ライフサイエンスコーパス: 7-dehydrocholesterol

1 fluids as a result of P450 7A1 oxidation of 7-dehydrocholesterol.

2 rs of ecdysone biosynthesis, cholesterol and 7-dehydrocholesterol.

3 d in skin through ultraviolet irradiation of 7-dehydrocholesterol.

4 (2020) reveal that type I IFN signaling and 7-dehydrocholesterol (7-DHC) accumulation form a positiv

5 ciency or treatment with the natural product 7-dehydrocholesterol (7-DHC) could specifically promote

6 7-Dehydrocholesterol (7-DHC) is the most oxidizable lipi

7 Children with SLOS have elevated serum 7-dehydrocholesterol (7-DHC) levels and typically have l

8 ) is biochemically characterized by elevated 7-dehydrocholesterol (7-DHC) levels in neonates, raising

9 ized by diminished cholesterol and increased 7-dehydrocholesterol (7-DHC) levels.

10 nts have decreased cholesterol and increased 7-dehydrocholesterol (7-DHC) levels.

11 The vitamin D precursor 7-dehydrocholesterol (7-DHC) may inhibit iron-dependent

12 ased activation of SREBP2 and a reduction in 7-dehydrocholesterol (7-DHC) reductase (DHCR7) expressio

13 recently identified 7-dehydrocholesterol (7-DHC), a sterol produced through

14 A mammalian analog of ergosterol, 7-dehydrocholesterol (7-DHC), accumulates in Smith-Lemli

15 n with standard, the identity of this ion is 7-dehydrocholesterol (7-DHC), an immediate dehydrogenate

16 radical chain oxidation of highly oxidizable 7-dehydrocholesterol (7-DHC), initiated by 2,2'-azobis(4

17 The mechanism of free radical oxygenation of 7-dehydrocholesterol (7-DHC), one of the biologically im

18 g ferroptosis through dictating the level of 7-dehydrocholesterol (7-DHC)-an intermediate metabolite

19 ich is characterized by a toxic elevation in 7-dehydrocholesterol (7-DHC).

20 olesterol and accumulation of its precursor, 7-dehydrocholesterol (7-DHC).

21 ected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC).

22 tion of the immediate cholesterol precursor, 7-dehydrocholesterol (7-DHC).

23 ulation of neurotoxic cholesterol precursor, 7-dehydrocholesterol (7-DHC).

24 d adrenals produced robust transformation of 7-dehydrocholesterol (7-DHC; precursor to cholesterol an

25 d an accumulation of its metabolic precursor 7-dehydrocholesterol (7DHC) in developing tissues.

26 hether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP1

27 in the Kandutsch-Russell pathway, converting 7-dehydrocholesterol (7DHC) to cholesterol.

28 ions in DHCR7, which impair the reduction of 7-dehydrocholesterol (7DHC) to cholesterol.

29 The vitamin D precursor, 7-dehydrocholesterol (7DHC), was significantly lower in

30 urprisingly ergosterol, a fungal sterol, and 7-dehydrocholesterol, a sterol present in elevated level

31 cholesterol synthesis, increasing levels of 7-dehydrocholesterol-a potent endogenous ferroptosis inh

32 synthesis pathway to generate intermediates-7-dehydrocholesterol and 7-dehydrodesmosterol-with prote

33 duced 94 mug/g vitamin D(3) from crystalline 7-dehydrocholesterol and 74 mug/g vitamin D(2) from crys

34 roduction.(12-16) Two other pathways produce 7-dehydrocholesterol and bile acid intermediates, neithe

35 let B (UVB) light exposure of its precursors 7-dehydrocholesterol and ergosterol.

36 e potently reversed by crude lipid extracts, 7-dehydrocholesterol, and a recently identified DAF-12 s

37 In addition, we describe the metabolism of 7-dehydrocholesterol by CYP11A1 to a single product iden

38 After feeding BM 15.766, hepatic 7-dehydrocholesterol delta 7-reductase activity decrease

39 piperazin-4-yl]ethyl]-benzoic acid) inhibits 7-dehydrocholesterol delta 7-reductase activity, reduces

40 ed birth disorder caused by markedly reduced 7-dehydrocholesterol delta 7-reductase activity, the fin

41 reductase, lathosterol 5-dehydrogenase, and 7-dehydrocholesterol delta 7-reductase are down-regulate

42 tic pathway, lathosterol 5-dehydrogenase and 7-dehydrocholesterol delta 7-reductase, were measured.

43 pathway catalyzed by the microsomal enzyme, 7-dehydrocholesterol-delta 7-reductase.

44 , lovastatin, and BM 15.766, an inhibitor of 7-dehydrocholesterol delta7-reductase, and were compared

45 unable to produce cholesterol and accumulate 7-dehydrocholesterol (DHC) in serum and tissue.

46 consists of direct hydroxylation at C-25 of 7-dehydrocholesterol hetero Diels-Alder adducts.

