ライフサイエンスコーパス: ABCC1

1 idrug resistance-associated protein 1 (MRP1, ABCC1).

2 sporter multidrug resistance protein 1 (MRP1/ABCC1).

3 pump P-glycoprotein (P-gp, ABCB1) and MRP1 (ABCC1).

4 egulate the drug transport activity of human ABCC1.

5 cts are recognized and, in turn, effluxed by ABCC1.

6 nt and up-regulates the expression levels of ABCC1.

7 he function of another ABC drug transporter, ABCC1.

8 etase inhibitor or shRNA led to reduction of ABCC1.

9 and ABCG2, but has no significant effects on ABCC1.

10 ve metabolite of CPT-11) AUC is explained by ABCC1 1684T>C, ABCB1 IVS9 -44A>G, and UGT1A1*93 (P = .00

11 that miR-185-5p and miR-326 both target the ABCC1 3'UTR.

12 beta1 induced the expression of Lpcat2/4 and Abcc1/4 and down-regulated Slc10a1 and Slco1a1 in primar

13 t qualified it as one of the ten best triple ABCC1/ABCB1/ABCG2 inhibitors in the literature.

14 These include ABCA2, ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCC10, ABCC11, ABCC1

15 ence cellular sensitivity to taxanes (ABCB1, ABCC1, ABCC2, ABCG2, CDKN1A, CYP1B1, CYP2C8, CYP3A4, CYP

16 esent study, we report on 3'-UTR variants of ABCC1, ABCC2, and ABCC3 mRNA.

17 ALL subtype (P = 1.1 x 10-14), the SLC19A1/(ABCC1 + ABCC4) transporter ratio (P = 3.6 x 10-4), the M

18 The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MTHFD1 significantly influenced

19 lar miRNAs were confirmed that target ABCA1, ABCC1, ABCC5, ABCC10, and ABCE1 genes and mediate change

20 11 pyrimidines were revealed as triple ABCB1/ABCC1/ABCG2 inhibitors.

21 pulmonary administered (11)C-BMP can measure ABCC1 activity at the lung epithelial barrier and may be

22 sms, or concomitant drug intake on pulmonary ABCC1 activity.

23 In conclusion, we provide evidence that ABCC1 acts as an anthocyanin transporter that depends on

24 1 (also known as MDR1 or P-glycoprotein) and ABCC1 (also known as MRP1) whose inhibition remains a pr

25 umps, ABCB1 (also known as MDR1 or P-gp) and ABCC1 (also known as MRP1), whose inhibition remains a p

26 encompassing the four ohnologs NDE1, MYH11, ABCC1 and ABCC6.

27 that E(2)-induced export of S1P mediated by ABCC1 and ABCG2 transporters and consequent activation o

28 MMP-2 and MMP-9 and drug resistance markers ABCC1 and ABCG2.

29 MCF7/WT cells led to increased expression of ABCC1 and associated drug resistance, consistent with ex

30 These results identify ABCC1 and glutathione metabolism as mechanisms limiting

31 up-regulates the expression and function of ABCC1 and suggest that its activation could represent an

32 action between a specific promoter region of ABCC1 and the N1(IC)-activated transcription factor CBF1

33 cancers (for example, regulatory regions of ABCC1 and VEGFA; GATA6 and FOX-family motifs), whereas o

34 -binding cassette subfamily C member 1 (MRP1/ABCC1) and the PI3/AKT pathway.

35 he human multidrug resistance protein (MRP1, ABCC1) and to assess the role of the extracellular domai

36 ein (ABCB1), multidrug resistance protein 1 (ABCC1), and breast cancer resistance protein (ABCG2) pla

37 idrug resistance-associated protein 1 (MRP1, ABCC1), and breast cancer resistance protein (BCRP, ABCG

38 promise or facilitate the CFTR(ABCC7)-, MRP1(ABCC1)-, and ABCC6-transporters posttranslational couple

39 drug resistance (MDR) mediated by the ABCB1, ABCC1, and ABCG2 drug-efflux transporters.

