ライフサイエンスコーパス: A-kinase

1 A kinase activity assay was used for proof of concept, a

2 A kinase activity was identified in mouse liver that pho

3 A kinase anchoring proteins (AKAPs) assemble and compart

4 A kinase and phosphatase screen for activators of transl

5 A kinase dead LIMK (LIM kinase) and a mutant Cofilin als

6 A kinase defective protein kinase D and a phospholipase

7 A kinase in HeLa nuclear extract that caused the shift w

8 A kinase insert domain-containing receptor (KDR) homolog

9 A kinase screen identified G-protein-coupled receptor ki

10 A kinase screen was undertaken to identify downstream ta

11 A kinase-anchoring proteins (AKAPs) organize compartment

12 A kinase-anchoring proteins (AKAPs) target PKA to specif

13 A kinase-dead mutant is not, consistent with autophospho

14 A kinase-dead mutation of Snf1 lowered iron resistance a

15 A kinase-dead tel1 mutation similarly increases Spo11-ol

16 A kinase-dead, dominant-negative mutant of TbetaRII bloc

17 A kinase-deficient mutant of PKCalpha stimulated PLD2 ac

18 A kinase-focused screening set of fragments has been ass

19 A kinase-inactivating point mutation, or a missense muta

20 A kinase-inactive cdk9 (D167N) expressed during the infe

21 A kinase/phosphatase imbalance could not account for ext

22 A-kinase anchor protein 350 kDa (AKAP350A, also called A

23 A-kinase anchoring protein (AKAP) 79/150 is a scaffold p

24 A-kinase anchoring protein 150 (AKAP150) is a scaffoldin

25 A-kinase anchoring protein 220 (AKAP220) is a multivalen

26 A-kinase anchoring protein 79 (AKAP79) is a human anchor

27 A-kinase anchoring proteins (AKAPs) are a family of scaf

28 A-kinase anchoring proteins (AKAPs) are scaffolding mole

29 A-kinase anchoring proteins (AKAPs) are well known for t

30 A-kinase anchoring proteins (AKAPs) bind and target PKA

31 A-kinase anchoring proteins (AKAPs) contain an amphipath

32 A-kinase anchoring proteins (AKAPs) coordinate cell sign

33 A-kinase anchoring proteins (AKAPs) function to target p

34 A-kinase anchoring proteins (AKAPs) have emerged as a co

35 A-kinase anchoring proteins (AKAPs) have emerged as impo

36 A-kinase anchoring proteins (AKAPs) influence the spatia

37 A-kinase anchoring proteins (AKAPs) localize PKA to AMPA

38 A-kinase anchoring proteins (AKAPs) mediate the intracel

39 A-kinase anchoring proteins (AKAPs) recruit signaling mo

40 A-kinase anchoring proteins (AKAPs) represent a family o

41 A-kinase anchoring proteins (AKAPs) restrict the range o

42 A-kinase anchoring proteins (AKAPs) sequester combinatio

43 A-kinase anchoring proteins (AKAPs) spatially constrain

44 A-kinase anchoring proteins (AKAPs) tether the cAMP-depe

45 A-kinase anchoring proteins form the core of multiprotei

46 A-kinase anchoring proteins tether PKA to specific intra

47 A-kinase-anchoring protein (AKAP) 79/150 organizes a sca

48 A-kinase-anchoring proteins (AKAP) help regulate the int

49 A-kinase-anchoring proteins (AKAPs) are a canonical fami

50 A-kinase-anchoring proteins (AKAPs) target PKA to glutam

51 A-kinase-anchoring proteins, of which there are 43 diffe

52 These include the presence in BIG2 of 3 A kinase-anchoring protein (AKAP) domains, one of which

53 lex comprising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein 150 (AKAP150), and protein ki

54 ll as a scaffolded complex containing AC5/6, A-kinase anchoring protein 150 (AKAP150), and PKA.

