ライフサイエンスコーパス: 5-HT1 receptor

1 ntrast to the classical role ascribed to the 5-HT1 receptors.

2 tryptamine (5-CT), a nonselective agonist of 5-HT1 receptors.

3 xhibit high binding affinities for the human 5-HT1D receptor.

4 VA Ca2+ currents were mediated by 5-HT1A and 5-HT1D receptors.

5 lay neurons to 5-carboxytryptamine (5-CT), a 5-HT1 receptor agonist that preferentially activates the

6 ylserotonin (100 microg kg-1, i.a.), and the 5-HT1 receptor agonist, 5-carboxamidotryptamine (100 mic

7 re elevated but then returned to normal by a 5-HT1 receptor agonist, sumatriptan.

8 e investigated the inhibitory effects of six 5-HT1 receptor agonists in this model: 3-(1,2,5,6-tetrah

9 ylation in response to serotonin, SSRIs, and 5-HT1 receptor agonists.

10 It has been observed that reported 5-HT1D receptor agonists have at least one heteroatom (N

11 y)alkylamines may represent a novel class of 5-HT1D receptor agonists.

12 Here, we also report the ability of a 5-HT1D receptor antagonist, GR127935, to antagonize 5-HT

13 5-HT1 receptor antagonists have been discovered with goo

14 Our finding, that 5-HT1D receptors are distributed in nociceptors througho

15 ible explanation for this difference is that 5-HT1D receptors are preferentially expressed by cranial

16 ght involve inhibition of MAP kinases, since 5-HT1 receptors can increase mitogen-activated protein (

17 Instead, activation of 5-HT1 receptors caused a slow and remarkably prolonged i

18 d G protein subunits to membranes containing 5-HT1D receptors caused a small increase in affinity for

19 lves the activation of serotonin subtype 1D (5-HT1D) receptors expressed on "pain-responsive" trigemi

20 gs indicate that preferential stimulation of 5-HT1 receptors, expressed on thin fiber muscle afferent

21 uggest that a "pain"-triggered regulation of 5-HT1D-receptor expression underlies the effectiveness o

22 g at least in part through the regulation of 5-HT1D-receptor gene expression.

23 We find that several serotonin type-1 (5-HT1) receptor genes are expressed in retinal ganglion

24 We compared the distribution of 5-HT1D receptor-immunoreactive (5-HT1D-IR) peripheral af

25 Moreover, the widespread expression of 5-HT1D receptor in somatic nociceptive afferents suggest

26 At the ultrastructural level, 5-HT1D receptors in the spinal cord dorsal horn are loca

27 emonstrate that activation of the endogenous 5-HT1 receptor is coupled to calcium signaling pathways

28 we show that agonist-mediated activation of 5-HT1 receptors leads to enhanced and ectopic axonal reg

29 c interneurons and direct inhibition via the 5-HT1 receptors on MCs.

30 stablish the existence of triptan-sensitive (5-HT1) receptors on postsynaptic central trigeminal neur

31 ells during regeneration and that inhibiting 5-HT1 receptors or components of the 5-HT pathway select

32 In contrast, the 5-HT1D receptor produced both voltage-dependent and -ind

33 Agonists at serotonin 1D (5-HT1D) receptors relieve migraine headache but are not

34 ptan (1 nM-1 microM), agonists at 5-HT1B and 5-HT1D receptors, respectively.

35 We show that 5-HT1 receptor signaling is dispensable during ON develo

36 This may largely be due to activation of a 5-HT1 receptor subtype and not to desensitization.

37 of EPSCs caused by 5-HT was mediated by the 5-HT1D receptor subtype, since the 5-HT1D agonist, sumat

38 s for further understanding the roles of the 5-HT1 receptor subtypes and providing new approaches for

39 brane environment these four closely related 5-HT1 receptor subtypes exhibit different G protein coup

40 e (8) binds with high affinity at calf brain 5-HT1D receptors, we explored the structure-affinity rel