ライフサイエンスコーパス: 5-HTP

1 5-HTP also caused monkeys to perseverate on their gaze r

2 5-HTP increased central concentrations of serotonin and

3 5-HTP SR might be used to treat patients with intestinal

4 5-HTP SR might in particular be therapeutically relevant

5 5-HTP SR produced plasma 5-HTP levels well within the ra

6 5-HTP SR robustly increased brain 5-HT synthesis and lev

7 5-HTP SR's pro-serotonergic effects were stronger in mic

8 5-HTP treatment gradually reduced the rhythmicity of the

9 Increased [11C]5-HTP influx rate was observed in the amygdala, raphe nu

10 The influx rate of [11C]5-HTP as a measure of serotonin synthesis rate capacity

11 n [SD] age, 34.7 [9.2] years) underwent [11C]5-HTP PET imaging.

12 Adjunct 5-HTP IR could not produce this therapy-like profile, pr

13 data, our mouse data suggest that an adjunct 5-HTP SR drug could safely and effectively elevate 5-HTE

14 In both lines of mice, adjunct 5-HTP SR synergized with SSRI to elevate 5-HTExt beyond

15 We tested adjunct 5-HTP SR in wild-type mice and in mice with low brain 5-

16 Small pilot trials suggest that adjunct 5-HTP can confer antidepressant response in treatment-re

17 deled oral 5-HTP SR in mice by administering 5-HTP via the food.

18 After 5-HTP treatment, microvoltammetric measurements indicate

19 ere may be additional regulation that allows 5-HTP to accumulate to varying levels.

20 study measured the activities of L-DOPA and 5-HTP decarboxylase (DDC and 5-HTPDC) in the substantia

21 These findings provide a causal link between 5-HTP and social gaze behaviors in nonhuman primates and

22 idence for a modulatory relationship between 5-HTP and social gaze behaviors in nonhuman primates and

23 the inhibition of N-methyltransferase blocks 5-HTP-induced head twitches in betaarr2-KO mice, indicat

24 Different sets of genes were impacted by 5-HTP or temperature, or by their interaction.

25 Pancreas uptake of (11)C-5-HTP (e.g., the volume of the endocrine pancreas) did n

26 The PET tracer (11)C-5-HTP can be used for quantitative imaging of the seroto

27 The pancreas uptake of (11)C-5-HTP correlated with the long-term metabolic control as

28 Pancreatic uptake of (11)C-5-HTP in nonhuman primates was markedly decreased by inh

29 yme dopa decarboxylase, which converts (11)C-5-HTP to (11)C-serotonin and increased after inhibition

30 n = 16), by (11)C-5-hydroxytryptophan ((11)C-5-HTP) positron emission tomography (PET) and MRI.

31 T tracer (11)C-5-hydroxy-l-tryptophan ((11)C-5-HTP).

32 Uptake of (11)C-5-HTP, and its specificity for key enzymes in the seroto

33 In rat, hepatic uptake of [(11)C]5-HTP correlated with the number of transplanted islets.

34 ion (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most ev

35 Accumulation of [(11)C]5-HTP in the pancreas of both HVs and subjects with T1D

36 tal islet graft (n = 8) underwent two [(11)C]5-HTP PET and MRI examinations 8 months apart.

37 [(11)C]5-HTP retention in the pancreas was reduced in T1D compa

38 n the beta-cell volume, implying that [(11)C]5-HTP retention is a useful noninvasive surrogate marker

39 oncept study, the ex vivo and in vivo [(11)C]5-HTP signal was compared with the number of islets tran

40 The endocrine marker [(11)C]5-HTP thus shows a correlation between hepatic uptake an

41 his was not mirrored by a decrease in [(11)C]5-HTP tracer accumulation in the pancreas.

42 The primary outcome was the [(11)C]5-HTP uptake and retention in pancreas, as a surrogate m

43 A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HVs, with larg

44 T) marker [(11)C]5-hydroxytryptophan ([(11)C]5-HTP) for this purpose.

45 [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP) positron emission tomography of the pancreas has

46 recursor [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP).

47 Feeding chow that contains 5-HTP slow release (5-HTP SR) to TPH2-R439H mice restore

48 Critically, 5-HTP selectively impaired the ability of monkeys to inh

49 5-HTP immediate release (IR) likely curtail 5-HTP IR's antidepressant potential.

50 In contrast, the morphine treatment enhances 5-HTP accumulation in dorsal raphe nucleus, cortex and c

51 with the 5-HT precursor 5-hydroxytryptophan (5-HTP) elevates 5-HTExt beyond the SSRI effect.