40 d five novel lead molecules as triple ABCB1, ABCC1, and ABCG2 inhibitors.

41 cell surface ABC transporters such as ABCB1, ABCC1, and ABCG2 that modulate intracompartmental and in

42 ion of new fluorescent substrates for ABCB1, ABCC1, and ABCG2.

43 ells deficient in 5-lipoxygenase, Abcb1, and Abcc1, and comparison of the effects of FTY720 with thos

44 SW480/Coti cells were found to overexpress ABCC1, and COTI-2 being a substrate for this efflux pump

45 nsporters such as P-glycoprotein/ABCB1, MRP1/ABCC1, and MXR/ABCG2 seems to be a major cause of failur

46 ion of the multidrug transporters, Abcb1 and Abcc1, and through 5-lipoxygenase activity.

47 epresentative, compound 37, reversed ABCB1-, ABCC1-, and ABCG2-mediated MDR, making it one of the thr

48 efflux, and, specifically, ABCB1, ABCG2 and ABCC1 are known to cause cancer chemoresistance.

49 insights into the structure and function of ABCC1 as a cGAMP exporter and lays a foundation for futu

50 Here, we identifed ABCC1 as a direct, ATP-dependent cGAMP exporter in mouse

51 SNPs within the efflux transporter genes ABCC1 (ATP-binding cassette, subfamily C, member 1) and

52 disclosed various 3'-UTR length variants of ABCC1, C2, and C3 mRNA, with loss of mRNA seed regions p

53 sette (ABC) transporter superfamily, such as ABCC1, causes enhanced efflux and, thus, decreased accum

54 porter, multidrug resistance protein 1 (MRP1/ABCC1), confers resistance to a broad range of anti-canc

55 The recognition by ABCC1 could be explained by the reduction kinetics of a

56 We demonstrate that ABCC1 deficiency exacerbated cGAS-dependent autoimmunity

57 eins as well as higher activity of N1(IC) in ABCC1-expressing MDR MCF7/VP cells compared with parenta

58 t experiments using microsomes isolated from ABCC1-expressing yeast cells showed that ABCC1 transport

59 Finally, collagen-mediated up-regulation of ABCC1 expression and function also requires actin polyme

60 The mechanisms driving ABCC1 expression are poorly understood.

61 ctor CBF1, suggesting that the regulation of ABCC1 expression by Notch1 is mediated by CBF1.

62 d be considered as an important regulator of ABCC1 expression in HGSOC.

63 s positively correlated with CD44, HAS3, and ABCC1 expression in squamous cell carcinoma datasets and

64 umulation, collagen-induced up-regulation of ABCC1 expression levels, and collagen-mediated cell surv

65 ted that the transcription factor JUN drives ABCC1 expression, resulting in multidrug resistance.

66 ults reveal a unique regulatory mechanism of ABCC1 expression.

67 etween multidrug resistance protein 1 (MRP1, ABCC1) expression and cellular sensitivity to mitoxantro

68 -domain multidrug resistance protein 1 (MRP1/ABCC1) extrudes a variety of drugs and organic anions ac

69 These structures reveal that ABCC1 forms a homodimer via its N-terminal transmembrane

70 tool for the investigation of cell-specific ABCC1 function.

71 Unlike most other ABC transporters, ABCC1 has an additional membrane-spanning domain (MSD0)

72 This was unexpected, as ABCC1 has strong selectivity for glutathione adducts.

73 , we present a characterization of the first Abcc1 humanized mouse line.

74 ron microscopy (cryo-EM) structures of human ABCC1 in a ligand-free state and a cGAMP-bound state.

75 s a foundation for future research targeting ABCC1 in infection and anti-cancer immunity.

76 ole of multidrug resistance protein (MRP) 1 (ABCC1) in the emergence of mitoxantrone (MX) cross-resis

77 Genetic and pharmacologic ABCC1 inactivation potentiates the anti-leukemic effects

78 Transport of S1P by ABCC1 influenced migration of mast cells toward antigen

79 e of them with scaffolds not associated with ABCC1 inhibition until now.

