ライフサイエンスコーパス: AMP kinase

1 that PP2A(Ppp2r2d) directly interacted with AMP kinase.

2 2 muscle was ATP-deficient and had activated AMP kinase.

3 driven by activation of the metabolic sensor AMP kinase.

4 ted by glucose-6-phosphate dehydrogenase and AMP kinase.

5 yl-CoA carboxylase, an established target of AMP kinase.

6 activity was dependent on the activation of AMP kinase.

7 of a transcriptional component regulated by AMP-kinase.

8 riptional coactivator p300 is a substrate of AMP-kinase.

9 ivated protein, and adenosine monophosphate (AMP) kinase.

10 S-1 in axon regrowth is the metabolic sensor AMP kinase, AAK-2.

11 hanisms by which p53 regulates mTOR involves AMP kinase activation and requires the tuberous sclerosi

12 phorylated Connexin 43 (Cx43) isoform P0 and AMP kinase activation by Western blotting and immunostai

13 d ROS, which is maintained by a feed-forward AMP kinase activation cascade, is reduced in diabetes an

14 the effects of adiponectin are mediated via AMP kinase activation in liver and skeletal muscle, the

15 Inhibition of AMP kinase activation using two pharmacological inhibito

16 is by extracellular flux analysis, increased AMP kinase activation, reduced mTOR activity, and increa

17 nduced autophagy and autophagic flux through AMP kinase activation.

18 horylation occurred without ATP depletion or AMP kinase activation.

19 e remote myocardium, possibly as a result of AMP kinase activation.

20 e-4-carboxamide ribonucleoside (AICAR), a 5'-AMP kinase activator, rapidly lowers malonyl-CoA both in

21 -ribofuranoside (AICAR) is widely used as an AMP-kinase activator, which regulates energy homeostasis

22 to impaired protein kinase C-zeta/lambda and AMP-kinase activities in striated muscle.

23 xidation in tissue suspensions and increased AMP kinase activity in dissected tissues.

24 nsistent with the possibility that increased AMP kinase activity in low glucose stimulates EF-2 kinas

25 also exhibit increased insulin signaling and AMP kinase activity in the liver.

26 AMP kinase activity in the remote region was significant

27 AMP kinase activity is regulated by phosphorylation, and

28 hus, PP2A(Ppp2r2d) may antagonize the aortic AMP kinase activity necessary for maintaining normal aor

29 gramming of skeletal muscle (i.e., increased AMP kinase activity, beta-oxidation and -uncoupling, and

30 Hepatic AMP-kinase activity was reduced but expression of Pepck

31 does not decrease phosphorylation levels of AMP kinase alpha (AMPKalpha).

32 me encodes five UMKs and three belong to the AMP KINASE (AMK)-like UMKs, which were characterized to

33 of this study was to examine the effects of AMP kinase (AMPK) activation on in vivo glucose and long

34 This study tests the hypothesis that AMP kinase (AMPK) activation with metformin directly imp

35 BPA resulted in intracellular energy sensor AMP kinase (AMPK) activation, increased phosphorylation

36 Reduced AMP kinase (AMPK) activity has been shown to play a key

37 Although metformin is a known inducer of AMP kinase (AMPK) activity, the hepatoprotective propert

38 active oxygen species-mediated activation of AMP kinase (AMPK) and the nuclear transcription factor E

39 nse and detected nominal interactions in the AMP kinase (AMPK) gene STK11, the AMPK subunit genes PRK

40 Here, we show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor

41 and empirical evidence, we demonstrate that AMP kinase (AMPK) is also an important regulator of syna

42 rheostats mammalian target of rapamycin and AMP kinase (AMPK) that recycles damaged or unused protei

43 ed macrophages was restored by activation of AMP kinase (AMPK), a central host metabolic regulator kn

44 increased activation of the metabolic sensor AMP kinase (AMPK), and increased expression of the AMPK-

45 to decreases in ATP:AMP ratio, activation of AMP Kinase (AMPK), and increased GDF15 production.

46 Overexpression of dominant-negative AMP kinase (AMPK), but not dominant-negative p38 MAPK, r

47 the treatment of type 2 diabetes, activates AMP kinase (AMPK), which negatively regulates mTOR.

48 The AMP kinase (AMPK)-activator AICAR (5-aminoimidazole-4-ca

49 titative PCR (qPCR) analyses to identify the AMP kinase (AMPK)-related kinase NUAK2 as a candidate ge

50 s depend on metformin-mediated activation of AMP kinase (AMPK).

51 gliflozin reduced NADPH oxidase activity via AMP kinase (AMPK)/Rac1signalling and improved NOS coupli

52 tabolite-induced chromatin accessibility and AMP-kinase (AMPK) signaling.

53 og of AMP, is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the response

54 the authors presented recent advances on 1) AMP kinase, an intracellular energy sensor; 2) PGC-1alph

55 tently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of

56 t with the suppression of phosphorylation of AMP kinase and acetyl-CoA carboxylase.

57 Suppression of AMP kinase and activation of mammalian target of rapamyc

58 e or affecting markers of NAD+ metabolism or AMP kinase and mTOR signaling.

59 AMP kinase and p38 activities were elevated.

60 thylation causes ROS-dependent activation of AMP kinase and the proapoptotic nuclear transcription fa

61 lmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1.

62 n unexpected link among myristic acid, CD36, AMP kinase, and eNOS activity.

