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1 mited bioavailability of the antitumor agent 2-methoxyestradiol.
2 ptosis induced by the chemotherapeutic agent 2-methoxyestradiol.
3 ug showed 32.34- to 40.07-fold resistance to 2-methoxyestradiol.
4 ced by the chemotherapeutic agents taxol and 2-methoxyestradiol.
5 lent agents colchicine, podophyllotoxin, and 2-methoxyestradiol.
6  efficiently converted 2-hydroxyestradiol to 2-methoxyestradiol.
7 usly studied endogenous estradiol metabolite 2-methoxyestradiol.
8 eater tubulin polymerization inhibition than 2-methoxyestradiol (1) and contained moieties that are e
9                 A series of new analogues of 2-methoxyestradiol (1) were synthesized to further eluci
10 st effective analogues, 14-dehydro-2-ME2 and 2-methoxyestradiol-15 alpha,16 alpha-acetonide, provided
11 iciently to the parent compound in vivo than 2-methoxyestradiol 17-phosphate, and it was also more cy
12                                              2-Methoxyestradiol (2-ME(2)), a promising anticancer dru
13                                              2-Methoxyestradiol (2-ME) is an endogenous metabolite of
14 te the efficacy of intravitreal injection of 2-Methoxyestradiol (2-ME) nanoemulsion in regressing neo
15                                              2-Methoxyestradiol (2-ME), a new anticancer agent curren
16                                              2-Methoxyestradiol (2-ME), an endogenous estrogen metabo
17                 We here report that low dose 2-methoxyestradiol (2-ME), an endogenous estrogen metabo
18              The antiproliferative action of 2-methoxyestradiol (2-ME), an endogenous estrogen metabo
19                                              2-Methoxyestradiol (2-ME), an endogenous estrogen metabo
20     We asked whether combined treatment with 2-methoxyestradiol (2-Me), which increases levels of wil
21 t under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estr
22  and determined that the estrogen derivative 2-methoxyestradiol (2-ME2) disrupted both cell-autonomou
23                                              2-Methoxyestradiol (2-ME2) is a natural estrogen metabol
24                                              2-Methoxyestradiol (2-MeO-E(2)), a well-known nonpolar e
25                                              2-Methoxyestradiol (2-MeO-E2), a nonpolar endogenous met
26                                      Because 2-methoxyestradiol (2-MeOE2) induces and stabilizes wild
27                                              2-Methoxyestradiol (2-MeOE2) treatment caused significan
28          The bis-sulfamoylated derivative of 2-methoxyestradiol (2-MeOE2), 2-methoxyestradiol-3,17-O,
29 NA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metab
30 uced neurotoxicity, cobalt chloride (CoCl2), 2-methoxyestradiol (2-MeOE2), small interfering RNA (siR
31                                              2-Methoxyestradiol (2ME(2)) is an endogenous metabolite
32                                              2-Methoxyestradiol (2ME(2)), a metabolite of 17-beta-est
33                                              2-Methoxyestradiol (2ME(2)), a physiologic metabolite of
34                                              2-Methoxyestradiol (2ME) is an endogenous mammalian cata
35                               The effects of 2-Methoxyestradiol (2ME)-induced apoptosis was examined
36                                              2-Methoxyestradiol (2ME2) an estrogen derivative, induce
37                                              2-Methoxyestradiol (2ME2) is a natural metabolite of est
38                                              2-Methoxyestradiol (2ME2) is an endogenous estradiol met
39                                              2-Methoxyestradiol (2ME2), a natural metabolite of estra
40                                              2-methoxyestradiol (2ME2), an estradiol metabolite with
41         Our previous study demonstrated that 2-methoxyestradiol (2ME2), an estrogen derivative, induc
42      The endogenous metabolite of estradiol, 2-Methoxyestradiol (2ME2), is an antimitotic and antiang
43 ect of the known dysregulator of HIF-1alpha, 2-methoxyestradiol (2ME2), on the levels of HIF-1alpha u
44                           Here, we show that 2-methoxyestradiol (2ME2)-induced apoptosis in multiple
45 me inhibitor PS-341, dexamethasone (Dex) and 2-Methoxyestradiol (2ME2).
46 ted with Minocycline (inhibitor of MMPs), or 2-Methoxyestradiol (2ME2, inhibitor of HIF-1alpha) and s
47                                The effect of 2-methoxyestradiol, 2ME2, an endogenous metabolite of 17
48                            In the absence of 2-methoxyestradiol, 2ME2R cells were characterized by an
49            The in vivo antitumor activity of 2-methoxyestradiol 3-phosphate at a dose of 200 mg/kg pe
50 gree with the in vivo anticancer activity of 2-methoxyestradiol 3-phosphate in a mouse Lewis lung car
51                                              2-methoxyestradiol 3-phosphate was metabolized more effi
52  derivative of 2-methoxyestradiol (2-MeOE2), 2-methoxyestradiol-3,17-O,O-bis-sulfamate (2-MeOE2bisMAT
53 oxyestrone, 2-hydroxyestrone-3-methyl ether, 2-methoxyestradiol, 4-methoxyestradiol, 2-hydroxyestrone
54                               Treatment with 2-methoxyestradiol (60-600 mg/kg/d) resulted in a dose-d
55 hip between the structures of colchicine and 2-methoxyestradiol, a B-ring-expanded 2-ethoxyestradiol
56                                              2-Methoxyestradiol, a mammalian metabolite of estradiol,
57                   Here, we evaluated whether 2-methoxyestradiol, a microtubule and HIF-1 inhibitor, w
58    Importantly, we identified a mechanism of 2-methoxyestradiol, a microtubule inhibitor currently un
59                                              2-Methoxyestradiol, a natural metabolite of estradiol an
60 mpt to improve on the anticancer activity of 2-methoxyestradiol, a naturally occurring mammalian tubu
61 n of docetaxel with the antiangiogenic agent 2-methoxyestradiol also overcomes the protective effect
62                                              2-Methoxyestradiol also suppressed VEGF-induced vascular
63 vinblastine, vincristine, 17-beta-estradiol, 2-methoxyestradiol) altered cyclooxygenase-2 (COX-2) exp
64 effects of docetaxel, whereas agents such as 2- methoxyestradiol and recombinant humanized monoclonal
65 e and the nature of the relationship between 2-methoxyestradiol and colchicine, a series of colchicin
66  with the proposed structural resemblance of 2-methoxyestradiol and colchicine.
