ライフサイエンスコーパス: ALDH2

1 etoxifying enzyme, aldehyde dehydrogenase 2 (ALDH2).

2 c nucleophile, Cys243, in ALDH3A1 but not in ALDH2.

3 at aortic rings and the function of purified ALDH2.

4 of organic nitrates to the catalytic site of ALDH2.

5 oactivation of GTN is catalyzed by cytosolic ALDH2.

6 tasis, the effect of which was alleviated by ALDH2.

7 d provides a lead for the design of improved ALDH2.

8 reases the K(m) for NAD(+), as compared with ALDH2.

9 amination of deposited electron densities of ALDH2.

10 nced deacylation, the rate-limiting step for ALDH2.

11 on each individual kinetic step of ALDH1 and ALDH2.

12 1.16 +/- 0.56, and 0.40 +/- 0.10 microM for ALDH2.

13 found to be heterozygous when genotyped for ALDH2.

14 are associated with increased expression of ALDH2.

15 in diabetic mouse heart which was rescued by ALDH2.

16 e-binding site of the free enzyme species of ALDH2.

17 lial cells infected with wild-type or mutant ALDH2.

18 cal significance of NO formation by purified ALDH2.

19 heast Asia that are genetically deficient in ALDH2.

20 ALDH2 protein in HeLa cell lines expressing ALDH2*1, ALDH2*2, or both were determined by the rate of

21 7 and is dominant over the wild-type allele, ALDH2*1.

22 ation in both wild-type and ALDH2-deficient, ALDH2*1/*2, heterozygotic knock-in mice.

23 tly, we have solved the crystal structure of ALDH2(*)2 complexed with coenzyme to 2.5A(.) We have als

24 ermediate between those of wild-type and the ALDH2(*)2 enzymes.

25 of structural integrity and low activity in ALDH2(*)2 even when complexed with coenzyme.

26 helix within the coenzyme binding pocket of ALDH2(*)2 is reordered, but the active site is only part

27 mitochondrial aldehyde dehydrogenase (ALDH2) ALDH2(*)2 polymorphism is associated with impaired ethan

28 Consistent with the structural data, ALDH2(*)2 showed a concentration-dependent increase in e

29 2 (ALDH2) alcohol flushing variant known as ALDH2*2 affects ~8% of the world's population.

30 These studies indicate that the ALDH2*2 allele exerts its dominant effect both by interf

31 c enzyme, results from inheriting one or two ALDH2*2 alleles.

32 ed as a preventative measure against CAD for ALDH2*2 carriers.

33 tion showed that human participants carrying ALDH2*2 exhibited impaired vasodilation after light alco

34 The ALDH2*2 gene encoding the inactive variant form of mitoc

35 ALDH2*2 has an increased Km for its coenzyme, NAD+, and

36 t on the enzyme activity, we now report that ALDH2*2 heterozygotes had lower levels of ALDH2 immunore

37 Together, our results suggest that ALDH2*2 induces EC dysfunction and that SGLT2i may poten

38 Studies in ALDH2*2 knock-in mice further demonstrated that empaglif

39 Further, we treated ALDH2*2 knock-in mice, a loss of ALDH2 function model, w

40 However, the contribution of ALDH2*2 to EC dysfunction and its relation to CAD are no

41 association study (GWAS) from Biobank Japan, ALDH2*2 was found to be one of the strongest single-nucl

42 ontrast to the missense variant ALDH2 rs671 (ALDH2*2), which is common only in East Asian populations

43 -1 was a particularly effective activator of ALDH2*2, an inactive mutant form of the enzyme that is f

44 A nearly inactive form of the enzyme, ALDH2*2, is found in about 40% of the East Asian populat

45 otein in HeLa cell lines expressing ALDH2*1, ALDH2*2, or both were determined by the rate of loss of

46 The ALDH2*2-encoded subunit (ALDH2K) reduces the activity of

47 al NO synthase (eNOS) pathways to ameliorate ALDH2*2-induced EC dysfunction.

48 r demonstrated that empagliflozin attenuated ALDH2*2-mediated vascular dysfunction in vivo.

49 ere we report the 2.1 A crystal structure of ALDH2*2.

