ライフサイエンスコーパス: 2',5'-oligoadenylate

1 The human 2', 5'-oligoadenylate (2-5A) synthetases are members of

2 Upon sensing dsRNA, OAS produces 2',5'-oligoadenylate (2-5A) as a second messenger to act

3 In this study, analysis of 2',5'-Oligoadenylate (2-5A) binding and activation of th

4 The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L sys

5 Three isoforms of the interferon-inducible 2',5'-oligoadenylate (2-5A) synthetase that require doub

6 ation of the NLRP3 inflammasome involves the 2',5'-oligoadenylate (2-5A) synthetase(OAS)/RNase L syst

7 Upregulation of key components of the 2',5'-oligoadenylate (2-5A) synthetase/RNase L pathway h

8 The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribon

9 The 2',5'-oligoadenylate (2-5A) system is an RNA degradation

10 s a unique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RN

11 Here, we developed a biosensor for 2',5'-oligoadenylate (2-5A), the natural activator of RN

12 RNase L is the 2',5'-oligoadenylate (2-5A)-dependent endoribonuclease t

13 ide against human telomerase RNA linked to a 2',5'-oligoadenylate (2-5A).

14 stant to apoptosis by the RNase L activator, 2',5'-oligoadenylate (2-5A).

15 synthetases that produce 5'-phosphorylated, 2',5'-oligoadenylates (2-5A) from ATP.

16 on sensing double-stranded RNA, OAS produces 2',5'-oligoadenylates (2-5A), which activate RNase L.

17 2'-5' oligoadenylate (2-5 (A)) synthetases are major com

18 Multiple 2'-5' oligoadenylate (2-5A) synthetases are important co

19 RNase L is activated by 5'-phosphorylated, 2'-5' oligoadenylates (2-5A) produced from IFN-inducible

20 of residues 321 to 344 of the 9-2 isozyme of 2'-5'-oligoadenylate (2-5(A)) synthetase causes a loss o

21 2'-5'-Oligoadenylate (2-5(A)) synthetases are a family o

22 is required for transcriptional induction of 2'-5'-oligoadenylate (2-5A) synthetases by interferon (I

23 se-pseudokinase that is activated by unusual 2,'5'-oligoadenylate (2-5A) second messengers and which

24 f the structure-function relationship of the 2'-5' oligoadenylate [2-5 (A)] synthetases has been hamp

25 that germline mutations in the gene encoding 2'-5'-oligoadenylate(2-5A)-dependent RNase L (RNASEL) se

26 its catalytic center to promote synthesis of 2'-5'-oligoadenylate and thus activation of endoribonucl

27 hanism of the enzymatic conversion of ATP to 2',5'-oligoadenylates by 2-5A synthetase.

28 nd OAS2, is hypothesized to be important for 2'-5'-oligoadenylate chain building.

29 ange and is activated to polymerize ATP into 2'-5'-oligoadenylate chains.

30 These studies demonstrate that 2',5' oligoadenylate covalently linked to antisense (2-5

31 Treatment of human cells with 2',5' oligoadenylate covalently linked to antisense (2-5

32 RNase L, the 2',5' oligoadenylate-dependent ribonuclease, is one of t

33 Ribonuclease L (RNase L), the 2',5'-oligoadenylate-dependent ribonuclease, is one of t

34 2',5'-Oligoadenylate-dependent RNase L functions in the

35 Radiolabeled azido 2'-5'-oligoadenylate dimers were enzymatically synthesiz

36 the 5'-monophosphate moiety, shortening the 2',5'-oligoadenylate domain, and substitution of 3',5'-l

37 e-stranded RNA and catalyze the synthesis of 2'-5' oligoadenylates from ATP.

