cell orientati

126 we develop a facile, cost-effective and one-step approach to create an artificial lithium metal/elec

127 urrent models for DNA loop formation are one-step, all-or-nothing models with a looped state and an u

128 reaction to proceed via an asynchronous one-step mechanism through a zwitterionic species.

129 Herein, we report a biomimetic, one-step preparation of archazolid F, the most potent and le

130 ith either the CRM-based adhesive (CBA), One-Step (OS; Bisco, Inc.), or a negative adhesive (NA) cont

131 We observe classical one-step pathways and nonclassical two-step pathways that pr

132 behavior for the four cobalt complexes; one-step one-electron partial VT, two-step VT, incomplete VT

133 echanism of 2D halide perovskites during one-step spin-coating.

134 red NAc-oligosaccharides by an efficient one-step chemical transformation.

135 Here we report an efficient one-step conversion of isolated mouse and human astrocytes t

136 Herein we report a simple and efficient one-step development of ultrasmall Cu(5.4)O nanoparticles (C

137 ovel method for the simple and efficient one-step synthesis of 1,2,4-triazines under mild conditions

138 Our strategy entailed one-step injection of two gRNAs, Cas9 protein and a long-sin

139 d for this novel synthesis is the facile one-step construction of a spiroketal trimer intermediate, w

140 cal bio-composite sensing film by facile one-step electro-deposition of 0D enzyme-polymer nanoparticl

141 aimed at investigating the use of a fast one-step solid-liquid extraction procedure followed by a dis

142 FAIRS is a general, one-step method and is naturally specific in detection.

143 und molecular photocatalysts focusing on one-step excitation processes via single component photocata

144 tion approaches (layer-by-layer (LbL) or one-step electrodeposition (EcD)), layers composition and st

145 ch section is subdivided into direct (or one-step) and two-step labeling approaches and will start wi

146 The development of practical, one-step installation and removal protocols further adds to

147 lectrode with analysis following a short one-step extraction using ethanol.

148 mineralization mechanism allows a simple one-step route for fabricating functionally graded materials

149 aligned polymer chains by using a simple one-step solution-shear/bar coating technique.

150 est offered rapid detection as a simple (one-step), cost-effective, instrument-free assay and no need

151 lipid extraction step, these simplified one-step methods offer a much higher throughput and a reduce

152 etter understood in terms of a two-stage one-step mechanism beyond molecular orbital considerations b

153 The one-step generated 0D-2D bio-composite sensing film demonstr

154 The one-step mechanism of these lithium cation Li(+)-catalyzed D

155 magOTfP5SOF-Ga(3+)) was designed for the one-step simultaneous enrichment of glycopeptides and phosph

156 The one-step syntheses of exotine A and exotine B, which compris

157 ue products that can be obtained through one-step, high-yielding, catalytic transformations of the mo

158 Recently, a unique one-step method for directly fabricating green and brown fil

159 derived quantum dots are synthesized via one-step liquid exfoliation method and biosurfactant was use

160 distinguished rapidly and accurately via one-step radical-induced dissociation.

161 ng three stereocenters were prepared via one-step synthesis in yields ranging from 88 to 96% and in e

162 scuous biotin ligases in comparison with one-step affinity purification approaches.

163 orize them according to the steps of a seven-step pipeline that they employ.

164 hnography, following Noblit and Hare's seven-step method of translation and synthesis to generate a n

165 at predefined intervals and enables a single-step batch correction and quantification for high-throug

166 ss aliphatic sulfonamides, applying a single-step hydrosulfamoylation using inexpensive olefins, tris

167 ted on ancient genomes, outperforms a single-step imputation from genotype likelihoods, suggesting th

168 le sets of chromosomes, we utilized a single-step method where CRISPR/Cas9-based gene knockout is com

169 A single-step sample treatment, for the simultaneous extraction a

170 We present a single-step, versatile strategy for the selective modification

171 Herein, we report an advantageous single-step, wash-free, and real-time bacterial detection platf

172 dium nanoparticles (Pd-BNP) catalyzed single-step, stereoselective domino synthesis of symmetrically

173 multicomponent reaction that enables single-step access to complex and diverse polysubstituted drug-

174 ese redefined modules can be used for single-step reactions or in multistep processes, where modules

175 We found that in single-step replication experiments, the final yields of HSV-1

176 e developed a conceptually innovative single-step immunosensing platform, avoiding blocking, separati

177 nalized expanded [11]helicene and its single-step transformation into two structurally and functional

178 reduce mosaicism to levels that make single-step embryo editing in cattle commercially feasible.

179 Although high-performance single-step biosensors based on the principle of Forster resona

180 The solid-phase, single-step aptasensor showed a linear range of 0.1-1000 ng mL(

181 The solid-phase, single-step aptasensor was developed based on Au nanocap-suppor

182 Solid-phase, single-step biosensors are crucial for the development of porta

183 gnaling pathways in a straightforward single-step analysis setup, without concurrent use of signal in

184 Analysis of the single-step displacements from ribosome and EF-Tu diffusive tra

185 The single-step method coupled with the super-sensitive AID system

186 n electrochemical methodology for the single-step reduction of TPPO to TPP using an aluminum anode in

187 ene (DMU-212) are synthesized by this single-step approach in high yield.