63 tal kinase mechanisms that govern cell fate, AMP kinase, and Jun kinase.

64 use of cells near blood vessels), activating AMP kinase, and regulating the relationship between cere

65 in endothelial cells that include the Nrf2, AMP kinase, and tight junction pathways.

66 NAs/proteins and inactive non-phosphorylated AMP kinase; and down-regulated silence regulator gene 1

67 r2d), regulates the phosphorylation state of AMP kinase by dephosphorylating Thr-172, a residue that

68 ntidiabetic drug phenformin, which activates AMP kinase, can promote axon regrowth.

69 Assays for actin, AMP-kinase, carbonic anhydrase, and lysozyme are shown t

70 protein, mTOR proteins RAPTOR and P70S6, the AMP-kinase catalytic subunit AMPKA, the IEG proteins FBJ

71 s phosphorylation/activation of hypothalamic AMP kinase causing phosphorylation/inactivation of acety

72 NF4Agamma, encoding the gamma subunit of the AMP Kinase complex.

73 the RNA-binding protein, HU antigen R, in an AMP kinase-dependent manner and stabilizes BRCA1 mRNA.

74 Cellular AMP kinase-dependent protein kinase activity provokes th

75 Phosphorylation of p300 at serine 89 by AMP-kinase dramatically reduced its interaction, in vitr

76 inases, including protein kinase A (PKA) and AMP kinase have also shown to phosphorylate eNOS-S(1179)

77 Snf1, the yeast AMP kinase homolog, is essential for derepression of glu

78 Also, the AMP kinase homologue, Snf1, and 14-3-3 proteins have bee

79 tyl CoA carboxylase, an enzyme downstream of AMP kinase in adipose cells.

80 ed, and osmotin, like adiponectin, activates AMP kinase in C2C12 myocytes via adiponectin receptors.

81 function for an S6 kinase acting through an AMP kinase in regenerative growth of injured axons.

82 phosphorylation/dephosphorylation of ACC by AMP kinase in response to changes in the AMP/ATP ratio,

83 , making it available for phosphorylation by AMP kinase in response to energy stress.

84 reduced ERK1/2 activation and stimulation of AMP kinase in skeletal muscle from smPit1(-/-); smPit2(-

85 sor and cellular energy sensor kinase, in an AMP kinase-independent manner.

86 These effects may be mediated by AMP kinase-induced fat oxidation, leading to reduced int

87 of Sestrin 1 and 2 genes, and stimulation of AMP kinase, inhibiting mTOR and hypophosphorylating 4E-B

88 AMP kinase is a heterotrimeric serine/threonine protein

89 ted by globular adiponectin, indicating that AMP kinase is integrally involved in the adiponectin sig

90 onal signaling pathways--involving Sirtuins, AMP kinase, Jun N-terminal kinase 1, and other master re

91 ha,beta-unsaturated carbonyls, inhibited the AMP-kinase kinase activity of cellular LKB1.

92 tion through AMP-activated protein kinase as AMP kinase knockout or inhibition by Compound C offset t

93 ses food intake mediated by the hypothalamic AMP-kinase/malonyl-CoA signaling system.

94 eolar RNA (snoRNA)-activated PARP-1 inhibits AMP kinase-mediated phosphorylation of adjacent H2B-Ser3

95 de phosphate oxidase activity, by preventing AMP kinase-mediated translocation of Rac1 and p47(phox)

96 metabolic enzymes, it has been proposed that AMP-kinase might also regulate gene expression.

97 AMP-activated protein kinase (AMP-kinase) modulates many metabolic processes in respon

98 eta-4-ribonucleoside (AICAR; an activator of AMP kinase), or glucose plus rapamycin into the dorsal h

99 dies with another pharmacological agent, the AMP kinase pan-activator, MK-8722.

100 s attenuated signals throughout the LKB1 --> AMP kinase pathway and disrupted its restraint of riboso

101 ed ATP generation, lactate accumulation, and AMP kinase phosphorylation with reduced cell proliferati

102 d genes as the serine/threonine kinase (SNF1/AMP kinase-related kinase (SNARK)), which is induced in

103 Inhibiting PP2A(Ppp2r2d) or activating AMP kinase represents a potential pharmacological treatm

104 the cell surface, induces constant cAMP and AMP kinase signaling at maximal amplitude, abolishes des

105 These findings indicate that the AMP-kinase signaling pathway selectively modulates a sub

106 carboxamide (AICA) riboside, a stimulator of AMP kinase, significantly inhibited glucose-mediated act

107 overed that Std1, the activator of the yeast AMP kinase Snf1, condensates into granules to tune Snf1

108 n response to glucose limitation, as did the AMP kinase Snf1.

109 yl-CoA-dehydrogenase, Sirtuin 6 (SIRT6), and AMP kinase subunit-alpha.

110 as of mice fed a high fat diet had decreased AMP kinase Thr-172 phosphorylation, and contained an Amp

111 gical activation of adenosine monophosphate (AMP)-kinase using 5-aminoimidazole-4-carboxamide-1-b-D-r

112 addition, the active phosphorylated form of AMP kinase was significantly increased in Atp7b (-/-) mi

113 crotubule hyperacetylation by activating the AMP kinase, which in turn mediates MEC-17 phosphorylatio

114 nished cellular metabolism and activation of AMP kinase, which induces AMPK/mammalian target of rapam