67  were interested in examining the effects of 2-methoxyestradiol and Fas ligand (FasL)/tumor necrosis
68                 Moreover, the combination of 2-methoxyestradiol and TRAIL reduces the tumor burden in
69 ta that suggest that endogenous formation of 2-methoxyestradiol (and its 2-hydroxyestradiol precursor
70 , epothilone B, discodermolide, vincristine, 2-methoxyestradiol, and colchicine.
71 ingly, the endogenous angiogenesis inhibitor 2-methoxyestradiol augments FasL/TRAIL-induced apoptosis
72 substrates, including PNP, 17beta-estradiol, 2-methoxyestradiol, catecholestrogens, the antiestrogen
73 cell line by stepwise exposure to increasing 2-methoxyestradiol concentrations.
74 antitubulin and antiproliferative effects of 2-methoxyestradiol, consistent with acquired tubulin mut
75 ation of members of death receptor family in 2-methoxyestradiol-exposed pancreatic cancer cells.
76 ls and to evaluate the effects of modulating 2-methoxyestradiol formation on estrogen-induced carcino
77           The endogenous estrogen metabolite 2-methoxyestradiol has modest antimitotic activity that
78 lfamate derivative of the endogenous steroid 2-methoxyestradiol, has shown promising anticancer poten
79     Subsequent structure-activity studies of 2-methoxyestradiol have yielded highly potent steroidal
80 adiol and colchicine, a series of colchicine/2-methoxyestradiol hybrids was synthesized.
81 s the effect of low or intermediate doses of 2-methoxyestradiol in combination with chemotherapeutic
82 e the metabolic formation and disposition of 2-methoxyestradiol in liver and in target cells and to e
83 giogenic effects of exogenously administered 2-methoxyestradiol in vitro and in vivo.
84 8, can render significant protection against 2-methoxyestradiol-induced apoptosis.
85                                              2-Methoxyestradiol inhibited DNA synthesis, cell numbers
86                                              2-Methoxyestradiol is a cytotoxic human metabolite of es
87                                              2-Methoxyestradiol is a physiologic metabolite of 17beta
88                                      Because 2-methoxyestradiol is able to trigger death receptor sig
89                                              2-Methoxyestradiol is an estradiol metabolite with signi
90 lthough the molecular mechanism of action of 2-methoxyestradiol is not clear, we suggest that some un
91 angiogenesis, and the angiogenesis inhibitor 2-methoxyestradiol may be a potential candidate for syst
92                    Our results indicate that 2-methoxyestradiol may be a promising chemotherapeutic a
93 lear, we suggest that some unique effects of 2-methoxyestradiol may be mediated by a specific intrace
94          Our previous studies indicated that 2-methoxyestradiol-mediated apoptosis involves the disap
95 lso implicate that oxidative stress precedes 2-methoxyestradiol-mediated c-Jun NH2-terminal kinase ac
96 dominant-negative FADD reverts the effect of 2-methoxyestradiol-mediated cell death.
97                    Intravitreal injection of 2-Methoxyestradiol nanoemulsion is a promising effective
98 th a dominant-negative form of HIF-1alpha or 2-methoxyestradiol reduced metastasis to both lung and b
99   To identify a molecular basis for acquired 2-methoxyestradiol resistance, we generated a stable 2-m
100 h acquired tubulin mutations contributing to 2-methoxyestradiol resistance.
101 yestradiol resistance, we generated a stable 2-methoxyestradiol-resistant (2ME2R) MDA-MB-435 human ca
102 ently, treatment of parental P435 cells with 2-methoxyestradiol resulted in a dose-dependent depolyme
103             Finally, systemic treatment with 2-methoxyestradiol significantly inhibited the growth of
104 ic treatment with the angiogenesis inhibitor 2-methoxyestradiol suppressed HIF-1alpha expression in v
105                                              2-Methoxyestradiol suppresses MDSC activation by inhibit
106 locked both by anti-androgens and a steroid (2-methoxyestradiol) that prevents the binding of estradi
107 gate biomarkers to determine the efficacy of 2-methoxyestradiol therapy: decreased HIF-1alpha levels,
108 , increasing cellular superoxide levels with 2-methoxyestradiol treatment or inhibition of autophagy/
109                                         Upon 2-methoxyestradiol treatment, levels of acetylated and d
110 phate, 17-phosphate, and 3,17-diphosphate of 2-methoxyestradiol were synthesized.

 
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