188 bition in cultured cancer cells using single-step, high-dose selection, these findings highlight that

189 to the key heterocyclic aglycon 7, (i) a six-step classical heterocyclization starting from 5-chloro-

190 A six-step synthesis of orthogonally protected (S)-epsilon-oxa

191 Key steps in this modular six-step sequence include a DMAP-mediated O- to C-acyl rearr

192 ying the current and voltage profiles of six-step, ten-minute fast-charging protocols for maximizing

193 A soliton-step transition has also been observed for the first tim

194 g of the entire complex and a rotational sub-step of F(o) associated with long-range conformational c

195 tes together with the stimulation of the sub-steps of mRNA decay provide an effective organization st

196 Therefore, a three-step approach was developed.

197 controlled by Stig cyclases through a three-step cascade involving Cope rearrangement, 6-exo-trig cy

198 ro-1-methyl-4-nitropyrazole and (ii) a three-step cross-coupling and cyclization approach starting fr

199 Using a three-step electrochemical procedure we developed, we deconvol

200 ethane PICC catheter was modified by a three-step lamination process, with thin fluoropolymer layers

201 The new approach is comprised of a three-step noise reduction stage, a novel feature extraction m

202 been achieved in good yields, using a three-step process, starting from N(tolyl)(3) in a highly dive

203 he title compounds were prepared via a three-step protocol starting with an Ugi four-component reacti

204 compounds were prepared according to a three-step sequence, involving an Ugi reaction, building of th

205 well plates is achieved herein using a three-step sequence, resulting in a homogeneous distribution o

206 A three-step, one-pot reaction protocol was developed, and a ser

207 ess, we further designed a continuous, three-step process, which enabled the synthesis of a sugar pol

208 An efficient three-step synthesis of a new heterocyclic system is described

209 Herein, we report on a newel three-step process to fabricate bulk high-entropy nitrides.

210 Our three-step electrochemical procedure also allowed us to evalua

211 consists of a one-pot straightforward three-step synthetic route, including (i) CuBr(2)-mediated alp

212 diate as the key building block, whose three-step conversion to the natural product allowed for an ex

213 n organism's metabolic activity at each time-step of a dynamic simulation, using the well-known techn

214 We estimated effect sizes with time-step fixed effects and clinic random effects (Model 1).

215 Two-step enrichment of these glycosylated nascent chains, co

216 asured in the fasting state and during a two-step (10 and 20 mU/m(2)/min) hyperinsulinemic-euglycemic

217 bine-nab-paclitaxel chemotherapy using a two-step adaptive continual re-assessment method trial desig

218 onditional regression models fit using a two-step algorithm.

219 ing oxygenase (ADO), which function in a two-step alkane biosynthesis pathway.

220 ted an early maturation in Ec and Ecl, a two-step and early maturation in Ei, and a late maturation i

221 It performs imputation using a two-step approach.

222 We implemented a two-step DEP sorting scheme, consisting of analysis to defin

223 GlyCLICK was suggested, consisting of a two-step enzymatic procedure to transform Fc-glycans present

224 Here, we report the discovery of a two-step enzymatic synthesis of (2S,6S)-6-methyl pipecolate

225 carbonylation reactions, we developed a two-step epoxidation/deoxygenation process that results in o

226 We employed a two-step fabrication process to ensure an even mixture and d

227 We presented a two-step framework to model miRNA-mRNA relationships and ide

228 muRN-eChem was shown to enable a two-step gram-scale electrosynthesis of a nematic liquid cry

229 hology generated in the second step of a two-step inorganic phototropic growth process depends on a p

230 graphene sheets were synthesized using a two-step laser liquid solid interaction approach.

231 The sensor showed a two-step linear response from 0.05 to 5 muM and 5-30 muM wit

232 spectroscopy studies lend support for a two-step mechanism involving generation of a lambda(3)-boran

233 of all the probes are consistent with a two-step mechanism involving ligand binding and isomerizatio

234 Together, our data points to a two-step mode of J-domain action, a recognition stage follow

235 Further, we propose a two-step model of electron or/and ion transfer and demonstra

236 Taken together, these data suggest a two-step model whereby the strength of self-peptide-induced

237 tal nucleus formation occurred through a two-step nucleation mechanism.

238 i(+)-catalyzed DA reactions changes to a two-step one for the reaction with dimethyl propynamine.