55 Here, we show that the PKA adaptor A-kinase interacting protein 1 (AKIP1) is up-regulated i

56 activity, but instead led to enhanced AKAP (A-kinase anchoring protein) binding with preferential lo

57 characterization of a novel sarcomeric AKAP (A-kinase anchoring protein), cardiac troponin T (cTnT).

58 roinjecting a cell-permeable synthetic AKAP (A-kinase anchor protein) peptide into the NAc to disrupt

59 ific variant of the scaffold protein AKAP12 (A-kinase anchor protein 12), AKAP12v2, in metastatic mel

60 sion by increased ubiquitination of AKAP121 (A-kinase anchor protein 121) leading to reduced phosphor

61 elial cells, and regulatory protein AKAP150 (A-kinase anchoring protein 150) enhances the activity of

62 The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmentalized p

63 require type II PKA interaction with AKAPs (A-kinase anchoring proteins).

64 on of phosphorylation by PKA anchored via an A kinase-anchoring protein (AKAP15).

65 sphate], protein kinase A inhibitors, and an A-kinase anchoring protein inhibitor significantly block

66 he pore forming alpha subunit of BKCa and an A-kinase-anchoring protein (AKAP79/150) for beta2 agonis

67 rotein originally identified in testis as an A-kinase anchor protein (AKAP)- binding protein.

68 3, has been identified by RII overlays as an A-kinase anchoring protein (AKAP) that localizes the cAM

69 aled that radial spoke protein (RSP) 3 is an A-kinase anchoring protein (AKAP).

70 ex with PI3K heterodimer and IRS-1, it is an A-kinase anchoring protein that binds the type I regulat

71 Yotiao is an A-kinase-anchoring protein (AKAP) that recruits the cycl

72 independent of its regulatory subunit or an A-kinase anchoring protein, providing an additional mech

73 pendent protein kinase (PKA) anchored via an A-kinase anchoring protein (AKAP15), and the most rapid

74 rminal domain of the alpha(1) subunit via an A-kinase anchoring protein (AKAP15).

75 pendent protein kinase (PKA) anchored via an A-kinase anchoring protein (AKAP15).

76 tagonizing the interaction between TRPV1 and A kinase anchoring protein 79 (AKAP79), a scaffolding pr

77 rmethylation: RAB32, a ras family member and A-kinase-anchoring protein, was methylated in 14 of 25 (

78 (cAMP)-dependent protein kinase A (PKA) and A-kinase anchoring proteins (AKAPs).

79 zonula occludens-1 (PDZ)-domain proteins and A-kinase anchoring proteins (AKAPs) increased receptor d

80 PDE1 coimmunoprecipitated with B-Raf and A-kinase anchoring protein 79, and AVP increased this in

81 and the role of auxiliary proteins (such as A kinase anchoring proteins) involved in PKA regulation.

82 By this means, signaling scaffolds, such as A-kinase anchoring proteins (AKAPs), compartmentalize ki

83 a family of scaffold proteins referred to as A-kinase anchoring proteins.

84 en that Ser-16 is an excellent Aurora A (Aur-A) kinase consensus phosphorylation site and the Aurora

85 Aurora A kinase (AAK) is overexpressed in aggressive lymphomas

86 Aurora A kinase (AAK) is upregulated in highly proliferative ly

87 Aurora A kinase (AURKA) is overexpressed in 96% of human cancer

88 Aurora A kinase localizes to centrosomes and is required for ce

89 Aurora A kinase plays an essential role in the proper assembly

90 showed reduced activation of Plk1 and Aurora A kinase at spindle poles and an impaired localization o

91 inositol trisphosphate 3-kinase, and Aurora A kinase potently enhance iPSC generation, and iPSCs der

92 of neuroendocrine prostate cancer as Aurora A kinase inhibitors promoting N-Myc destabilization prog

93 e efficacy of novel therapies such as Aurora A kinase inhibitors.

