ライフサイエンスコーパス: 2',5'-oligoadenylate synthetase

1 ulated genes myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase.

2 to be conserved among all known isozymes of 2'-5'-oligoadenylate synthetase.

3 ear the amino terminus of the 9-2 isozyme of 2'-5'-oligoadenylate synthetase.

4 e genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases.

5 an isozyme of the medium size class of human 2'-5' oligoadenylate synthetases.

6 te-binding sites of the P69 isozyme of human 2'-5'-oligoadenylate synthetases.

7 High expression of 2',5'-oligoadenylate synthetase 1 (OAS1), which adds AMP

8 Upon interferon activation by dsRNA, 2',5'-oligoadenylate synthetase 1 (OAS1A) is induced; it

9 The upregulation of endogenous IFN-beta and 2',5'-oligoadenylate synthetase 1 mRNA expression was al

10 ted increased expression of interferon-beta, 2',5'-oligoadenylate synthetase 1, interferon-alpha, and

11 activation, as evidenced by upregulation of 2',5'-oligoadenylate synthetase 1.

12 vidence of concerted evolution of paralogous 2'-5' oligoadenylate synthetase 1 genes was obtained in

13 The prenylated form of the human 2'-5'-oligoadenylate synthetase 1 (OAS1) protein has bee

14 ne (ISG) expression screening to reveal that 2'-5'-oligoadenylate synthetase 1 (OAS1), through ribonu

15 acterial role for the classic antiviral gene 2'-5'-oligoadenylate synthetase 1 (OAS1).

16 d IFN-stimulated gene expression (tracked by 2'-5'-oligoadenylate synthetase 1 and myxovirus (influen

17 vels and no significant difference in IFNB1, 2'-5'-oligoadenylate synthetase 1, or myxovirus (influen

18 d in all animals with increased intrahepatic 2'5' oligoadenylate synthetase 1 (2OAS-1) messenger RNA

19 Human 2'-5' oligoadenylate synthetase-1 (OAS1) is central in i

20 ulation and an IFN-inducible antiviral gene, 2',5'-oligoadenylate synthetase 1a (OAS), were determine

21 r of the mouse flavivirus resistance protein 2',5'-oligoadenylate synthetase 1B (OAS1B).

22 e Flv locus was previously identified as the 2'-5' oligoadenylate synthetase 1b (Oas1b) gene.

23 Flavivirus is conferred by an allele of the 2'-5' oligoadenylate synthetase 1b gene that encodes the

24 ISG noted on the microarrays, such as STAT1, 2'5'-oligoadenylate synthetase 2, and ISG15, also suppor

25 ins dsRNA-activated protein kinase (PKR) and 2',5'-oligoadenylate synthetase (2',5'-OAS) were down-re

26 Specifically, we demonstrate that 2',5'-oligoadenylate synthetases (2-5AS), RNase L, and d

27 The mRNA for IRF-1, p40, and p69 isoforms of 2'-5' oligoadenylate synthetase (2-5 AS) are detectable,

28 Interferon (IFN)-induced 2'-5' oligoadenylate synthetase (2-5A synthetase)/RNase

29 Here we report that one of these targets, 2,5 oligoadenylate synthetase (2,5 OAS), is a mediator o

30 , including those coding for MHC I proteins, 2'-5' oligoadenylate synthetase [2'-5'(A)N], and IFN reg

31 Unlike other RNA polymerases, 2'-5' oligoadenylate synthetases, a family of interferon

32 o-IFN-beta was supported by induction of the 2'-5' oligoadenylate synthetase, an indicator of IFN act

33 IFN-responsive genes OAS and ISG54 (encoding 2'-5' oligoadenylate synthetase and an IFN-stimulated ge

34 as well as the effector genes, for example, 2'-5'-oligoadenylate synthetase and myxovirus proteins,

35 ted proteins interferon regulatory factor 1, 2',5'-oligoadenylate synthetase, and double-stranded-RNA

36 randed RNA-dependent protein kinase R (PKR), 2',5'-oligoadenylate synthetase, and Mx1 mRNAs in swine

37 s, including myxovirus resistance protein A, 2',5'-oligoadenylate synthetase, and the IFN-stimulated

38 of mRNA for dsRNA-activated protein kinase, 2'5'-oligoadenylate synthetase, and Toll-like receptor 3

39 The 2'-5'-oligoadenylate synthetases are activated by viral

40 2'-5'-Oligoadenylate synthetases are interferon-induced

41 2'-5'-oligoadenylate synthetases are interferon-induced,

42 trong as that of another IFN-inducible gene, 2'-5' oligoadenylate synthetase, but in contrast to 2'-5

43 ed N-terminal domain with the known forms of 2'-5' oligoadenylate synthetases, but differs completely

44 The 2'-5' oligoadenylate synthetases form a well conserved f

45 HC class I, IFN regulatory factor-1, MxA and 2',5-oligoadenylate synthetase gene expression, transcri

46 We have addressed the evolution of the 2'-5' oligoadenylate synthetase gene family, in the ligh

47 lv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.