52 5-hydroxytryptophan (5-HTP) has shown therapeutic promise in a range of human

53 vivo of accumulation of 5-hydroxytryptophan (5-HTP) in tissue from the dorsal and median raphe nuclei

54 Accumulation of 5-hydroxytryptophan (5-HTP) in vivo, in the presence of the aromatic amino ac

55 the serotonin precursor 5-hydroxytryptophan (5-HTP) increased the intensity of serotonin immunolabeli

56 th the direct precursor 5-hydroxytryptophan (5-HTP) would modulate the ability of rhesus macaques (bo

57 iate precursor of 5-HT, 5-hydroxytryptophan (5-HTP), in two model opisthobranch molluscs, the nudibra

58 and after injection of 5-hydroxytryptophan (5-HTP).

59 CON, 8 mL/day n = 4) or 5-hydroxytryptophan (5-HTP, 90 mg/day, n = 4) for 10 consecutive days.

60 that SR delivery will substantially improve 5-HTP's drug properties, by minimizing adverse effects a

61 Sound stress increases 5-HTP accumulation in median raphe nucleus, hippocampus,

62 s indicated EcN also increases intracellular 5-HTP and reduces 5-HIAA.

63 We modeled 5-HTP SR with minipumps, 5-HTP IR with injections, and chronic SSRI with dietary

64 We modeled 5-HTP SR with minipumps, 5-HTP IR with injections, and c

65 s upregulated by all doses except TN-200 muM 5-HTP, and cell survival gene, FOXO3, was upregulated by

66 3, was upregulated by HS-50, 200 and 500 muM 5-HTP, suggesting 5-HTP involvement in cell turnover und

67 But native 5-HTP immediate release (IR) is poorly druggable, as rap

68 pletely blocked the enhanced accumulation of 5-HTP, but had no effect on basal accumulation of 5-HTP,

69 , but had no effect on basal accumulation of 5-HTP, except at the highest doses of 1.0 or 3.3 nmol, w

70 Administration of 5-HTP SR to adult TPH2-R439H mice restored 5-HT to enter

71 Administration of 5-HTP SR to mice restored 5-HT to the ENS and normalized

72 Systemic administrations of 5-HTP effectively increased central serotonin levels and

73 Furthermore, the effects of 5-HTP on performance correlated with a constriction of t

74 e, suggesting that the disruptive effects of 5-HTP on social gaze behaviors are likely driven by a do

75 The intensity of 5-HTP immunolabeling varied between cell types and was c

76 The overall intensity of 5-HTP immunoreactivity in individual ganglia agreed with

77 onergic neurons also displayed low levels of 5-HTP immunolabeling that were above background levels.

78 ssed rats had significantly higher levels of 5-HTP in cortex and midbrain compared to sham-stressed c

79 esults support the notion that production of 5-HTP is a rate-limiting step in serotonin synthesis and

80 Supplementation of 5-HTP increased cell proliferation and total cell number

81 nin pathway, through oral supplementation of 5-HTP, influences signaling pathways and cellular proces

82 ined effects of sound stress and morphine on 5-HTP accumulation are identical to those obtained by ea

83 Adult TPH2-R439H mice given oral 5-HTP SR had normalized numbers of enteric neurons, tota

84 Here we modeled oral 5-HTP SR in mice by administering 5-HTP via the food.

85 5-HTP SR produced plasma 5-HTP levels well within the range enhancing brain 5-HT

86 y of the components of this cascade prevents 5-HTP-induced, but not N-methyltryptamine-induced, head

87 ata, appreciated in the context of published 5-HTP clinical data, suggest that 5-HTP SR could represe

88 eding chow that contains 5-HTP slow release (5-HTP SR) to TPH2-R439H mice restores levels of 5-HT in

89 In a comprehensive screen, 5-HTP SR was devoid of overt toxicological effects.

90 nistering the direct precursor of serotonin, 5-HTP, on orienting and inhibiting social gaze in nonhum

91 Specific 5-HTP immunoreactivity was colocalized with serotonin in

92 When administered with an SSRI, 5-HTP SR enhanced 5-HT-sensitive behaviors and neurotrop

93 rapid absorption and elimination of standard 5-HTP immediate release (IR) likely curtail 5-HTP IR's a

94 by HS-50, 200 and 500 muM 5-HTP, suggesting 5-HTP involvement in cell turnover under HS.

95 Supplementing 5-HTP at various concentrations in vitro to pBMEC modula

96 Recently, we reported that 5-HTP delivered as slow-release (SR) in mice augmented t

97 HPLC measurements showed that 5-HTP is present at approximately the same level as the

98 published 5-HTP clinical data, suggest that 5-HTP SR could represent a new therapeutic approach to t

99 d muscle fiber area was not different in the 5-HTP group.

100 Serotonin and 5-hydroxy-L-tryptophan (5-HTP) induce a head-twitch response in wild-type (WT) m

101 50, 200, or 500 muM 5-Hydroxy-L-tryptophan (5-HTP; 5-HT precursor) for 8-, 12- or 24-h.

102 out the usual adverse events associated with 5-HTP IR.

103 the effects of feeding chow, with or without 5-HTP SR, to mice with the TPH2-R439H mutation and witho