50 in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2.

51 ucleotides (ASOs) can mimic the low-activity ALDH2-2 Asian phenotype.

52 mimic the protective effects afforded by the ALDH2-2 phenotype.

53 liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or a

54 vered highly ordered filament arrays of Ald4(ALDH2), a conserved aldehyde dehydrogenase that is highl

55 Aldehyde dehydrogenase 2 (ALDH2), a key enzyme for detoxification the ethanol meta

56 ncy in mitochondrial aldehyde dehydrogenase (ALDH2), a tetrameric enzyme, results from inheriting one

57 Pregnant mice lacking Aldh2, a key enzyme that detoxifies reactive aldehydes,

58 clude signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the dif

59 enes across different trait pairs, including ALDH2, ACAD10, TMEM116, SH2B3 (all at 12q24.12), TMED6 (

60 ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is t

61 eceptors, which triggers PKCepsilon-mediated ALDH2 activation in cardiac mast cells, contributing to

62 Furthermore, ALDH2 activation inhibited degranulation and renin relea

63 cardiac 4-HNE levels through pharmacological ALDH2 activation is sufficient to re-establish Dicer act

64 n HMC-1, and PKCepsilon inhibition prevented ALDH2 activation.

65 water-soluble, potent, and highly selective ALDH2 activator.

66 Thus, pharmacologic enhancement of ALDH2 activity may be useful for patients with wild-type

67 ion in liver ALDH2 mRNA, a 40% inhibition in ALDH2 activity, and a fourfold (P < 0.001) increase in c

68 hibit ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2 activity.

69 Mitochondrial aldehyde dehydrogenase (ALDH2) activity is produced at low levels in many tissue

70 liver mitochondrial aldehyde dehydrogenase (ALDH2) activity than do other people.

71 from each participant for genotyping at the ALDH2, ADH2, and ADH3 loci.

72 ight into the preventive role of oesophageal ALDH2 against acetaldehyde-derived DNA damage.

73 The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as ALDH2*2 affects

74 screen yielded a small-molecule activator of ALDH2 (Alda-1) that, when administered to rats before an

75 common mitochondrial aldehyde dehydrogenase (ALDH2) ALDH2(*)2 polymorphism is associated with impaire

76 problems associated with mutations of ALDH1, ALDH2, ALDH4, ALDH10 and succinic semialdehyde (SSDH) ge

77 mitochondrial aldehyde dehydrogenase type-2 (ALDH2) also mimicked and prevented, respectively, the ca

78 in alcohol metabolizing genes, for example, ALDH2 and ADH1B, are strongly associated with alcohol co

79 w that formaldehyde is a common substrate of ALDH2 and ADH5 and establish methods to quantify elevate

80 res protection by the detoxification enzymes ALDH2 and ADH5 and the Fanconi anemia (FA) DNA repair pa

81 ingle nucleotide polymorphism (SNP) rs671 in ALDH2 and alcohol drinker status (odd ratio (OR)=0.40, P

82 s encoding cytosolic ALDH1 and mitochondrial ALDH2 and ALDH5 were disrupted in the genome of strain T

83 activity and immunoblot results showed that ALDH2 and ATP synthase were also inhibited through oxida

84 pt ALDH16A1), including ABCG2, SLC2A9, GCKR, ALDH2 and CNIH2, were replicated.

85 our psoralen and coumarin derivatives toward ALDH2 and compared them to the ALDH2 inhibitor daidzin f

86 s, as measured by Aldefluor stain, is due to Aldh2 and correlates with this protection.

87 aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly shortened lifes

88 Consistent with our high-level calculations, ALDH2 and GAPDH, enzymes implicated in nitroglycerin bio

89 e the potency and selectivity for ALDH1A1 or ALDH2 and generate chemical probes to examine the unique

90 We found that Glu504Lys of ALDH2 and Glu4Gly of BRAP are involved in the negative r

91 ree-dimensional structures of wild-type (WT) ALDH2 and of a triple mutant of the protein that exhibit

92 stimation (utilizing interaction of rs671 in ALDH2 and sex as an instrument) strengthens causal infer

93 eruraria lobata), is a specific inhibitor of ALDH2 and suppresses ethanol consumption.