94 egulatory proteins securin, cyclin B, aurora A kinase, and polo-like kinase 1, the anaphase promoting

95 18)O label into bacterially expressed Aurora A kinase phosphorylation sites and resulted in the repre

96 g, with additional contributions from Aurora A kinase.

97 2 and an upstream activator of HDAC6, aurora A kinase.

98 rt here the design of the first human Aurora A kinase (as-AurA) engineered by chemical genetics techn

99 nd TPX2-mediated activation) in human Aurora A kinase.

100 ates the mitotic programme, including Aurora A kinase (Aurka), in stratified epithelia, and endogenou

101 other centrosome components including Aurora A kinase and CP60.

102 Increased aurora A kinase (AAK) expression occurs in acute myeloid leukae

103 Inhibiting Aurora A kinase activity attenuated BMI1-induced tumor growth i

104 N-targeted small-molecule inhibitors, Aurora A kinase inhibitor alisertib (MLN8237) and mTOR inhibito

105 One of these mitotic controllers is Aurora A kinase, which is itself highly regulated.

106 MLN8054 is a selective small-molecule Aurora A kinase inhibitor that has entered Phase I clinical tri

107 Inhibition of Cdk1 activity, but not Aurora A kinase activity, prevents the translation of Mos or Cc

108 established a conditional deletion of Aurora A kinase (AurA) in Cdk1 analogue-sensitive DT40 cells to

109 simple nanomolar-level inhibition of Aurora A kinase activity.

110 xpression of p53, reduced activity of aurora A kinase and a subsequent delay in the activation of pol

111 ntry predominantly occurs upstream of Aurora A kinase and Polo-like kinase 1, resulting in a failure

112 siological activator and substrate of Aurora A kinase and these interactions help to maintain mitotic

113 chments are restored by inhibition of Aurora A kinase at spindle poles.

114 Knowledge of Aurora A kinase functions is limited to premetaphase events, pa

115 lso shed new light on the function of Aurora A kinase in the reprogramming process.

116 Here we investigate the role of Aurora A kinase on AR-Vs in models of CRPC and show depletion o

117 MLN8054 is a selective inhibitor of Aurora A kinase that robustly inhibits growth of human tumor xe

118 dle formation and known substrates of Aurora A kinase, resulting in spindle assembly and cytokinesis

119 LN8054, a small-molecule inhibitor of Aurora A kinase.

120 r patients treated with inhibitors of Aurora A kinase.

121 tion of MCAK function is dependent on Aurora A kinase, which is regionally enhanced by signaling from

122 sion drug felodipine to the oncogenic Aurora A kinase protein via hydrogen bonding interactions with

123 as a specific inhibitor for oncogenic Aurora A kinase.

124 Alisertib is an oral Aurora A kinase inhibitor with preclinical activity in neurobla

125 e have determined that phosphorylated Aurora A kinase is in dynamic equilibrium between a DFG-in-like

126 cestors of two colocalizing proteins, Aurora A kinase and its allosteric activator TPX2 (targeting pr

127 MLN8054 inhibits recombinant Aurora A kinase activity in vitro and is selective for Aurora A

128 Here, we report that Aurora A kinase (AAK) opposes the stabilizing effect of PEFs.

129 In this study we show that Aurora A kinase activity is altered in different ways in three

130 In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated t

131 Additionally, we demonstrate that Aurora A kinase associates with inner centromere protein (INCEN

132 Recent studies show that Aurora A kinase promotes microtubule assembly from centrosomes

133 In this study, we demonstrate that Aurora A kinase regulates kinetochore-microtubule dynamics of m

134 We show that Aurora A kinase, which functions in centrosome activity and spi

135 hput drug screening revealed that the Aurora A kinase (Aurora A)/Polo-like kinase 1 (PLK1)/cyclin-dep

136 ell, Zhao et al. (2019) show that the Aurora A kinase AIR-1 is the long-sought cue that downregulates

137 at C. elegans zygotes depleted of the Aurora A kinase AIR-1 or lacking centrosomes entirely usually e

138 tudy, x-ray crystal structures of the Aurora A kinase domain delineate redox-sensitive cysteine resid

139 ue promote autophosphorylation of the Aurora A kinase domain.