47 e catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholest

48 old increase of the 27-hydroxy metabolite of 7-dehydrocholesterol in the plasma of children with Smit

49 The content of the vitamin D(3) precursor 7-dehydrocholesterol in the skin of obese and nonobese s

50 Solar ultraviolet B photons are absorbed by 7-dehydrocholesterol in the skin, leading to its transfo

51 in the pathway, lead to the accumulation of 7-dehydrocholesterol in tissues and fluids of SLOS patie

52 ncentrations reduced 25%, and the precursor, 7-dehydrocholesterol, increased to represent 71% of the

53 The finding that 7-dehydrocholesterol is a precursor of 7-ketocholesterol

54 7-Dehydrocholesterol is highly reactive, giving rise to

55 holesterol (k(p)= 11 +/- 2 M(-1) s(-1)), and 7-dehydrocholesterol (k(p)= 2260 +/- 40 M(-1) s(-1)).

56 d or lovastatin could reduce elevated plasma 7-dehydrocholesterol levels induced by BM 15.766.

57 ces plasma cholesterol levels, and increases 7-dehydrocholesterol levels to reproduce the biochemical

58 ls and a marked increase of serum and tissue 7-dehydrocholesterol levels.

59 The oxidation of 7-dehydrocholesterol occured with predominant formation

60 he consequences of the extreme reactivity of 7-dehydrocholesterol on human health is the focus of a c

61 The mechanism of 7-dehydrocholesterol oxidation to 7-ketocholesterol is p

62 Mutations in the gene for Delta(7)-dehydrocholesterol reductase (Delta(7)-reductase), wh

63 shed by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an

64 rol reductase (C14SR, also known as TM7SF2), 7-dehydrocholesterol reductase (DHCR7) and 24-dehydrocho

65 Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected

66 utations in both copies in the gene encoding 7-dehydrocholesterol reductase (DHCR7) cause Smith-Lemli

67 and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression.

68 7-Dehydrocholesterol reductase (DHCR7) is the terminal e

69 sterol reductases in cholesterol production, 7-dehydrocholesterol reductase (DHCR7), 14-dehydrocholes

70 pitz syndrome (SLOS) is caused by defects in 7-dehydrocholesterol reductase (DHCR7), an enzyme cataly

71 encoding the cholesterol biosynthetic enzyme 7-dehydrocholesterol reductase (DHCR7).

72 fferent autosomal recessive mutations of the 7-dehydrocholesterol reductase gene leading to deficient

73 Since a defect of 7-dehydrocholesterol reductase is associated with Smith-

74 1790349, located in DHCR7, the gene encoding 7-dehydrocholesterol reductase that synthesizes choleste

75 Mutations within the gene encoding 7-dehydrocholesterol reductase, the last enzyme in the p

76 esterol biosynthesis due to dysregulation of 7-dehydrocholesterol reductase.

77 crophage cells with a raft-promoting sterol (7-dehydrocholesterol) rescued this phagocytic deficiency

78 Repletion with 7-dehydrocholesterol restored phosphorylation, whereas r

79 sterol levels dropped 75% and the precursor, 7-dehydrocholesterol rose substantially.

80 reductase that synthesizes cholesterol from 7-dehydrocholesterol; rs6599638 in the region harboring

81 d with various sterols, only desmosterol and 7-dehydrocholesterol supported internalization.

82 76% and was associated with a marked rise of 7-dehydrocholesterol that could be almost entirely preve

83 esterol have been established, we found that 7-dehydrocholesterol (the immediate precursor of cholest

84 free radical propagation rate constants, and 7-dehydrocholesterol, the immediate biosynthetic precurs

85 nd relative plasma cholesterol, but not with 7-dehydrocholesterol, the immediate precursor, confirmin

86 aenoate (20:5), docosahexaenoate (22:6), and 7-dehydrocholesterol to be 115 +/- 7, 145 +/- 8, 172 +/-

87 y rat liver microsomes, of the conversion of 7-dehydrocholesterol to cholesta-5,8-dien-3 beta-ol is a

88 an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of

89 The conversion of 7-dehydrocholesterol to cholesterol is the last reaction

90 tase gene leading to deficient conversion of 7-dehydrocholesterol to cholesterol, the RSH (so-called

91 ations of DHCR7 that impair the reduction of 7-dehydrocholesterol to cholesterol.

92 UVB, 280-310 nm) results in isomerization of 7-dehydrocholesterol to previtamin D that spontaneously

93 that is initiated by the photoconversion of 7-dehydrocholesterol to previtamin D(3) An action spectr

94 olet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in chi

95 7A1 converted lathosterol (Delta(5)-dihydro-7-dehydrocholesterol) to a mixture of the 7-keto and 7al

96 In some experiments, cholesterol or 7-dehydrocholesterol was incorporated into the lipid mix

97 Ampoules containing 7-dehydrocholesterol were exposed to a LED that emitted

98 containing 7-8 double bonds (lathosterol and 7-dehydrocholesterol) were better raft stabilizers than

99 s of cholesterol/desmosterol and cholesterol/7-dehydrocholesterol (which represent 24- and 7-reductas