ライフサイエンスコーパス: 15-lipoxygenase

1 and DPAn-3 proved to be good substrates for 15-lipoxygenase.

2 lles in rabbit reticulocytes is initiated by 15-lipoxygenase.

3 yl-end first" as has been proposed for human 15-lipoxygenase.

4 he binding of fatty acid substrates in human 15-lipoxygenase.

5 SPM biosynthetic enzymes 12-lipoxygenase and 15-lipoxygenase.

6 described to date to bind to a derivative of 15-lipoxygenase.

7 compared with the previously reported human 15S-lipoxygenase.

8 e identity to the known human 5S-, 12S-, and 15S-lipoxygenases.

9 % identity to the known human 5S-, 12S-, and 15S-lipoxygenases.

10 icosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic aci

11 To examine for the expression of 15-lipoxygenase 1 (15-LOX1) and 15-LOX2 in human retinal

12 in vitro, adenovirus-mediated expression of 15-lipoxygenase 1 (15-Lox1) enhanced BI-induced EGFR, Sr

13 To understand the role of human 15-lipoxygenase 1 (15-LOX1) in vascular wall remodeling,

14 Epithelial 15-lipoxygenase 1 (15LO1) and activated ERK are increase

15 of human platelet-type 12- and reticulocyte 15-lipoxygenase-1 (12-hLO and 15-hLO) using structure-ba

16 lipoxygenase (12-hLO) and human reticulocyte 15-lipoxygenase-1 (15-hLO) were tested with arachidonic

17 Human reticulocyte 15-lipoxygenase-1 (15-hLO-1) and human platelet 12-lipox

18 Human reticulocyte 15-lipoxygenase-1 (15-hLO-1), which catalyzes the dioxyg

19 Human colon tumors have elevated levels of 15-lipoxygenase-1 (15-LO-1), suggesting that 15-LO-1 may

20 uman prostate tumors have elevated levels of 15-lipoxygenase-1 (15-LOX-1) and data suggest that 15-LO

21 can induce in these cells the expression of 15-lipoxygenase-1 (15-LOX-1) and in so doing up-regulate

22 us studies, we have found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-

23 15-Lipoxygenase-1 (15-LOX-1) contributes significantly t

24 n tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression in colorectal ca

25 induce apoptosis in these cells by restoring 15-lipoxygenase-1 (15-LOX-1) expression.

26 In this respect, 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that cataly

27 15-Lipoxygenase-1 (15-LOX-1) is transcriptionally silenc

28 ienoic acid (13-S-HODE), the main product of 15-lipoxygenase-1 (15-LOX-1) metabolism of linoleic acid

29 Transcriptional silencing of 15-lipoxygenase-1 (15-LOX-1) promotes tumorigenesis.

30 We previously found that (a) 15-lipoxygenase-1 (15-LOX-1) protein and its product 13-

31 15-Lipoxygenase-1 (15-LOX-1), which is crucial to produc

32 ithelial cells (HAECs) and determine whether 15-lipoxygenase-1 (15LO1) binding with phosphatidylethan

33 tion of 15-HpETE-PE depends on activation of 15-lipoxygenase-1 (15LO1) in complex with PE-binding pro

34 Human 15-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygena

35 Endogenously generated metabolites of 15-lipoxygenase-1 also inhibit thioredoxin reductase in

36 a mechanistic link between the induction of 15-lipoxygenase-1 by a HDAC inhibitor and apoptosis in c

37 Conditional, highly selective induction of 15-lipoxygenase-1 caused an inhibition of ribonucleotide

38 The expression of 15-lipoxygenase-1 correlates with suberoylanilide hydrox

39 er, our data propose that V-ATPase regulates 15-lipoxygenase-1 expression and consequent SPM biosynth

40 IL-4-induced human M2 polarization abrogated 15-lipoxygenase-1 expression and prevented the related b

41 ordingly, the ERK-1/2 pathway contributes to 15-lipoxygenase-1 expression and SPM formation in M2-lik

42 ide hydroxamic acid induce the expression of 15-lipoxygenase-1 in human colorectal cancer cells.