94 de clearance through ALDH2 by using global- (Aldh2 (-/-)) and tissue-specific Aldh2-deficient mice, a

95 dehyde dehydrogenase 2 (a protein encoded by ALDH2) and Glu4Gly of BRCA1-associated protein (a protei

96 The inactive aldehyde dehydrogenase (ALDH2) and the super-active alcohol dehydrogenase (ADH2)

97 exhibit differential inhibition of ALDH1A1, ALDH2, and ALDH3A1.

98 otes and six (GCKR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, and GOT2) in heterozygotes, with five showing gen

99 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIG

100 ated that DPI binds to the catalytic site of ALDH2, and this was confirmed by experiments showing sub

101 fic missense variant, rs671 (p.Glu457Lys) of ALDH2, and two traits including aspartate aminotransfera

102 tabolism, and ion channels, including SPTA1, ALDH2, ANK1, HK1, MAPKAPK5, AQP1, PIEZO1, and SLC4A1/ban

103 LPL, MYB, NXPH1, PER2, TNFA), gene-alcohol (ALDH2, APOA5, APOC3, CETP, LPL), gene-smoking (APOC3, CY

104 the gene encoding aldehyde dehydrogenase 2 (ALDH2) are at increased risk of cardiovascular disease (

105 Our data identify ALDH2 as highly sensitive target of DPI and explain inhi

106 e of a mitochondrial aldehyde dehydrogenase (ALDH2) as a model.

107 fied mitochondrial aldehyde dehydrogenase 2 (ALDH2) as an enzyme whose activation correlates with red

108 ysis with the aldehyde dehydrogenase 2 gene (ALDH2) as an instrumental variable to examine the associ

109 The inhibition of ALDH1 and activation of ALDH2 at pH 7.4 are due to their different rate-limiting

110 lude mitochondrial aldehyde dehydrogenase 2 (ALDH2), ATP synthase, acyl-CoA dehydrogenase, 3-ketoacyl

111 Selective deletion of PN ALDH2 blocked the LTP-related GABA enhancement and impai

112 ther study is needed to clarify the roles of ALDH2, BRAP and CUX2 in the liver-brain endocrine axis c

113 ssive alcohol consumption is associated with ALDH2, BRAP and CUX2.

114 ent organs in acetaldehyde clearance through ALDH2 by using global- (Aldh2 (-/-)) and tissue-specific

115 , acetaldehyde-catabolism-competent mothers (Aldh2(+/-)) can support the development of double-mutant

116 ve previously shown that a minor reaction of ALDH2-catalyzed GTN bioconversion, accounting for about

117 The present study demonstrates that ALDH2-catalyzed NO formation is necessary and sufficient

118 Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (gly

119 Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antiangin

120 Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antiangin

121 r isolated aortas with adenovirus containing ALDH2 cDNA with or without the mitochondrial signal pept

122 ng on the cofactor used, while mitochondrial ALDH2 contributed the rest.

123 SA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits

124 ion approach to correct for this bias in our ALDH2 data and, also, to explore the effect of bias on t

125 Glial cell- or neuron-specific Aldh2 deficiency did not affect voluntary alcohol consum

126 However, the role of ALDH2 deficiency in the pathogenesis of alcoholic liver

127 Moreover, ALDH2 deficiency was associated with kidney fibrosis inv

128 lar localization of ALDH2 using immortalized ALDH2-deficient aortic smooth muscle cells and mouse aor

129 Overexpression of ALDH2 in the cytosol of ALDH2-deficient aortic smooth muscle cells led to a sign

130 Infection of ALDH2-deficient aortic smooth muscle cells or isolated a

131 dent from causing hepatocyte death, and that ALDH2-deficient individuals may be resistant to steatosi

132 ng global- (Aldh2 (-/-)) and tissue-specific Aldh2-deficient mice, and to examine whether liver-speci

133 e ethanol intoxication in both wild-type and ALDH2-deficient, ALDH2*1/*2, heterozygotic knock-in mice

134 uch mutation is in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2.

135 ediated through an aldehyde dehydrogenase 2 (ALDH2)-dependent mechanism.