140 es demonstrate unequivocally that the Aurora A kinase inhibitor, alisertib, specifically neutralizes

141 as a novel mitotic substrate for the Aurora A kinase, a key regulator of critical mitotic events, li

142 l regulator for the activation of the Aurora A kinase.

143 wo similar hydrophobic pockets in the Aurora A kinase.

144 and destabilization of N-Myc through Aurora A kinase inhibition reduces tumor burden.

145 1b mutant in mammalian cells leads to Aurora A kinase activation and abnormal centrosome amplificatio

146 his was phenocopied by treatment with Aurora A kinase inhibitor, suggesting a centrosomal role for th

147 nown phosphorylation sites of Xenopus Aurora A kinase, as well as several novel sites in the Xenopus

148 ect the relationship between Cdk1 and Aurora A kinases during G(2)/M transition.

149 ins can be phosphorylated in vitro by Aurora A kinases, but the significance of this remains unclear.

150 Aurora-A kinase is frequently overexpressed/activated in human

151 Aurora-A kinase is frequently overexpressed/activated in variou

152 Aurora-A kinase is necessary for centrosome maturation, for ass

153 Moreover, aberrant Aurora-A kinase activity induced phosphorylation and nuclear tr

154 assembly factor TPX2, which activates Aurora-A kinase and stimulates local microtubule nucleation.

155 E3 ubiquitin ligase is controlled by Aurora-A kinase and protein phosphatase 1 alpha-mediated phosph

156 The centrosomal Aurora-A kinase (AURKA) regulates mitotic progression, and over

157 ent of Pkd1(-/-) mice with a clinical Aurora-A kinase inhibitor exacerbated cystogenesis.

158 The catalytic activity of human AURORA-A kinase (AURKA) regulates mitotic progression, and its

159 in sequence, directly activated human Aurora-A kinase.

160 activity of MLN8237, a small-molecule Aurora-A kinase inhibitor.

161 cological and molecular inhibition of Aurora-A kinase activity restored a CD24(+) epithelial phenotyp

162 for the first time the causal role of Aurora-A kinase in the activation of EMT pathway responsible fo

163 manner that is partially dependent on Aurora-A kinase and cytoplasmic dynein.

164 s spatially controlled through a Rac1-Aurora-A kinase pathway that locally inhibits the MT depolymeri

165 to inhibit PP1 and directly stimulate Aurora-A kinase.

166 gs, our data clearly demonstrate that Aurora-A kinase does not regulate TACC3-chTOG complex formation

167 We show that Aurora-A kinase modulates the BRCA1 inhibition of centrosome fu

168 Here, we found that Aurora-A kinase, a major mitotic kinase, specifically binds to

169 ich also requires the activity of the Aurora-A kinase AIR-1.

170 Here, we report that the Aurora-A kinase inhibitor alisertib exhibits potent efficacy ag

171 N-Myc forms a complex with the Aurora-A kinase, which protects N-Myc from proteasomal degradat

172 Aurora-A kinases are highly conserved mitotic kinases required

173 fluorescence resonance energy transfer-based A-kinase activity reporter (AKAR1), we find that PKA act

174 Here, we assessed the role of BIG2 A kinase-anchoring protein (AKAP) domains in the regulat

175 NFAT) transcription factors, orchestrated by A kinase-anchoring protein (AKAP)79/150.

176 Dynamic sensitization of TRPV1 activity by A-kinase anchoring protein 150 demonstrates a critical r

177 CaN is recruited to the channel by A-kinase anchoring protein (AKAP) 79/150, which binds to

178 ptors uses PKC, recruited to the channels by A-kinase anchoring protein (AKAP)79/150.

179 which is scaffolded to Ca(V)1.2 channels by A-kinase anchoring proteins (AKAPs).

180 restricted to specific cell compartments by A-kinase anchoring proteins (AKAPs).