38 The IFN-gamma response can be blocked by 2',5'-oligoadenylate-linked antisense chimeras against P

39 al product that functions as an inhibitor of 2',5'-oligoadenylate phosphodiesterase (2'-PDE), a key r

40 of Streptomyces sp. SANK 61196 that inhibits 2',5'-oligoadenylate phosphodiesterase (2'-PDE), a key r

41 milarly, direct activation of RNase L with a 2',5'-oligoadenylate resulted in p62(SQSTM1) degradation

42 The 2',5'-oligoadenylate/RNase L system is a virus-activated

43 easuring Stat-1 tyrosine phosphorylation and 2',5'-oligoadenylate synthase and myxovirus resistance g

44 The role of 2'-5'-oligoadenylate synthase-like protein 1 (OASL1), an

45 proliferation, apoptosis, and inflammation (2'5'-oligoadenylate synthase, cyclooxygenase-2, and an I

46 we demonstrate that HSV-1 infection inhibits 2'-5' oligoadenylate synthesis in interferon-stimulated

47 o lack of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in re

48 70-fold and myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase mRNA expression (107- an

49 ulated genes myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase.

50 ins dsRNA-activated protein kinase (PKR) and 2',5'-oligoadenylate synthetase (2',5'-OAS) were down-re

51 acokinetics, pharmacodynamic measurements of 2',5'-oligoadenylate synthetase (OAS) activity, and indu

52 2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-

53 h the wild-type (WT) virus uses to block the 2',5'-oligoadenylate synthetase (OAS)-RNase L (RNase L)

54 The 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway is

55 ivity, which blocks the interferon inducible 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway to

56 response to AZA treatment occurs through the 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway.

57 nterferon response through counteracting the 2',5'-oligoadenylate synthetase (OAS)/RNase L system.

58 luding Myxovirus resistance protein 2 (Mx2), 2',5'-oligoadenylate synthetase (OAS-1), Virus inhibitor

59 elevation of the IFN-induced antiviral gene 2',5'-oligoadenylate synthetase (OAS1a) but not dsRNA-de

60 High expression of 2',5'-oligoadenylate synthetase 1 (OAS1), which adds AMP

61 Upon interferon activation by dsRNA, 2',5'-oligoadenylate synthetase 1 (OAS1A) is induced; it

62 The upregulation of endogenous IFN-beta and 2',5'-oligoadenylate synthetase 1 mRNA expression was al

63 ted increased expression of interferon-beta, 2',5'-oligoadenylate synthetase 1, interferon-alpha, and

64 activation, as evidenced by upregulation of 2',5'-oligoadenylate synthetase 1.

65 ulation and an IFN-inducible antiviral gene, 2',5'-oligoadenylate synthetase 1a (OAS), were determine

66 r of the mouse flavivirus resistance protein 2',5'-oligoadenylate synthetase 1B (OAS1B).

67 The RNase L activity associated with 2',5'-oligoadenylate synthetase is not activated or is b

68 ated Gene 15 (ISG15), Interleukin 16 (IL16), 2',5'-Oligoadenylate Synthetase Like (OASL), and Adhesio

69 ted proteins interferon regulatory factor 1, 2',5'-oligoadenylate synthetase, and double-stranded-RNA

70 randed RNA-dependent protein kinase R (PKR), 2',5'-oligoadenylate synthetase, and Mx1 mRNAs in swine

71 s, including myxovirus resistance protein A, 2',5'-oligoadenylate synthetase, and the IFN-stimulated

72 protein 10, and preferential upregulation of 2',5'-oligoadenylate synthetase, Mx1, and indoleamine 2,

73 novel murine cDNA encoding an ovary-specific 2',5'-oligoadenylate synthetase-like protein, OAS1D, whi

74 kinase (PKR) and the endoribonuclease of the 2',5'-oligoadenylate synthetase-RNase L system (PKR(-/-)

75 clease component of the interferon-regulated 2',5'-oligoadenylate synthetase-RNase L system, demonstr

76 HC class I, IFN regulatory factor-1, MxA and 2',5-oligoadenylate synthetase gene expression, transcri

77 The mRNA for IRF-1, p40, and p69 isoforms of 2'-5' oligoadenylate synthetase (2-5 AS) are detectable,

78 Interferon (IFN)-induced 2'-5' oligoadenylate synthetase (2-5A synthetase)/RNase

79 on, the eIF2alpha protein kinase PKR and the 2'-5' oligoadenylate synthetase (OAS) are both activated