136 nce that the pattern of genetic variation at ALDH2 differs from that expected under a standard neutra

137 t Asian-specific missense variant (rs671) in ALDH2 displayed a significant association on chromosome

138 ts suggest that transgenic overexpression of ALDH2 effectively antagonizes chronic alcohol intake-eli

139 s missense variant leads to a severe loss of ALDH2 enzymatic activity and has been linked to an incre

140 60 million East Asians, resulting in reduced ALDH2 enzymatic activity.

141 Acquired ALDH2 enzyme deficiency within the respiratory tract in

142 ded subunit (ALDH2K) reduces the activity of ALDH2 enzyme in cell lines expressing the wild-type subu

143 ncy allele for the aldehyde dehydrogenase 2 (ALDH2) enzyme, a critical protein involved in the metabo

144 development and progression of CKD involving ALDH2, especially among East Asian populations.

145 ose from restriction enzyme digestion of the ALDH2 exon 12 functional polymorphism (Glu-487-Lys) in 1

146 vitro stimulation with IL-4/IL-13 decreased ALDH2 expression in EpC cultures.

147 ALDH2 expression was assessed in nasal scrapings from AE

148 uman and mouse kidneys and demonstrated that ALDH2 expression was significantly reduced, and that the

149 Remarkably, transferring Aldh2(-/-)Fanca(-/-) embryos into wild-type mothers supp

150 Here we report that aged Aldh2(-/-) Fancd2(-/-) mutant mice that do not develop l

151 the p53 response is vigorously activated in Aldh2(-/-)Fancd2(-/-) HSCs, while p53 deletion rescued t

152 Lastly, Aldh2(-/-)Fancd2(-/-) mice spontaneously develop acute l

153 an support the development of double-mutant (Aldh2(-/-)Fancd2(-/-)) mice.

154 reducing toxic aldehyde levels by activating ALDH2 for metabolic diseases.

155 nd not more mature blood precursors, require Aldh2 for protection against acetaldehyde toxicity.

156 glucose) and identified several cis-eGenes (ALDH2 for systolic and diastolic blood pressure, MCM6 an

157 taldehyde metabolism, a cumulative effect of ALDH2 from other organs likely also contributes to syste

158 we treated ALDH2*2 knock-in mice, a loss of ALDH2 function model, with aristolochic acid and found t

159 tely 40-50% of East Asians carry an inactive ALDH2 gene and exhibit acetaldehyde accumulation after a

160 Using a genetic variant in the ALDH2 gene associated with alcohol consumption, rs671, w

161 which is an important regulatory element of ALDH2 gene expression.

162 A missense Glu504Lys mutation of the ALDH2 gene is prevalent in 560 million East Asians, resu

163 We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the asso

164 s associated with the E2 isozyme (product of aldh2 gene) of aldehyde dehydrogenase.

165 ADH6, and ADH7 genes), 4 markers within the ALDH2 gene, and 38 unlinked ancestry-informative markers

166 d reductions in ALDH2 mRNA levels of 85% and ALDH2 (half-life of 22 h) activity of 55% equivalent to

167 Inhibition of ALDH2 has hence become a possible strategy to treat alco

168 ns with alcohol-metabolizing enzymes (ADH1B, ALDH2) have been replicated definitively.

169 ldh2 (-/-) mice, but moderately decreased in Aldh2 (Hep-/-) mice compared to controls.

170 mes from ethanol-containing bottles, whereas Aldh2 (Hep-/-) mice showed reduced alcohol preference at

171 evels in hepatocyte-specific Aldh2 knockout (Aldh2 (Hep-/-)) mice were significantly higher than thos

172 However, the ALDH2 hypothesis has not been reconciled with early stud

173 at ALDH2*2 heterozygotes had lower levels of ALDH2 immunoreactive protein in autopsy liver samples.

174 However, little is known about the role of ALDH2 in CKD.

175 The structure of daidzin/ALDH2 in complex at 2.4 A resolution shows the isoflavon

176 tection and the increased phosphorylation of ALDH2 in females, but had no effect in males.