181 alized multimolecular signaling complexes by A-kinase anchoring proteins.

182 specificity of PKA are largely controlled by A-kinase anchoring proteins (AKAPs).

183 cAMP signaling is conferred in large part by A-kinase anchoring proteins (AKAPs) that localize protei

184 o-localization with its signaling partner by A-kinase anchoring proteins (AKAPs).

185 e CaV1.2 pore-forming subunit is promoted by A-kinase anchoring proteins (AKAPs) that target cAMP-dep

186 onding to UV-induced DNA damage regulated by A-kinase-anchoring protein 12 (AKAP12).

187 protein kinase A (PKA) to its substrates by A-kinase-anchoring proteins (AKAPs).

188 o its substrates by protein scaffolds called A kinase anchoring proteins (AKAPs).

189 d with cells coexpressing FLC markers [CD68, A-kinase anchoring protein 12 (AKAP12), cytokeratin 7, e

190 , the coaE gene, encoding dephospho-coenzyme A kinase, which is involved in the final step of coenzym

191 transcription (TAT)-AKAD for TAT-conjugated A-kinase-anchoring disruptor, using the PKA binding regi

192 BIG proteins also contain A-kinase anchoring protein (AKAP) sequences that can act

193 e-associated protein 97 (SAP97) that contain A-kinase anchoring protein 79/150 (AKAP79/150), protein

194 hospholamban in a complex that also contains A-kinase anchoring protein-18, protein kinase type A-RII

195 re, we show that the Rho-GTPase Rac contains A-kinase anchoring protein properties and forms a dynami

196 mutants where the N0 area homologous to dual A-kinase-anchoring protein-1 or the acyl-CoA signature m

197 re sites for binding protein kinase A, i.e., A kinase-anchoring protein (AKAP) sequences.

198 f native human kinases, including the Ephrin A kinase family, that are sensitive to commonly used PP

199 scribe three alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which

200 damage, PINK1 triggers PKA displacement from A-kinase anchoring protein 1.

201 ization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regul

202 By directing PKC to GluA1, A-kinase anchoring protein 79 (AKAP79) facilitates Ser-8

203 and substrate-enhanced activation of type-I A-kinase, we measured the kinetics of A-kinase regulator

204 ys and mass spectrometry, we have identified A kinase-anchoring protein (AKAP)150 and the protein pho

205 In the present study, we identified A-kinase-anchoring protein 95 (AKAP95) as a caspase 3-bi

206 tyrosine 987 by the Insulin receptor isoform-A kinase-associated activity in response to the autocrin

207 nally distinct from classical protein kinase A kinases.

208 Two novel PEC markers A-kinase anchor protein 12 and annexin A3 exhibited simi

209 on of Nek8, a NIMA-related (never in mitosis A) kinase, and polycystins in jck cilia is shown for the

210 The scaffolding molecule A-kinase anchoring protein (AKAP)79/150 targets both the

211 imerization domain to interact with multiple A-kinase anchoring proteins (AKAP) that localize it to d

212 scaffold proteins, including by multivalent A-kinase anchoring proteins (AKAPs) that bind protein ki

213 and RSK3 anchoring using a competing muscle A-kinase anchoring protein peptide inhibited the hypertr

214 ed by the scaffold protein mAKAPbeta (muscle A-kinase anchoring protein beta), such that increased SR

215 ce suggests that the scaffold protein muscle A-kinase anchoring protein beta (mAKAPbeta) serves as a

216 F2D and CaN bind the scaffold protein muscle A-kinase-anchoring protein beta (mAKAPbeta), which is lo

217 The muscle A-kinase anchoring protein (mAKAP) tethers cAMP-dependen

218 the regulated binding of RSK3 to the muscle A-kinase anchoring protein scaffold, defining a novel ki

219 of association with IPF susceptibility near A-kinase anchoring protein 13 (AKAP13; rs62025270, odds

220 rylatable ATR-S435A construct or deletion of A kinase-anchoring protein 12 (AKAP12) impeded platinum

221 protein kinase and the anchoring domains of A kinase anchor proteins for general application in cons

222 s review we will focus on the description of A-kinase anchoring protein function in the regulation of

223 1) agonist NF546 is blocked by disruption of A-kinase anchoring protein 5 (AKAP5) function in arteria

224 id blast crisis (Lbc), the oncogenic form of A-kinase anchoring protein 13 (AKAP13).