80 Twelve 2'-5' oligoadenylate synthetase (Oas) genes were identif

81 The 2'-5' oligoadenylate synthetase (OAS) locus encodes for

82 influenza virus resistance allele Mx(+) and 2'-5' oligoadenylate synthetase (OAS) proteins was not r

83 d cDNAs, including inhibitor of apoptosis-1, 2'-5' oligoadenylate synthetase (OAS), a 2'-5' OAS-like

84 fter CpG and correlated with serum levels of 2'-5' oligoadenylate synthetase (OAS), a validated inter

85 antiviral interferon-stimulated gene product 2'-5' oligoadenylate synthetase (OAS), and the chemokine

86 h includes conventional poly(A) polymerases, 2'-5' oligoadenylate synthetase (OAS), and yeast Trf4p .

87 nes (ISGs) with antiviral properties such as 2'-5' oligoadenylate synthetase (OAS), stimulated trans-

88 NA-responsive defenses controlled by PKR and 2'-5' oligoadenylate synthetase (OAS), which respectivel

89 nd two immunologic surrogates, neopterin and 2'-5' oligoadenylate synthetase (OAS).

90 hesis mediated by protein kinase R (PKR) and 2'-5' oligoadenylate synthetase (OAS).

91 The importance of the 2'-5' oligoadenylate synthetase (OAS)/RNase L and double

92 We hypothesized that the 2'-5' oligoadenylate synthetase (OAS)/RNase L system, an

93 vidence of concerted evolution of paralogous 2'-5' oligoadenylate synthetase 1 genes was obtained in

94 e Flv locus was previously identified as the 2'-5' oligoadenylate synthetase 1b (Oas1b) gene.

95 Flavivirus is conferred by an allele of the 2'-5' oligoadenylate synthetase 1b gene that encodes the

96 , including those coding for MHC I proteins, 2'-5' oligoadenylate synthetase [2'-5'(A)N], and IFN reg

97 IFN-responsive genes OAS and ISG54 (encoding 2'-5' oligoadenylate synthetase and an IFN-stimulated ge

98 We have addressed the evolution of the 2'-5' oligoadenylate synthetase gene family, in the ligh

99 2'-5' oligoadenylate synthetase is stimulated by dsRNA t

100 in the light of both this new member and new 2'-5' oligoadenylate synthetase sequence data from other

101 o-IFN-beta was supported by induction of the 2'-5' oligoadenylate synthetase, an indicator of IFN act

102 trong as that of another IFN-inducible gene, 2'-5' oligoadenylate synthetase, but in contrast to 2'-5

103 ligoadenylate synthetase, but in contrast to 2'-5' oligoadenylate synthetase, TP/PD-ECGF mRNA levels

104 Human 2'-5' oligoadenylate synthetase-1 (OAS1) is central in i

105 Interferon-inducible 2'-5' oligoadenylate synthetase-like (OASL) protein is d

106 Among them, the gene encoding 2'-5' oligoadenylate synthetase-like (OASL) underwent th

107 egulatory role for endothelial expression of 2'-5' oligoadenylate synthetase-like 1 (OASL1) in mainta

108 This protein, which we named p59 2'-5' oligoadenylate synthetase-like protein (p59OASL),

109 Several 2'-5' oligoadenylate synthetase-like proteins, which lac

110 bsence of IFN-stimulated antiviral proteins, 2'-5' oligoadenylate synthetase/RNase L, and dsRNA-depen

111 The interferon-induced enzymes 2'-5'-oligoadenylate synthetase (OAS) and RNase L are ke

112 nce that the host interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS) and RNase L pathwa

113 ation in the gene encoding the 1b isoform of 2'-5'-oligoadenylate synthetase (OAS), a member of the O

114 p and also functions as an antagonist of the 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway.

115 The prenylated form of the human 2'-5'-oligoadenylate synthetase 1 (OAS1) protein has bee

116 ne (ISG) expression screening to reveal that 2'-5'-oligoadenylate synthetase 1 (OAS1), through ribonu

117 acterial role for the classic antiviral gene 2'-5'-oligoadenylate synthetase 1 (OAS1).