80 ound library to gain new scaffolds regarding ABCC1 inhibition.

81 -)) rats, wild-type rats pretreated with the ABCC1 inhibitor MK571, and wild-type control rats underw

82 mising candidates revealed four compounds as ABCC1 inhibitors, three of them with scaffolds not assoc

83 ABCC1 is expressed in the exocarp throughout berry devel

84 knockdown studies show that up-regulation of ABCC1 is necessary for collagen-mediated reduction of in

85 t ATP-binding cassette subfamily C member 1 (ABCC1) is a cGAMP exporter.

86 The ATP-binding cassette transporter (ABCC1) is associated with poor survival and chemotherapy

87 idrug resistance-associated protein 1 (Mrp1; Abcc1) is expressed in sarcolemma of murine heart, where

88 sporter multidrug resistance protein 1 (MRP1/ABCC1) is responsible for the cellular export of a chemi

89 phate-binding cassette subfamily C member 1 [ABCC1]) is abundantly expressed at the lung epithelial b

90 tion in ANC nadir is explained by UGT1A1*93, ABCC1 IVS11 -48C>T, SLCO1B1*1b, ANC baseline levels, sex

91 reducing intracellular drug levels, and high ABCC1 levels predicts poor response to Venetoclax therap

92 nt biochemical evidence that an ABC protein, ABCC1, localizes to the tonoplast and is involved in the

93 ous targeting of collagen/beta1 integrin and ABCC1 may be more efficient in preventing drug resistanc

94 Thus, ABCC1-mediated cGAMP export is a key regulatory mechanis

95 erately potent, competitive inhibitor of the ABCC1-mediated transport of calcein AM which also sensit

96 ne triphosphate binding cassette transporter ABCC1 mediates MRTX849 resistance.

97 nsport were inhibited by the human ABCB1 and ABCC1 modulator verapamil.

98 ative polyadenylation (APA) can give rise to ABCC1 mRNAs which differ only in the length of their 3'u

99 e (SUOX) expression and the drug-transporter ABCC1 (MRP1) were linked to thiopurine sensitivity, sugg

100 transporters such as ABCB1 (P-glycoprotein), ABCC1 (MRP1), and ABCG2 (BCRP) are well known for their

101 discovery of novel multitarget ABCB1 (P-gp), ABCC1 (MRP1), and ABCG2 (BCRP) inhibitors.

102 ease was inhibited by MK571, an inhibitor of ABCC1 (MRP1), but not by inhibitors of ABCB1 (MDR-1, P-g

103 ter proteins ABCB1 (P-gp), ABCG2 (BCRP), and ABCC1 (MRP1), which are involved in the formation of mul

104 (Mdr1) and the leukotriene C(4) transporter Abcc1 (Mrp1).

105 orters such as ABCB1/P-glycoprotein/MDR1 and ABCC1/MRP1 causes multidrug resistance in cancer chemoth

106 These findings suggest that ABCC1/MRP1 may exist and function as a dimer and that MS

107 tus of the human full-length ABC transporter ABCC1/MRP1 using several biochemical approaches.

108 cell by the ATP-binding cassette transporter ABCC1/MRP1, and is then able to initialize cascades down

109 ted for therapeutic development to sensitize ABCC1/MRP1-mediated drug resistance in cancer chemothera

110 ive function when coexpressed with wild-type ABCC1/MRP1.

111 f multidrug resistance-associated protein 1 (ABCC1/MRP1; herein referred to as ABCC1), we measured N1

112 tidrug-resistant-associated protein 1 (MRP1; ABCC1), MRP2 (ABCC2), and MRP4 (ABCC4).

113 tor (EGF-R) activation and the expression of ABCC1 multidrug transporter gene, thus contributing to t

114 is but not meiotic mapping could exclude the Abcc1 multidrug transporter, and this was confirmed furt

115 rmacological inhibitors or gene silencing of ABCC1 (multidrug resistant protein 1) or ABCG2 (breast c

116 onfirmed further by phenotypic evaluation of Abcc1 null mice.

