ライフサイエンスコーパス: AKAP

1 AKAP palmitoylation was regulated by seizure activity in

2 AKAP-Lbc facilitates PKA phosphorylation of Shp2, which

3 AKAP-Lbc facilitates PKA phosphorylation of Shp2, which

4 AKAP-Lbc integrates PKA and Shp2 signaling in the heart.

5 AKAP-Lbc interacts with Shp2, facilitating its regulatio

6 AKAP-Lbc is a scaffold protein that coordinates cardiac

7 AKAP-Lbc-tethered PKA is implicated in cardiac hypertrop

8 AKAP-PKA disruption had minimal effects on whole-cell cA

9 AKAPs anchor protein kinase A (PKA) through PKA regulato

10 AKAPs coordinate compartmentalized cAMP signaling in ASM

11 re we show that AKAP13 (also known as Brx-1, AKAP-Lbc, and proto-Lbc), a unique protein kinase A-anch

12 Protein kinase A-anchoring protein 79/150 (AKAP), residing at the plasma membrane in neurons, scaff

13 review, we summarize recent evidence for AC-AKAP complexes and requirements for compartmentalization

14 pr161 functions as a selective high-affinity AKAP for type I PKA regulatory subunits (RI).

15 adaptor proteins AKAP9 (AKAP450) and AKAP13 (AKAP-Lbc).

16 ts used heterologous expression with AKAP15, AKAP-KL, and AKAP79 in Xenopus oocytes.

17 Although AKAPs have been recently shown to bind adenylyl cyclase

18 ly interacts with radial spoke protein 3 (an AKAP), which is located at the base of the spoke.

19 s class I ADP-ribosylation factors and as an AKAP for RIIbeta that localizes PKA signaling within cel

20 g to melanosomes and shown to function as an AKAP on mitochondria.

21 over, we show that Gpr161, functioning as an AKAP, recruits PKA RI to primary cilia in zebrafish embr

22 se results confirm that flagellar RSP3 is an AKAP and reveal that a mutation in the PKA binding domai

23 Thus, we propose that Gpr161 is itself an AKAP and that the cAMP-sensing Gpr161:PKA complex acts a

24 This is the first example of an AKAP capable of binding a small molecule.

25 ify PC2 and PDE4C as unique components of an AKAP complex in primary cilia and reveal a common mechan

26 tical role for the PKA phosphorylation of an AKAP in the functional regulation of an ion channel prot

27 el activity, and indicate the key role of an AKAP, possibly AKAP79, in the spatial organization these

28 rin in ERM-knockdown cells, expression of an AKAP-deficient mutant of radixin did not fully rescue gr

29 Here we demonstrate that an AKAP, RSP3, forms a dimeric structural scaffold in the f

30 tory subunit type I (RI) interacting with an AKAP in this process.

31 ENaC activity was unaffected by AKAP79 and AKAP-KL expression.

32 yocyte-like cells and that selective PDZ and AKAP interactions are responsible for the integration of

33 cal hypersensitivity requires both TRPA1 and AKAP.

34 rrent concept about anchoring mechanisms and AKAPs.

35 sruption of the interactions between PKA and AKAPs decreases the nuclear accumulation of active RSK1

36 Knockdown of specific membrane-associated AKAPs using RNAi identified gravin (AKAP250) as the cent

37 cat binding; however, no competition between AKAP and beta-cat binding to cadherins was detected in v

38 Thus, PDE3A in these BIG1 and BIG2 AKAP complexes may contribute to the regulation of ARF f

39 d transcription coactivator function on BIG2 AKAP-C sequence.

40 Inferring a requirement for BIG1 and/or BIG2 AKAP sequence in PKA modification of beta-catenin and it

41 that involved the binding of RIIbeta to BIG2 AKAP domains B and C.