43 Here we report that several metabolites of 15-lipoxygenase-1 inhibit purified thioredoxin reductase

44 ite of linoleic acid formed by the action of 15-lipoxygenase-1 is 13(S)-hydroxy-cis-9, trans-11-octad

45 These results demonstrate that 15-lipoxygenase-1 is activated by oxidative stress in AR

46 s, suggesting that the increased activity of 15-lipoxygenase-1 is due to activation of pre-existing p

47 The influences of 15-lipoxygenase-1 on (1)inflammation, cell growth, and s

48 with inhibition of thioredoxin reductase via 15-lipoxygenase-1 overexpression.

49 macrophages displayed higher RvD1 levels and 15-lipoxygenase-1 protein abundance, which were prevente

50 or the deficient cells showed an increase in 15-lipoxygenase-1 protein content after 16 h of oxidativ

51 Furthermore, specific inhibition of 15-lipoxygenase-1 significantly reduced the suberoylanil

52 cid, a metastable hydroperoxide generated by 15-lipoxygenase-1, and 4-hydroxy-2-nonenal, its non-enzy

53 lipid hydroperoxide metabolites of 5-, 12-, 15-lipoxygenase-1, and cyclooxygenase-2 oxidize the 2-Cy

54 receptor, 5-lipoxygenase-activating protein, 15-lipoxygenase-1, prostaglandin D2, and proinflammatory

55 Recently, 15-lipoxygenase-1, the enzyme that converts arachidonic

56 The 15-lipoxygenase-1-deficient cells exhibited 30% of the p

57 thermore, when ataxin-1 82Q was expressed in 15-lipoxygenase-1-deficient cells, apoptosis was greatly

58 cell line using short hairpin RNA to target 15-lipoxygenase-1.

59 hanisms by which HDAC inhibitors up-regulate 15-lipoxygenase-1.

60 The enzyme 12/15 lipoxygenase (12/15LO) has been implicated in the oxi

61 ucose increases production of endothelial 12/15 lipoxygenase (12/15LO) products in vitro.

62 The 12/15 lipoxygenase (12/15LOX) enzyme is increased in pathol

63 e recently reported that mouse macrophage 12/15-lipoxygenase (12/15-LO) activity promotes F-actin for

64 ases (Noxes) nor mitochondria, but rather 12/15-lipoxygenase (12/15-LO) are pivotal ROS sources invol

65 nstrate that mice deficient in the enzyme 12/15-lipoxygenase (12/15-LO) develop a myeloproliferative

66 The 12/15-lipoxygenase (12/15-LO) enzyme is upregulated in the

67 in WT mice high fat diet feeding induced 12/15-lipoxygenase (12/15-LO) expression in the endothelium

68 It was reported recently that 12/15-lipoxygenase (12/15-LO) expression is increased in hi

69 The enzyme 12/15-lipoxygenase (12/15-LO) has been implicated in the ox

70 Recently, we discovered a novel role for 12/15-lipoxygenase (12/15-LO) in mediating IL-12p40 express

71 The enzyme 12/15-lipoxygenase (12/15-LO) introduces peroxyl groups in

72 12/15-Lipoxygenase (12/15-LO) is an enzyme widely distribut

73 convincing body of evidence suggests that 12/15-lipoxygenase (12/15-LO) plays a role in atheroscleros

74 12/15-Lipoxygenase (12/15-LO) produces 15-hydroxyeicosatetr

75 We have shown that the 12/15-lipoxygenase (12/15-LO) product 12S-hydroxyeicosatetr

76 Mice lacking leukocyte type 12/15-lipoxygenase (12/15-LO) show reduced atherosclerosis

77 12/15-lipoxygenase (12/15-LO), one of a family of fatty aci

78 PPARgamma) ligands by inducing macrophage 12/15-lipoxygenase (12/15-LO).

79 a and its natural ligand-producing enzyme 12/15-lipoxygenase (12/15-LOX) in IL-4-treated cells.

80 lerosis, here we investigated the role of 12/15-lipoxygenase (12/15-LOX) in TF expression.