117 APA of ABCC1 occurs in all three cell lines resulting in mRNAs

118 im of this study was to assess the impact of ABCC1 on the pulmonary disposition of 6-bromo-7-(11)C-me

119 1/Pgp), multidrug resistance protein 1 (MRP1/ABCC1), or multidrug resistance protein 2 (MRP2/ABCC2).

120 ransport of calcein AM which also sensitized ABCC1-overexpressing cells toward daunorubicin.

121 We show that ABCC1 overexpression enhanced cGAMP export and limited S

122 Conversely, ABCC1 overexpression induces resistance to BCL-2 inhibit

123 glutamate-cysteine ligase catalytic subunit, ABCC1, peroxiredoxin 1).

124 Using an ABCC1 promoter construct, we observed both its reduced t

125 nesis of these CBF1 binding sites within the ABCC1 promoter region attenuated promoter-reporter activ

126 ate the functionality of the expressed human ABCC1 protein in brain and lungs using functional positr

127 Caov-3 and Ovcar-3 express higher levels of ABCC1 protein than normal cells.

128 significantly differed between wild-type and Abcc1 ((-/-)) rats, but differences were more pronounced

129 from the lungs (k (E,lung)) was 70% lower in Abcc1 ((-/-)) rats, whereas after intratracheal administ

130 Methods: Groups of Abcc1 ((-/-)) rats, wild-type rats pretreated with the A

131 352% higher and k (E,lung) was 86% lower in Abcc1 ((-/-)) rats.

132 and limited STING signaling and that loss of ABCC1 reduced cGAMP export and potentiated STING signali

133 molecular basis of cGAMP export mediated by ABCC1 remains unclear.

134 Knocking down ABCC1 resulted in decreased cell viability, but did not

135 Inhibition of ABCC1 reversed drug resistance of N1(IC)-overexpressing

136 With one SNP in ABCC1, rs246240, the carriage of two copies of allele 1

137 Consistent with ABCC1-specific export of glutathionylated substrates, in

138 CRISPR/Cas9 screening, we find that loss of ABCC1 strongly increases the sensitivity of AML cells to

139 arly conjugated with glutathione to form the ABCC1 substrate S-(6-(7-(11)C-methylpurinyl))glutathione

140 on the three transporters, ABCB1, ABCG2 and ABCC1, that are known to be of clinical importance.

141 ABC transporters, shortening of the 3'UTR of ABCC1 through 3'UTR-APA would eliminate microRNA binding

142 of Abcb1, SP1 receptors, 5-lipoxygenase, and Abcc1 to enhance T cell migration and homing.

143 1) and multidrug resistance protein 1 (MRP1, ABCC1) to confirm the selectivity toward BCRP.

144 nd function of the ATP-binding cassette C 1 (ABCC1) transporter, also known as multidrug resistance-a

145 and endogenous glucocorticoids by ABCB1 and ABCC1 transporters provide a mechanism whereby different

146 rom ABCC1-expressing yeast cells showed that ABCC1 transports malvidin 3-O-glucoside.

147 protein, multidrug resistance protein (MRP1/ABCC1), transports conjugated organic anions (e.g. leuko

148 idrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug

149 ltidrug resistance-associated protein (MRP1, ABCC1) was identified in small cell lung cancer followed

150 protein 1 (ABCC1/MRP1; herein referred to as ABCC1), we measured N1(IC) and presenilin 1 (PSEN1), the

151 ing cassette transporters (ABCB1, ABCB4, and ABCC1) were present.

152 Moreover, down-regulation of ABCC1 with small interfering RNA, which decreased its ce

153 ABCC1 within a cluster showing linkage is a cannabinoid

154 of the inhibitory activity toward ABCB1 and ABCC1 yielded a high selectivity toward ABCG2 for the qu