118 d IFN-stimulated gene expression (tracked by 2'-5'-oligoadenylate synthetase 1 and myxovirus (influen

119 vels and no significant difference in IFNB1, 2'-5'-oligoadenylate synthetase 1, or myxovirus (influen

120 as well as the effector genes, for example, 2'-5'-oligoadenylate synthetase and myxovirus proteins,

121 lv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.

122 One 2'-5'-oligoadenylate synthetase gene, Oas1b, was identif

123 METTL3 silencing enhanced 2'-5'-oligoadenylate synthetase levels by increasing its

124 This crystal structure of a 2'-5'-oligoadenylate synthetase reveals a structural con

125 ining E3 ubiquitin-protein ligase 5 (HERC5); 2'-5'-oligoadenylate synthetase-like (OASL); and helicas

126 ding inflammatory (S100A8/A9/A12, CXCL1, and 2'-5'-oligoadenylate synthetase-like [OASL]) and barrier

127 2'-5'-Oligoadenylate synthetase-like protein (OASL) is a

128 to be conserved among all known isozymes of 2'-5'-oligoadenylate synthetase.

129 ear the amino terminus of the 9-2 isozyme of 2'-5'-oligoadenylate synthetase.

130 ude the demonstration that the gene encoding 2'-5'oligoadenylate synthetase is responsible for murine

131 ms of IL-29 and IFN-alpha induced equivalent 2'5' oligoadenylate synthetase (OAS) and MX1 gene expres

132 d in all animals with increased intrahepatic 2'5' oligoadenylate synthetase 1 (2OAS-1) messenger RNA

133 ed genes for IFN-regulatory factors 1 and 7, 2'5' oligoadenylate synthetase, Mx, and TNF superfamily

134 106 (+/-63.3) pg/ml increase (P < 0.01); and 2'5'-oligoadenylate synthetase (OAS) had a 163 (+/-120.6

135 on of protein kinase R (PKR) and stimulating 2'5'-oligoadenylate synthetase (OAS).

136 ISG noted on the microarrays, such as STAT1, 2'5'-oligoadenylate synthetase 2, and ISG15, also suppor

137 of mRNA for dsRNA-activated protein kinase, 2'5'-oligoadenylate synthetase, and Toll-like receptor 3

138 nown interferon-stimulated genes such as the 2'5'-oligoadenylate synthetase, MX1, IRF-7, and toll-lik

139 Here we report that one of these targets, 2,5 oligoadenylate synthetase (2,5 OAS), is a mediator o

140 Specifically, we demonstrate that 2',5'-oligoadenylate synthetases (2-5AS), RNase L, and d

141 2-5A is produced by interferon-inducible 2',5'-oligoadenylate synthetases (OAS) upon activation b

142 RNA-dependent protein kinase (PKR), but not 2',5'-oligoadenylate synthetases (OAS), in vaginal tissu

143 2'-5' Oligoadenylate synthetases (OAS) are a family of e

144 The 2'-5' oligoadenylate synthetases (OAS) represent a famil

145 The 2'-5' oligoadenylate synthetases form a well conserved f

146 Unlike other RNA polymerases, 2'-5' oligoadenylate synthetases, a family of interferon

147 ed N-terminal domain with the known forms of 2'-5' oligoadenylate synthetases, but differs completely

148 an isozyme of the medium size class of human 2'-5' oligoadenylate synthetases.

149 e genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases.

150 The 2'-5'-oligoadenylate synthetases (OAS) are innate immune

151 2'-5'-Oligoadenylate synthetases (OAS) are innate immune

152 The 2'-5'-oligoadenylate synthetases are activated by viral

153 2'-5'-Oligoadenylate synthetases are interferon-induced

154 2'-5'-oligoadenylate synthetases are interferon-induced,

155 te-binding sites of the P69 isozyme of human 2'-5'-oligoadenylate synthetases.

156 Ns2 cleaves 2',5'-oligoadenylate, the product of OAS, to prevent act

157 2H-phosphodiesterase domain that can cleave 2'-5' oligoadenylates, thereby preventing RNase L activa

158 One such regulator is PDE12 which degrades 2'-5' oligoadenylate units, thereby decreasing RNAseL ac

159 initiate a cellular response by synthesizing 2'-5'-oligoadenylates, which in turn activate RNase L.