81 e experiments, cells were pretreated with 12/15-lipoxygenase (12/15-LOX) inhibitor cinnamyl-3,4-dihyd

82 12/15-Lipoxygenase (12/15-LOX) is induced in beta-cells and

83 Either 90 nM recombinant Sema3A, or the 12/15-lipoxygenase (12/15-LOX) metabolites 12-HETE and 12-H

84 12/15-Lipoxygenase (12/15-LOX) plays a pathogenic role in a

85 hat it is produced by a pathway involving 12/15-lipoxygenase (12/15-LOX), and that S. enterica serova

86 drug target between species, such as with 12/15-lipoxygenase (12/15-LOX), which contributes to ischem

87 We recently discovered that 12/15-lipoxygenase (12/15-LOX), which oxidizes unsaturated

88 Our results further demonstrate that 12/15-lipoxygenase (12/15-LOX)-derived, but not cyclooxygen

89 Herein, we establish a critical role for 12/15-lipoxygenase (12/15-LOX)-mediated unsaturated fatty a

90 The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed w

91 e with an inducible, endothelium-specific 12/15-lipoxygenase (12/15Lo) knockout were protected simila

92 12/15-Lipoxygenase (12/15LO) plays a role in the pathogenes

93 The 12/15-lipoxygenases (12/15-LOX) catalyze the stereo-specifi

94 A human 15-lipoxygenase (15-HLO) assay has been employed to disc

95 The selective inhibition of human 15-lipoxygenase (15-hLO) could serve as a promising ther

96 Human reticulocyte 15-lipoxygenase (15-hLO-1) and epithelial 15-lipoxygenas

97 te 15-lipoxygenase (15-hLO-1) and epithelial 15-lipoxygenase (15-hLO-2) have been implicated in a num

98 ment of atherosclerosis, an oxidative enzyme 15-lipoxygenase (15-LO) and a scavenger receptor CD36.

99 ere we report that synergistic activities of 15-lipoxygenase (15-LO) and secreted phospholipase A(2)

100 1 and Stat3 is required for the induction of 15-lipoxygenase (15-LO) expression by IL-13.

101 green fluorescent 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) fusion proteins were expressed i

102 The human 15-lipoxygenase (15-LO) gene was transfected into rat ki

103 es that is capable of inducing expression of 15-lipoxygenase (15-LO) in primary human monocytes.

104 IL-13 induces profound expression of 15-lipoxygenase (15-LO) in primary human monocytes.

105 ave evidence that subacute hypoxia activates 15-lipoxygenase (15-LO) in small PAs of neonatal rabbits

106 d the expression of cyclooxygenase (Cox) and 15-lipoxygenase (15-LO) in the human colorectal carcinom

107 The enzyme 15-lipoxygenase (15-LO) participates in the dioxygenatio

108 onic acid (AA) is metabolized by endothelial 15-lipoxygenase (15-LO) to several vasodilatory eicosano

109 ion of several proteins is induced including 15-lipoxygenase (15-LO), a lipid-peroxidating enzyme and

110 3 induction of M2 gene expression, including 15-lipoxygenase (15-LO).

111 15-lipoxygenase (15-LOX) and lipoxin A(4) receptors (ALX

112 of purified soybean and rabbit reticulocyte 15-lipoxygenase (15-LOX) and PA317 cells transfected wit

113 The cornea expresses 15-lipoxygenase (15-LOX) and receptors for lipoxin A(4)

114 vious studies have suggested that activating 15-lipoxygenase (15-LOX) is a promising strategy to inte

115 The expression of 15-lipoxygenase (15-LOX) peaks in reticulocytes immediat

116 15-Lipoxygenase (15-LOX)-2 is expressed in benign prosta

117 reported the induction of reticulocyte type 15-lipoxygenase (15-Lox-1) in a human colorectal carcino

118 nsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsa

119 15-Lipoxygenase 2 (15-LOX2) is a recently cloned human l

120 15-Lipoxygenase 2 (15-LOX2), a lipid-peroxidizing enzyme

121 Several pieces of evidence implicate 15-lipoxygenase 2 (15-LOX2), a molecule with a restricte

122 s project, we studied the gene regulation of 15-lipoxygenase 2 (15-LOX2), the most abundant arachidon

123 15-Lipoxygenase 2 (15-LOX2), the most abundant arachidon

124 Expression of 15-lipoxygenase 2 was increased in epithelium from patie

125 elationship exists between the expression of 15-lipoxygenase-2 (15-LOX-2) and peroxisome proliferator

126 The enzyme 15-lipoxygenase-2 (15-LOX-2) is highly expressed in larg

127 anced eicosanoid production via an activated 15-lipoxygenase-2 (15-LOX2) pathway.