42 -activated PKA phosphorylated BIG1 and BIG2 (AKAPs for assembly of PKA, PDE3A, and other molecules),

43 Given the important cardiac roles of both AKAP-Lbc and Shp2, we investigated the AKAP-Lbc-Shp2 int

44 gnaling complex to promote its activation by AKAP-anchored calcineurin.

45 ling by promoting phosphorylation of PLD1 by AKAP-associated kinases, enhancing production of PA.

46 ing that local control of cAMP signalling by AKAP proteins is more intricate than previously apprecia

47 Calcineurin anchoring by AKAPs confers specificity to calcineurin function in the

48 physiological relevance of PKA anchoring by AKAPs in general and AKAP150 specifically in the regulat

49 and Western blotting revealed two candidate AKAPs that are known to be targeted to mitochondria, AKA

50 proteomic analyses were used to characterize AKAP expression in ASM.

51 KA anchoring are patterned after a conserved AKAP motif.

52 Proteins that contain AKAP sequences act as scaffolds for the assembly of PKA

53 GSKIP, and ascribe a function to a cytosolic AKAP-PKA interaction as a regulatory factor in the contr

54 Our results define AKAP signaling complexes of CaV1.2 and CaV1.3 channels i

55 ed to dissect the contributions of different AKAP-targeted pools of PKA.

56 wn of AKAP5 or St-Ht31 treatment, to disrupt AKAP interaction with the PKA RIIbeta regulatory subunit

57 hor protein) peptide into the NAc to disrupt AKAP-dependent signaling revealed that inhibition of AKA

58 peptides AKAP-IS or Ht31 was used to disrupt AKAP-PKA interactions, and global and compartmentalized

59 depolymerize postsynaptic F-actin disrupted AKAP-cadherin interactions and resulted in loss of the A

60 A peptide inhibitor (HT31) that disrupts AKAP/PKA interactions stimulates oocyte maturation in th

61 n MAP2, indicating that MAP2 is the dominant AKAP in neurons.

62 Here, we describe a Drosophila AKAP protein, MDI that recruits a translation stimulator

63 Knockdown of the Drosophila AKAP-like scaffolding protein Nervy also reduces PDF res

64 Intrinsic targeting domains in each AKAP determine the subcellular localization of these com

65 (RSelect) sequences were obtained for eight AKAPs following competitive selection screening.

66 loss of PKA from binding sites on endogenous AKAPs.

67 Whereas several endogenous AKAPs were identified in HEK-293 cells, small interferin

68 alytic activity, but instead led to enhanced AKAP (A-kinase anchoring protein) binding with preferent

69 cell, appraise recent advances in exploiting AKAPs as platforms for precision pharmacology, and explo

70 we uncovered a novel, ubiquitously expressed AKAP, termed small membrane (sm)AKAP due to its specific

71 e examined the roles of epithelial-expressed AKAPs in regulating the epithelial Na+ channel (ENaC).

72 r, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes impor

73 ts in Chinese hamster ovary cells expressing AKAP-9 and either PDE4D3 or PDE4D5 isoforms revealed mod

74 in Chinese hamster ovary cells co-expressing AKAP-9, and PDE4D3, but not PDE4D5, co-immunoprecipitate

75 from cultured rat sensory neurons following AKAP siRNA transfection and from AKAP-knock-out mice had

76 of gravin behaves as a dominant-negative for AKAP gravin regulation of receptor resensitization/recyc

77 asymmetry provides greater possibilities for AKAP docking.

78 These studies uncover a role for AKAP-Lbc in which increased expression of the anchoring

79 lusitropy, thereby indicating a key role for AKAP-targeted PKA in control of heart rate and contracti

80 ory subunit (RII) can alter its affinity for AKAPs and the catalytic subunit (PKA(cat)).

81 Our results suggest a multifaceted role for AKAPs in the cell.

82 nitially detected in a two-hybrid screen for AKAPs.

83 s following AKAP siRNA transfection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685

84 es with AKAP mutants indicated that impaired AKAP-mediated PKA scaffolding significantly reduces DOR-

85 Using knockin mice that are deficient in AKAP-anchoring of either PKA or the opposing phosphatase

86 ated a link between genetic perturbations in AKAP and human disease in general and AKAP9 and LQTS in

87 teral membranes, and beta-cat was present in AKAP-cadherin complexes isolated from epithelial cells,

88 AMPA glutamate receptors, and the inhibitory AKAP peptide reduced the PSD content of protein kinase A

89 nd actin polymerization redistributed intact AKAP-cadherin complexes from lateral membranes to intrac

90 Here we describe an ERK1/2-interacting AKAP and suggest a mechanism by which cAMP-dependent pro

91 Gene knockdown of potential RI-interacting AKAPs expressed in alveolar macrophages revealed that AK

92 the anchoring domain (AD) of an interactive AKAP are each attached to a biologic entity, and the res

93 Consistent with its AKAP function, BIG2 was required for the cAMP-induced PK

94 anism by which cAMP-dependent protein kinase-AKAP binding can be modulated by the activity of other e

95 on of a palmitoylation-independent lipidated AKAP mutant in DHHC2-deficient neurons largely restored

96 Many AKAPs recruit a diverse set of binding partners that coo

97 Many AKAPs were discovered solely based on the AH-RIIa intera

98 Most AKAPs exhibit nanomolar affinity for the regulatory (RII

99 ASM expresses multiple AKAP family members, with gravin and ezrin among the mos

100 N-myristoylation was found to affect neither AKAP macroscopic localization nor AKAP function.

101 The neuronal AKAP MAP2B, which also interacts with CaV1.2 and CaV1.3

102 ct neither AKAP macroscopic localization nor AKAP function.

103 cues GABAergic metaplasticity and normalizes AKAP signaling in MD animals.

104 In this paper, we report a novel AKAP-dependent localization of RIalpha to distinct organ

105 Collectively, these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1

106 ing analyses revealed the molecular basis of AKAP-selective interactions and shed new light on native

107 native contact points for the side chains of AKAP peptides that allow them to adopt different binding

108 s have also been identified as components of AKAP complexes, namely AKAP79, Yotiao, and mAKAP.

109 rotein interaction domains, form the core of AKAP function.

110 Moreover, disruption of AKAP-PKA anchoring does not affect glutamatergic synapse

111 To test the importance of AKAP-mediated targeting of PKA on cardiac function, we d

112 endent signaling revealed that inhibition of AKAP signaling impaired the reinstatement of cocaine see

113 of PKA-RII localization and that movement of AKAP-PKA complexes underlies PKA redistribution.

114 basal and cAMP responsive phosphorylation of AKAP-associated substrates.

115 PKAc, and it is disrupted by the presence of AKAP peptides, mutations in the RIalpha AKAP-binding sit

116 ever, we do not understand how regulation of AKAP targeting controls AMPAR endosomal trafficking.

117 The ability of AKAPs to assemble intricate feedback loops to control sp

118 tion of rut-derived cAMP signals at level of AKAPs might serve as counting register that accounts for

119 KA binds to an amphipathic helical region of AKAPs via an N-terminal domain of the regulatory subunit

120 be tightly tethered by a novel repertoire of AKAPs, providing a new perspective on spatio-temporal co

121 This study aimed to assess the role of AKAPs in regulating global and compartmentalized beta(2)

122 inase A (PKA) is a well-recognized target of AKAPs, with other kinases now emerging as additional tar

123 the impact of methodological innovations on AKAP research.

124 protein kinase A (PKA) anchoring protein or AKAP.

125 Protein kinase A anchoring proteins or AKAPs regulate the activity of many ion channels.

126 e in the expression of AKAP150 but not other AKAPs.

127 mutants that are selective for a particular AKAP.

128 Stable expression or injection of peptides AKAP-IS or Ht31 was used to disrupt AKAP-PKA interaction

129 Disruption of the PKA-AKAP interaction is sufficient to cause a long-lasting r

130 ses onto DA neurons, suggesting that the PKA-AKAP-CaN complex is uniquely situated at GABA(A) recepto

131 of the beta(1)-AR because disruption of PKA/AKAP interactions or small interfering RNA-mediated down

132 hat Ht-31 peptide-mediated disruption of PKA/AKAP interactions prevented the recycling and functional

133 ied in testis as an A-kinase anchor protein (AKAP)- binding protein.

134 n with a protein kinase A anchoring protein (AKAP 95) and CSR-BPs participate in forming CSR-protein

135 pound binding to A kinase anchoring protein (AKAP) 1, modulating its localization to mitochondria and

136 -95, and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a PDZ-dependent manner

137 nd protein kinase A (PKA)-anchoring protein (AKAP) 5, which anchor the receptor in the plasma membran

138 argeting protein A-kinase anchoring protein (AKAP) 79 and interferes with ionomycin-induced transloca

139 A-kinase anchoring protein (AKAP) 79/150 is a scaffold protein found in dendritic sp

140 scaffold protein A-kinase anchoring protein (AKAP) 79/150 is required for its targeting to recycling

141 A-kinase-anchoring protein (AKAP) 79/150 organizes a scaffold of cAMP-dependent prot

142 o the channel by A-kinase anchoring protein (AKAP) 79/150, which binds to the LTCC C-terminus via a m

143 scaffold protein A-kinase anchoring protein (AKAP) 79/150.

144 the role of BIG2 A kinase-anchoring protein (AKAP) domains in the regulation of TNFR1 exosome-like ve

145 nce in BIG2 of 3 A kinase-anchoring protein (AKAP) domains, one of which is identical in BIG1.

146 The A-kinase anchoring protein (AKAP) GSK3beta interaction protein (GSKIP) is a cytosoli

147 a unique protein kinase A-anchoring protein (AKAP) guanine nucleotide exchange region belonging to th

148 e A (PKA) or PKA/A-kinase anchoring protein (AKAP) interaction blocked an immediate return of subplas

149 ins also contain A-kinase anchoring protein (AKAP) sequences that can act as scaffolds for multimolec

150 kinase A, i.e., A kinase-anchoring protein (AKAP) sequences.

151 I overlays as an A-kinase anchoring protein (AKAP) that localizes the cAMP-dependent protein kinase (

152 Yotiao is an A-kinase-anchoring protein (AKAP) that recruits the cyclic AMP-dependent protein kin

153 PH3 is a protein kinase A-anchoring protein (AKAP) that scaffolds the cAMP-dependent protein kinase h

154 s identified the A-kinase anchoring protein (AKAP) WAVE1 as an effector of OxPL action in vitro.

155 (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits protein kinase A)

156 component of the A-kinase-anchoring protein (AKAP)-Lbc complex.

157 t of the protein kinase A anchoring protein (AKAP)-Lbc complex.

158 covered that the A-Kinase Anchoring Protein (AKAP)-Lbc is upregulated in hypertrophic cardiomyocytes.

159 in (RSP) 3 is an A-kinase anchoring protein (AKAP).

160 have identified A kinase-anchoring protein (AKAP)150 and the protein phosphatase calcineurin as bind

161 folding molecule A-kinase anchoring protein (AKAP)79/150 targets both the cAMP-dependent protein kina

162 ious work showed A-kinase-anchoring protein (AKAP)79/150-mediated protein kinase C (PKC) phosphorylat

163 orchestrated by A kinase-anchoring protein (AKAP)79/150.

164 the channels by A-kinase anchoring protein (AKAP)79/150.

165 ffolding protein A-kinase-anchoring protein (AKAP)79/150.

166 that a specific A-kinase anchoring protein, AKAP-Lbc, is a major contributor to the formation of the

167 t with multiple A-kinase anchoring proteins (AKAP) that localize it to different parts of the cell.

168 inks rut-AC1 to A-kinase anchoring proteins (AKAP)-sequestered protein kinase A at the level of Kenyo

169 A-kinase-anchoring proteins (AKAPs) are a canonical family of scaffold proteins known

170 A-kinase anchoring proteins (AKAPs) are a family of scaffolding proteins that target

171 A-kinase anchoring proteins (AKAPs) are scaffolding molecules that coordinate and int

172 A-kinase anchoring proteins (AKAPs) are well known for their ability to scaffold prot

173 A kinase anchoring proteins (AKAPs) assemble and compartmentalize multiprotein signal

174 ) subunits with A-kinase-anchoring proteins (AKAPs) confers location, and catalytic (C) subunits phos

175 A-kinase anchoring proteins (AKAPs) contain an amphipathic helix (AH) that binds the

176 A-kinase anchoring proteins (AKAPs) coordinate cell signaling events.

177 A-Kinase Anchoring Proteins (AKAPs) ensure the fidelity of second messenger signaling

178 PKA) by protein kinase A-anchoring proteins (AKAPs) facilitates local protein phosphorylation.

179 A-kinase anchoring proteins (AKAPs) have emerged as a converging point of diverse sig

180 A-kinase anchoring proteins (AKAPs) have emerged as important regulatory molecules th

181 tors of protein kinase A anchoring proteins (AKAPs) implicated PKA regulatory subunit type I (RI) int

182 in proteins and A-kinase anchoring proteins (AKAPs) increased receptor diffusion, indicating that the

183 Protein kinase A-anchoring proteins (AKAPs) influence fundamental cellular processes by direc

184 A-kinase anchoring proteins (AKAPs) influence the spatial and temporal regulation of

185 nding of PKA to A-kinase anchoring proteins (AKAPs) inhibited currents through ARC channels, and bloc

186 ase A (PKA) via A-kinase-anchoring proteins (AKAPs) is important for cAMP responsiveness in many cell

187 nase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate localised signalling compl

188 A-kinase anchoring proteins (AKAPs) localize PKA to AMPARs leading to enhanced phosph

189 A-kinase anchoring proteins (AKAPs) mediate the intracellular localization of PKA and

190 A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinas

191 Protein kinase A-anchoring proteins (AKAPs) participate in the formation of macromolecular si

192 Protein kinase A-anchoring proteins (AKAPs) play important roles in the compartmentation of c

193 cAMP signaling, A-kinase anchoring proteins (AKAPs) provide a molecular mechanism for cAMP compartmen

194 Protein kinase A-anchoring proteins (AKAPs) provide spatio-temporal specificity for the omnip

195 A-kinase anchoring proteins (AKAPs) recruit signaling molecules and present them to d

196 A-kinase anchoring proteins (AKAPs) represent a family of structurally diverse protei

197 A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases w

198 A-kinase anchoring proteins (AKAPs) sequester combinations of signaling enzymes withi

199 A-kinase anchoring proteins (AKAPs) spatially constrain phosphorylation by cAMP-depen

200 A-kinase-anchoring proteins (AKAPs) target PKA to glutamate receptor and ion channel

201 A kinase-anchoring proteins (AKAPs) target PKA to specific microdomains by using an a

202 A-kinase anchoring proteins (AKAPs) tether the cAMP-dependent protein kinase (PKA) to

203 by multivalent A-kinase anchoring proteins (AKAPs) that bind protein kinase A and other important si

204 n large part by A-kinase anchoring proteins (AKAPs) that localize protein kinase A and other signalin

205 is promoted by A-kinase anchoring proteins (AKAPs) that target cAMP-dependent protein kinase (PKA) t

206 ffolds, such as A-kinase anchoring proteins (AKAPs), compartmentalize kinase activity and ensure subs

207 Protein kinase A anchoring proteins (AKAPs), defined by their capacity to target the cAMP-dep

208 ough binding to A-kinase-anchoring proteins (AKAPs), RI subunits are primarily diffuse in the cytopla

209 ng with protein kinase A anchoring proteins (AKAPs), the present study was undertaken to identify the

210 mbrane-anchored A-Kinase-Anchoring Proteins (AKAPs).

211 E) 4D3 binds to A kinase-anchoring proteins (AKAPs).

212 1.2 channels by A-kinase anchoring proteins (AKAPs).

213 caffolds called A kinase anchoring proteins (AKAPs).

214 nase A bound to A-kinase anchoring proteins (AKAPs).

215 s substrates by A-kinase-anchoring proteins (AKAPs).

216 y controlled by A-kinase anchoring proteins (AKAPs).

217 subunit, R, to A-kinase-anchoring proteins (AKAPs).

218 ase A (PKA) and A-kinase anchoring proteins (AKAPs).

219 compartments by A-kinase anchoring proteins (AKAPs).

220 ssociation with A-kinase anchoring proteins (AKAPs).

221 f RSK1 with A-kinase PKA anchoring proteins (AKAPs).

222 ry subunit with A-kinase anchoring proteins (AKAPs).

223 ediated through A-kinase anchoring proteins (AKAPs).

224 on with protein kinase A anchoring proteins (AKAPs).

225 ling partner by A-kinase anchoring proteins (AKAPs).

226 ) subunits with A-kinase anchoring proteins (AKAPs).

227 lecules such as A-Kinase Anchoring Proteins (AKAPs).

228 otein kinase A-anchoring family of proteins (AKAPs), which target the cAMP-dependent protein kinase (

229 Kinases A and C (PKA and PKC, respectively), AKAP facilitates phosphorylation and sensitization of TR

230 ed to cellular substructures, whereas PKA-RI-AKAP complexes have remained largely undiscovered.

231 e of AKAP peptides, mutations in the RIalpha AKAP-binding site, or knockdown of AKAP11.

232 nteractions and shed new light on native RII-AKAP interactions.

233 Many PKA-RII-AKAP complexes are heavily tethered to cellular substruc

234 We postulate that radial spokes use the RIIa/AKAP module to regulate ciliary and flagellar beating; a

235 n of PKA stimulates the formation of a SAP97-AKAP/PKA-GluA1 protein complex leading to synaptic deliv

236 n and characterization of a novel sarcomeric AKAP (A-kinase anchoring protein), cardiac troponin T (c

237 le for cTnT as a dual-specificity sarcomeric AKAP.

238 mAKAP (muscle-selective AKAP) localizes PKA and its substrates such as phosphodi

239 KA is also found in the N termini of several AKAP-binding proteins unrelated to PKA as well as a 24-k

240 Several AKAPs have been identified in oocytes including one at 1

241 Several AKAPs have been shown to accelerate, amplify, and specif

242 ly expressed AKAP, termed small membrane (sm)AKAP due to its specific localization at the plasma memb

243 helical motif from D-AKAP2, a dual-specific AKAP, bound to the RIIalpha D/D domain.

244 ng protein (SKIP) is a truly type I-specific AKAP.

245 melanophores, Rab32 is a melanosome-specific AKAP that is essential for regulation of melanosome tran

246 of PKA in neurons and the roles of specific AKAPs are poorly understood.

247 studies show that cTnT is a dual specificity AKAP, interacting with both PKA-regulatory subunits type

248 endosomes, enlargement of dendritic spines, AKAP recruitment to spines, and potentiation of AMPAR-me

249 e sub-structures, in concert with the static AKAP-regulatory subunit interface, generates a solid-sta

250 by microinjecting a cell-permeable synthetic AKAP (A-kinase anchor protein) peptide into the NAc to d

251 s that can regulate cocaine relapse and that AKAP proteins may contribute to relapse vulnerability by

252 PKA and Shp2 signaling in the heart and that AKAP-Lbc-associated Shp2 activity is reduced in hypertro

253 PKA and Shp2 signaling in the heart and that AKAP-Lbc-associated Shp2 activity is reduced in hypertro

254 egy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term d

255 Our data indicate that AKAP-Lbc integrates PKA and Shp2 signaling in the heart

256 Overall, our data indicate that AKAP-Lbc integrates PKA and Shp2 signaling in the heart

257 Here, we show that AKAP function is required for DCC-mediated activation of

258 s, and RNA interference techniques show that AKAP-Lbc couples activation of protein kinase D (PKD) wi

259 It was shown that AKAP 95 as well as RII formed a direct linkage with CSR

260 These findings suggest that AKAP scaffolds PKA to increase plasma membrane targeting

261 addition, our observations demonstrate that AKAPs serve not solely as stationary anchors in cells bu

262 cellular systems, and evidence suggests that AKAPs play an important role in cardiac signaling.

263 The AKAP gravin is a scaffold for protein kinases, phosphata

264 opy contributions to the binding between the AKAP protein HT31 with the D/D domain of RII alpha-regul

265 Here we show that both the AKAP function of GSKIP, i.e. its direct interaction with

266 noline-sulfon-amide 2HCl), as well as by the AKAP inhibitory peptide Ht31.

267 We exploited the AKAP targeting concept to create genetically encoded pla

268 present study was undertaken to identify the AKAP involved in PKA-mediated phosphorylation of the bet

269 ne kinase Src plays an essential role in the AKAP gravin-mediated receptor resensitization and recycl

270 both AKAP-Lbc and Shp2, we investigated the AKAP-Lbc-Shp2 interaction in the heart.

271 Mapping the AKAP binding site in cadherins identified overlap with b

272 se effector protein MyRIP is a member of the AKAP family.

273 Immunoprecipitaiton of the AKAP from rat brain extract found that the PP1 catalytic

274 ion against RIalpha in the N terminus of the AKAP helix, the hydrophobic groove discriminates against

275 Here, we report that palmitoylation of the AKAP N-terminal polybasic domain targets it to postsynap

276 rin interactions and resulted in loss of the AKAP, but not cadherins, from synapses.

277 er, the LZ mutation had little impact on the AKAP-LTCC interaction or LTCC function, as measured by F

278 f beta-catenin by GSKIP is specific for this AKAP as AKAP220, which also binds PKA and GSK3beta, did

279 FICANCE: Inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously unrecognized mecha

280 process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously unrecognized mecha

281 process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously unrecognized mecha

282 ctivity regulation that relies on binding to AKAPs and consequent modulation of the enzyme activation

283 Inhibition of protein kinase A binding to AKAPs by Ht-31 peptide reduces ASIC currents in cortical

284 We show that blockade of PKA binding to AKAPs in the nucleus accumbens shell of Sprague-Dawley r

285 that competes with PKARIalpha for binding to AKAPs, decreased the amount of PP2Ac in the RSK1 complex

286 The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmenta

287 d the effects of disrupting PKA targeting to AKAPs in the heart by expressing the 24-amino acid regul

288 , little is known about how PKA targeting to AKAPs is regulated in the intact cell.

289 serine 96 on RII regulates PKA targeting to AKAPs, downstream substrate phosphorylation and calcium

290 These two AKAP proteins form signaling complexes containing protei

291 ated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C.

292 ase 1, is recruited to the I(Ks) channel via AKAP-9 and contributes to its critical regulation by cAM

293 d DOR desensitization is directed by PKA via AKAP scaffolding.

294 , but not PDE4D5, co-immunoprecipitated with AKAP-9.

295 Moreover, overexpression studies with AKAP mutants indicated that impaired AKAP-mediated PKA s

296 ic anchoring of PKA through association with AKAPs plays an important role in the regulation of AMPA

297 uce LTF require type II PKA interaction with AKAPs (A-kinase anchoring proteins).

298 We show that PKA interaction with AKAPs is essential for two sequential steps in the matur

299 wn that blocking the interaction of PKA with AKAPs disrupts its subcellular location and prevents LTP

300 he A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits protein kinase A) and protein ph