177 ovide new evidence for the essential role of ALDH2 in GTN bioactivation and may have implications to

178 This data indicates a potential key role of ALDH2 in influencing acrolein levels, oxidative stress,

179 , we characterized the expression pattern of ALDH2 in normal and CKD human and mouse kidneys and demo

180 Overexpression of ALDH2 in the cytosol of ALDH2-deficient aortic smooth mu

181 , but the generation and functional roles of ALDH2 in the oesophagus remain elusive.

182 Several SNPs that function as eQTLs for ALDH2 in various tissues showed evidence of strong posit

183 of the function of aldehyde dehydrogenase 2 (ALDH2) in EAE mice using either a pharmacological or gen

184 flanking the aldehyde dehydrogenase 2 locus, ALDH2, in populations of Japanese alcoholics and control

185 one or two copies of the G allele in rs671 (ALDH2) increased the risk of excessive alcohol consumpti

186 t eliminates acetaldehyde, and impairment of ALDH2 increases the risk of ESCC.

187 Liver-targeted ALDH2 inhibition can decrease heavy drinking without aff

188 mice, and to examine whether liver-specific ALDH2 inhibition can prevent alcohol-seeking behavior.

189 atives toward ALDH2 and compared them to the ALDH2 inhibitor daidzin for selectivity against five ALD

190 Disulfiram, a potent ALDH2 inhibitor, is an approved drug for the treatment o

191 iram (DSF) a known aldehyde dehydrogenase 2 (ALDH2) inhibitor.

192 Accordingly, established ALDH2 inhibitors attenuate GTN-induced vasorelaxation in

193 ALDH2 is a key enzyme in alcohol metabolism that protect

194 ALDH2 is a major enzyme responsible for 4-HNE removal.

195 In this context, ALDH2 is essential for functional skeletal muscle mainte

196 e intact maternal aldehyde catabolism, fetal Aldh2 is essential for hematopoiesis.

197 ow that the acetaldehyde-catabolising enzyme Aldh2 is essential for the development of Fancd2(-/-) em

198 Quantitative Western blotting revealed that ALDH2 is mainly cytosolic in mouse aorta and human coron

199 ALDH2 is produced in various tissues including the liver

200 The homotetramer (ALDH1 or ALDH2) is a dimer of dimers (A-B + C-D).

201 Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that eliminates acetaldehyde, and

202 Aldehyde dehydrogenase 2 (ALDH2) is an essential detoxifying enzyme for exogenous

203 Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme that metabolizes acetaldehyde

204 Mitochondrial aldehyde dehydrogenase (ALDH2) is the major enzyme that oxidizes ethanol-derived

205 Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme responsible for counteracti

206 n against ALDH1A1 over ALDH3A1, ALDH1B1, and ALDH2 isozymes as well as other dehydrogenases such as H

207 uding compound 36, a selective inhibitor for ALDH2 (Ki = 2.4 muM), and compound 32, which was 10-fold

208 es of the brown adipose tissue from the male Aldh2 knock-in mice identifies increased 4-hydroxynonena

209 Finally, specific liver Aldh2 knockdown via injection of shAldh2 markedly decrea

210 both Aldh2-knockout mouse keratinocytes and ALDH2-knockdown human keratinocytes treated with acetald

211 Acetaldehyde levels in hepatocyte-specific Aldh2 knockout (Aldh2 (Hep-/-)) mice were significantly

212 inactivation of aldehyde catabolism (through Aldh2 knockout) and the Fanconi anaemia DNA-repair pathw

213 xyguanosine were higher in the oesophagus of Aldh2-knockout mice than in wild-type mice upon ethanol

214 e-2'-deoxyguanosine levels increased in both Aldh2-knockout mouse keratinocytes and ALDH2-knockdown h

215 context, interventions capable of increasing ALDH2 levels and/or activity are considered promising th

216 m) and mitochondrial aldehyde dehydrogenase (ALDH2, low Km) in Escherichia coli and purified the enzy

217 control populations would have detected the ALDH2 marker as a putative QTL.

218 Wild-type FVB and ALDH2 mice were placed on a 4% alcohol diet or a control

219 paradigm and the drinking-in-the-dark model, Aldh2 (-/-) mice drank negligible volumes from ethanol-c

220 Aldh2 (-/-) mice showed markedly higher acetaldehyde con

221 e and motility were dramatically dampened in Aldh2 (-/-) mice, but moderately decreased in Aldh2 (Hep

222 ge, but did not reach the levels observed in Aldh2 (-/-) mice.

223 anol-treated precision-cut liver slices from ALDH2(-/-) mice and in Kupffer cells isolated from ethan

224 ALDH2(-/-) mice are resistant to ethanol-induced steatos

225 Compared with wild-type mice, ethanol-fed ALDH2(-/-) mice had higher levels of malondialdehyde-ace

226 cription 3 (STAT3) was higher in ethanol-fed ALDH2(-/-) mice than in wild-type mice.

227 d in Kupffer cells isolated from ethanol-fed ALDH2(-/-) mice than those levels in wild-type mice.

228 Finally, ethanol-fed ALDH2(-/-) mice were more prone to CCl4 -induced liver i

229 In the present study, wild-type and ALDH2(-/-) mice were subjected to ethanol feeding and/or

230 eased steatosis and hepatocellular damage in ALDH2(-/-) mice.

231 oligonucleotide (ASO-9) showed reductions in ALDH2 mRNA levels of 85% and ALDH2 (half-life of 22 h) a

232 Although the content of ALDH2 mRNA was decreased after BT-474 cell treatment wit

233 to rats resulted in a 50% reduction in liver ALDH2 mRNA, a 40% inhibition in ALDH2 activity, and a fo

234 lar smooth muscle cells (VSMC) expressing an ALDH2 mutant that reduces GTN to NO but lacks clearance-

235 r the KCNQ1 (rs2237892, P = 9.29 x 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 x 10(-11); rs12229654, P = 4

236 elihood from genotypes at six closely linked ALDH2 nucleotide substitutions.

237 The F statistic was 77 for ALDH2 on alcohol use, suggesting little weak-instrument

238 some 4) and one aldehyde dehydrogenase gene (ALDH2 on chromosome 12) exhibit functional polymorphisms

239 prior studies reported effects of ADH1B and ALDH2 on lifetime measures, such as risk of alcohol depe

240 overexpression of aldehyde dehydrogenase-2 (ALDH2) on chronic alcohol ingestion-induced myocardial d

241 Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes th

242 udies published in the last decade show that ALDH2 overexpression downregulates atrophic genes; meanw

243 However, ALDH2 overexpression protected proximal tubule epithelia

244 sphorylation regulates context-specific Ald4(ALDH2) polymerization.

245 which is due to an alcohol dehydrogenase 2 (ALDH2) polymorphism that leads to impaired alcohol metab

246 sociations exist between the ADH2, ADH3, and ALDH2 polymorphisms and alcohol dependence in a group of

247 ldehyde, an alcohol catabolite detoxified by ALDH2, precipitates similar effects.

248 periments revealed that acetaldehyde induced ALDH2 production in both mouse and human oesophageal ker

249 e, we report that ethanol drinking increased ALDH2 production in the oesophagus of wild-type mice.

250 decreased transcriptional activity from the ALDH2 promoter approximately 50% in reporter gene assays

251 lete linkage disequilibrium with the derived ALDH2 promoter variant rs886205, which is associated wit

252 Thus, the proximal ALDH2 promoter was bound by NF-Y/CP1 and this transcript

253 orm of mitochondrial aldehyde dehydrogenase (ALDH2) protects nearly all carriers of this gene from al

254 Nasal polyp ALDH2 protein and nasal EpC ALDH2 transcripts were lower

255 ALDH2 protein and transcript were measured in surgically

256 The half-lives of ALDH2 protein in HeLa cell lines expressing ALDH2*1, ALD

257 d aldehyde adducts, and that an activator of ALDH2 reduced I/R injury in males but had no significant

258 ALDH2 reduced the chronic alcohol ingestion-induced elev

259 tructures of the triple mutant and wild-type ALDH2 reflect binding of GTN to the catalytic site and t

260 and may have implications to other fields of ALDH2 research, such as hepatic ethanol metabolism and c

261 Cytosolic overexpression of ALDH2 restored GTN-induced relaxation and GTN denitratio

262 Thus, we hypothesize that ALDH2 restores 4HNE-induced downregulation of APN signal

263 C expressing either wild-type or C301S/C303S ALDH2 resulted in pronounced intracellular NO elevation,

264 In contrast to the missense variant ALDH2 rs671 (ALDH2*2), which is common only in East Asia

265 s pathway may explain how subjects harboring ALDH2 rs671 are at a greater risk for numerous other dis

266 xperiments that reveal a pathway wherein the ALDH2 rs671 mutant is phosphorylated by AMPK and translo

267 pecific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major genetic determinant of al

268 results were maintained when controlling for ALDH2 (rs671) and ADH1B (rs1229984) markers and when exa

269 In men, ALDH2-rs671 and ADH1B-rs1229984 genotypes predicted 60-f

270 two variants that alter alcohol metabolism, ALDH2-rs671 and ADH1B-rs1229984.

271 ths among 168 050 participants genotyped for ALDH2-rs671 and ADH1B-rs1229984.

272 ng to have a structure very similar to human ALDH2, scallop Omega-crystallin was enzymatically inacti

273 Conversely, forced production of ALDH2 sharply diminished the N(2)-ethylidene-2'-deoxygua

274 When given together with the ALDH2-specific activator, Alda-1, Alda-89 reduced acetal

275 0(3) s-1 M-1 ALDH1-sulfone, ALDH1-sulfoxide, ALDH2-sulfone, and ALDH2-sulfoxide, respectively.

276 sulfone, ALDH1-sulfoxide, ALDH2-sulfone, and ALDH2-sulfoxide, respectively.

277 ty of 55% equivalent to a >90% inhibition in ALDH2 synthesis.

278 nking, providing molecular basis for hepatic ALDH2 targeting/editing for the treatment of AUD.

279 In ALDH2, the 3-keto group is surrounded by the adjacent Cy

280 gate the causes of linkage disequilibrium in ALDH2, the gene that encodes aldehyde dehydrogenase 2.

281 cigarettes per day (EPHX2-CLU, RET and CUX2-ALDH2), three loci associated with smoking initiation (D

282 liver mitochondrial aldehyde dehydrogenase (ALDH2) to change from deacylation to hydride transfer.

283 of IL-4Ralpha with dupilumab increased nasal ALDH2 transcript.

284 Nasal polyp ALDH2 protein and nasal EpC ALDH2 transcripts were lower in AERD patients than in as

285 In addition, the ALDH2 transgene significantly attenuated chronic alcohol

286 METHODS AND ALDH2 transgenic mice were produced with the chicken bet

287 affected by the subcellular localization of ALDH2 using immortalized ALDH2-deficient aortic smooth m

288 n of mitochondrial aldehyde dehydrogenase 2 (ALDH2) using Alda-1 or its improved orally bioavailable

289 ALDH2 was not significantly protected from inactivation

290 The commercial ALDH (designated ALDH2) was partially sequenced and appears to be a mitoc

291 In the absence of Aldh2, we find that purines are the metabolic end produc

292 es and diplotypes of ADH1A, ADH1B, ADH7, and ALDH2 were associated with AD in European Americans and/

293 Notably, PKCepsilon and ALDH2 were both activated by A(2b)/A(3) receptor stimula

294 the esterase and dehydrogenase activities of ALDH2 were inhibited to the same extent by MeDTC sulfone

295 overed loci, four (GCKR, ADH1B, ALDH1A1, and ALDH2) were suggested to interact with rs671 in the risk

296 o solved the structures of a mutated form of ALDH2 where Arg-475 is replaced by Gln (R475Q).

297 useful for patients with wild-type or mutant ALDH2 who are subjected to cardiac ischemia, such as dur

298 nd improves glucose homeostasis in both male Aldh2 wild-type and knock-in mice.

299 leles at the CHRNA3-CHRNA5 locus, ADH1B, and ALDH2 with respect to phenotypic traits related to anthr

300 ociations of genetic variants (e.g. rs671 in ALDH2) with such risk factors in women - who drank littl

301 human mitochondrial aldehyde dehydrogenase (ALDH2) yielded an unexpected result: the chemically reas