128 EGCs expressed 15-lipoxygenase-2 and produced high levels of 15-HETE, w

129 Thus, the strongest 15-lipoxygenase-2 expression is in the androgen regulate

130 15-Lipoxygenase-2 has a limited tissue distribution in e

131 Strong 15-lipoxygenase-2 immunostaining was also observed in se

132 Meibomian glands were uniformly negative for 15-lipoxygenase-2 in all cases examined (n = 9), and seb

133 Strong uniform 15-lipoxygenase-2 in situ hybridization (n = 6) and immu

134 This compares with the prostate, in which 15-lipoxygenase-2 is expressed in differentiated prostat

135 exhibited 30% of the protein expression, and 15-lipoxygenase-2 remained unchanged, as compared with a

136 In this study the distribution of 15-lipoxygenase-2 was characterized in human skin using

137 The product of 15-lipoxygenase-2, 15-hydroxyeicosatetraenoic acid, may

138 Human 15S-lipoxygenase-2 (15-LOX-2) is a recently identified l

139 ipoxygenase (8-LOX) and its human homologue, 15S-lipoxygenase-2 (15-LOX-2), share 78% identity in ami

140 Inhibition of 15-lipoxygenase activity reduced PD1n-3 DPA and augmente

141 of VCAM-1 on endothelium, mucin production, 15-lipoxygenase activity, and Th2 lymphocyte stimulation

142 15-diHETE, indicating that T. gondii carries 15-lipoxygenase activity.

143 urable 5-lipoxygenase protein or 5-, 12-, or 15-lipoxygenase activity.

144 2 yielded a chimeric enzyme with exclusively 15S-lipoxygenase activity.

145 one peroxidase 4 (GPX4) and arachidonic acid 15-lipoxygenase (ALOX15) are antagonizing enzymes in the

146 sted the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver dis

147 te 12-lipoxygenase, 12S type [Alox12]) or 12/15-lipoxygenase (Alox15) to compare the influence of eac

148 d with the expression levels of arachidonate 15-lipoxygenase (ALOX15), and SAT1-induced ferroptosis i

149 L-4 with elevated expression of arachidonate 15-lipoxygenase (ALOX15).

150 termined that the gene encoding arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the surv

151 of Stat3 with DNA and maximal expression of 15-lipoxygenase, an important regulator of inflammation

152 ogenesis by in vivo delivery of the gene for 15-lipoxygenase, an oxidizing enzyme present in atherosc

153 This effect was shown to involve 12/15 lipoxygenase and activation of peroxisome-proliferato

154 pe mice displayed increased sciatic nerve 12/15-lipoxygenase and 12(S)-hydroxyeicosatetraenoic acid l

155 IgG4 plasma cells; and abundant arachidonate 15-lipoxygenase and 25-hydroxyvitamin D-1 alpha hydroxyl

156 hatidylethanolamine, increased expression of 15-lipoxygenase and acyl-CoA synthetase long-chain famil

157 zymes of arachidonate metabolism, namely, 12/15-lipoxygenase and cyclooxygenase-2.

158 eases (>1.5-fold expression) in arachidonate 15-lipoxygenase and gamma-glutamyltransferase transcript

159 foam cell differentiation markers including 15-lipoxygenase and lectin-type oxidized LDL receptor-1

160 he ribonucleases) together with arachidonate-15-lipoxygenase and protease inhibitor plasminogen activ

161 o show that inhibitors of enzymes such as 12/15-lipoxygenase and the cyclooxygenases that produce kno

162 activates the RhoA/Rho kinase/CPI-17 via 12/15-lipoxygenases and thereby contributes to diabetes-ass

163 Inhibition of lipoxygenases, particularly 15-lipoxygenase, and cyclooxygenases, but not cytochrome

164 s derived from the COX-2, cytochrome P450, 5/15-lipoxygenase, and non-enzymatic oxidative pathways we

165 vating AMPK abolished cellular production of 15-lipoxygenase arachidonic acid metabolites in IL-4-sti

166 With the combination of 15-lipoxygenase, arachidonic acid, and aortic homogenate

167 12-Lipoxygenase and 12/15-lipoxygenase are related but distinct enzymes that ar

168 This study establishes inhibition of 12/15-lipoxygenase as a viable strategy for first-line stro

169 In vitro, the purified rabbit reticulocyte 15-lipoxygenase binds and permeabilizes organellar membr

170 pathogen as well as exogenously administered 15-lipoxygenase can interact with host biosynthetic circ