225 type-I A-kinase, we measured the kinetics of A-kinase regulatory subunit interactions using a stopped

226 Hinke et al illustrate the significance of A-kinase anchoring protein 150 in tethering protein phos

227 nts of the type Ialpha regulatory subunit of A-kinase, RIalpha (91-244).

228 er analyses indicate that the proto-oncogene A-kinase anchoring protein-Lbc is up-regulated in FLC an

229 e Golgi distribution of its binding partner, A-kinase anchor protein 450 (AKAP450).

230 reorganize and amplify the intracellular PKA-A-kinase anchoring protein signaling network and suggest

231 isoproterenol, and PP2A is recruited to PKA/A kinase-anchoring protein complex.

232 erases (PDE4), protein kinase A (PKA) or PKA/A-kinase anchoring protein (AKAP) interaction blocked an

233 e endings where it is bound to two prominent A kinase-anchoring-proteins (AKAPs).

234 ll-specific deletion of the scaffold protein A kinase anchoring protein 9 (AKAP9) and use models of i

235 hipBA, encodes HipA (high persister protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX

236 iao is a member of a large family of protein A-kinase anchoring proteins with important roles in the

237 ylation of the AMPAR-linked scaffold protein A-kinase anchoring protein (AKAP) 79/150 is required for

238 he AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (AKAP) 79/150.

239 The scaffolding protein A-kinase anchoring protein 150 (AKAP150) is a key regula

240 receptors coupled by the scaffolding protein A-kinase-anchoring protein (AKAP)79/150.

241 a interaction with the PKC-targeting protein A-kinase anchoring protein (AKAP) 79 and interferes with

242 The scaffold proteins A-kinase-anchoring protein 79/150 (AKAP79/150) and posts

243 naling module, containing PKA and a putative A kinase adapter protein, Acyl CoA binding domain protei

244 [Hsp90], Hsp10), and phosphatase regulators (A-kinase anchor protein 1 [AKAP149], protein phosphatase

245 The multivalent neuronal scaffold A-kinase-anchoring protein 79 (AKAP79) is known to bind

246 The postsynaptic scaffolding A-kinase anchoring protein 79/150 (AKAP79/150) signaling

247 ic modifications of postsynaptic scaffolding A-kinase anchoring protein 79/150 (AKAP79/150) signaling

248 kinases and phosphatases by the scaffolding A-kinase anchoring protein 79/150 (AKAP79/150).

249 Previous work showed A-kinase-anchoring protein (AKAP)79/150-mediated protein

250 For cAMP signaling, A-kinase anchoring proteins (AKAPs) provide a molecular

251 found to be scaffolded to a muscle-specific A kinase anchoring protein (mAKAPbeta) in heart and NRVM

252 PLCepsilon scaffolded to muscle-specific A kinase-anchoring protein (mAKAP), along with PKCepsilo

253 We further find that a specific A-kinase anchoring protein, AKAP-Lbc, is a major contrib

254 Dual-specific A-kinase-anchoring protein 2 (D-AKAP2/AKAP10), which int

255 ng complex maintained by the muscle-specific A-kinase anchoring protein (mAKAP) that includes PKA, PD

256 ependent kinase II (CaMKII), muscle-specific A-kinase anchoring protein, and myomegalin.

