ライフサイエンスコーパス: 4'-phosphopantetheine

1 that hydrolyzes fatty acyl-CoA to yield acyl 4'-phosphopantetheine.

2 onal protein modification, the attachment of 4'-phosphopantetheine.

3 R)-4'-phospho-N-pantothenoylcysteine to form 4'-phosphopantetheine.

4 HlyC was also able to bind in vivo 4'-phosphopantetheine.

5 consensus sequence, DSLD, for attachment of 4'-phosphopantetheine.

6 ified by attachment of the prosthetic group, 4'-phosphopantetheine (4'-PP), which is transferred from

7 transferases (PPTs) catalyze the transfer of 4'-phosphopantetheine (4-PP) from coenzyme A to a conser

8 ole of ACP depends upon its covalently bound 4'-phosphopantetheine (4-PP)-conjugated acyl chain to su

9 tivities and a site for the prosthetic group 4'-phosphopantetheine (acyl carrier protein).

10 proof of concept, the method was applied to 4'-phosphopantetheine adenylyltransferase (PPAT) from My

11 rified active Orf* confirmed the presence of 4'-phosphopantetheine and 27-hydroxyoctacosanoic acid in

12 erting the terminal thiol of the E. coli ACP 4'-phosphopantetheine arm into a mixed disulfide with 2-

13 of the acetyl-Coenzyme A precursor S-acetyl-4'-phosphopantetheine as a possible treatment for neurod

14 odified) by AcpS, the PPTase responsible for 4'-phosphopantetheine attachment to the acyl carrier pro

15 The structure also reveals the 4'-phosphopantetheine-conjugated acyl-group of ACP occup

16 AcpS catalyzes the transfer of 4'-phosphopantetheine from coenzyme A (CoA) to apo-ACP,

17 cyl carrier protein (apoACP) via transfer of 4'-phosphopantetheine from coenzyme A (CoA) to the conse

18 the covalent posttranslational attachment of 4'-phosphopantetheine from coenzyme A (CoA), and this mo

19 purified ACP was properly modified with its 4'-phosphopantetheine functional group, (ii) it was not

20 acyl intermediates linked to its prosthetic 4'-phosphopantetheine group among four acyltransferases,

21 ing probable snapshots of ACP in action: the 4'-phosphopantetheine group of AcpP first binds an argin

22 po- and holo-forms of AcpM revealed that the 4'-phosphopantetheine group oscillates between two state

23 nally modified by covalent attachment of the 4'-phosphopantetheine group to the highly conserved seri

24 An unanticipated conformational shift of 4'-phosphopantetheine groups within the LpxD catalytic c

25 did not prevent binding of the fatty acyl or 4'-phosphopantetheine groups.

26 nd rely on the acyl carrier protein-tethered 4'-phosphopantetheine (holo-ACP).

27 CoA in vivo and excreted significantly more 4'-phosphopantetheine into the medium compared to cells

28 f the phenylalanyl moiety presented as Phe-S-4'-phosphopantetheine-modified (Ppant) acyl enzyme.

29 are enzymes that catalyse the transfer of a 4'-phosphopantetheine moiety from CoA to a conserved ser

30 ynthase (AcpS) catalyzes the transfer of the 4'-phosphopantetheine moiety from coenzyme A (CoA) onto

31 enate (vitamin B(5)) is the precursor of the 4'-phosphopantetheine moiety of coenzyme A and acyl-carr

32 The enzyme is capable of transferring the 4'-phosphopantetheine moiety of coenzyme A to a conserve

33 s, CoA, NAD, and FAD, from their precursors, 4'-phosphopantetheine, NMN, and FMN, respectively.

34 nslocation of saturated acyl chains from the 4'-phosphopantetheine of the acyl carrier protein to the

35 thetases suggests nucleophilic attack by the 4'-phosphopantetheine on the alpha-phosphate of ATP.

36 Specific, stepwise truncation of CoA to 4-phosphopantetheine, pantetheine, and finally cysteamin

37 y transferring an adenylyl group from ATP to 4'-phosphopantetheine (PhP) to form dephosphocoenzyme A.

38 in with the uptake of pantetheine (PanSH) or 4'-phosphopantetheine (PPanSH) as initial CoA precursors

39 reactive acyl intermediates with a swinging 4'-phosphopantetheine (Ppant) arm and interact with a su

40 le transfer of an adenylyl group from ATP to 4'-phosphopantetheine (Ppant) in the presence of magnesi

41 athway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a

42 '-monophosphate diester (L-Phe-AMP), L-Phe-S-4'-phosphopantetheine(Ppant)- and D-Phe-S-4'-Ppant-acyl

43 transferase (PptT), an enzyme that transfers 4'-phosphopantetheine (Ppt) from coenzyme A (CoA) to div

44 The 4'-phosphopantetheine prosthetic group of a holo-ACP is

45 hain assembly intermediates attached via the 4'-phosphopantetheine prosthetic group.

46 ACP) and stearate (18:0-ACP) attached to the 4'-phosphopantetheine prosthetic group.

47 ies, which remained covalently linked to the 4'-phosphopantetheine residues of the two acyl carrier p

48 A 4'-phosphopantetheine swinging arm bound through a phosp

49 e octanoyl-transferase mainly recognizes the 4'-phosphopantetheine-tethered acyl-chain of its donor s

50 These carrier proteins use the 4'-phosphopantetheine thiol to shuttle intermediates bet

51 transfer of saturated acyl moieties from the 4'-phosphopantetheine thiol to the active site cysteine

52 sfer of an adenylyl group from Mg(2+):ATP to 4'-phosphopantetheine to form 3'-dephospho-CoA (dPCoA) a

53 o-ACP complex and the subsequent transfer of 4'-phosphopantetheine to the apo-ACP of the complex.

54 The human 4'-phosphopantetheine transferase is also capable of pho

55 A single candidate 4'-phosphopantetheine transferase, identified by BLAST s

56 n contrast to yeast, which utilizes separate 4'-phosphopantetheine transferases to service each of th

57 pathway converting 4'-phosphopantothenate to 4'-phosphopantetheine, was confirmed in Escherichia coli

58 ein close in space to the fatty acid and the 4'-phosphopantetheine were identified using filtered/edi

59 main carries the growing chain tethered to a 4'-phosphopantetheine whereas the TE domain catalyses hy

60 ketide mimetic tethered to a stably modified 4'-phosphopantetheine, which provides important empirica

61 biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyro

62 y transferring an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA).