ライフサイエンスコーパス: 50% inhibitory concentration

1 und DTG concentrations exceeded the in vitro 50% inhibitory concentration (0.21 ng/mL) by a median of

2 E2-stimulated HPV DNA replication in vitro (50% inhibitory concentration = 0.56 nM).

3 emely potent against a wide spectrum of HIV (50% inhibitory concentration, 0.0003 to 0.0005 microM).

4 ving received a variety of antiviral agents (50% inhibitory concentration, 0.0005 to 0.0055 microM).

5 lity to the drug in the NA inhibition assay (50% inhibitory concentration, 0.35-0.5 nM).

6 bits P. gingivalis adherence to S. gordonii (50% inhibitory concentration = 1.3 microM) and prevents

7 V-1 infection in 293T, CEM-SS, and H9 cells (50% inhibitory concentration = 2 to 13 micro M) and exhi

8 NiV at a concentration of 1 microM in vitro (50% inhibitory concentration, 2 microM), which is less t

9 logous viruses but were much less efficient (50% inhibitory concentration, 20- to 40-fold) at neutral

10 L-arginine, the end product of the pathway (50% inhibitory concentration, 26 microM).

11 mannin with similar dose-response curves and 50% inhibitory concentrations (3.5 microM).

12 dently (1-30 micromol/L) inhibited by PPADS (50%-inhibitory concentration, 3 micromol/L).

13 s sensitive to inhibition by coumermycin A1 (50% inhibitory concentration, 32 microM) but insensitive

14 GPCMV proved to be sensitive to BDCRB (50% inhibitory concentration = 4.7 microM), although som

15 ce and was sensitive to exogenous thymidine (50% inhibitory concentration = 5.5 microM).

16 fluid that greatly exceeded the in vitro IC(50) (inhibitory concentration 50%).

17 e binding affinity for alphavbeta3-integrin (50% inhibitory concentration, 67.5 +/- 7.8 nmol/L [mean

18 One MAb, IM-CKV063, was highly neutralizing (50% inhibitory concentration, 7.4 ng/ml), demonstrated h

19 93, a novel high-affinity radioligand (human 50% inhibitory concentration = 9.6 nM) for the PAM site

20 tant that exhibited a marked increase in the 50% inhibitory concentrations against all tested NAIs (8

21 de was a significant fusion inhibitor with a 50% inhibitory concentration and a 50% effective concent

22 irapine was 971 ng/mL, at least 40 times the 50% inhibitory concentration and similar to peak concent

23 heterogeneous, both in degree (gradation of 50% inhibitory concentrations) and in distribution acros

24 N-terminal six-histidine tag, are inhibited (50% inhibitory concentration approximately 35 microM) by

25 These inhibitors (1) inhibit EBOV infection (50% inhibitory concentration, approximately 0.28 and app

26 scrapie agent-infected neuroblastoma cells (50% inhibitory concentration, approximately 10 nM) and p

27 ls became sensitive to lacosamide with IC50 (50% inhibitory concentration) around 70-80 microM.

28 neutralized sCD4-pretreated HIV-2 in titers (50% inhibitory concentration) as high as 1:143,000.

29 and cross-reactive inhibitory activity with 50% inhibitory concentrations below 0.04 and 0.6 microg/

30 further increased oseltamivir and peramivir 50% inhibitory concentrations by 790- and >5000-fold, re

31 o 300 mg) were five to 10 times the cellular 50% inhibitory concentration for PKC412 of 0.2 to 0.7 mi

32 sma concentrations and exceeded the in vitro 50% inhibitory concentration for wild-type HIV (0.2 ng/m

33 stable EVG concentrations that exceeded the 50% inhibitory concentration for wild-type HIV, suggesti

34 ta include protease amino acid sequences and 50% inhibitory concentrations for SQV and IDV at baselin

35 ed by a drug sensitivity assay, in which the 50% inhibitory concentrations for thymine 1-beta-d-arabi

36 t inhibit BVDV polymerase activity in vitro (50% inhibitory concentration > 300 microM), we developed

37 ompletely insensitive to PD 184352 in vitro (50% inhibitory concentration >10 micro M).

38 42M, not only had the highest BG resistance (50% inhibitory concentration, >500 microM) but also offe

39 in the B and C cohorts; however, the median 50% inhibitory concentration (IC(50) titer) reached by a

40 ls by ranolazine were generally weak, with a 50% inhibitory concentration (IC(50)) >/= 60 microM.

41 Seven of 9 isolates with a 50% inhibitory concentration (IC(50)) >600 microM by DHA

42 f each compound was obtained by dividing its 50% inhibitory concentration (IC(50)) against Pc, Tg, or

43 A-related serine/threonine phosphatase, at a 50% inhibitory concentration (IC(50)) comparable to that

44 y enhanced neutralization efficiency, with a 50% inhibitory concentration (IC(50)) decrease over a 2-

45 e analyzed for sensitivity to T-20, the mean 50% inhibitory concentration (IC(50)) for isolates that

46 The observed 50% inhibitory concentration (IC(50)) for the HRPII neut

47 3/TZM-bl virus entry assay median reciprocal 50% inhibitory concentration (IC(50)) NAb titers of 1.7

48 that could identify top-ranking samples with 50% inhibitory concentration (IC(50)) neutralization tit

49 gonucleotide, ISIS 2922, demonstrated a mean 50% inhibitory concentration (IC(50)) of 0.04 and 0.24 m

50 VRC34.01 neutralized SHIV(BG505) with a 50% inhibitory concentration (IC(50)) of 0.58 mug/ml, wh

51 ntified a modified structure, ST-193, with a 50% inhibitory concentration (IC(50)) of 1.6 nM against

52 papillomavirus pseudovirions tested, with a 50% inhibitory concentration (IC(50)) of 130 to 1,000 pM

53 he antiproliferative effects of AN-9, with a 50% inhibitory concentration (IC(50)) of 45.8 +/- 4.1 mi

54 In addition, the 50% inhibitory concentration (IC(50)) of lopinavir again

55 gnitudes of responses, defined as reciprocal 50% inhibitory concentration (IC(50)) titers for positiv

56 Although in vitro 50% inhibitory concentration (IC(50)) values for specifi

57 V2 regions isolated during VF displayed high 50% inhibitory concentration (IC(50)) values relative to

58 Mean 50% inhibitory concentration (IC(50)) values were lower

59 ing to human MDA-MB-435 breast cancer cells, 50% inhibitory concentration (IC(50)), and serum stabili

60 anti-Env MAbs exhibited significantly higher 50% inhibitory concentration (IC(50)s) against VS-mediat

61 rzolamide in a dose-dependent manner with an 50% inhibitory concentration (IC)(50) of 2.4 micro M (95

62 -catalytic residue play a role in increasing 50% inhibitory concentrations (IC(50) concentrations) fo

63 The 50% inhibitory concentrations (IC(50)) for the inactivat

64 l as to the broad-based inhibitor TL-3, with 50% inhibitory concentrations (IC(50)) of 30 to 40 nM, c

65 In vitro, the 50% inhibitory concentrations (IC(50)) of ddC and cidofo

66 The median 50% inhibitory concentrations (IC(50)) of lopinavir agai

67 ES inhibition of 13 primary NSI R5 isolates; 50% inhibitory concentrations (IC(50)) ranged from 0.04

68 The median 50% inhibitory concentrations (IC(50)s) for these MAbs w

69 burg virus (MARV) in cell-based assays, with 50% inhibitory concentrations (IC(50)s) of 10 muM and 12

70 ated UFH, and 6-O-desulfated enoxaparin with 50% inhibitory concentrations (IC(50)s) of 5.99 ug/liter

71 trations and displayed significant shifts in 50% inhibitory concentrations (IC(50)s), characteristic

72 ced permeability at 1, 10, and 100 nanomolar 50% inhibitory concentrations (IC(50)s), respectively.

73 of resistance, we measured the half maximal (50%) inhibitory concentration (IC(50)) of DAC and found

74 e classified into lower-level (3- to 25-fold 50% inhibitory concentration [IC(50) ] increase: V36A/M,

75 ing antibodies reaching breadths of 40%-60% (50% inhibitory concentration [IC(50)] < 50 mug/mL) and t

76 IL-8 secretion was more sensitive to U0126 (50% inhibitory concentration [IC(50)] = 0.5 microM) than

77 fected 293T cells was inhibited by both GCV (50% inhibitory concentration [IC(50)] = 1.5 microM) and

78 NCB018424 inhibited interleukin-6 signaling (50% inhibitory concentration [IC(50)] = 281nM), and prol

79 gnificantly higher ANAb responses at 1 year (50% inhibitory concentration [IC(50)] geometric mean tit

80 erred resistance to oseltamivir carboxylate (50% inhibitory concentration [IC(50)] increases, >250-fo

81 istance to oseltamivir (>10-fold increase in 50% inhibitory concentration [IC(50)]) and reduction in

82 The LF-sVNT neutralizing antibody titers (50% inhibitory concentration [IC(50)]) were determined f

83 and the degree of inhibition of RT in vitro (50% inhibitory concentration [IC(50)]).

84 ent among the 10 clinical isolates examined (50% inhibitory concentration [IC(50)], <1 microM).

85 ly or moderately susceptible to oseltamivir (50% inhibitory concentration [IC(50)], <5.1 to 50 nM).

86 oad and potent (91% coverage; geometric mean 50% inhibitory concentration [IC(50)], 0.09 mug/ml).

87 sence of Spm8CHAS were completely protected (50% inhibitory concentration [IC(50)], 13.6 microg/ml),

88 hibited S. pyogenes NadD (sp.NadD) in vitro (50% inhibitory concentration [IC(50)], 15 muM), exhibiti

89 Ab titers (50% inhibitory plasma dilution or 50% inhibitory concentration [IC(50)], 1:7,000 to 1:1,00

90 on: E. coli K1/r was relatively susceptible (50% inhibitory concentration [IC(50)], approximately 10

91 was preferentially inhibited by calyculin A (50% inhibitory concentration [IC(50)], approximately 2 n

92 of hepatitis A virus (HAV) in cell culture (50% inhibitory concentrations [IC(50)s] of 32.13 uM and

93 fferent genotypes, and showed differences in 50% inhibitory concentration (IC50 ) correlating with cl

94 in SP with TDF, but 9.6-fold higher than the 50% inhibitory concentration (IC50) (11.5 ng/mL).

95 the viral entry process with a submicromolar 50% inhibitory concentration (IC50) (IC50 = 0.61 +/- 0.2

96 stimulated by chemoattractants such as FMLP (50% inhibitory concentration (IC50) approximately 11 nM

97 At a 50% inhibitory concentration (IC50) cutoff of 1 mug/ml p

98 The 50% inhibitory concentration (IC50) for CMV of ODG-PFA w

99 o a membrane diacylglyceroglycolipid), had a 50% inhibitory concentration (IC50) for inhibition of SR

100 n D results in only a modest increase in the 50% inhibitory concentration (IC50) for the drug.

101 The serum 50% inhibitory concentration (IC50) for this strain is 1

102 HIV-1 pseudotyped viruses tested with a mean 50% inhibitory concentration (IC50) of 0.002 mug/mL.

103 s, neutralizing 97% of viruses with a median 50% inhibitory concentration (IC50) of 0.055 mug/ml.

104 16V KIT-transformed Ba/F3 cell growth with a 50% inhibitory concentration (IC50) of 30 nM to 40 nM.

105 clohexanecarboxylic acid (compound A) with a 50% inhibitory concentration (IC50) of approximately 10

106 When added before virus adsorption, the 50% inhibitory concentration (IC50) of carrageenan was 5

107 ither was passaged, titrated, or assayed for 50% inhibitory concentration (IC50) of cidofovir.

108 had significantly greater fold increases in 50% inhibitory concentration (IC50) of EFV than viruses

109 ion (EC50) ranging from 1.7 to 20 microM and 50% inhibitory concentration (IC50) ranging from 40 to 6

110 The 50% inhibitory concentration (IC50) values of imatinib m

111 nce of kelch13 mutations, higher piperaquine 50% inhibitory concentration (IC50) values, and lower me

112 ribavirin increased the error rate, and the 50% inhibitory concentration (IC50) was 27 muM.

113 (75%) peptides with high binding affinities (50% inhibitory concentration (IC50), 2-50 nM) and 7 of 1

114 imination constant, time to protein-adjusted 50% inhibitory concentration (IC50), and week 5 nevirapi

115 ical isolates of H. pylori with a millimolar 50% inhibitory concentration (IC50).

116 55-63%), T-cell surface expression of CD25 (50% inhibitory concentration (IC50); 0.18 microM) and CD

117 e compounds tested, 11 derivatives exhibited 50% inhibitory concentrations (IC50) of less than 3 micr

118 a majority of circulating strains in vitro (50% inhibitory concentration [IC50] > 5 mug/ml).

119 tion by SIV-infected macaque plasma samples (50% inhibitory concentration [IC50] < 10(-5)) and monocl

120 lovir (9-[(2-hydroxyethoxy)-methyl]guanine) (50% inhibitory concentration [IC50] = 60-80 microM), but

121 The two compounds (i) are potent (50% inhibitory concentration [IC50] of 0.3 to 5.9 muM);

122 s bound to GRPR with high affinity (range of 50% inhibitory concentration [IC50] values, 0.3 nM [SARN

123 hydrazyl (DPPH) radical quenching potential (50% inhibitory concentration, IC50 approximately 0.59mg/

124 The 50% inhibitory concentrations (IC50s) for S-1X, S-2X, S-

125 trix metalloproteinases MMP-2 and MMP-9 with 50% inhibitory concentrations (IC50s) of 0.57 and 0.25 m

126 The 50% inhibitory concentrations (IC50s) were determined.

127 variations (CNVs) with in-vitro piperaquine 50% inhibitory concentrations (IC50s), and tested whethe

128 association (P < .05) with either cytarabine 50% inhibitory concentration in leukemia cells or clinic

129 uscular vaccinations with ADS-MVA alone, the 50% inhibitory concentration in serum was achieved with

130 ral infectivity in tissue culture cells with 50% inhibitory concentrations in the micromolar range.

131 ound to the majority of subtypes tested with 50% inhibitory concentrations less than 500 nM.

132 mmunodeficiency virus (HIV) infection have a 50% inhibitory concentration </=0.4-fold that of HIV typ

133 ed by [N-ethyl-N-isopropyl]-2'-4'-amiloride (50% inhibitory concentration of < 1 microM).

134 e channels are inhibited by amiloride with a 50% inhibitory concentration of < 1 microM, and some are

135 ogen Box and validated 14 hits (defined as a 50% inhibitory concentration of <1 muM).

136 at was inhibited by soluble protein A with a 50% inhibitory concentration of (3.3 +/- 0.7) x 10(-7) M

137 ensitive to neutralization by MAb M2, with a 50% inhibitory concentration of 1 mug/ml.

138 on exchange mediated by mouse pendrin with a 50% inhibitory concentration of 1-3 microM, without affe

139 by a maximum of 75.7 +/- 3% (n = 13) with a 50% inhibitory concentration of 1.3 microM.

140 In 293T cells, an 50% inhibitory concentration of 10 U of IFN-alpha2a/ml w

141 mAb WNV-86 neutralized WNV with a 50% inhibitory concentration of 2 ng ml(-1), one of the

142 rototypic R5 clade B primary isolate, with a 50% inhibitory concentration of 3.2 nM (0.16 microg/ml)

143 ed oocyst development in the mosquito with a 50% inhibitory concentration of 30 nM (range: 23-39).

144 eaction is inhibited by fosmidomycin, with a 50% inhibitory concentration of 310 nM.

145 onist 1alpha,25 dihydroxyvitamin D(3) with a 50% inhibitory concentration of 5 x 10 -8 mol/L, whereas

146 ed recombinant T. elongatus BP-1 SQS, with a 50% inhibitory concentration of 95.5 +/- 13.6 nM.

147 onoclonal antibodies, 447-52D and F425 B4e8 (50% inhibitory concentration of [IC(50)] <0.005 microg/m

148 ], 2.9 x 10(-9) M) and neutralized it with a 50% inhibitory concentration of approximately 0.25 micro

149 l diarrhea virus (BVDV) in cell culture at a 50% inhibitory concentration of approximately 20 nM.

150 UL8 interaction: the most potent exhibited a 50% inhibitory concentration of approximately 5 microM.

151 The 50% inhibitory concentration of autologous serum was sim

152 The 50% inhibitory concentration of AZT was determined to be

153 The 50% inhibitory concentration of compound 6 for MAO-B was

154 hepatocyte-derived cell lines, in which the 50% inhibitory concentration of geldanamycin was 8.7-11.

155 and ATP binding cassette A1 (ABCA1), with a 50% inhibitory concentration of less than 0.2 ng/ml, as

156 rategy, inhibiting virion infectivity with a 50% inhibitory concentration of only 4% of the mutant re

157 ductions in HCV RNA and protein levels, with 50% inhibitory concentrations of 0.1 to 0.2 microM.

158 reverse transcriptase (RT) activity, having 50% inhibitory concentrations of 0.46, 0.75, and 0.94 mi

159 tection) in our mouse models of HypoPP, with 50% inhibitory concentrations of 0.8 +/- 0.13 muM and 2.

160 against orthopoxviruses, inhibiting VV with 50% inhibitory concentrations of 3 to 12 microM.

161 The order-of-magnitude lower 50% inhibitory concentrations of 4-GU-DANA (and also DAN

162 bited the proliferation of tumor cells, with 50% inhibitory concentrations of 6.09, 1.12, 0.65, 0.49,

163 larizing potentials on hNav1.5 channels with 50% inhibitory concentrations of 9.67 +/- 0.25 microM an

164 22L mouse scrapie agent-infected cells, with 50% inhibitory concentrations of approximately 0.5 and a

165 Overall, the mean 50% inhibitory concentrations of enfuvirtide and T-649 f

166 We find that, with iron, the 50% inhibitory concentrations of nickel (IC(50) [Ni(II)]

167 NT/A Lc of 1.47 x 10(-)(10) M and an IC(50) (50% inhibitory concentration) of 4.7 x 10(-)(10) M and w

168 The mean promastigote MIL susceptibility (50% inhibitory concentration) of isolates from definite

169 (131)I-RPS-027, with a 50% inhibitory concentration (PSMA) of 15 nM and a disso

170 The 50% inhibitory concentration range for 1263W94 was 0.15

171 se CCR5 as their entry coreceptor, with mean 50% inhibitory concentrations ranging between 0.4 and 9

172 imatinib at steady-state, which exceeds the 50% inhibitory concentration required to inhibit prolife

173 The 50% inhibitory concentration required was 5.67, 3.49, 3.

174 (IFN-alpha), albeit with an eightfold-higher 50% inhibitory concentration than type 1b replicons.

175 two of the isolates with significantly lower 50% inhibitory concentrations than did IgG1 b12.

176 The neutralizing 50% inhibitory concentration titers for pseudovirus and

177 Increases in 50% inhibitory concentrations to PSC-RANTES with env(m58

178 CI 2.4-12]; p<0.0001) and higher piperaquine 50% inhibitory concentration (triple mutant 34 nM [28-41

179 irus concentrations and serum addition, with 50% inhibitory concentrations typically ranging from 1 t

180 5)I-[Tyr(4)]BBN against PC-3 cells yielded a 50% inhibitory concentration value of 2.2 +/- 0.5 nmol/L

181 The 50% inhibitory concentration values for (19)F-, (69)Ga-,

182 The 50% inhibitory concentration values for NOTA-Z(HER2)(:23

183 ri pseudotypes, with four- to sixfold-higher 50% inhibitory concentration values for the three anti-C

184 Kinetic enzyme inhibition analysis produced 50% inhibitory concentration values for these inhibitors

185 ssue:blood penetration ratios were above the 50% inhibitory concentration values in almost 100% of ca

186 city, four promising candidates emerged with 50% inhibitory concentration values in the 3 to 26 muM r

187 hibit R5 HIV-1 infection of macrophages with 50% inhibitory concentration values of 0.11 to 1.2 nM.

188 reatly (>24-fold to >130-fold differences in 50% inhibitory concentration values).

189 negatively correlated (r = -0.52; P =018) to 50% inhibitory concentration values.

190 t ATPase activities of the enzyme with IC50 (50% inhibitory concentration) values less than 100 nM.

191 Among the viruses neutralized, the median 50% inhibitory concentration was 0.001 mug/ml.

192 isolates with remarkable potency: the median 50% inhibitory concentration was 0.001 mug/ml.

193 sed its cell fusion inhibitory activity: the 50% inhibitory concentration was decreased more than 10-

194 Their 50% inhibitory concentrations were 1.09 +/- 0.25 micro M