171 and determination of the in vivo role of 12/15-lipoxygenase-catalyzed oxidation of LDL in atherogene

172 The mRNAs in question encode 15-lipoxygenase, ceruloplasmin, and histones.

173 he amino acid sequence has 78% identity to a 15S-lipoxygenase cloned recently from human skin and app

174 ncreased in the ischemic mouse brain, and 12/15-lipoxygenase colocalized with a marker for oxidized l

175 12/15-Lipoxygenase deficiency in this strain led to approxi

176 12/15-lipoxygenase deficiency prevented or alleviated diabe

177 E-deficient mice with 1) global leukocyte 12/15-lipoxygenase deficiency, 2) normal enzyme expression,

178 While studying 12/15-lipoxygenase-deficient macrophages in culture, we dis

179 Additionally, 12/15-lipoxygenase-deficient macrophages, which are unable

180 P < 0.006), whereas retinas from diabetic 12/15-lipoxygenase-deficient mice had significantly less le

181 e observation that bone marrow cells from 12/15-lipoxygenase-deficient mice retain sensitivity to IL-

182 mice, 5-lipoxygenase-deficient mice, and 12/15-lipoxygenase-deficient mice were assessed 1) after 9

183 and streptozotocin-diabetic wild-type and 12/15-lipoxygenase-deficient mice were maintained for 14 to

184 Thus, 12/15-lipoxygenase-deficient mice will be useful for the st

185 d and 17.2-fold in diabetic wild-type and 12/15-lipoxygenase-deficient mice, respectively.

186 in 5-lipoxygenase-deficient mice, but not 12/15-lipoxygenase-deficient mice.

187 5-lipoxygenase-deficient mice, but not in 12/15-lipoxygenase-deficient mice.

188 mice by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade

189 tion of alveolar macrophages by arachidonate 15-lipoxygenase-derived eicosanoids to express chemokine

190 Similarly, 5, 12-, and 15-lipoxygenase-derived hydroxy-PUFAs as well as those f

191 oagulant phospholipid surface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-pho

192 s mouse DRG neurons lacking expression of 12/15-lipoxygenase display protection of axons in this cont

193 both support an antiatherogenic role for 12/15-lipoxygenase downstream actions.

194 We showed previously that deletion of the 12/15-lipoxygenase enzyme (12/15-LO, Alox15 gene) in NOD mi

195 Together, these results indicate that 15-lipoxygenase expressed by a pathogen as well as exoge

196 ed (P < 0.001, n = 12) when compared with 12/15-lipoxygenase-expressing controls (apo E-/-/L-12LO+/+)

197 studies demonstrated that the IL-13-induced 15-lipoxygenase expression in primary human monocytes is

198 Results from these indicate that 12/15-lipoxygenase expression protects mice against atheros

199 and 15-hLO, based on the structure of rabbit 15-lipoxygenase, for in silico screening of a large comp

200 12/15-lipoxygenase gene deficiency did not affect weight ga

201 Administration of plant 15-lipoxygenase generated endogenous LXA4 and mimicked t

202 Human 15-lipoxygenase (h15-LO) is present on chromosome 17p13.

203 Pharmacological and genetic inhibition of 12/15-lipoxygenases has effects on high glucose-induced CPI

204 e of the mouse 8S-lipoxygenase and its human 15S-lipoxygenase homologue.

205 These include Fc epsilonRII (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and

206 provide in vivo evidence for the role of 12/15-lipoxygenase in atherogenesis and demonstrate diminis

207 eceptor (LDL-R) deficiency has implicated 12/15-lipoxygenase in atherogenesis.