257 alpha4 integrins are type I PKA-specific A-kinase anchoring proteins, and we now find that type I

258 Of importance, we illustrated that A-kinase anchoring proteins are crucial for BCAM/Lu rece

259 Finally, we showed that A-kinase anchoring proteins play an essential role in IC

260 The A kinase anchor protein AKAP150 recruits the cAMP-depend

261 The A kinase anchoring protein 350 (AKAP350) is a multiply s

262 ha-(KCNQ1) and beta-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which

263 KA is recruited to postsynaptic sites by the A kinase anchor protein AKAP150.

264 perimentally using a modified version of the A kinase activity reporter (AKAR) protein kinase A (PKA)

265 Recent evidence indicates that the A kinase anchor protein AKAP5 (AKAP79/150) interacts not

266 with the AMPA receptor GluR1 subunit via the A kinase anchor protein AKAP150 is crucial for GluR1 pho

267 , PDE10A was found to be associated with the A kinase anchoring protein AKAP150 suggesting the existe

268 ed to the synapse by an interaction with the A kinase-anchoring protein, AKAP79/150.

269 The A-kinase anchoring protein (AKAP) GSK3beta interaction p

270 The A-kinase anchoring protein 79/150 (AKAP79/150) signaling

271 The A-kinase anchoring protein AKAP79/150 interacts with pro

272 er 3, and to signaling pathways, such as the A-kinase anchor protein 2/protein kinase A pathway.

273 naling complex containing PKA and I-1 by the A-kinase anchoring protein 18 (AKAP18) facilitates this

274 Gene silencing approaches identified the A-kinase anchoring protein (AKAP) WAVE1 as an effector o

275 ere, we demonstrate the critical role of the A-kinase anchoring protein AKAP150 in PKA-dependent modu

276 ine phosphatase, Shp2, is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex.

277 Here we demonstrate that the A-kinase anchor protein 150 (AKAP150) is critical for PK

278 In this report we demonstrate that the A-kinase anchoring protein AKAP-Lbc assembles an activat

279 the channel and the kinase mediated through A-kinase anchoring proteins (AKAPs).

280 of action may be through compound binding to A kinase anchoring protein (AKAP) 1, modulating its loca

281 at neuron cultures because of its binding to A kinase-anchoring protein 150 (AKAP150), a scaffold for

282 gulated phosphodiesterase (PDE) 4D3 binds to A kinase-anchoring proteins (AKAPs).

283 hat are either freely diffusible or bound to A kinase anchoring proteins, we demonstrate that the dif

284 tic two-step mechanism that links rut-AC1 to A-kinase anchoring proteins (AKAP)-sequestered protein k

285 aN) are targeted to GluA1 through binding to A-kinase anchoring protein 150 (AKAP150) in a complex wi

286 ete cellular compartments through binding to A-kinase-anchoring proteins (AKAPs), RI subunits are pri

287 he beta-adrenergic receptor and PKA bound to A-kinase anchoring protein 15 (AKAP15).

288 processes through protein kinase A bound to A-kinase anchoring proteins (AKAPs).

289 , whilst disruption of the binding of PKA to A-kinase anchoring proteins (AKAPs) inhibited currents t

290 sult of binding of regulatory subunit, R, to A-kinase-anchoring proteins (AKAPs).

291 Localization of protein kinase A (PKA) via A-kinase-anchoring proteins (AKAPs) is important for cAM

292 PKA activity or its ability to interact with A kinase anchoring proteins inhibited the activity of th

293 near its substrates through association with A-kinase anchoring proteins (AKAPs).

294 This autoinhibitory complex, with A-kinase anchoring protein-15 (AKAP15) bound to the DCT,

295 n (NHR) 3 domain, which shares homology with A-kinase anchoring proteins and interacts with the regul

296 tions ensure the colocalization of RSK1 with A-kinase PKA anchoring proteins (AKAPs).

297 interactions of the regulatory subunit with A-kinase anchoring proteins (AKAPs).

298 f its regulatory type II (RII) subunits with A-kinase anchoring proteins (AKAPs).

299 f PKA regulatory type II (RII) subunits with A-kinase-anchoring proteins (AKAPs) confers location, an

300 lity in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B a