239 A two-step photon-assisted tunneling charge pumping mechanism

240 Here, we evaluate a two-step pipeline for the imputation of common variants in a

241 We performed a two-step positive end-expiratory pressure trial with change

242 oxindoles are accessed from isatin via a two-step procedure involving a phospha-Brook rearrangement a

243 Here, we provide evidence for a two-step process for the development of neurologic adverse e

244 to show that electrophiles act through a two-step process in which modification of a highly reactive

245 self-assembly pathway, but rather via a two-step process involving first liquid-liquid phase separat

246 aching, (*)OH exposure degrades CDs in a two-step process that will span several decades in natural w

247 e rate dependence of epsilon is due to a two-step process, where diffusive transport of U(VI) from th

248 arbon bond between these substances in a two-step process.

249 of adamantane dications takes place in a two-step process: barrierless cage opening followed by Coulo

250 ized Matryoshka structure is formed in a two-step PSM procedure using trifluoroacetyl isocyanate foll

251 e, to address this problem, we develop a two-step rational design method for the discovery of oligome

252 chanisms for signaling, we implemented a two-step screen that uses coexpression analysis of human fib

253 ntial and structural features and used a two-step strategy to select the relevant features.

254 A two-step strategy was used while reviewing publications: 1)

255 lecule which is readily accessible via a two-step synthesis.

256 on-body measurements are supported by a two-step validation protocol: with the biosensor operating o

257 Here, we report a two-step, high-yielding synthesis toward a new class of hete

258 Using a two-step, in vitro/in vivo epigenomic shRNA inhibition scree

259 ibited early maturation in Ec and Ecl, a two-step/early maturation in Ei and a late maturation in Er.

260 Our findings present an alternative two-step explanation for the formation of actin bundles due

261 fficiently prepared using an alternative two-step procedure and controlled hydrogenation conditions.

262 eived an oral glucose tolerance test and two-step hyperglycemic clamp (100 and 300 mg/dL) followed by

263 subdivided into direct (or one-step) and two-step labeling approaches and will start with DNA before

264 experiments and show that both one- and two-step pathways are driven by thermodynamics alone.

265 thiotungstate ((NH(4))(2)WS(4)) films by two-step high temperature annealing without additional sulph

266 derived exosomes (EDEs) were enriched by two-step immunoabsorption from four groups of participants w

267 lar results as compared to the classical two-step method (i.e. lipid extraction and FA methylation) w

268 unds provide an avenue toward controlled two-step VT interconversions of the form {Co(III)-cat-cat-Co

269 rtuzumab was prepared via a conventional two-step process using prepurified onartuzumab and DFO-Bn-NC

270 subunit fail to form skin tumors during two-step chemical tumorigenesis, indicating a protumorigenic

271 nded metal-organic frameworks exhibiting two-step cooperative CO(2) adsorption, we report a family of

272 thway is followed by features exhibiting two-step nucleation.

273 Combined with a protecting group free two-step enzymatic glycosylation of vancomycin aglycon, this

274 sical one-step pathways and nonclassical two-step pathways that proceed via a solid-solid transformat

275 s a clear path to the next generation of two-step VT complexes through incorporation of mixed-valence

276 iplex, one-pot detection method based on two-step amplification of the signal measured by Reflective

277 r VT complexes confers an advantage over two-step spin crossover complexes for future applications in

278 of the C-borylated indoles in an overall two-step, one-pot process providing an efficient method for

279 ed either as a direct one-pot or one-pot two-step procedure depending on the reactivity of the electr

280 ines, and TMSN(3) afforded, in a one-pot two-step procedure, valuable scaffolds such as ketene aminal

281 ~ 5.7 nm) were synthesized via a one-pot two-step reverse microemulsion method.

282 he synthesis of alkenes using a one-pot, two-step experimental setup.

283 s trinitro-TANG precursor via a one-pot, two-step reaction involving Pd-catalyzed hydrogenation and p

284 babilities increase during this proposed two-step association process.

285 ar spliceosomal introns and use the same two-step splicing pathway.

286 A general, scalable two-step regio- and diastereoselective method has been descr

287 a histidine tag and purified by a simple two-step procedure.

288 ice using a chemotherapy followed by the two-step carcinogenesis protocol potentiated the conversion

289 t converts sorbitol into fructose in the two-step polyol pathway previously implicated in diabetic ne

290 Described herein is the two-step process involving the initial formation of aldimine

291 Specifically, the two-step solid-solid transition is governed by a competition

292 The utility of this two-step aminoethylation strategy was demonstrated in the sh

293 This two-step reaction is associated to NAD(+) regeneration, esse

294 This two-step sample preparation led to excellent extraction effi

295 A cascade one-pot variant of this two-step strategy offers a comparable overall yield of the f

296 les through an unusual and unprecedented two-step process as elucidated by solid-state NMR and molecu

297 Second, we used two-step MR to investigate whether DNA methylation mediates

298 a single component photocatalysts or via two-step excitation processes mimicking the Z-scheme of natu

299 lexes; one-step one-electron partial VT, two-step VT, incomplete VT, and temperature-invariant {Co(II

300 ion, simplicity, enzyme-free nature, and two-steps process without any immobilization and washing has

301 rPV IGR and the 40S subunit consisted of two-steps: an initial fast binding step of the IRES to the 4