208 to explore other potential mechanisms for 12/15-lipoxygenase in atherosclerosis using apolipoprotein

209 This study evaluated the role for 12/15-lipoxygenase in diabetic large and small fiber periph

210 eted gene disruption or overexpression of 12/15-lipoxygenase in mice on the genetic background of apo

211 been shown to inhibit induction of CD23 and 15-lipoxygenase in monocytes; however, the effects of IF

212 e findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands

213 The data support indirectly a role for 12/15-lipoxygenase in the oxidative modification of low den

214 The combined data indicate a role for 12/15-lipoxygenase in the pathogenesis of atherosclerosis a

215 e overexpression of murine leukocyte-type 12/15-lipoxygenase in VSMCs increased the levels of cell-as

216 Reciprocally, stable overexpression of 12/15-lipoxygenase increased AT1R expression in cultured me

217 arrel/catalytic domain chimeras with 12- and 15-lipoxygenase indicated that only the N-terminal domai

218 his CO increased phagocytosis was blocked by 15-lipoxygenase inhibition, and SPM stimulated phagocyto

219 ion, and treatment of these mice with the 12/15-lipoxygenase inhibitor ML-351 rescued the dysglycemic

220 ndomized to receive vehicle or baicalein (12/15-lipoxygenase inhibitor) at 10-15 minutes postinjury.

221 f endpoints for future clinical trials of 12/15-lipoxygenase inhibitors.

222 These data demonstrate that 15-lipoxygenase is capable of disrupting the pH gradient

223 ere was no correlation between expression of 15-lipoxygenase isozymes or their products and tumor gro

224 esangial cells and glomeruli derived from 12/15-lipoxygenase knockout mice compared with control mice

225 utoantibodies to oxidized LDL epitopes in 12/15-lipoxygenase knockout mice crossbred with atheroscler

226 e, we demonstrate that ectopic expression of 15-lipoxygenase leads to the collapse of the mitochondri

227 4 and IL-13 are the only known activators of 15-lipoxygenase (LO) expression in cultured macrophages.

228 We have now evaluated 15-lipoxygenase (LO)-1-mediated arachidonic acid (AA) me

229 xidation in vivo is its modification with 12/15-lipoxygenase (LO).

230 synthesis is blocked with an inhibitor of 12/15-lipoxygenase (LO).

231 Products of arachidonate 15-lipoxygenases (LO) types I and II display both benefi

232 tudies attributed this impairment to reduced 15-lipoxygenase (LOX) activity rather than altered DHA c

233 differentiation: translational silencing of 15-lipoxygenase (Lox) mRNA and stabilization of alpha-gl

234 n D1 (NPD1) are lipid autacoids formed by 12/15-lipoxygenase (LOX) pathways that exhibit anti-inflamm

235 Two prominent enzymes, 12/15-lipoxygenase (LOX), which generates antiinflammatory

236 Transcriptional suppression of 15-lipoxygenase (LOX)-1 (15-LOX-1) helps enable human co

237 ocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuron

238 There are two human 15-lipoxygenases (LOX), 15-LOX-1 and -2, which convert a

239 oid formed from sequential actions of 5- and 15-lipoxygenases (LOX), facilitate resolution of inflamm

240 A novel inhibitor of 12/15-lipoxygenase, LOXBlock-1, protected neuronal HT22 cel

241 12/15-Lipoxygenases (LOXs) in monocytes and macrophages gen

242 gnaling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammato

243 th pathway that results from accumulation of 15-lipoxygenase-mediated lipid oxidation products, speci

244 erefore, oxidized lipids generated by the 12/15-lipoxygenase-mediated metabolism of arachidonic acid

245 he coordinate induction of PPAR-gamma and 12/15-lipoxygenase mediates interleukin-4-dependent transcr

246 Here, we determined that 12/15-lipoxygenase-meditated (12/15-LO-mediated) enzymatic

247 enzyme that at least partly accounts for the 15S-lipoxygenase metabolism of arachidonic acid in certa

248 Pretreatment with the 15-lipoxygenase metabolite, 15(S)-hydroxyeicosatetraenoi

249 athogenic phase of the infection, whereas 12/15-lipoxygenase metabolites were associated with the res

250 cis-element in the 3'-untranslated region of 15-lipoxygenase mRNA that is known to bind hnRNP E1 also

251 Retinal ganglion cell axons from 12/15-lipoxygenase-null mice were similarly protected from

252 ion also results from genetic deletion of 12/15-lipoxygenase or inhibiting its activity with nordihyd

253 12/15-Lipoxygenase or p47phox deficiency resulted in attenu

254 ALOX15 (12/15-lipoxygenase) orthologs have been implicated in matur

255 The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavi

256 ine and poly(ADP-ribose) accumulation and 12/15-lipoxygenase overexpression in peripheral nerve and d

257 yme expression, or 3) macrophage-specific 12/15-lipoxygenase overexpression.