48 One 2'-5'-oligoadenylate synthetase gene, Oas1b, was identif

49 The RNase L activity associated with 2',5'-oligoadenylate synthetase is not activated or is b

50 2'-5' oligoadenylate synthetase is stimulated by dsRNA t

51 ude the demonstration that the gene encoding 2'-5'oligoadenylate synthetase is responsible for murine

52 METTL3 silencing enhanced 2'-5'-oligoadenylate synthetase levels by increasing its

53 ated Gene 15 (ISG15), Interleukin 16 (IL16), 2',5'-Oligoadenylate Synthetase Like (OASL), and Adhesio

54 novel murine cDNA encoding an ovary-specific 2',5'-oligoadenylate synthetase-like protein, OAS1D, whi

55 Interferon-inducible 2'-5' oligoadenylate synthetase-like (OASL) protein is d

56 Among them, the gene encoding 2'-5' oligoadenylate synthetase-like (OASL) underwent th

57 egulatory role for endothelial expression of 2'-5' oligoadenylate synthetase-like 1 (OASL1) in mainta

58 This protein, which we named p59 2'-5' oligoadenylate synthetase-like protein (p59OASL),

59 Several 2'-5' oligoadenylate synthetase-like proteins, which lac

60 ining E3 ubiquitin-protein ligase 5 (HERC5); 2'-5'-oligoadenylate synthetase-like (OASL); and helicas

61 ding inflammatory (S100A8/A9/A12, CXCL1, and 2'-5'-oligoadenylate synthetase-like [OASL]) and barrier

62 2'-5'-Oligoadenylate synthetase-like protein (OASL) is a

63 70-fold and myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase mRNA expression (107- an

64 ed genes for IFN-regulatory factors 1 and 7, 2'5' oligoadenylate synthetase, Mx, and TNF superfamily

65 protein 10, and preferential upregulation of 2',5'-oligoadenylate synthetase, Mx1, and indoleamine 2,

66 nown interferon-stimulated genes such as the 2'5'-oligoadenylate synthetase, MX1, IRF-7, and toll-lik

67 o lack of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in re

68 acokinetics, pharmacodynamic measurements of 2',5'-oligoadenylate synthetase (OAS) activity, and indu

69 2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-

70 h the wild-type (WT) virus uses to block the 2',5'-oligoadenylate synthetase (OAS)-RNase L (RNase L)

71 The 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway is

72 ivity, which blocks the interferon inducible 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway to

73 response to AZA treatment occurs through the 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway.

74 nterferon response through counteracting the 2',5'-oligoadenylate synthetase (OAS)/RNase L system.

75 luding Myxovirus resistance protein 2 (Mx2), 2',5'-oligoadenylate synthetase (OAS-1), Virus inhibitor

76 2-5A is produced by interferon-inducible 2',5'-oligoadenylate synthetases (OAS) upon activation b

77 RNA-dependent protein kinase (PKR), but not 2',5'-oligoadenylate synthetases (OAS), in vaginal tissu

78 on, the eIF2alpha protein kinase PKR and the 2'-5' oligoadenylate synthetase (OAS) are both activated

79 Twelve 2'-5' oligoadenylate synthetase (Oas) genes were identif

80 The 2'-5' oligoadenylate synthetase (OAS) locus encodes for

81 influenza virus resistance allele Mx(+) and 2'-5' oligoadenylate synthetase (OAS) proteins was not r

82 d cDNAs, including inhibitor of apoptosis-1, 2'-5' oligoadenylate synthetase (OAS), a 2'-5' OAS-like

83 fter CpG and correlated with serum levels of 2'-5' oligoadenylate synthetase (OAS), a validated inter

84 antiviral interferon-stimulated gene product 2'-5' oligoadenylate synthetase (OAS), and the chemokine

85 h includes conventional poly(A) polymerases, 2'-5' oligoadenylate synthetase (OAS), and yeast Trf4p .

86 nes (ISGs) with antiviral properties such as 2'-5' oligoadenylate synthetase (OAS), stimulated trans-

87 NA-responsive defenses controlled by PKR and 2'-5' oligoadenylate synthetase (OAS), which respectivel

88 hesis mediated by protein kinase R (PKR) and 2'-5' oligoadenylate synthetase (OAS).

89 nd two immunologic surrogates, neopterin and 2'-5' oligoadenylate synthetase (OAS).

90 The importance of the 2'-5' oligoadenylate synthetase (OAS)/RNase L and double

91 We hypothesized that the 2'-5' oligoadenylate synthetase (OAS)/RNase L system, an

92 2'-5' Oligoadenylate synthetases (OAS) are a family of e

93 The 2'-5' oligoadenylate synthetases (OAS) represent a famil

94 The interferon-induced enzymes 2'-5'-oligoadenylate synthetase (OAS) and RNase L are ke

95 nce that the host interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS) and RNase L pathwa

96 ation in the gene encoding the 1b isoform of 2'-5'-oligoadenylate synthetase (OAS), a member of the O

97 p and also functions as an antagonist of the 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway.

98 The 2'-5'-oligoadenylate synthetases (OAS) are innate immune

99 2'-5'-Oligoadenylate synthetases (OAS) are innate immune

100 ms of IL-29 and IFN-alpha induced equivalent 2'5' oligoadenylate synthetase (OAS) and MX1 gene expres

101 106 (+/-63.3) pg/ml increase (P < 0.01); and 2'5'-oligoadenylate synthetase (OAS) had a 163 (+/-120.6

102 on of protein kinase R (PKR) and stimulating 2'5'-oligoadenylate synthetase (OAS).

103 elevation of the IFN-induced antiviral gene 2',5'-oligoadenylate synthetase (OAS1a) but not dsRNA-de

104 This crystal structure of a 2'-5'-oligoadenylate synthetase reveals a structural con

105 kinase (PKR) and the endoribonuclease of the 2',5'-oligoadenylate synthetase-RNase L system (PKR(-/-)

106 clease component of the interferon-regulated 2',5'-oligoadenylate synthetase-RNase L system, demonstr

107 bsence of IFN-stimulated antiviral proteins, 2'-5' oligoadenylate synthetase/RNase L, and dsRNA-depen

108 in the light of both this new member and new 2'-5' oligoadenylate synthetase sequence data from other

109 ligoadenylate synthetase, but in contrast to 2'-5' oligoadenylate synthetase, TP/PD-ECGF mRNA levels