258 results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy

259 controlled cortical impact, suggesting that 15-lipoxygenase pathway might be a valuable therapeutic

260 The 12/15-lipoxygenase pathway of arachidonate metabolism and i

261 support for a novel mechanism linking the 12/15-lipoxygenase pathway to a known immunomodulatory Th1

262 AA is also metabolized via the 15-lipoxygenase pathway, predominantly to 15-hydroxyeico

263 iments show a range of responses with the 12/15-lipoxygenase pathways in atherosclerosis.

264 with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development.

265 on in murine peritonitis, demonstrating that 15-lipoxygenase possesses antiinflammatory properties.

266 of DHA, DPAn-3, and DPAn-6 with 5-, 12-, and 15-lipoxygenases produced oxylipins, which were identifi

267 ed rat mesangial cells, we found that the 12/15-lipoxygenase product 12(S)-hydroxyeicosatetraenoic ac

268 duct migrated on reverse-phase HPLC with the 15-lipoxygenase product, 15-hydroxy-eicosa-trienoic acid

269 One paradigm concerns regulation of 15-lipoxygenase production during reticulocyte maturatio

270 Temporal control of 15-lipoxygenase production in reticulocytes is often cit

271 15-Lipoxygenase proved to be the most efficient enzyme o

272 atic brain injury, and whether inhibition of 15-lipoxygenase provided neuroprotection.

273 action products obtained from the DPAn-6 and 15-lipoxygenase reaction.

274 In vivo, modified siRNA targeting 12/15-lipoxygenase reduced glomerular AT1R expression in a

275 However, it is unclear whether 12/15-lipoxygenase regulates expression of AT1R.

276 subunit 1) and ALOX15 (encoding arachidonate 15-lipoxygenase), show significant association with IL-6

277 15-Lipoxygenase-silenced cells also displayed an exacerb

278 NPD1 selectively and potently rescued 15-lipoxygenase-silenced cells from oxidative stress-ind

279 achidonic acid, [U-14C]arachidonic acid plus 15-lipoxygenase (soybean lipoxidase), or [U-14C]15-hydro

280 angiotensin II induced greater levels of 12/15-lipoxygenase, TGF-beta1, and fibronectin (FN) in AT1R

281 metabolizing enzymes cyclooxygenase-2 and 12/15-lipoxygenase that generate inflammatory lipids.

282 and arachidonic acids, respectively, by a 12/15-lipoxygenase that is upregulated by the TH2-derived c

283 tochondrial pH was observed with a mutant of 15-lipoxygenase that lacks enzymatic activity.

284 eal injections of 15-HETE or an inhibitor of 15-lipoxygenase (the enzyme that produces 15-HETE); colo

285 gest that arachidonic acid is metabolized by 15-lipoxygenase to 15-HPETE, which undergoes an enzymati

286 nolenic acid, it is transformed by epidermal 15-lipoxygenase to mainly 13-hydroxyoctadecadienoic acid

287 For instance, epidermal 15-lipoxygenase transforms dihomo-gamma-linolenic acid (

288 by blockage of a key SPM biosynthesis enzyme 15-lipoxygenase type 1.

289 In conclusion, whereas 12/15-lipoxygenase up-regulation provides an important cont

290 Here we show that the activity of 12/15-lipoxygenase was increased in the ischemic mouse brai

291 of AT1R protein expression decreased when 12/15-lipoxygenase was knocked down with specific short hai

292 The mechanism postulated for 15-lipoxygenase was pieced together in vitro and has nev

293 biosynthesis, cytosolic phospholipase A2 and 15-lipoxygenase, was altered in AD hippocampus.

294 pancreatic lipase, acetylcholinesterase and 15-lipoxygenase were performed.

295 lipoxygenase pathways (5-lipoxygenase and 12/15-lipoxygenase), which are important enzymes for specia

296 Up-regulation of 12/15-lipoxygenase, which converts arachidonic acid to 12(S

297 te- macrophages and eosinophils also express 15-lipoxygenase, which converts arachidonic acid to 15(S

298 e KSHV miRNA cluster probably targets enzyme 15-lipoxygenase, which is involved in lipoxin A4 synthes

299 atures contrast with the previously reported 15S-lipoxygenase, which oxygenates arachidonic acid main

300 rachidonate-binding to mammalian 5-, 12- and 15-lipoxygenases, would appear to be true also for linol